ApoList – February 2019


Bcl-2 family proteins


Small-molecule allosteric inhibitors of BAX – Thomas P. Garner, Dulguun Amgalan, Denis E. Reyna, Sheng Li, Richard N. Kitsis & Evripidis Gavathiotis. https://www.nature.com/articles/s41589-018-0223-0

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis – Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski. https://elifesciences.org/articles/40712

Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2 – Mart Bittremieux, Rita M. La Rovere, Haidar Akl, Claudio Martines, Kirsten Welkenhuyzen, Kathia Dubron, Myriam Baes, Ann Janssens, Peter Vandenberghe, Luca Laurenti, Katja Rietdorf, Giampaolo Morciano, Paolo Pinton, Katsuhiko Mikoshiba, Martin D. Bootman, Dimitar G. Efremov, Humbert De Smedt, Jan B. Parys and Geert Bultynck. https://www.nature.com/articles/s41418-018-0142-3

Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477 – David J. Mallick, Ryan S. Soderquist, Darcy Bates and Alan Eastman. https://www.nature.com/articles/s41419-019-1426-3

Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas – Raphael Koch, Amanda L. Christie, Jennifer L. Crombie, Adam C. Palmer, Deborah Plana, Kay Shigemori, Sara N. Morrow, Alexandria Van Scoyk, Wenchao Wu, Elizabeth A. Brem, J. Paul Secrist, Lisa Drew, Alwin G. Schuller, Justin Cidado, Anthony Letai and David M. Weinstock. http://bloodjournal.org/content/133/6/566.abstract

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer – Xiaowei Wu, Qingyu Luo, Pengfei Zhao, Wan Chang, Yating Wang, Tong Shu, Fang Ding, Bin Li, and Zhihua Liu. https://www.pnas.org/content/116/8/2961.abstract

LncRNA H19 overexpression induces bortezomib resistance in multiple myeloma by targeting MCL-1 via miR-29b-3p – Yafang Pan, Yu Zhang, Wenwen Liu, Yan Huang, Xianjuan Shen, Rongrong Jing, Jiang Pu, Xudong Wang, Shaoqing Ju, Hui Cong and Hongmei Chen. https://www.nature.com/articles/s41419-018-1219-0

Folding/unfolding kinetics of G-quadruplexes upstream of the P1 promoter of the human BCL-2 oncogene – Yuanlei Cheng, Qingnan Tang, Yutong Li, Yashuo Zhang, Chuyuan Zhao, Jie Yan and Huijuan You. http://www.jbc.org/content/early/2019/02/20/jbc.RA119.007516.abstract

The pro-apoptotic Bcl-2 family member Harakiri (HRK) induces cell death in glioblastoma multiforme – Ezgi Kaya-Aksoy, Ahmet Cingoz, Filiz Senbabaoglu, Fidan Seker, Ilknur Sur-Erdem, Alisan Kayabolen, Tolga Lokumcu, Gizem Nur Sahin, Sercin Karahuseyinoglu and Tugba Bagci-Onder. https://www.nature.com/articles/s41420-019-0144-z


Death receptors, FADD


Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling – Simone Füllsack, Alevtina Rosenthal, Harald Wajant and Daniela Siegmund. https://www.nature.com/articles/s41419-019-1396-5

TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 – John P. Dowling, Mohamed Alsabbagh, Christina Del Casale, Zheng-Gang Liu and Jianke Zhang. https://www.nature.com/articles/s41467-019-08584-5

Engagement of Fas differentially regulates the production of LPS‐induced proinflammatory cytokines and type I interferons – Kiva Brennan, Caitriona Lyons, Philana Fernandes, Sarah Doyle, Aileen Houston, Elizabeth Brint. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14727

The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding – Sara Mouasni, Virginie Gonzalez, Alain Schmitt, Evangeline Bennana, François Guillonneau. https://www.nature.com/articles/s41419-019-1412-9

Death receptor 5 is activated by fucosylation in colon cancer cells – Baojie Zhang, Ingrid A. M. van Roosmalen, Carlos R. Reis, Rita Setroikromo, Wim J. Quax. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14742

Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization – Agathe Dubuisson, Cécile Favreau, Eric Fourmaux, Sabrina Lareure, Rafael Rodrigues-Saraiva, Catherine Pellat-Deceunynck, Said El Alaoui and Olivier Micheau. https://www.nature.com/articles/s41419-019-1343-5

Tumor necrosis factor‐related apoptosis‐inducing ligand reduces the expression of the neuroprotective Na+/Ca2+ exchanger isoform NCX3 in human neuroblastoma SH‐SY5Y cells – Giulia Di Benedetto, Oriana Valerio, Vincenzo Lariccia, Chiara Burgaletto, Laurence Lempereur, Carmela Parenti, Guido Nicola Zanghì, Alessandra Matteucci, Salvatore Amoroso, Renato Bernardini, Giuseppina Cantarella. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14732

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells – Peiying Song, Songpeng Yang, Hui Hua, Hongying Zhang, Qingbin Kong, Jiao Wang, Ting Luo and Yangfu Jiang. http://www.jbc.org/content/early/2019/02/19/jbc.RA118.006029.abstract

Insights into ligand binding by a viral tumor necrosis factor (TNF) decoy receptor yield a selective soluble human type 2 TNF receptor – Sergio M. Pontejo, Carolina Sanchez, Begoña Ruiz-Argüello and Antonio Alcami. http://www.jbc.org/content/early/2019/02/05/jbc.RA118.005828.abstract

Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes – Sunmi Lee, Joo Young Lee, Eun Woo Lee, Sujin Park, Dong Hoon Kang, Chengchun Min, Doo Jae Lee, Dongmin Kang, Jaewhan Song, Jongbum Kwon, Sang Won Kang. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30110-X

Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease – Francisco Javier Cubero, Marius Maximilian Woitok, Miguel E. Zoubek, Alain de Bruin, Maximilian Hatting and Christian Trautwein. https://www.nature.com/articles/s41419-019-1391-x


Caspases and IAPs


RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation – Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J. Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schünke, Luca L. Fava, Manuel D. Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A. Harris, John Bertin, Peter J. Gough, Andreas Villunger, John Silke, Manolis Pasparakis, Katiuscia Bianchi, Pascal Meier. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30980-8

SERPINB1-mediated checkpoint of inflammatory caspase activation – Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen, Jun Yan, Alvin Lu, Jianbin Ruan, Hye-Ra Lee, Hao Wu, Brad Spellberg and Jae U. Jung. https://www.nature.com/articles/s41590-018-0303-z

XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation – Xing Huang, Xiao-nan Wang, Xiao-dong Yuan, Wen-yong Wu, Peter E. Lobie and Zhengsheng Wu. https://www.nature.com/articles/s41388-018-0513-8

Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress – Behnaz Ahangarian Abhari, Nicole McCarthy, Marie Le Berre, Michelle Kilcoyne, Lokesh Joshi. https://www.nature.com/articles/s41419-019-1381-z


Necroptosis / ferroptosis


DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway – Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Yuki Makino, Tasuku Nakabori, Satoshi Tanaka, Ryoko Yamada, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi and Tetsuo Takehara. https://www.nature.com/articles/s41418-018-0131-6

Necroptosis directly induces the release of full‐length biologically active IL‐33 in vitroand in an inflammatory disease model – Inbar Shlomovitz, Ziv Erlich, Mary Speir, Sefi Zargarian, Noam Baram, Maya Engler, Liat Edry‐Botzer, Ariel Munitz, Ben A. Croker, Motti Gerlic. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14738

Chaperone-mediated autophagy is involved in the execution of ferroptosis – Zheming Wu, Yang Geng, Xiaojuan Lu, Yuying Shi, Guowei Wu, Mengmeng Zhang, Bing Shan, Heling Pan and Junying Yuan. https://www.pnas.org/content/116/8/2996.abstract

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity – Jennifer Yinuo Cao, Aunoy Poddar, Leslie Magtanong, Jennifer H. Lumb, Trevor R. Mileur, Michael A. Reid, Cole M. Dovey, Jin Wang, Jason W. Locasale, Everett Stone, Susan P.C. Cole, Jan E. Carette, Scott J. Dixon. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30061-0

Necroptosis in primate luteolysis: a role for ceramide – Konstantin Bagnjuk, Jan Bernd Stöckl, Thomas Fröhlich, Georg Josef Arnold, Rüdiger Behr, Dieter Berg, Lars Kunz, Cecily Bishop, Jing Xu and Artur Mayerhofer. https://www.nature.com/articles/s41420-019-0149-7

Ferroptosis as a target for protection against cardiomyopathy – Xuexian Fang, Hao Wang, Dan Han, Enjun Xie, Xiang Yang, Jiayu Wei, Shanshan Gu, Feng Gao, Nali Zhu, Xiangju Yin, Qi Cheng, Pan Zhang, Wei Dai, Jinghai Chen, Fuquan Yang, Huang-Tian Yang, Andreas Linkermann, Wei Gu, Junxia Min and Fudi Wang. https://www.pnas.org/content/116/7/2672.abstract?etoc


Efferocytosis


Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development – Colleen N. McLaughlin, Jahci J. Perry-Richardson, Jaeda C. Coutinho-Budd, Heather T. Broihier. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)31087-6

Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death – Katharina Klöditz and Bengt Fadeel. https://www.nature.com/articles/s41420-019-0146-x

Calpain cleaves phospholipid flippase ATP8A1 during apoptosis inplatelets – Weidong Jing, Mehmet Yabas, Angelika Bröer, Lucy Coupland, Elizabeth E.Gardiner, Anselm Enders and Stefan Bröer. http://www.bloodadvances.org/content/3/3/219.abstract?etoc


Miscellanous


Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts – Lucy E. Métayer, Richard D. Brown, Saskia Carlebur, G. A. Amos Burke and Guy C. Brown. https://link.springer.com/article/10.1007/s10495-018-1506-3

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress – Jeffrey Knupp, Peter Arvan and Amy Chang. https://www.nature.com/articles/s41418-018-0133-4


Reviews


To the edge of cell death and back – Yi‐Nan Gong, Jeremy Chase Crawford, Bradlee L. Heckmann, Douglas R. Green. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14714

BCL-2 family isoforms in apoptosis and cancer – Chloe F. A. Warren, Michelle W. Wong-Brown and Nikola A. Bowden. https://www.nature.com/articles/s41419-019-1407-6

Targeting intrinsic cell death pathways to control fungal pathogens – Author links open overlay panelMadhuraKulkarni, Zachary D.Stolp, J. MarieHardwick. https://www.sciencedirect.com/science/article/abs/pii/S0006295219300188

Cancer therapeutics based on BCL-2 functional conversion – Martin C. Pearce, Arnold C. Satterthwait, Xiao-kun Zhang and Siva Kumar Kolluri. https://link.springer.com/article/10.1007/s10495-018-1504-5

TAK1 mediates convergence of cellular signals for death and survival – Sabreena Aashaq, Asiya Batool and Khurshid I. Andrabi. https://link.springer.com/article/10.1007/s10495-018-1490-7


Comments


Paradoxical Puma Prohibits Pyruvate Pumps to Prime Pathology – Douglas R. Green. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30050-9

Death Eaters Rely on Metabolic Signaling to Wield Anti-inflammatory Responses – Antonietta Pietrangelo, Mireille Ouimet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30010-5

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