ApoList – September 2019

Death receptors

NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing – Isabel Prager, Clarissa Liesche, Hanna van Ooijen, Doris Urlaub, Quentin Verron, Niklas Sandström, Frank Fasbender,  Maren Claus, Roland Eils, Joël Beaudouin, Björn Önfelt, Carsten Watzl. http://jem.rupress.org/content/216/9/2113?etoc

TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP – Janin Knop, Lisanne M. Spilgies, Stefanie Rufli, Ramona Reinhart, Lazaros Vasilikos, Monica Yabal, Erika Crowley, Philipp J. Jost, Rebecca A. Marsh, Harald Wajant, Mark D. Robinson, Thomas Kaufmann and W. Wei-Lynn Wong. https://www.nature.com/articles/s41419-019-1938-x

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms – Dario Priem, Michael Devos, Sarah Druwé, Arne Martens, Karolina Slowicka, Adrian T. Ting, Manolis Pasparakis, Wim Declerq, Peter Vandenabeele, Geert van Loo and Mathieu J. M. Bertrand. https://www.nature.com/articles/s41419-019-1937-y

The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain–Fas-associated death domain interaction – Sophia Koutsogiannaki, Lifei Hou, Hasan Babazada, Toshiaki Okuno, Nathan Blazon-Brown, Sulpicio G. Soriano, Takehiko Yokomizo and Koichi Yuki. https://www.fasebj.org/doi/abs/10.1096/fj.201901360R?ai=ts&ui=ly8&af=T

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform – Matveeva A, Fichtner M, McAllister K, McCann C, Sturrock M, Longley DB, Prehn JHM. https://www.ncbi.nlm.nih.gov/pubmed/31553717


Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis – Kim Newton, Katherine E. Wickliffe, Debra L. Dugger, Allie Maltzman, Merone Roose-Girma, Monika Dohse, László Kőműves, Joshua D. Webster and Vishva M. Dixit. https://www.nature.com/articles/s41586-019-1548-x

Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis – Rajni Kumari, Ruhi S. Deshmukh and Sanjeev Das. https://www.nature.com/articles/s41467-019-12194-6

Salvador–Warts–Hippo pathway regulates sensory organ development via caspase-dependent nonapoptotic signaling – Lan-Hsin Wang and Nicholas E. Baker. https://www.nature.com/articles/s41419-019-1924-3


Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3 – Emma J. Petrie, Jarrod J. Sandow, Wil I.L. Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N. Young, Wilhelmus J.A. Kersten, Cheree Fitzgibbon, André L. Samson, Annette V. Jacobsen, Kym N. Lowes, Amanda E. Au, Hélène Jousset Sabroux, Najoua Lalaoui, Andrew I. Webb, Guillaume Lessene, Gerard Manning, Isabelle S. Lucet, James M. Murphy. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31103-9

TAK1 regulates endothelial cell necroptosis and tumor metastasis – Lida Yang, Sayali Joseph, Tianliang Sun, Julia Hoffmann, Sophia Thevissen, Stefan Offermanns and Boris Strilic. https://www.nature.com/articles/s41418-018-0271-8

Cell cycle arrest in mitosis promotes interferon-induced necroptosis – Tanja Frank, Marcel Tuppi, Manuela Hugle, Volker Dötsch, Sjoerd J. L. van Wijk and Simone Fulda. https://www.nature.com/articles/s41418-019-0298-5

The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression – Yu Xiong, Linli Li, Liting Zhang, Yangyang Cui, Chengyong Wu, Hui Li, Kai Chen, Qiuyuan Yang, Rong Xiang, Yiguo Hu, Shile Huang, Yuquan Wei and Shengyong Yang. https://www.nature.com/articles/s41418-018-0262-9

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis – Xixi Zhang, Haiwei Zhang, Chengxian Xu, Xiaoming Li, Ming Li, Xiaoxia Wu, Wenjuan Pu, Bin Zhou, Haikun Wang, Dali Li, Qiurong Ding, Hao Ying, Hui Wang and Haibing Zhang. https://www.nature.com/articles/s41467-019-11839-w

