ApoList – October 2019


Bcl-2 family proteins


Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies – Romain Guièze, Vivian M. Liu, Daniel Rosebrock, Alexis A. Jourdain, María Hernández-Sánchez, Aina Martinez Zurita, Jing Sun, Elisa Ten Hacken, Kaitlyn Baranowski, Philip A. Thompson, Jin-Mi Heo, Zachary Cartun, Ozan Aygün, J. Bryan Iorgulescu, Wandi Zhang, Giulia Notarangelo, Dimitri Livitz, Shuqiang Li, Matthew S. Davids, Anat Biran, Stacey M. Fernandes, Jennifer R. Brown, Ana Lako, Zoe B. Ciantra, Matthew A. Lawlor, Derin B. Keskin, Namrata D. Udeshi, William G. Wierda, Kenneth J. Livak, Anthony G. Letai, Donna Neuberg, J. Wade Harper, Steven A. Carr, Federica Piccioni, Christopher J. Ott, Ignaty Leshchiner, Cory M. Johannessen, John Doench, Vamsi K. Mootha, Gad Getz, Catherine J. Wu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30373-3

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide – Abbas Hadji, Greta K. Schmitt, Mathew R. Schnorenberg, Lauren Roach, Connie M. Hickey, Logan B. Leak, Matthew V. Tirrell and James L. LaBelle. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27262&path[]=87960

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1 – Steven P. O’Hara, Patrick L. Splinter, Christy E. Trussoni, E. Guicciardi, Noah P. Splinter, Mohammed S. Al Suraih, Navine Nasser-Ghodsi, Deborah Stollenwerk, Gregory J. Gores and Nicholas F. LaRusso. http://www.jbc.org/content/early/2019/10/28/jbc.RA119.010176.abstract


Death receptors, caspases and IAPs


Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins – Alexandre Desroches and Jean-Bernard Denault. https://www.pnas.org/content/116/43/21521.abstract?etoc

Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development – Xueqing Liu, Veronica Castle and Teruko Taketo. https://www.nature.com/articles/s41419-019-2019-x

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV− and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy – Roy Xiao, Yi An, Wenda Ye, Adeeb Derakhshan, Hui Cheng, Xinping Yang, Clint Allen, Zhong Chen, Nicole C. Schmitt and Carter Van Waes. https://clincancerres.aacrjournals.org/content/25/21/6463

Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Regulates Deubiquitinase USP5 In Tumor Cells – Harish Potu, Malathi Kandarpa, Luke F. Peterson, Nicholas J. Donato and Moshe Talpaz. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27196&path[]=87593


Necroptosis


Pannexin‐1 limits the production of proinflammatory cytokines during necroptosis – Tiphaine Douanne, Gwennan André‐Grégoire, Kilian Trillet, An Thys, Antonin Papin, Magalie Feyeux, Philippe Hulin, David Chiron, Julie Gavard, Nicolas Bidère. https://www.embopress.org/doi/abs/10.15252/embr.201947840


Ferroptosis


FSP1 is a glutathione-independent ferroptosis suppressor – Sebastian Doll, Florencio Porto Freitas, Ron Shah, Maceler Aldrovandi, Milene Costa da Silva, Irina Ingold, Andrea Goya Grocin, Thamara Nishida Xavier da Silva, Elena Panzilius, Christina Scheel, André Mourão, Katalin Buday, Mami Sato, Jonas Wanninger, Thibaut Vignane, Vaishnavi Mohana, Markus Rehberg, Andrew Flatley, Aloys Schepers, Andreas Kurz, Daniel White, Markus Sauer, Michael Sattler, Edward William Tate, Werner Schmitz, Almut Schulze, Valerie O’Donnel, Bettina Proneth, Grzegorz M. Popowicz, Derek Pratt, José Pedro Friedmann Angeli and Marcus Conrad. https://www.nature.com/articles/s41586-019-1707-0

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis – Kirill Bersuker, Joseph Hendricks, Zhipeng Li, Leslie Magtanong, Breanna Ford, Peter H. Tang, Melissa A. Roberts, Bingqi Tong, Thomas J. Maimone, Roberto Zoncu, Michael C. Bassik, Daniel K. Nomura, Scott J. Dixon and James A. Olzmann. https://www.nature.com/articles/s41586-019-1705-2

Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis – Alexia Belavgeni, Stefan R. Bornstein, Anne von Mässenhausen, Wulf Tonnus, Julian Stumpf, Claudia Meyer, Evelyn Othmar, Markus Latk, Waldemar Kanczkowski, Matthias Kroiss, Constanze Hantel, Christian Hugo, Martin Fassnacht, Christian G. Ziegler, Andrew V. Schally, Nils P. Krone and Andreas Linkermann. https://www.pnas.org/content/116/44/22269.abstract?etoc

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion – Yang Li, Dongcheng Feng, Zhanyu Wang, Yan Zhao, Ruimin Sun, Donghai Tian, Deshun Liu, Feng Zhang, Shili Ning, Jihong Yao and Xiaofeng Tian. https://www.nature.com/articles/s41418-019-0299-4

Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death – Lia Tesfay, Bibbin T. Paul, Anna Konstorum, Zhiyong Deng, Anderson O. Cox, Jingyun Lee, Cristina M. Furdui, Poornima Hegde, Frank M. Torti and Suzy V. Torti. https://cancerres.aacrjournals.org/content/79/20/5355

