ApoList – May 2019

 


Bcl-2 family proteins


BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models – Xiaohong Zhao, Yuan Ren, Matthew Lawlor, Bijal D. Shah, Paul M.C. Park, Tint Lwin, Xuefeng Wang, Kenian Liu, Michelle Wang, Jing Gao, Tao Li, Mousheng Xu, Ariosto S. Silva, Kaplan Lee, Tinghu Zhang, John M. Koomen, Huijuan Jiang, Praneeth R. Sudalagunta, Mark B. Meads, Fengdong Cheng, Chengfeng Bi, Kai Fu, Huitao Fan, William S. Dalton, Lynn C. Moscinski, Kenneth H. Shain, Eduardo M. Sotomayor, Gang Greg Wang, Nathanael S. Gray, John L. Cleveland, Jun Qi, Jianguo Tao. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30200-4

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane – Trey Farmer, Katelyn L. O’Neill, Naava Naslavsky, Xu Luo and Steve Caplan. https://www.molbiolcell.org/doi/10.1091/mbc.E19-01-0044?ai=s5&ui=2oy6&af=T

Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia – Ernesto Diaz-Flores, Evan Q. Comeaux, Kailyn L. Kim, Ella Melnik, Kyle Beckman, Kara L. Davis, Kevin Wu, Jon Akutagawa, Olga Bridges, Roberta Marino, Margo Wohlfeil, Benjamin S. Braun, Charles G. Mullighan and Mignon L. Loh. http://cancerres.aacrjournals.org/content/79/9/2339

Venetoclax plus R- or G-CHOP in non-Hodgkin lymphoma: results from the CAVALLI phase 1b trial – Andrew D. Zelenetz, Gilles Salles, Kylie D. Mason, Carla Casulo, Steven Le Gouill, Laurie H. Sehn, Herve Tilly, Guillaume Cartron, Martine E. D.  Chamuleau, Andre Goy, Constantine S. Tam, Pieternella J. Lugtenburg, Adam M. Petrich, Arijit Sinha, Divya Samineni, Sylvia Herter, Ellen Ingalla,  Edith Szafer-Glusman, Christian Klein, Deepak Sampath, Martin Kornacker, Mehrdad Mobasher and Franck Morschhauser. http://bloodjournal.org/content/133/18/1964.abstract?etoc

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival – Erinna F. Lee, Tiffany J. Harris, Sharon Tran, Marco Evangelista, Surein Arulananda, Thomas John, Celeste Ramnac, Chloe Hobbs, Haoran Zhu, Gency Gunasingh, David Segal, Andreas Behren, Jonathan Cebon, Alexander Dobrovic, John M. Mariadason, Andreas Strasser, Leona Rohrbeck, Nikolas K. Haass, Marco J. Herold and W. Douglas Fairlie. https://www.nature.com/articles/s41419-019-1568-3

Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism – Jasdeep Mann, John Maringa Githaka, Timothy W. Buckland, Ning Yang, Rachel Montpetit, Namrata Patel, Lei Li, Shairaz Baksh, Roseline Godbout, Hélène Lemieux and Ing Swie Goping. https://www.nature.com/articles/s41388-018-0673-6


Death receptors / IAPs / caspases


Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation – Jieqiong Zhang, Joshua D. Webster, Debra L. Dugger, Tatiana Goncharov, Merone Roose-Girma, Jeffrey Hung, Youngsu C. Kwon, Domagoj Vucic, Kim Newton, Vishva M. Dixit. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30601-1

RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer – Bo Ram Kim, Seong Hye Park, Yoon A Jeong, Yoo Jin Na, Jung Lim Kim, Min Jee Jo, Soyeon Jeong, Hye Kyeong Yun, Sang Cheul Oh and Dae-Hee Lee. https://www.nature.com/articles/s41388-019-0693-x

Regulation of death receptor signaling by the autophagy protein TP53INP2 – Saška Ivanova, Mira Polajnar, Alvaro Jesus Narbona‐Perez, Maria Isabel Hernandez‐Alvarez, Petra Frager, Konstantin Slobodnyuk, Natalia Plana, Angel R Nebreda, Manuel Palacin, Roger R Gomis, Christian Behrends and Antonio Zorzano. http://EMBOJ.embopress.org/content/38/10/e99300

CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants – David T. Bloomer, Tanja Kitevska-Ilioski, Delara Pantaki-Eimany, Yanhao Ji, Mark A. Miles, Begona Heras and Christine J. Hawkins. http://www.biochemj.org/content/476/9/1335?etoc


Pyroptosis


IRF2 transcriptionally induces GSDMD expression for pyroptosis – Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, Opher S. Kornfeld, Karen O’Rourke, Kathleen M. Mirrashidi, Benjamin Haley, Colin Watanabe, Merone Roose-Girma, Zora Modrusan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Christopher C. Goodnow, Edward M. Bertram and Vishva M. Dixit. https://stke.sciencemag.org/content/12/582/eaax4917

Caspase-1 initiates apoptosis in the absence of gasdermin D – Kohsuke Tsuchiya, Shinsuke Nakajima, Shoko Hosojima, Dinh Thi Nguyen, Tsuyoshi Hattori, Thuong Manh Le, Osamu Hori, Mamunur Rashid Mahib, Yoshifumi Yamaguchi, Masayuki Miura, Takeshi Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, Toshihiko Shiroishi and Takashi Suda. https://www.nature.com/articles/s41467-019-09753-2

