ApoList – January 2019

 


Bcl-2 family proteins


Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation – Jinchul Kim, Lili Yu, Wancheng Chen, Yanxia Xu, Meng Wu, Dilyana Todorova, Qingshuang Tang, Bingbing Feng, Lei Jiang, Jingjin He, Guihua Chen, Xuemei Fu, Yang Xu. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30584-1

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy – Jonathan P Bernardini, Jason M Brouwer, Iris KL Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou and Grant Dewson. http://EMBOJ.embopress.org/content/38/2/e99916?etoc

BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL – Hector Flores-Romero, Olatz Landeta, Begoña Ugarte-Uribe, Katia Cosentino, Miguel García-Porras, Ana J. García-Sáez and Gorka Basañez. https://www.nature.com/articles/s41418-018-0258-5

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators – Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Kahlin Cheung-Ong, Cheryl Eifert, Craig Furman, Zhenhua Jeremy Wu, Michael Seiler, Silvia Buonamici, Peter Fekkes, Craig Karr, James Palacino, Eunice Park, Peter G. Smith, Lihua Yu, Yoshiharu Mizui, Markus Warmuth, Agustin Chicas, Laura Corson and Ping Zhu. https://www.nature.com/articles/s41467-018-08150-5

A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy – Tomokazu Murakawa, Koji Okamoto, Shigemiki Omiya, Manabu Taneike, Osamu Yamaguchi, Kinya Otsu. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31980-6

Functional profiling of venetoclax sensitivity can predict clinical response in multiple myeloma – Shannon M. Matulis, Vikas A. Gupta,  Paola Neri, Nizar J. Bahlis, Paulo Maciag, Joel D. Leverson, Leonard T. Heffner Jr., Sagar Lonial, Ajay K. Nooka, Jonathan L. Kaufman and Lawrence H. Boise. https://www.nature.com/articles/s41375-018-0374-8


Death receptors


STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells – Prajna Guha, Jillian Gardell, Josephine Darpolor, Marissa Cunetta, Matthew Lima, George Miller, N. Joseph Espat, Richard P. Junghans and Steven C. Katz. https://www.nature.com/articles/s41388-018-0449-z

TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment – Hsiu-Jung Liao, Hwei-Fang Tsai, Chien-Sheng Wu, I.-Tsu Chyuan & Ping-Ning Hsu. https://www.nature.com/articles/s41419-019-1353-3

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity – Hisamichi Naito, Tomohiro Iba, Taku Wakabayashi, Ikue Tai-Nagara, Jun-ichi Suehiro, Weizhen Jia, Daisuke Eino, Susumu Sakimoto, Fumitaka Muramatsu, Hiroyasu Kidoya, Hiroyuki Sakurai, Takashi Satoh, Shizuo Akira, Yoshiaki Kubota, Nobuyuki Takakura. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)31035-9


Caspases and IAPs


Caspase selective reagents for diagnosing apoptotic mechanisms – Marcin Poreba, Katarzyna Groborz, Mario Navarro, Scott J. Snipas, Marcin Drag and Guy S. Salvesen. https://www.nature.com/articles/s41418-018-0110-y

Transcriptome profiling of caspase-2deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling – Loretta Dorstyn, Emily Hackett-Jones, Andrej Nikolic, Murray D. Norris, Yoon Lim, John Toubia, Michelle Haber and Sharad Kumar. https://www.nature.com/articles/s41419-018-1296-0

The prodomain of caspase-3 regulates its own removal and caspase activation – Katelyn G. Ponder and Lawrence H. Boise. https://www.nature.com/articles/s41420-019-0142-1

The transcription factor SP3 drives TNF-α expression in response to Smac mimetics – Shawn T. Beug , Herman H. Cheung, Tarun Sanda, Martine St-Jean, Caroline E. Beauregard, Hapsatou Mamady, Stephen D. Baird, Eric C. LaCasse, Robert G. Korneluk. http://stke.sciencemag.org/content/12/566/eaat9563


Necroptosis and RIP kinases


The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons – Brian P. Daniels, Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, Jason W. Locasale, Jennifer Martinez, Michael Gale Jr., Yueh-Ming Loo, Andrew Oberst. https://www.cell.com/immunity/fulltext/S1074-7613(18)30525-9

Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice – Patrice N. Wagner, Qiong Shi, Christi T. Salisbury-Ruf, Jing Zou, Michael R. Savona, Yuri Fedoriw and Sandra S. Zinkel. http://bloodjournal.org/content/133/2/107.abstract?etoc

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis – Rose Nganga, Natalia Oleinik, Jisun Kim, Shanmugam Panneer Selvam, Ryan De Palma, Kristen A. Johnson, Rasesh Y. Parikh, Vamsi Gangaraju, Yuri Peterson, Mohammed Dany, Robert V. Stahelin, Christina Voelkel-Johnson, Zdzislaw M. Szulc, Erhard Bieberich and Besim Ogretmen. http://www.jbc.org/content/294/2/502.abstract.html

