ApoList – September 2018

 


Caspases and cFLIP


ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P – Ju Youn Kim, Ricard Garcia-Carbonell, Shinichiro Yamachika, Peng Zhao, Debanjan Dhar, Rohit Loomba, Randal J. Kaufman, Alan R. Saltiel, Michael Karin. https://www.cell.com/cell/fulltext/S0092-8674(18)31036-5

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model – Joseph Flores, Anastasia Noël, Bénédicte Foveau, Jeffrey Lynham, Clotilde Lecrux & Andréa C. LeBlanc. https://www.nature.com/articles/s41467-018-06449-x

Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer – Miran Rada, Sameera Nallanthighal, Jennifer Cha, Kerry Ryan, Jessica Sage, Catherine Eldred, Maria Ullo, Sandra Orsulic & Dong-Joo Cheon. https://www.nature.com/articles/s41388-018-0297-x

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling – Masahiko Shigemura , Emilia Lecuona, Martín Angulo, Tetsuya Homma, Diego A. Rodríguez, Francisco J. Gonzalez-Gonzalez, Lynn C. Welch, Luciano Amarelle, Seok-Jo Kim, Naftali Kaminski, G. R. Scott Budinger, Julian Solway, Jacob I. Sznajder. http://stm.sciencemag.org/content/10/457/eaat1662

PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis – Jay R. Radke, Iris Figueroa, John M. Routes & James L. Cook. https://www.nature.com/articles/s41420-018-0100-3

Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis – Lugain Alkurdi, François Virard, Béatrice Vanbervliet, Kathrin Weber, Florent Toscano, Marc Bonnin, Nolwenn Le Stang, Sylvie Lantuejoul, Olivier Micheau, Toufic Renno, Serge Lebecque & Yann Estornes. https://www.nature.com/articles/s41419-018-0850-0


Bcl-2 family proteins


Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance – Justin Kale, Ozgur Kutuk, Glauber Costa Brito, Tallulah S Andrews, Brian Leber, Anthony Letai and David W Andrews. http://EMBOr.embopress.org/content/19/9/e45235?etoc

Topology of active, membrane-embedded Bax in the context of a toroidal pore – Stephanie Bleicken, Tufa E. Assafa, Carolin Stegmueller, Alice Wittig, Ana J. Garcia-Saez & Enrica Bordignon. https://www.nature.com/articles/s41418-018-0184-6

Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest – Lindsey A Allan, Agnieszka Skowyra, Katie I Rogers, Désirée Zeller and Paul R Clarke. http://EMBOJ.embopress.org/content/37/17/e96831?etoc

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia – Matthew S. Davids, Michael Hallek, William Wierda, Andrew W. Roberts, Stephan Stilgenbauer, Jeffrey A. Jones, John F. Gerecitano, Su Young Kim, Jalaja Potluri, Todd Busman, Andrea Best, Maria E. Verdugo, Elisa Cerri, Monali Desai, Peter Hillmen and John F. Seymour. http://clincancerres.aacrjournals.org/content/24/18/4371

SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy – Daorong Feng, Dulguun Amgalan, Rajat Singh, Jianwen Wei, Jennifer Wen, Tszki Peter Wei, Timothy E. McGraw, Richard N. Kitsis, and Jeffrey E. Pessin. https://www.jci.org/articles/view/99217

BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis – Ulrike Heinicke, Tinka Haydn, Sarah Kehr, Meike Vogler & Simone Fulda. https://www.nature.com/articles/s41388-018-0212-5

Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma – Yvonne de Jong, David Monderer, Emeline Brandinelli, Morgane Monchanin, Brendy E. van den Akker, Jolieke G. van Oosterwijk, Jean Yves Blay, Aurélie Dutour & Judith V. M. G. Bovée. https://www.nature.com/articles/s41389-018-0084-0

Mex-3B induces apoptosis by inhibiting miR-92a access to the Bim-3’UTR – Takeaki Oda, Yusuke Yamazumi, Takatoshi Hiroko, Atsushi Kamiya, Saori Kiriya, Saki Suyama, Yumi Shiozaki-Sato & Tetsu Akiyama. https://www.nature.com/articles/s41388-018-0336-7

MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells – Lin Lin, Dapeng Ding, Yanmei Jiang, Yan Li & Shijun Li. https://www.nature.com/articles/s41389-018-0078-y

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities – Stephanie Grabow, Andrew J. Kueh, Francine Ke, Hannah K. Vanyai, Bilal N. Sheikh, Michael A. Dengler, William Chiang, Samantha Eccles, Ian M. Smyth, Lynelle K. Jones, Frederic J. de Sauvage, Mark Scott, Lachlan Whitehead, Anne K. Voss, Andreas Strasser. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31334-2

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress – Jared T. Field, Matthew D. Martens, Wajihah Mughal, Yan Hai, Donald Chapman, Grant M. Hatch, Tammy L. Ivanco, William Diehl-Jones & Joseph W. Gordon. https://www.nature.com/articles/s41420-018-0104-z