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly – Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar and Petr Broz. http://EMBOJ.embopress.org/content/38/10/e101638?etoc

Diverse small molecules prevent macrophage lysis during pyroptosis – Wendy P. Loomis, Andreas B. den Hartigh, Brad T. Cookson and Susan L. Fink. https://www.nature.com/articles/s41419-019-1559-4


Necroptosis


RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases – Snahel Patel, Joshua D. Webster, Eugene Varfolomeev, Youngsu C. Kwon, Jason H. Cheng, Juan Zhang, Debra L. Dugger, Kate E. Wickliffe, Allie Maltzman, Swathi Sujatha-Bhaskar, Pawan Bir Kohli, Sreema Ramaswamy, Gauri Deshmukh, Bianca M. Liederer, Rina Fong, Greg Hamilton, Patrick Lupardus, Patrick Caplazi, Wyne P. Lee, Menno van Lookeren Campagne, Adam Johnson, Brent S. McKenzie, Melissa R. Junttila, Kim Newton and Domagoj Vucic. https://www.nature.com/articles/s41418-019-0347-0

TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis – Jie Li, Jingyu Zhang, Yusuo Zhang, Zichuang Wang, Yanmei Song, Shanwen Wei, Meijun He, Shoujiang You, Jia Jia and Jian Cheng. https://www.nature.com/articles/s41419-019-1558-5

Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis – Weiliang Fan, Jia Guo, Beichen Gao, Wenbin Zhang, Liucong Ling, Tao Xu, Chenjie Pan, Lin Li, She Chen, Hua Wang, Jing Zhang and Xiaodong Wang. https://stke.sciencemag.org/content/12/583/eaaw3423


Ferroptosis


CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy – Weimin Wang, Michael Green, Jae Eun Choi, Miguel Gijón, Paul D. Kennedy, Jeffrey K. Johnson, Peng Liao, Xueting Lang, Ilona Kryczek, Amanda Sell, Houjun Xia, Jiajia Zhou, Gaopeng Li, Jing Li, Wei Li, Shuang Wei, Linda Vatan, Hongjuan Zhang, Wojciech Szeliga, Wei Gu, Rebecca Liu, Theodore S. Lawrence, Candice Lamb, Yuri Tanno, Marcin Cieslik, Everett Stone, George Georgiou, Timothy A. Chan, Arul Chinnaiyan and Weiping Zou. https://www.nature.com/articles/s41586-019-1170-y

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway – Bo Chu, Ning Kon, Delin Chen, Tongyuan Li, Tong Liu, Le Jiang, Shujuan Song, Omid Tavana and Wei Gu. https://www.nature.com/articles/s41556-019-0305-6

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death – Melania Guerrero-Hue, Cristina García-Caballero, Alejandra Palomino-Antolín, Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, Carmen Herencia, Diego Martín-Sanchez, Víctor Farré-Alins, Javier Egea, Pablo Cannata, Manuel Praga, Alberto Ortiz, Jesús Egido, Ana Belén Sanz and Juan Antonio Moreno. https://www.fasebj.org/doi/abs/10.1096/fj.201900077R?ai=ts&ui=ly8&af=T


Efferocytosis


Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death – Amy A. Baxter, Thanh Kha Phan, Eric Hanssen, Michael Liem, Mark D. Hulett, Suresh Mathivanan and Ivan K. H. Poon. https://www.nature.com/articles/s41598-019-44021-9

Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins – Noëlle Callizot, Maud Combes, Alexandre Henriques, Philippe Poindron. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215277

Drosophila p53 directs nonapoptotic programs in postmitotic tissue – Paula Kurtz, Amanda E. Jones, Bhavana Tiwari, Nichole Link, Annika Wylie, Charles Tracy, Helmut Krämer and John M. Abrams. https://www.molbiolcell.org/doi/10.1091/mbc.E18-12-0791?ai=s5&ui=2oy6&af=T


Reviews


The Coming Decade of Cell Death Research: Five Riddles – Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(19)30443-X

Targeting RIPK1 for the treatment of human diseases – Alexei Degterev, Dimitry Ofengeim and Junying Yuan. https://www.pnas.org/content/116/20/9714.abstract

Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling networks – Kamil Seyrek and Inna N. Lavrik. https://link.springer.com/article/10.1007/s10495-019-01540-0

The role of necroptosis in cancer: A double-edged sword? – Xia Qin, Dan Ma, Ye-xiong Tan, Hong-yang Wang, Zhenyu Cai. https://www.sciencedirect.com/science/article/abs/pii/S0304419X18302105


Comments


Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases – Anna M Gram, Lee M Booty and Clare E Bryant. http://EMBOJ.embopress.org/content/38/10/e102065?etoc

Venetoclax: R-CHOP rocket booster? – Charles Herbaux and Matthew S. Davids. http://bloodjournal.org/content/133/18/1922?etoc

Potential role of anastasis in cancer initiation and progression – Thirumal Raj, Supriya Kheur, Ramesh Bhonde, Archana A. Gupta, Vikrant R. Patil and Avinash Kharat. https://link.springer.com/article/10.1007/s10495-019-01538-8

Targeting MCL1, Companies Aim to Unblock Apoptosis – http://cancerdiscovery.aacrjournals.org/content/9/5/572

Venetoclax–Obinutuzumab Elicits High Response Rates in CLL – http://cancerdiscovery.aacrjournals.org/content/9/5/OF5

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