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases – Yue Li, Marita Führer, Ehsan Bahrami, Piotr Socha, Maja Klaudel-Dreszler, Amira Bouzidi, Yanshan Liu, Anna S. Lehle, Thomas Magg, Sebastian Hollizeck, Meino Rohlfs, Raffaele Conca, Michael Field, Neil Warner, Slae Mordechai, Eyal Shteyer, Dan Turner, Rachida Boukari, Reda Belbouab, Christoph Walz, Moritz M. Gaidt, Veit Hornung, Bernd Baumann, Ulrich Pannicke, Eman Al Idrissi, Hamza Ali Alghamdi, Fernando E. Sepulveda, Marine Gil, Geneviève de Saint Basile, Manfred Hönig, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Klaus Schwarz, Christoph Klein and Daniel Kotlarz. https://www.pnas.org/content/116/3/970.abstract?etoc

Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis – Muhammad Farooq, Aveline Filliol, Mélanie Simoes Eugénio, Claire Piquet-Pellorce, Sarah Dion, Céline Raguenes-Nicol, Aurélien Jan, Marie-Thérèse Dimanche-Boitrel, Jacques Le Seyec and Michel Samson. https://www.nature.com/articles/s41419-018-1277-3

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis – Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Chi G. Weindel, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Maxim Sorokin, Anton Buzdin, Katherine A. Fitzgerald and Alexander Poltorak. https://www.nature.com/articles/s41418-018-0122-7


Autophagic cell death / Ferroptosis


Autophagic cell death restricts chromosomal instability during replicative crisis – Joe Nassour, Robert Radford, Adriana Correia. https://www.nature.com/articles/s41586-019-0885-0

Role of Mitochondria in Ferroptosis – Minghui Gao, Junmei Yi, Jiajun Zhu, Alexander M. Minikes, Prashant Monian, Craig B. Thompson, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30936-5

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State – Leslie Magtanong, Pin-Joe Ko, Milton To, Daniel K. Nomura, James A. Olzmann, Scott J. Dixon. https://www.cell.com/cell-chemical-biology/pdf/S2451-9456(18)30438-0.pdf


Miscellanous


Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin – Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C. https://www.nature.com/articles/s41467-018-05850-w


Reviews


Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins – Rumani Singh, Anthony Letai & Kristopher Sarosiek. https://www.nature.com/articles/s41580-018-0089-8

RIP Kinases in Liver Cell Death, Inflammation and Cancer – Vangelis Kondylis, Manolis Pasparakis. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30203-X

BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker – Benoît Tessoulin, Antonin Papin, Patricia Gomez-Bougie, Celine Bellanger, Martine Amiot, Catherine Pellat-Deceunynck and David Chiron. https://www.frontiersin.org/articles/10.3389/fonc.2018.00645/full

Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis – Hasini A. Kalpage, Viktoriia Bazylianska, Maurice A. Recanati, Alemu Fite, Jenney Liu, Junmei Wan, Nikhil Mantena, Moh H. Malek, Izabela Podgorski, Elizabeth I. Heath, Asmita Vaishnav, Brian F. Edwards, Lawrence I. Grossman, Thomas H. Sanderson, Icksoo Lee and Maik Hüttemann. https://www.fasebj.org/doi/abs/10.1096/fj.201801417R?ai=s4&ui=ly8&af=T

Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill – Rubem Figueiredo Sadok Menna-Barreto. https://www.nature.com/articles/s41419-019-1370-2


Comments


BH3 mimetics: Weapons of cancer cell destruction – Tríona Ní Chonghaile. http://stm.sciencemag.org/content/11/475/eaaw5311

Think We Understand the Role of DRP1 in Mitochondrial Biology? Zinc Again! – Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)31100-6

Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy – Nieves Peltzer, Henning Walczak. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30011-5

BID-ding on necroptosis in MDS – Ben A. Croker and Michelle A. Kelliher. http://www.bloodjournal.org/content/133/2/103

RIPK3: Beyond Necroptosis – Azia S. Evans, Carolyn B. Coyne. https://www.cell.com/immunity/fulltext/S1074-7613(18)30579-X

Defying Death: The (W)hole Truth about the Fate of GSDMD Pores – Charles L. Evavold, Jonathan C. Kagan. https://www.cell.com/immunity/fulltext/S1074-7613(18)30580-6

Profile of Hao Wu – Farooq Ahmed. https://www.pnas.org/content/116/4/1078?etoc=

Retrospective. Gordon Shore (1945 – 2018).http://www.asbmb.org/asbmbtoday/201901/Retrospective/Shore/#disqus_thread

Upcoming meetings

Genes and Cancer 2019 / 8 – 11 April 2019. Cambridge, UK,

https://www.eacr.org/meeting/genes-and-cancer-2019

2nd Cell Death, Cell Stress and Metabolism Conference / 27 May 2019 – 30 May 2019. Puerto Vallarta, México

https://www.fusion-conferences.com/conference94.php

Cold Spring Harbor Cell Death meeting / August 13 – 17, 2019

https://meetings.cshl.edu/meetings.aspx?meet=pcd&year=19

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