ApoList – August 2019


Necroptosis and RIP kinases


RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity – Susana L. Orozco, Brian P. Daniels, Nader Yatim, Michelle N. Messmer, Giovanni Quarato, Haiyin Chen-Harris, Sean P. Cullen, Annelise G. Snyder, Pooja Ralli-Jain, Sharon Frase, Stephen W.G. Tait, Douglas R. Green, Matthew L. Albert, Andrew Oberst. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30981-7

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome – Seung Baek Lee, Jung Jin Kim, Sang-Ah Han, Yingfang Fan, Li-Sha Guo, Khaled Aziz, Somaira Nowsheen, Sung Sun Kim, Seon-Young Park, Qifeng Luo, Jin Ook Chung, Sung Il Choi, Asef Aziz, Ping Yin, Seo-Yun Tong, Fabienne C. Fiesel, Wolfdieter Springer, Jin-San Zhang and Zhenkun Lou. https://www.nature.com/articles/s41556-019-0356-8

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL – Ayaz Najafov, Adnan K. Mookhtiar, Hoang Son Luu, Alban Ordureau, Heling Pan, Palak P. Amin, Ying Li, Qingxian Lu, Junying Yuan. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30394-6


Bcl-2 family proteins


BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress – Fei-Yun Chen, Min-Yu Huang, Yu-Min Lin, Chi-Huan Ho, Shu-Yu Lin, Hsin-Yi Chen, Mien-Chie Hung, Ruey-Hwa Chen. http://jcb.rupress.org/content/early/2019/08/05/jcb.201901156

The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells – Shaheen Kabir, Justin Cidado, Courtney Andersen, Cortni Dick, Pei-Chun Lin, Therese Mitros, Hong Ma, Seung Hyun Baik, Matthew A Belmonte, Lisa Drew, Jacob E Corn. https://elifesciences.org/articles/44288

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling – Felix Seyfried, Salih Demir, Rebecca Louise Hörl, Felix Uli Stirnweiß, Jeremy RyanAnnika Scheffold, , Mariana Villalobos-Ortiz, Elena Boldrin, Julia Zinngrebe, Stefanie Enzenmüller, Silvia Jenni, Yi-Chien Tsai, Beat Bornhauser, Axel Fürstberger, Johann Michael Kraus, Hans Armin Kestler, Jean-Pierre Bourquin, Stephan Stilgenbauer, Anthony Letai, Klaus-Michael Debatin and Lüder Hinrich Meyer. https://www.nature.com/articles/s41419-019-1801-0

Noxa mitochondrial targeting domain induces necrosis via VDAC2 and mitochondrial catastrophe – Ji-Hye Han, Junghee Park, Seung-Hyun Myung, Sung Hang Lee, Hwa-Young Kim, Kyung Sook Kim, Young-Woo Seo and Tae-Hyoung Kim. https://www.nature.com/articles/s41419-019-1753-4

DHX33 Interacts with AP-2β To Regulate Bcl-2 Gene Expression and Promote Cancer Cell Survival – Jiuling Wang, Weimin Feng, Zhen Yuan, Jason D. Weber and Yandong Zhang. http://mcb.asm.org/content/39/17/e00017-19.abstract


Death receptors and IAPs


Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression – Mingli Li, Shiyao Sun, Jessica Priest, Xiaolin Bi and Yun Fan. https://www.nature.com/articles/s41419-019-1862-0

Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5 – Carles Solà-Riera, Shawon Gupta, Kimia T. Maleki, Patricia González-Rodriguez, Dalel Saidi, Christine L. Zimmer, Sindhu Vangeti, Laura Rivino, Yee-Sin Leo, David Chien Lye, Paul A. MacAry, Clas Ahlm, Anna Smed-Sörensen, Bertrand Joseph, Niklas K. Björkström, Hans-Gustaf Ljunggren, Jonas Klingström. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30970-2

The anticonvulsive Phenhydan® suppresses extrinsic cell death – Caroline Moerke, Isabel Jaco, Christin Dewitz, Tammo Müller, Annette V. Jacobsen, Jérémie Gautheron, Jürgen Fritsch, Jessica Schmitz, Jan Hinrich Bräsen, Claudia Günther, James M. Murphy, Ulrich Kunzendorf, Pascal Meier and Stefan Krautwald. https://www.nature.com/articles/s41418-018-0232-2

SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation – John Rizk , Joseph Kaplinsky, Rasmus Agerholm, Darshana Kadekar, Fredrik Ivars, William W. Agace, W. Wei-Lynn Wong, Matthew J. Szucs, Samuel A. Myers, Steven A. Carr, Ari Waisman, Vasileios Bekiaris. https://stke.sciencemag.org/content/12/596/eaaw3469


Caspases


Caspase-8 modulates physiological and pathological angiogenesis during retina development – Nathalie Tisch, Aida Freire-Valls, Rosario Yerbes, Isidora Paredes, Silvia La Porta, Xiaohong Wang,Rosa Martín-Pérez, Laura Castro, Wendy Wei-Lynn Wong, Leigh Coultas, Boris Strilic, Hermann-Josef Gröne, Thomas Hielscher, Carolin Mogler, Ralf Adams, Peter Heiduschka, Lena Claesson-Welsh,Massimiliano Mazzone, Abelardo López-Rivas, Thomas Schmidt, Hellmut G. Augustin and Carmen Ruiz de Almodovar. https://www.jci.org/articles/view/122767

