ApoList – August 2018


Bcl-2 family proteins and MOMP


Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis – Joel S Riley, Giovanni Quarato, Catherine Cloix, Jonathan Lopez,Jim O’Prey, Matthew Pearson, James Chapman, Hiromi Sesaki, Leo M Carlin, João F Passos, Ann P Wheeler, Andrew Oberst, Kevin M Ryan, Stephen WG Tait.

http://emboj.embopress.org/content/early/2018/07/31/embj.201899238

 

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity – Ryan S. Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Grace R. Anderson, Kevin H. Lin, Peter S. Winter, Merve Cakir & Kris C. Wood.

https://www.nature.com/articles/s41467-018-05815-z

 

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy – Leverson JD, Phillips DC, Mitten MJ, Boghaert ER, Diaz D, Tahir SK, Belmont LD, Nimmer P, Xiao Y, Ma XM, Lowes KN, Kovar P, Chen J, Jin S, Smith M, Xue J, Zhang H, Oleksijew A, Magoc TJ, Vaidya KS, Albert DH2, Tarrant JM, La N, Wang L, Tao ZF, Wendt MD, Sampath D, Rosenberg SH, Tse C, Huang DC, Fairbrother WJ, Elmore SW, Souers AJ.

http://stm.sciencemag.org/content/7/279/279ra40.short

 

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1 – Loïc Lionnard, Pauline Duc, Margs S. Brennan, Andrew J. Kueh, Martin Pal, Francesca Guardia, Barbara Mojsa, Maria-Alessandra Damiano, Stéphan Mora, Iréna Lassot, Ramya Ravichandran, Claude Cochet, Abdel Aouacheria, Patrick Ryan Potts, Marco J. Herold, Solange Desagher & Jérôme Kucharczak.

https://www.nature.com/articles/s41418-018-0169-5

 

Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer – Kyle Knickelbein, Jingshan Tong, Dongshi Chen, Yi-Jun Wang, Sandra Misale, Alberto Bardelli, Jian Yu & Lin Zhang.

https://www.nature.com/articles/s41388-018-0289-x

 

Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition – Clare E. Weeden, Casey Ah-Cann, Aliaksei Z. Holik, Julie Pasquet, Jean-Marc Garnier, Delphine Merino, Guillaume Lessene & Marie-Liesse Asselin-Labat.

https://www.nature.com/articles/s41388-018-0268-2

 

RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-xLin developing thymocytes – Davinna L. Ligons , SuJin Hwang, Adam T. Waickman, Joo-Young Park, Megan A. Luckey, Jung-Hyun Park.

http://stke.sciencemag.org/content/11/545/eaam8939

 


Death receptors


 

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress – Mable Lam, David A. Lawrence, Avi Ashkenazi & Peter Walter.

https://www.nature.com/articles/s41418-018-0155-y

 

A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer – Gururaj Shivange, Karol Urbanek, Piotr Przanowski, Justin S.A. Perry, James Jones, Robert Haggart, Christina Kostka, Tejal Patki, Edward Stelow, Yuliya Petrova, Danielle Llaneza, Marty Mayo, Kodi S. Ravichandran, Charles N. Landen, Sanchita Bhatnagar, Jogender Tushir-Singh.

https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30310-6

 

Early activation of CD95 is limited and localized to the cytotoxic synapse – María Florencia Sánchez, Fabronia Murad, Gülce S. Gülcüler Balta, Ana Martin-Villalba, Ana J. García-Sáez and Dolores C. Carrer.

https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14518

 

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate – Tsun-Kai Chang, David A. Lawrence, Min Lu, Jenille Tan, Jonathan M. Harnoss, Scot A. Marsters, Peter Liu, Wendy Sandoval, Scott E. Martin, Avi Ashkenazi.

https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30513-6

 


Caspases


 

HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC – Jie Han, Leslie A. Goldstein, Wen Hou, Suman Chatterjee, Timothy F. Burns & Hannah Rabinowich.

https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1434471

 


Necroptosis / RIPK


 

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation – Delphine Cuchet-Lourenço, Davide Eletto, Changxin Wu, Vincent Plagnol, Olivier Papapietro, James Curtis, Lourdes Ceron-Gutierrez, Chris M. Bacon, Scott Hackett, Badr Alsaleem, Mailis Maes, Miguel Gaspar, Ali Alisaac, Emma Goss, Eman AlIdrissi, Daniela Siegmund, Harald Wajant, Dinakantha Kumararatne, Mofareh S. AlZahrani, Peter D. Arkwright, Mario Abinun, Rainer Doffinger, Sergey Nejentsev.

http://science.sciencemag.org/content/361/6404/810

 

Kinase domain dimerization drives RIPK3-dependent necroptosis – Saravanan Raju , Daniel M. Whalen, Meron Mengistu, Carter Swanson, John G. Quinn, Susan S. Taylor, Joshua D. Webster, Kim Newton, Andrey S. Shaw.

