ApoList – June 2019


Bcl-2 family proteins

A non‐death function of the mitochondrial apoptosis apparatus in immunity – Dominik Brokatzky, Benedikt Dörflinger, Aladin Haimovici, Arnim Weber, Susanne Kirschnek, Juliane Vier,Arlena Metz, Julia Henschel, Tobias Steinfeldt, Ian E Gentle, Georg Häcker. https://www.embopress.org/doi/10.15252/embj.2018100907

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations – Richard W. Birkinshaw, Jia-nan Gong, Cindy S. Luo, Daisy Lio, Christine A. White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C. S. Huang, Peter M. Colman and Peter E. Czabotar. https://www.nature.com/articles/s41467-019-10363-1

α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins – Brent Dawe, Hong Yu, Shenyan Gu, Alissa N. Blackler, Jose A. Matta, Edward R. Siuda, Elizabeth B. Rex and David S. Bredt. https://www.nature.com/articles/s41467-019-10723-x

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice – Natasha S. Anstee, Rebecca A. Bilardi, Ashley P. Ng, Zhen Xu, Mikara Robati, Cassandra J. Vandenberg and Suzanne Cory. https://www.nature.com/articles/s41418-018-0209-1

Alcohol exposure alters pre-mRNA splicing of antiapoptotic Mcl-1L isoform and induces apoptosis in neural progenitors and immature neurons – Martina Donadoni, Stephanie Cicalese, Dipak K. Sarkar, Sulie L. Chang and Ilker Kudret Sariyer. https://www.nature.com/articles/s41419-019-1673-3

Resistance to anti-microtubule drug-induced cell death is determined by regulation of BimEL expression – Weimei Ruan, Gireedhar Venkatachalam, Radoslaw Mikolaj Sobota, Liyan Chen, Loo Chien Wang, Alena Jacobson, Kathirvel Paramasivam and Uttam Surana. https://www.nature.com/articles/s41388-019-0727-4

MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways – Anh T. Tran, Eric M. Chapman, Mathieu N. Flamand, Bin Yu, Samuel J. Krempel, Thomas F. Duchaine, Matthew Eroglu and W. Brent Derry. https://www.nature.com/articles/s41418-019-0325-6

XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis – Zhi-Chuan Zhu, Ji-Wei Liu, Can Yang, Miao Zhao and Zhi-Qi Xiong. https://www.nature.com/articles/s41419-019-1627-9

Death receptors

DR4-Ser424 O-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death – Hyeonjeong Lee, Yumin Oh, Young-Jun Jeon, Song-Yi Lee, Hyunjoo Kim, Ho-June Lee and Yong-Keun Jung. http://cancerres.aacrjournals.org/content/79/11/2839

c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma – Tobias Luebke, Lisa Schwarz, Yan Yan Beer, Sabrina Schumann, Maria Misterek, Frida Ewald Sander, Carlos Plaza-Sirvent and Ingo Schmitz. https://www.nature.com/articles/s41419-019-1609-y


Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain – Hyun Ho Par. https://www.nature.com/articles/s41418-018-0200-x

Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against Toxoplasma gondii – Alexandra A. DeLaney, Corbett T. Berry, David A. Christian, Andrew Hart, Elisabet Bjanes, Meghan A. Wynosky-Dolfi, Xinyuan Li, Bart Tummers, Irina A. Udalova, Youhai H. Chen, Uri Hershberg, Bruce D. Freedman, Christopher A. Hunter and Igor E. Brodsky. https://www.pnas.org/content/116/24/11926.abstract?etoc

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila – Augusto V. Gonçalves, Shally R. Margolis , Gustavo F. S. Quirino, Danielle P. A. Mascarenhas, Isabella Rauch, Randilea D. Nichols, Eduard Ansaldo, May F. Fontana, Russell E. Vance and Dario S. Zamboni. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007886


Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing – Kazuhito Sai, Cameron Parsons, John S. House, Sophia Kathariou and Jun Ninomiya-Tsuji. http://jcb.rupress.org/content/218/6/1994

Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis – Jue Hou, Jie Ju, Zili Zhang, Cong Zhao, Zhanhui Li, Jiyue Zheng, Tian Sheng, Hongjian Zhang, Linkun Hu, Xiaoliang Yu, Wei Zhang, Yangxin Li, Meng Wu, Haikuo Ma, Xiaohu Zhang and Sudan He. https://www.nature.com/articles/s41419-019-1735-6