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation – Yong Tang, Hailin Tu, Jie Zhang, Xueqiang Zhao, Yini Wang, Jun Qin and Xin Lin. https://www.nature.com/articles/s41467-019-12033-8

Bcl-2 family proteins

Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment – Jan Jezek, Kai‐Ti Chang, Amogh M Joshi, Randy Strich. https://www.embopress.org/doi/10.15252/embr.201847425

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers – Michelle M. Williams, David L. Elion, Bushra Rahman, Donna J. Hicks, Violeta Sanchez and Rebecca S. Cook. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27070&path[]=87031


A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells – Sacha Benaoudia, Amandine Martin, Marta Puig Gamez, Gabrielle Gay, Brice Lagrange, Maxence Cornut, Kyrylo Krasnykov, Jean‐Baptiste Claude, Cyril F Bourgeois, Sandrine Hughes, Benjamin Gillet, Omran Allatif, Antoine Corbin, Romeo Ricci, Thomas Henry. https://www.embopress.org/doi/10.15252/embr.201948235


The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma – Wen-Hsuan Yang, Chien-Kuang Cornelia Ding, Tianai Sun, Gabrielle Rupprecht, Chao-Chieh Lin, David Hsu, Jen-Tsan Chi. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31023-X


Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System – Yunlu Zhu, Samantha C. Crowley, Andrew J. Latimer, Gwendolyn M. Lewis, Rebecca Nash, Sarah Kucenas. https://www.cell.com/cell/fulltext/S0092-8674(19)30889-X

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases – Naoya Fujino, Oliver J. Brand, David J. Morgan, Toshifumi Fujimori, Aleksander M. Grabiec, Christopher P. Jagger, Rose A. Maciewicz, Mitsuhiro Yamada, Koji Itakura, Hisatoshi Sugiura, Masakazu Ichinose, Tracy Hussell. http://jem.rupress.org/content/216/9/2184?etoc


Single-Cell and Population-Level Analyses Using Real-Time Kinetic Labeling Couples Proliferation and Cell Death Mechanisms – Jesse D. Gelles, Jarvier N. Mohammed, Luis C. Santos, Diana Legarda, Adrian T. Ting, Jerry E. Chipuk. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30699-9

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials [including caspase-3 activators] – Ann Lin , Christopher J. Giuliano, Ann Palladino, Kristen M. John, Connor Abramowicz, Monet Lou Yuan, Erin L. Sausville, Devon A. Lukow, Luwei Liu, Alexander R. Chait, Zachary C. Galluzzo, Clara Tucker, Jason M. Sheltzer. https://stm.sciencemag.org/content/11/509/eaaw8412

In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose – Li Dong, Boris Reljic, Jen G. Cheung, Elizabeth S. Ng, Lisa M. Lindqvist, Andrew G. Elefanty, David L. Vaux and Hoanh Tran. https://www.nature.com/articles/s41418-019-0275-z

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit – Francisco J. Roca, Laura J. Whitworth, Sarah Redmond, Ana A. Jones, Lalita Ramakrishnan. https://www.cell.com/cell/fulltext/S0092-8674(19)30892-X

Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover – Dianrong Li, Jie Chen, Youwei Ai, Yang Cao, Xiangbin Qi, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30497-6


Population Dynamics in Cell Death: Mechanisms of Propagation – Michelle Riegman, Michelle S. Bradbury, Michael Overholtzer. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30147-5

Apoptotic cell death regulation in neurons – Emilie Hollville, Selena E. Romero, Mohanish Deshmukh. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14970


The Neural Crest Pitches In to Remove Apoptotic Debris – Aglaja Kopf, Michael Sixt. https://www.cell.com/cell/fulltext/S0092-8674(19)30966-3

The Dark Side of Estrogen Stops Translation to Induce Apoptosis – Heather M. Lamb, J. Marie Hardwick. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30661-6


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