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis – Tian-Xiang Wang, Jun-Yun Liang, Cheng Zhang, Yue Xiong, Kun-Liang Guan and Hai-Xin Yuan. https://www.nature.com/articles/s41419-019-1984-4


Efferocytosis


Resolution metabolomes activated by hypoxic environment – Paul C. Norris, Stephania Libreros and Charles N. Serhan. https://advances.sciencemag.org/content/5/10/eaax4895

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization – Claudia M. Rival, Wenhao Xu, Laura S. Shankman, Sho Morioka, Sanja Arandjelovic, Chang Sup Lee, Karen M. Wheeler, Ryan P. Smith, Lisa B. Haney, Brant E. Isakson, Scott Purcell, Jeffrey J. Lysiak and Kodi S. Ravichandran. https://www.nature.com/articles/s41467-019-12406-z


Phagoptosis, entosis etc


Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development – Jingyi Gong, Thomas N. Gaitanos, Olivia Luu, Yunyun Huang, Louise Gaitanos, Jana Lindner, Rudolf Winklbauer and Rüdiger Klein. http://jcb.rupress.org/content/218/10/3455?etoc

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival – Crystal A. Tonnessen-Murray, Wesley D. Frey, Sonia G. Rao, Ashkan Shahbandi, Nathan A. Ungerleider, Joy O. Olayiwola, Lucas B. Murray, Benjamin T. Vinson, Douglas B. Chrisey, Christopher J. Lord, James G. Jackson. http://jcb.rupress.org/content/early/2019/09/16/jcb.201904051


Natural killers


Extracellular NK histones promote immune cell anti-tumor activity by inducing cell clusters through binding to CD138 receptor – Beatriz Martín-Antonio, G. Suñe, A. Najjar, L. Perez-Amill, A. Antoñana-Vildosola, M. Castella, S. León, M. Velasco-de Andrés, F. Lozano, E. Lozano, C. Bueno, J. M. Estanyol, C. Muñoz-Pinedo, S. N. Robinson and A. Urbano-Ispizua. https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0739-1

The Mechanism of Anti–PD-L1 Antibody Efficacy against PD-L1–Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic Effector – Wenjuan Dong, Xiaojin Wu, Shoubao Ma, Yufeng Wang, Ansel P. Nalin, Zheng Zhu, Jianying Zhang, Don M. Benson, Kai He, Michael A. Caligiuri and Jianhua Yu. https://cancerdiscovery.aacrjournals.org/content/9/10/1422


Miscellanous


Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity – Hasini A. Kalpage, Asmita Vaishnav, Jenney Liu, Ashwathy Varughese, Junmei Wan, Alice A. Turner, Qinqin Ji, Matthew P. Zurek, Alexandr A. Kapralov, Valerian E. Kagan, Joseph S. Brunzelle, Maurice-Andre Recanati, Lawrence I. Grossman, Thomas H. Sanderson, Icksoo Lee, Arthur R. Salomon, Brian F. P. Edwards and Maik Hüttemann. https://www.fasebj.org/doi/abs/10.1096/fj.201901120R

Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses – Oleg Timofeev, Boris Klimovich, Jean Schneikert, Michael Wanzel, Evangelos Pavlakis, Julia Noll, Samet Mutlu, Sabrina Elmshäuser, Andrea Nist, Marco Mernberger, Boris Lamp, Ulrich Wenig, Alexander Brobeil, Stefan Gattenlöhner, Kernt Köhler, Thorsten Stiewe. https://www.embopress.org/doi/full/10.15252/embj.2019102096

Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma – Jinkyu Jung, Ying Zhang, Orieta Celiku, Wei Zhang, Hua Song, Brian J. Williams, Amber J. Giles, Jeremy N. Rich, Roger Abounader, Mark R. Gilbert and Deric M. Park. https://cancerres.aacrjournals.org/content/79/20/5218

Cell Competition Is Driven by Autophagy – Rina Nagata, Mai Nakamura, Yuya Sanaki, Tatsushi Igaki. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30701-4


Reviews


The Diversification of Cell Death and Immunity: Memento Mori – Arnaud J. Legrand, Maria Konstantinou, Emily F. Goode, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30691-4

Perspective: The Incomplete Puzzle of the BCL2 Proteins – Hector Flores-Romero and Ana J. García-Sáez. https://www.mdpi.com/2073-4409/8/10/1176


Comments


Senescent cells feed on their neighbours – Michael Overholtzer. https://www.nature.com/articles/d41586-019-03271-3

A powerful cell-protection system prevents cell death by ferroptosis – Brent R. Stockwell. https://www.nature.com/articles/d41586-019-03145-8

p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill – James J Manfredi. https://www.embopress.org/doi/abs/10.15252/embj.2019103322

Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives – Michele Carbone and Gerry Melino. https://cancerres.aacrjournals.org/content/79/20/5149

Cell Competition Triggers Suicide by Autophagy – Caroline Dillard, Tor Erik Rusten. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30770-1

Eph receptors and ephrins engage in cellular cannibalism – Elena B. Pasquale. http://jcb.rupress.org/content/218/10/3168?etoc

Apoptotic Caspases: A Double-Edged Sword in Radiation-Induced Immunogenicity – Mara De Martino, Claire Vanpouille-Box. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30159-X

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