FKBP12 mediates necroptosis by initiating RIPK1–RIPK3–MLKL signal transduction in response to TNF receptor 1 ligation – Zicheng Wang, Jiannan Feng, Jiyun Yu and Guozhu Chen. http://jcs.biologists.org/content/132/10/jcs227777?etoc

Interferon-γ induces the cell surface exposure of phosphatidylserine by activating MLKL in the absence of caspase-8 activity – Jiancheng Chen, Shunsuke Kuroki, Masataka Someda and Shin Yonehara. http://www.jbc.org/content/early/2019/06/19/jbc.RA118.007161.abstract


Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation – Wenjun Li, Guoshuai Feng, Jason M. Gauthier, Inessa Lokshina, Ryuji Higashikubo, Sarah Evans, Xinping Liu, Adil Hassan, Satona Tanaka, Markus Cicka, Hsi-Min Hsiao, Daniel Ruiz-Perez, Andrea Bredemeyer, Richard W. Gross, Douglas L. Mann, Yulia Y. Tyurina, Andrew E. Gelman, Valerian E. Kagan, Andreas Linkermann, Kory J. Lavine and Daniel Kreisel. https://www.jci.org/articles/view/126428


A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis – Eric M. Chapman, Benjamin Lant, Yota Ohashi, Bin Yu, Michael Schertzberg, Christopher Go, Deepika Dogra, Janne Koskimäki, Romuald Girard, Yan Li, Andrew G. Fraser, Issam A. Awad, Salim Abdelilah-Seyfried, Anne-Claude Gingras and W. Brent Derry. https://www.nature.com/articles/s41467-019-09829-z

Discerning the mechanism of action of HtrA4: a serine protease implicated in the cell death pathway – Raghupathi Kummari, Shubhankar Dutta, Lalith K. Chaganti and Kakoli Bose. http://www.biochemj.org/content/476/10/1445?etoc

AIF-regulated oxidative phosphorylation supports lung cancer development – Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J. Cronin, Zhigang She, Franz Quehenberger, Helmut Popper, Lukas Kenner, Jody J. Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer and Josef M. Penninger. https://www.nature.com/articles/s41422-019-0181-4


Caspases in Cell Death, Inflammation, and Disease – Nina Van Opdenbosch, Mohamed Lamkanfi. https://www.cell.com/immunity/fulltext/S1074-7613(19)30240-7

Targeting Ferroptosis to Iron Out Cancer – Behrouz Hassannia, Peter Vandenabeele, Tom Vanden Berghe. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30197-7

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion – José Pedro Friedmann Angeli, Dmitri V. Krysko and Marcus Conrad. https://www.nature.com/articles/s41568-019-0149-1

Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy – Viacheslav V. Senichkin, Alena Y. Streletskaia, Boris Zhivotovsky, Gelina S. Kopeina. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30047-9

Autophagy-Independent Functions of the Autophagy Machinery – Lorenzo Galluzzi, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(19)30554-9

FAIM: An Antagonist of Fas-Killing and Beyond – Jianxin Huo, Shengli Xu and Kong-Peng Lam. https://www.mdpi.com/2073-4409/8/6/541


Mitochondria and pathogen immunity: from killer to firestarter – Joel S Riley, Stephen WG Tait. https://www.embopress.org/doi/full/10.15252/embj.2019102325

Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis – Ting Zhang, Siddharth Balachandran. http://jcb.rupress.org/content/218/6/1773?etoc

A New Current for the Mitochondrial Permeability Transition – Massimo Bonora, Paolo Pinton. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30089-1

Cell Death: N-degrons Fine-Tune Pyroptotic Cell Demise – Mohamed A. Eldeeb, Mohamed A. Ragheb, Edward A. Fon. https://www.cell.com/current-biology/fulltext/S0960-9822(19)30537-8

Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire – Laura C. Burzynski, Murray C.H. Clarke. https://www.cell.com/immunity/fulltext/S1074-7613(19)30235-3

Cancer and the death domain – Wei Wong. https://stke.sciencemag.org/content/12/584/eaay2357


Bax channel triplet: co-operativity and voltage gating – Shang H. Lin, Nuval Cherian, Benjamin Wu, Hyo Phee, Christy Cho and Marco Colombini. http://www.biochemj.org/content/476/10/1571?etoc

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