BH3 mimetics induce apoptosis independent of DRP-1 in melanoma – Nabanita Mukherjee, Andrew Strosnider, Bay Vagher, Karoline A. Lambert, Sarah Slaven, William A. Robinson, Carol M. Amato, Kasey L. Couts, Judson G. T. Bemis, Jacqueline A. Turner, David A. Norris& Yiqun G. Shellman. https://www.nature.com/articles/s41419-018-0932-z

Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis – Qi Shen, Jun Li, Junhua Mai, Zhe Zhang, Andrew Fisher, Xiaoyan Wu, Zhaoqi Li, Maricela R. Ramirez, Shuqing Chen & Haifa Shen. https://www.nature.com/articles/s41419-018-1040-9


Death receptors


LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L – Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke & Henning Walczak. https://www.nature.com/articles/s41467-018-06155-8

Delivery of a TNF-α–derived peptide by nanoparticles enhances its antitumor activity by inducing cell-cycle arrest and caspase-dependent apoptosis – Qiuxia Yan, Xueming Chen, Huizhen Gong, Pei Qiu, Xing Xiao, Shiying Dang, An Hong, and Yi Ma. https://www.fasebj.org/doi/abs/10.1096/fj.201800377R?ai=ts&ui=ly8&af=T

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis – Christoph Klatt, Irena Krüger, Saskia Zey, Kim-Jürgen Krott, Martina Spelleken, Nina Sarah Gowert, Alexander Oberhuber, Lena Pfaff, Wiebke Lückstädt, Kerstin Jurk, Martin Schaller, Hadi Al-Hasani, Jürgen Schrader, Steffen Massberg, Konstantin Stark, Hubert Schelzig, Malte Kelm, and Margitta Elvers. https://www.jci.org/articles/view/92077

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death – Ricard Garcia-Carbonell, Jerry Wong, Ju Youn Kim, Lisa Abernathy Close, Brigid S. Boland, Thomas L. Wong, Philip A. Harris, Samuel B. Ho, Soumita Das, Peter B. Ernst, Roman Sasik, William J. Sandborn, John Bertin, Pete J. Gough, John T. Chang, Michelle Kelliher, David Boone, Monica Guma, and Michael Karin. http://www.pnas.org/content/115/39/E9192?etoc=

K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death – Jinho Seo, Eun-Woo Lee, Jihye Shin, Daehyeon Seong, Young Woo Nam, Manhyung Jeong, Seon-Hyeong Lee, Cheolju Lee & Jaewhan Song. https://www.nature.com/articles/s41388-018-0323-z

TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling – Daniela Siegmund, Martin Ehrenschwender & Harald Wajant. https://www.nature.com/articles/s41419-018-0973-3

Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia – Dattesh Verlekar, Sung-Jen Wei, Hwangeui Cho, Shengping Yang & Min H. Kang. https://www.nature.com/articles/s41419-018-0964-4

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation – Laura Faletti, Lukas Peintner, Simon Neumann, Sandra Sandler, Thomas Grabinger, Sabine Mac Nelly, Irmgard Merfort, Chun-Hao Huang, Darjus Tschaharganeh, Tae-Won Kang, Florian Heinzmann, Luana D’Artista, Ulrich Maurer, Thomas Brunner, Scott Lowe, Lars Zender & Christoph Borner. https://www.nature.com/articles/s41419-018-0935-9


Necroptosis, RIP kinases, MLKL


Necroptosis microenvironment directs lineage commitment in liver cancer – Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof & Lars Zender. https://www.nature.com/articles/s41586-018-0519-y

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging – Daichao Xu, Taijie Jin, Hong Zhu, Hongbo Chen, Dimitry Ofengeim, Chengyu Zou, Lauren Mifflin, Lifeng Pan, Palak Amin, Wanjin Li, Bing Shan, Masanori Gomi Naito, Huyan Meng, Ying Li, Heling Pan, Liviu Aron, Xian Adiconis, Joshua Z. Levin, Bruce A. Yankner, Junying Yuan. https://www.cell.com/cell/fulltext/S0092-8674(18)30969-3

Necroptosis mediates myofibre death in dystrophin-deficient mice – Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni & Maximilien Bencze. https://www.nature.com/articles/s41467-018-06057-9

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD – Hui Chen, Yulu Fang, Jianfeng Wu, Hong Chen, Zhenhuan Zou, Xiaohong Zhang, Jing Shao & Yanfang Xu. https://www.nature.com/articles/s41419-018-0936-8

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation – Julian Buchrieser, Maria Jose Oliva-Martin, Michael D. Moore, Joshua C. D. Long, Sally A. Cowley, Jose Antonio Perez-Simón, William James & Jose Luis Venero. https://www.nature.com/articles/s41419-018-1053-4

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer – Ayaz Najafov , Ioannis K. Zervantonakis, Adnan K. Mookhtiar, Patricia Greninger, Ryan J. March, Regina K. Egan, Hoang Son Luu, Daniel G. Stover, Ursula A. Matulonis, Cyril H. Benes, Junying Yuan. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005756

