ApoList – July 2019

 


Mitochondria and Bcl-2 family proteins


BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals – Rahul Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim, Daniel Bachmann, Tatiana Rabachini, Lahiru Gangoda, Sanjay Shahi, Jason Glab, Joseph Menassa, Laura Osellame, Tao Nelson, Yuniel Fernandez-Marrero, Fiona Brown, Andrew Wei, Francine Ke, Lorraine O’Reilly, Marcel Doerflinger, Cody Allison, Andrew Kueh, Rob Ramsay, Brian J. Smith, Suresh Mathivanan, Thomas Kaufmann and Hamsa Puthalakath. https://www.pnas.org/content/116/31/15469.abstract?etoc

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1 – Liu, T., Kuwana, T., Zhang, H., Vander Heiden, M. G., Lerner, R. A. and Newmeyer, D. D. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004413

The mitophagy receptor Bcl-2–like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice – Makoto Fujiwara, Li Tian, Phuong T. Le, Victoria E. DeMambro, Kathleen A. Becker, Clifford J. Rosen and Anyonya R. Guntur. http://www.jbc.org/content/early/2019/07/02/jbc.RA119.008630.abstract

JNK1 regulates RANKL-induced osteoclastogenesis via activation of a novel Bcl-2-Beclin1-autophagy pathway – Dianshan Ke, Lianmei Ji, Yu Wang, Xiaomin Fu, Jinyan Chen, Fan Wang, Dongbao Zhao, Ying Xue, Xuhua Lan and Jianming Hou. https://www.fasebj.org/doi/abs/10.1096/fj.201802597RR

Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction – Tian-Ying Zhang, Hong-Ying Chen, Jia-Li Cao, Hua-Long Xiong, Xiao-Bing Mo, Tian-Liang Li, Xiao-Zhen Kang, Jing-Hua Zhao, Bo Yin, Xiang Zhao, Cheng-Hao Huang, Quan Yuan, Ding Xue, Ning-Shao Xia and Y. Adam Yuan. https://www.nature.com/articles/s41467-019-11173-1

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis – Mateus Milani, Alison J. Beckett, Aoula Al-Zebeeby, Xu Luo, Ian A. Prior, Gerald M. Cohen and Shankar Varadarajan. https://www.nature.com/articles/s41420-019-0199-x

Mcl-1 and Bcl-xL are essential for survival of the developing nervous system – Lauren C. Fogarty, Robert T. Flemmer, Brittany A. Geizer, Maria Licursi, Ahila Karunanithy, Joseph T. Opferman, Kensuke Hirasawa and Jacqueline L. Vanderluit. https://www.nature.com/articles/s41418-018-0225-1

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes – Yuhao Jiao, Joanne E. Davis, Jai Rautela, Emma M. Carrington, Mandy J. Ludford-Menting, Wilford Goh, Rebecca B. Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T. Kile, Andrew M. Lew, David S. Ritchie and Nicholas D. Huntington. https://www.nature.com/articles/s41418-018-0228-y


Bcl-2 family inhibitors


BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics – Mariana Villalobos-Ortiz, Jeremy Ryan, Thelma N. Mashaka, Joseph T. Opferman and Anthony Letai. https://www.nature.com/articles/s41418-019-0391-9

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment – Xufeng Chen, Christina Glytsou, Hua Zhou, Sonali Narang, Denis E. Reyna, Andrea Lopez, Theodore Sakellaropoulos, Yixiao Gong, Andreas Kloetgen, Yoon Sing Yap, Eric Wang, Evripidis Gavathiotis, Aristotelis Tsirigos, Raoul Tibes and Iannis Aifantis. http://cancerdiscovery.aacrjournals.org/content/9/7/890

The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells – Tamilla Nechiporuk, Stephen E. Kurtz, Olga Nikolova, Tingting Liu, Courtney L. Jones, Angelo D’Alessandro, Rachel Culp-Hill, Amanda d’Almeida, Sunil K. Joshi, Mara Rosenberg, Cristina E. Tognon, Alexey V. Danilov, Brian J. Druker, Bill H. Chang, Shannon K McWeeney and Jeffrey W. Tyner. http://cancerdiscovery.aacrjournals.org/content/9/7/910

Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma – Dana Prukova, Ladislav Andera, Zuzana Nahacka, Jana Karolova, Michael Svaton, Magdalena Klanova, Ondrej Havranek, Jan Soukup, Karla Svobodova, Zuzana Zemanova, Diana Tuskova, Eva Pokorna, Karel Helman, Kristina Forsterova, Mariana Pacheco-Blanco, Petra Vockova, Adela Berkova, Eva Fronkova, Marek Trneny and Pavel Klener. http://clincancerres.aacrjournals.org/content/25/14/4455

Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables – Andrew W. Roberts, Shuo Ma, Thomas J. Kipps, Steven E. Coutre, Matthew S.Davids, Barbara Eichhorst, Michael Hallek, John C. Byrd, KathryHumphrey, Lang Zhou, Brenda Chyla, Jacqueline Nielsen, Jalaja Potluri, Su Young Kim, Maria Verdugo, Stephan Stilgenbauer, William G. Wierda and John F. Seymour. http://bloodjournal.org/content/134/2/111.abstract?etoc

Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice – Lindsey E. Roeker, Christopher P. Fox, Toby A. Eyre, Danielle M. Brander, John N. Allan, Stephen J. Schuster, Chadi Nabhan, Brian T. Hill, Nirav N. Shah, Frederick Lansigan, Maryam Yazdy, Bruce D. Cheson, Nicole Lamanna, Arun K. Singavi, Catherine C. Coombs, Paul M. Barr, Alan P. Skarbnik, Mazyar Shadman, Chaitra S. Ujjani, Hande H. Tuncer, Allison M. Winter, Joanna Rhodes, Colleen Dorsey, Hannah Morse, Charlene Kabel, John M. Pagel, Annalynn M. Williams, Ryan Jacobs, Andre Goy, Sivraj Muralikrishnan, Laurie Pearson, Andrea Sitlinger, Neil Bailey, Anna Schuh, Amy A. Kirkwood and Anthony R. Mato. http://clincancerres.aacrjournals.org/content/25/14/4264


Death receptors


TNFR1 membrane reorganization promotes distinct modes of TNFα signaling – Penny E. Morton , Camille Perrin, James Levitt, Daniel R. Matthews, Richard J. Marsh, Rosemary Pike, David McMillan, Alison Maloney, Simon Poland, Simon Ameer-Beg, Maddy Parsons. https://stke.sciencemag.org/content/12/592/eaaw2418

Dendritic cell NLRC4 regulates influenza A virus–specific CD4+ T cell responses through FasL expression – Emma E. Hornick, Jargalsaikhan Dagvadorj, Zeb R. Zacharias, Ann M. Miller, Ryan A. Langlois, Peter Chen, Kevin L. Legge, Gail A. Bishop, Fayyaz S. Sutterwala and Suzanne L. Cassel. https://www.jci.org/articles/view/124937

Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions – Yingying Shen, Zhengbo Song, Xinliang Lu, Zeyu Ma, Chaojie Lu, Bei Zhang, Yinghu Chen, Meng Duan, Lionel Apetoh, Xu Li, Jufeng Guo, Ying Miao, Gensheng Zhang, Diya Yang, Zhijian Cai and Jianli Wang. https://www.nature.com/articles/s41467-019-10889-4

Crystal structure and activation mechanism of DR3 death domain – Xueying Yin, Wenqian Li, Huan Ma, Weihong Zeng, Chao Peng, Yajuan Li, Muziying Liu, Quan Chen, Rongbin Zhou, Tengchuan Jin. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14834

The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines – Oksana B. Serebrennikova, Maria D. Paraskevopoulou, Elia Aguado-Fraile, Vasiliki Taraslia, Wenying Ren, Geeta Thapa, Jatin Roper, Keyong Du, Carlo M. Croce and Philip N. Tsichlis. https://www.pnas.org/content/116/28/14039.abstract

Minimal dosing of leukocyte targeting TRAIL decreases triple-negative breast cancer metastasis following tumor resection – Nidhi Jyotsana, Zhenjiang Zhang, Lauren E. Himmel, Fang Yu and Michael R. King. https://advances.sciencemag.org/content/5/7/eaaw4197

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold – David W. Vredevoogd, Thomas Kuilman, Maarten A. Ligtenberg, Julia Boshuizen, Kelly E. Stecker, Beaunelle de Bruijn, Oscar Krijgsman, Xinyao Huang, Juliana C.N. Kenski, Ruben Lacroix, Riccardo Mezzadra, Raquel Gomez-Eerland, Mete Yildiz, Ilknur Dagidir, Georgi Apriamashvili, Nordin Zandhuis, Vincent van der Noort, Nils L. Visser, Christian U. Blank, Maarten Altelaar, Ton N. Schumacher, Daniel S. Peeper. https://www.cell.com/cell/fulltext/S0092-8674(19)30677-4