http://stke.sciencemag.org/content/11/544/eaar2188

 

Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke – Li W, Liu J, Chen JR, Zhu YM, Gao X, Ni Y, Lin B, Li H, Qiao SG, Wang C, Zhang HL, Ao GZ.

https://www.sciencedirect.com/science/article/abs/pii/S0306452218305190

 

RIPK1–RIPK3–MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils – Laiana Arlego-Barbosa, Paloma Peixoto Fiuza, Letícia Jambeiro Borges, Fillipe dosAnjos Rolim, Mayara Borges Andrade, Nivea F Luz, Graziele Quintela-Carvalho, Jonilson Berlink Lima, Roque P. Almeida, Francis Kaming Chan, Marcelo Torres Bozza, Valeria M Borges, Deboraci Brito Prates.

https://www.frontiersin.org/articles/10.3389/fimmu.2018.01818/full

 

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes – Lien Van Hoecke, Sandra Van Lint, Kenny Roose, Alexander Van Parys, Peter Vandenabeele, Johan Grooten, Jan Tavernier, Stefaan De Koker & Xavier Saelens.

https://www.nature.com/articles/s41467-018-05979-8

 


Gasdermin D, pyroptosis


 

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis [necrosulfonamide is a Gasdermin D inhibitor] – Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah C. Kondolf, Bryan L. Benson, Steven M. Chirieleison, Alex Y. Huang, George R. Dubyak, Tsan S. Xiao, Xiaoxia Li, Derek W. Abbott.

http://immunology.sciencemag.org/content/3/26/eaat2738.full

 

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps – Kaiwen W. Chen, Mercedes Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D. Condon, Jessica B. von Pein, Petr Broz, Matthew J. Sweet, Kate Schroder.

http://immunology.sciencemag.org/content/3/26/eaar6676

 

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps – Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn, Peter Habenberger, Raffaella Di Lucrezia, Susanne Kordes, Sascha Menninger, Jan Eickhoff, Peter Nussbaumer, Bert Klebl, Renate Krüger, Alf Herzig, Arturo Zychlinsky.

http://immunology.sciencemag.org/content/3/26/eaar6689

 

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion – Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder.

https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31117-3

 


Other forms of cell death


 

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity – Xinxin Song, Shan Zhu, Pan Chen, Wen Hou, Qirong Wen, Jiao Liu, Yangchun Xie, Jinbao Liu, Daniel J. Klionsky, Guido Kroemer, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang.

https://www.cell.com/current-biology/fulltext/S0960-9822(18)30764-4

 

Programmed cell removal by calreticulin in tissue homeostasis and cancer – Mingye Feng, Kristopher D. Marjon, Fangfang Zhu, Rachel Weissman-Tsukamoto, Aaron Levett, Katie Sullivan, Kevin S. Kao, Maxim Markovic, Paul A. Bump, Hannah M. Jackson, Timothy S. Choi, Jing Chen, Allison M. Banuelos, Jie Liu, Phung Gip, Lei Cheng, Denong Wang & Irving L. Weissman.

https://www.nature.com/articles/s41467-018-05211-7

 

Genomic instability in mutant p53 cancer cells upon entotic engulfment – Hannah L. Mackay, David Moore, Callum Hall, Nicolai J. Birkbak, Mariam Jamal-Hanjani, Saadia A. Karim, Vinaya M. Phatak, Lucia Piñon, Jennifer P. Morton, Charles Swanton, John Le Quesne & Patricia A. J. Muller.

https://www.nature.com/articles/s41467-018-05368-1

 


Miscellanous


 

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion – Elisabet Barbero-Camps, Vicente Roca-Agujetas, Isabel Bartolessis, Cristina de Dios, Jose C. Fernández-Checa, Montserrat Marí, Albert Morales, Tobias Hartmann & Anna Colell.

https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1438807#metrics-content

 

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation – Yumi Uetake and Greenfield Sluder.

https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-01-0026

 

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin – Amelia J. Brennan, Ruby H. P. Law, Paul J. Conroy, Tahereh Noori, Natalya Lukoyanova, Helen Saibil, Hideo Yagita, Annette Ciccone, Sandra Verschoor, James C. Whisstock, Joseph A. Trapani & Ilia Voskoboinik.

https://www.nature.com/articles/s41418-018-0057-z

 


Reviews / comments


 

RIP kinases as modulators of inflammation and immunity – Sudan He & Xiaodong Wang.

https://www.nature.com/articles/s41590-018-0188-x

 

Ripk1 and haematopoiesis: a case for LUBAC and Ripk3 – Alessandro Annibaldi & Pascal Meier.

https://www.nature.com/articles/s41418-018-0135-2

 

Different apoptosis pathways in Leishmania parasites – Louise Basmaciyan, Nadine Azas & Magali Casanova.

https://www.nature.com/articles/s41420-018-0092-z

 

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