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils – Akshay A. D’Cruz , Mary Speir, Meghan Bliss-Moreau, Sylvia Dietrich, Shu Wang, Alyce A. Chen, Mathilde Gavillet, Arshed Al-Obeidi, Kate E. Lawlor, James E. Vince, Michelle A. Kelliher, Razq Hakem, Manolis Pasparakis, David A. Williams, Maria Ericsson, Ben A. Croker. http://stke.sciencemag.org/content/11/546/eaao1716

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis – Katherine A. Davies, Maria C. Tanzer, Michael D. W. Griffin, Yee Foong Mok, Samuel N. Young, Rui Qin, Emma J. Petrie, Peter E. Czabotar, John Silke & James M. Murphy. https://www.nature.com/articles/s41418-018-0061-3


Miscellanous


Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms – Christian S Backes, Kim S Friedmann, Sebastian Mang, Arne Knörck, Markus Hoth and Carsten Kummerow. http://www.jbc.org/content/early/2018/09/06/jbc.RA118.004549.abstract

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia – Darren C. Johnson, Cornelius Y. Taabazuing, Marian C. Okondo, Ashley J. Chui, Sahana D. Rao, Fiona C. Brown, Casie Reed, Elizabeth Peguero, Elisa de Stanchina, Alex Kentsis & Daniel A. Bachovchin. https://www.nature.com/articles/s41591-018-0082-y

The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells – Ryan Haley, Ying Wang, Zheng Zhou. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007558

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death – Haruko Miura, Yohei Kondo, Michiyuki Matsuda, Kazuhiro Aoki. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31274-9

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death – Marta Bogacz, R Luise Krauth-Siegel. https://elifesciences.org/articles/37503

BAP1 links metabolic regulation of ferroptosis to tumour suppression – Yilei Zhang, Jiejun Shi, Xiaoguang Liu, Li Feng, Zihua Gong, Pranavi Koppula, Kapil Sirohi, Xu Li, Yongkun Wei, Hyemin Lee, Li Zhuang, Gang Chen, Zhen-Dong Xiao, Mien-Chie Hung, Junjie Chen, Peng Huang, Wei Li & Boyi Gan. https://www.nature.com/articles/s41556-018-0178-0

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis – Ishita Banerjee, Bharat Behl, Morena Mendonca, Gaurav Shrivastava, Ashley J. Russo, Antoine Menoret, Arundhati Ghosh, Anthony T. Vella, Sivapriya Kailasan Vanaja, Saumendra N. Sarkar, Katherine A. Fitzgerald, Vijay A.K. Rathinam. https://www.cell.com/immunity/fulltext/S1074-7613(18)30326-1

Dynein links engulfment and execution of apoptosis via CED-4/Apaf1 in C. elegans – Rikke Hindsgaul Harders, Tine Hørning Morthorst, Anna Dippel Lande, Marianne Overgaard Hesselager, Ole Aalund Mandrup, Emøke Bendixen, Allan Stensballe & Anders Olsen. https://www.nature.com/articles/s41419-018-1067-y


Reviews


Life, death and autophagy – Johnna Doherty & Eric H. Baehrecke. https://www.nature.com/articles/s41556-018-0201-5

Nutrient scavenging in cancer – Brendan T. Finicle, Vaishali Jayashankar & Aimee L. Edinger. https://www.nature.com/articles/s41568-018-0048-x

BCL-2 inhibition in AML: an unexpected bonus? – Marina Konopleva and Anthony Letai. http://bloodjournal.org/content/132/10/1007.abstract?etoc

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer – Bano D, Prehn JHM. https://linkinghub.elsevier.com/retrieve/pii/S2352-3964(18)30100-2

Autophagy-dependent cell death – where, how and why a cell eats itself to death – Shani Bialik, Santosh K. Dasari and Adi Kimchi. http://jcs.biologists.org/content/131/18/jcs215152?etoc

Apoptosis and necroptosis in the liver: a matter of life and death – Robert F. Schwabe & Tom Luedd. https://www.nature.com/articles/s41575-018-0065-y

The rise of apoptosis: targeting apoptosis in hematologic malignancies – Rebecca Valentin, Stephanie Grabow and Matthew S. Davids. http://bloodjournal.org/content/132/12/1248.abstract?etoc

The induction and consequences of Influenza A virus-induced cell death – Georgia K. Atkin-Smith, Mubing Duan, Weisan Chen & Ivan K. H. Poon. https://www.nature.com/articles/s41419-018-1035-6


Comments


Ion Man: GSDMD Punches Pores to Knock Out cGAS – Rebecca Feltham, James E. Vince. https://www.cell.com/immunity/fulltext/S1074-7613(18)30389-3

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1 – Haiyang Yu, Don W. Cleveland. https://www.cell.com/cell/fulltext/S0092-8674(18)31096-1

C. elegans RAB-35: Dual roles in apoptotic cell clearance – Christian E. Rocheleau. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007534

Neighbourhood deaths cause a switch in cancer subtype – Eli Pikarsky. https://www.nature.com/articles/d41586-018-06217-3

Retraction: ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteinshttp://cancerres.aacrjournals.org/content/78/17/5185

Metabolic control of ferroptosis in cancer – Michael P. Murphy. https://www.nature.com/articles/s41556-018-0209-x

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