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling – Zhi-Xiang Xu, Ji-Wei Tan, Haifei Xu, Cassandra J. Hill, Olga Ostrovskaya, Kirill A. Martemyanov and Baoji Xu. https://www.nature.com/articles/s41467-019-11575-1

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury – Miao N, Yin F, Xie H, Wang Y, Xu Y, Shen Y, Xu D, Yin J, Wang B, Zhou Z, Cheng Q, Chen P, Xue H, Zhou L, Liu J, Wang X, Zhang W, Lu L. https://www.ncbi.nlm.nih.gov/pubmed/31405732

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress – Anna Shemorry, Jonathan M Harnoss, Ofer Guttman, Scot A Marsters, László G Kőműves, David A Lawrence, Avi Ashkenazi. https://elifesciences.org/articles/47084


Efferocytosis / immunogenicity


Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes – Amar Singh, Sabarinathan Ramachandran, Melanie L. Graham, Saeed Daneshmandi, David Heller, Wilma Lucia Suarez-Pinzon, Appakalai N. Balamurugan, Jeffrey D. Ansite, Joshua J. Wilhelm, Amy Yang, Ying Zhang, Nagendra P. Palani, Juan E. Abrahante, Christopher Burlak, Stephen D. Miller, Xunrong Luo and Bernhard J. Hering. https://www.nature.com/articles/s41467-019-11338-y


Pyroptosis


ATP induces caspase-3/gasdermin E-mediated pyroptosis in NLRP3 pathway-blocked murine macrophages – Chen-Ying Zeng, Chen-Guang Li, Jun-Xiang Shu, Li-Hui Xu, Dong-Yun Ouyang, Feng-Yi Mai, Qiong-Zhen Zeng, Cheng-Cheng Zhang, Rui-Man Li and Xian-Hui He. https://link.springer.com/article/10.1007/s10495-019-01551-x


Miscellanous


NAD+ cleavage activity by animal and plant TIR domains in cell death pathways – Shane Horsefield, Hayden Burdett, Xiaoxiao Zhang, Mohammad K. Manik, Yun Shi, Jian Chen, Tiancong Qi, Jonathan Gilley, Jhih-Siang Lai, Maxwell X. Rank, Lachlan W. Casey, Weixi Gu, Daniel J. Ericsson, Gabriel Foley, Robert O. Hughes, Todd Bosanac, Mark von Itzstein, John P. Rathjen, Jeffrey D. Nanson, Mikael Boden, Ian B. Dry, Simon J. Williams, Brian J. Staskawicz, Michael P. Coleman, Thomas Ve, Peter N. Dodds, Bostjan Kobe. https://science.sciencemag.org/content/365/6455/793

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death – Li Wan, Kow Essuman, Ryan G. Anderson, Yo Sasaki, Freddy Monteiro, Eui-Hwan Chung, Erin Osborne Nishimura, Aaron DiAntonio, Jeffrey Milbrandt, Jeffery L. Dangl, Marc T. Nishimura. https://science.sciencemag.org/content/365/6455/799

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer – Marcel A. Dammert, Johannes Brägelmann, Rachelle R. Olsen, Stefanie Böhm, Niloufar Monhasery, Christopher P. Whitney, Milind D. Chalishazar, Hannah L. Tumbrink, Matthew R. Guthrie, Sebastian Klein, Abbie S. Ireland, Jeremy Ryan, Anna Schmitt, Annika Marx, Luka Ozretić, Roberta Castiglione, Carina Lorenz, Ron D. Jachimowicz, Elmar Wolf, Roman K. Thomas, John T. Poirier, Reinhard Büttner, Triparna Sen, Lauren A. Byers, H. Christian Reinhardt, Anthony Letai, Trudy G. Oliver and Martin L. Sos. https://www.nature.com/articles/s41467-019-11371-x

Meiotic viral attenuation through an ancestral apoptotic pathway [yeast] – Jie Gao, Sabrina Chau, Fuad Chowdhury, Tina Zhou, Saif Hossain, G. Angus McQuibban and Marc D. Meneghini. https://www.pnas.org/content/116/33/16454.abstract?etoc

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD – Jason Karch , Michael J. Bround, Hadi Khalil, Michelle A. Sargent, Nadina Latchman, Naohiro Terada, Pablo M. Peixoto, Jeffery D. Molkentin. https://advances.sciencemag.org/content/5/8/eaaw4597


Reviews / comments


Parkin inhibits necroptosis to prevent cancer – Kai Cao and Stephen W. G. Tait. https://www.nature.com/articles/s41556-019-0350-1

Parkin protects against necroptosis – Wei Wong. https://stke.sciencemag.org/content/12/595/eaaz1464

Parkin and AMPK team up against necroptosis – Paulina Strzyz. https://www.nature.com/articles/s41580-019-0165-8

Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins – Anatoly B. Uzdensky. https://link.springer.com/article/10.1007/s10495-019-01556-6

Still on time to register for ECDO conference 2019 in Dresden – https://www.ecdo.eu/ecdo2019/

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