Caspases


Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases – Matthew Ravalin, Panagiotis Theofilas, Koli Basu, Kwadwo A. Opoku-Nsiah, Victoria A. Assimon, Daniel Medina-Cleghorn, Yi-Fan Chen, Markus F. Bohn, Michelle Arkin, Lea T. Grinberg, Charles S. Craik and Jason E. Gestwicki. https://www.nature.com/articles/s41589-019-0322-6

Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity – Eri Ohta, Masanori Itoh, Masashi Ueda, Yoko Hida, Miao-xing Wang, Miki Hayakawa-Ogura, Shimo Li, Emika Nishida, Kazunori Ohta, Tana, Saiful Islam, Kiyomi Nakagawa, Tomomi Sunayama, Huayue Chen, So Hirata, Masashi Endo, Yoya Ohno, Toshiyuki Nakagawa. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219782

Caspase-8 restricts antiviral CD8 T cell hyperaccumulation – Yanjun Feng, Lisa P. Daley-Bauer, Linda Roback, Hongyan Guo, Heather S. Koehler, Marc Potempa, Lewis L. Lanier and Edward S. Mocarski. https://www.pnas.org/content/116/30/15170.abstract?etoc

E1A oncogene induced sensitization to NK cell induced apoptosis requires PIDD and Caspase-2 – Jay R. Radke, John M. Routes and James L. Cook. https://www.nature.com/articles/s41420-019-0189-z


Necroptosis and/or RIP kinases


Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity – Annelise G. Snyder, Nicholas W. Hubbard, Michelle N. Messmer, Sigal B. Kofman, Cassidy E. Hagan, Susana L. Orozco, Kristy Chiang, Brian P. Daniels, David Baker and Andrew Oberst. https://immunology.sciencemag.org/content/4/36/eaaw2004.long

Central nervous system regeneration is driven by microglia necroptosis and repopulation – Amy F. Lloyd, Claire L. Davies, Rebecca K. Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C. Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W. Pollard, Anne des Rieux, Josef Priller and Veronique E. Miron. https://www.nature.com/articles/s41593-019-0418-z


Pyroptosis


Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization – Zhonghua Liu, Chuanping Wang, Jie Yang, Bowen Zhou, Rui Yang, Rajesh Ramachandran, Derek W. Abbott, Tsan Sam Xiao. https://www.cell.com/immunity/fulltext/S1074-7613(19)30197-9


Necrosis


Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies – Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel and Christine Skerk. https://www.nature.com/articles/s41467-019-10766-0

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling – Jiao Wu, Alexander M. Minikes, Minghui Gao, Huijie Bian, Yong Li, Brent R. Stockwell, Zhi-Nan Chen and Xuejun Jiang. https://www.nature.com/articles/s41586-019-1426-6

Clockophagy is a novel selective autophagy process favoring ferroptosis – Minghua Yang, Pan Chen, Jiao Liu, Shan Zhu, Guido Kroemer, Daniel J. Klionsky, Michael T. Lotze, Herbert J. Zeh, Rui Kang and Daolin Tang. https://advances.sciencemag.org/content/5/7/eaaw2238.full

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death – Melania Guerrero-Hue, Cristina García-Caballero, Alejandra Palomino-Antolín, Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, Carmen Herencia, Diego Martín-Sanchez, Víctor Farré-Alins, Javier Egea, Pablo Cannata, Manuel Praga, Alberto Ortiz, Jesús Egido, Ana Belén Sanz and Juan Antonio Moreno. https://www.fasebj.org/doi/abs/10.1096/fj.201900077R?ai=s4&ui=ly8&af=T


Reviews


Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease – Beatriz E. Bolívar, Tiphanie P. Vogel, Lisa Bouchier‐Hayes. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14926

Mitochondria and Inflammation: Cell Death Heats Up – Esmee Vringer and Stephen W. G. Tait. https://www.frontiersin.org/articles/10.3389/fcell.2019.00100/full

Cell death–mediated cytokine release and its therapeutic implications – David E. Place and Thirumala-Devi Kanneganti. http://jem.rupress.org/content/216/7/1474?etoc


Comments


Keeping the Death Protein in Check – Longfei Wang, Hao Wu. https://www.cell.com/immunity/fulltext/S1074-7613(19)30281-X

Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade – Michael R. Savona and Jeffrey C. Rathmell. http://cancerdiscovery.aacrjournals.org/content/9/7/831

A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System – Brent R. Stockwell, Xuejun Jiang. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30315-8

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