ApoList – October 2018

Bcl-2 family proteins

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use – Margs S. Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas  Strasser, Grant Dewson, Gemma L. Kelly and Marco J. Herold. http://bloodjournal.org/content/132/15/1573.abstract?etoc

Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation – Vijay Pandey, Baocheng Wang, Chakrabhavi Dhananjaya Mohan, Ainiah Rushdiana Raquib, Shobith Rangappa, Venkatachalaiah Srinivasa, Julian E. Fuchs, Kesturu S. Girish, Tao Zhu, Andreas Bender, Lan Ma, Zhinan Yin, Basappa, Kanchugarakoppal S. Rangappa and Peter E. Lobie. http://www.pnas.org/content/115/44/E10505?etoc=

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation – Yumi Uetake and Greenfield Sluder. https://www.molbiolcell.org/doi/10.1091/mbc.E18-01-0026?ai=s5&ui=2oy6&af=T

Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1 – Eugene Y. Kim, Kuladeep Sudini, Anil K. Singh, Mahamudul Haque, Douglas Leaman, Sadik Khuder and Salahuddin Ahmed. https://www.fasebj.org/doi/abs/10.1096/fj.201800425R?ai=s4&ui=ly8&af=T

Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis – Seiji Arai, Oliver Jonas, Matthew A. Whitman, Eva Corey, Steven P. Balk and Sen Chen. http://clincancerres.aacrjournals.org/content/24/21/5458

Death receptors

CD95/Fas ligand mRNA is toxic to cells – Will Putzbach, Ashley Haluck-Kangas … Marcus E Peter. https://elifesciences.org/articles/38621

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis – Yong Tang, Donghyun Joo, Guangna Liu, Hailin Tu, Jeffrey You, Jianping Jin, Xueqiang Zhao, Mien-Chie Hung and Xin Lin. http://www.jbc.org/content/early/2018/10/25/jbc.RA118.005449.abstract


Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9 – Michael J. Holliday, Ryan Ferrao, Gladys de Leon Boenig, Alberto Estevez, Elizabeth Helgason, Alexis Rohou, Erin C. Dueber and Wayne J. Fairbrother. http://www.jbc.org/content/293/43/16803.abstract.html

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 – Yang Li, Tian-Min Fu, Alvin Lu, Kristen Witt, Jianbin Ruan, Chen Shen and Hao Wu. http://www.pnas.org/content/115/43/10845?etoc=


LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance – Larissa D. Cunha, Mao Yang, Robert Carter, Clifford Guy, Lacie Harris, Jeremy C. Crawford, Giovanni Quarato, Emilio Boada-Romero, Halime Kalkavan, Michael D.L. Johnson, Sivaraman Natarajan, Meghan E. Turnis, David Finkelstein, Joseph T. Opferman, Charles Gawad, Douglas R. Green. https://www.cell.com/cell/fulltext/S0092-8674(18)31122-X

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution – Jonathan D. Proto, Amanda C. Doran, Galina Gusarova, Arif Yurdagul Jr., Erdi Sozen, Manikandan Subramanian, Mohammad N. Islam, Christina C. Rymond, Jasper Du, Jaime Hook, George Kuriakose, Jahar Bhattacharya, Ira Tabas. https://www.cell.com/immunity/fulltext/S1074-7613(18)30335-2

RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death – Lena M. Kutscher, Wolfgang Keil, Shai Shaham. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30685-3

Apoptotic β-cells induce macrophage reprogramming under diabetic conditions – Meliza G. Ward, Ge Li and Mingming Hao. http://www.jbc.org/content/293/42/16160.abstract.html


The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma – Heike Miess, Beatrice Dankworth, Arvin M. Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W. Felsher, Barrie Peck and Almut Schulze. https://www.nature.com/articles/s41388-018-0315-z

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells – Zili Zhang, Zhen Yao, Ling Wang, Hai Ding, Jiangjuan Shao, Anping Chen, Feng Zhang and Shizhong Zheng. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1503146


Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury – Zhengxin Ying, Chenjie Pan, Tianyu Shao, Liqing Liu, Lin Li, Dejia Guo, Sitao Zhang, Tianyi Yuan, Ran Cao, Zhaodi Jiang, She Chen, Fengchao Wang, Xiaodong Wang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30782-2

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation – Natalie C. Marshall, Theo Klein, Maichael Thejoe, Niklas von Krosigk, Jayachandran Kizhakkedathu, B. Brett Finlay and Christopher M. Overall. https://pubs.acs.org/doi/10.1021/acs.jproteome.8b00675#.W9q0UN6qJiJ

Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells – Jerry J. Fong, Chih-Ming Tsai, Sudeshna Saha, Victor Nizet, Ajit Varki and Jack D. Bui. http://www.pnas.org/content/115/41/10410?etoc=

Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms – Sang-Hyun Park, Kyung-Hwa Baek, Insu Shin, Injae Shin. https://www.sciencedirect.com/science/article/pii/S2451945618302241


Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez and Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease – Anna Vilalta, Guy C. Brown. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14323

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti, Jean-Ehrland Ricci. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30125-9


MIM through MOM: the awakening of Bax and Bak pores – Katia Cosentino, Ana J García‐Sáez. http://emboj.embopress.org/content/37/17/e100340

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration – Peter Vandenabeele, Wim Declercq, Ria Roelandt, Tom Vanden Berghe. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30885-2

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Neighbourly deaths dictate fatehttps://www.nature.com/articles/s41568-018-0064-x

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism – Sofia Avnet, Nicola Baldini, Lucie Brisson, Angelo De Milito, Angela M. Otto, Silvia Pastoreková, Paolo E. Porporato, Gyorgy Szabadkai and Pierre Sonveaux. https://www.frontiersin.org/articles/10.3389/fonc.2018.00329/full

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