ApoList – July 2018

 


Bcl-2 family proteins


Statins enhance efficacy of venetoclax in blood cancers – J. Scott Lee, Andrew Roberts, Dennis Juarez, Thanh-Trang T. Vo, Shruti Bhatt, Lee-or Herzog, Sharmila Mallya, Richard J. Bellin, Suresh K. Agarwal, Ahmed Hamed Salem, Tu Xu, Jia Jia, Lingxiao Li, John R. Hanna, Matthew S. Davids, Angela G. Fleischman, Susan O’Brien, Lloyd T. Lam, Joel D. Leverson, Anthony Letai, Jonathan H. Schatz and David A. Fruman

http://stm.sciencemag.org/content/10/445/eaaq1240

 

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion – Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E. Au, Rachael M. Lane, Katya J. Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E. Jarman, Sarah Ellis, Donald Metcalf, Shaun P. Jackson, Simone M. Schoenwaelder, Benjamin T. Kile and Emma C. Josefsson

http://bloodjournal.org/content/132/2/197.abstract?etoc

 

DNA repair processes are critical mediators of p53-dependent tumor suppression – Ana Janic, Liz J. Valente, Matthew J. Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J. Vandenberg, Andrew J. Kueh, Shinsuke Mizutani, Margs S. Brennan, Robyn L. Schenk, Lisa M. Lindqvist, Anthony T. Papenfuss, Liam O’Connor, Andreas Strasser & Marco J. Herold

https://www.nature.com/articles/s41591-018-0043-5

 

Phosphorylation alters Bim-mediated Mcl-1 stabilization and priming – Jason E. Conage-Pough and Lawrence H. Boise

https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14505

 

Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers [and low Bcl-2] – Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.

https://link.springer.com/article/10.1007%2Fs00109-018-1675-0


Death receptors


Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress – David Lawrence, Avi Ashkenazi & Peter Walter

https://www.nature.com/articles/s41418-018-0155-y

 

Fas-L promotes the stem cell potency of adipose-derived mesenchymal cells – Inna Solodeev, Benjamin Meilik, Ilan Volovitz, Meirav Sela, Sharon Manheim, Shai Yarkoni, Dov Zipori, Eyal Gur & Nir Shani

https://www.nature.com/articles/s41419-018-0702-y

 

Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors – Simon Sirtl, Gertrud Knoll, Dieu Thuy Trinh, Isabell Lang, Daniela Siegmund, Stefanie Gross, Beatrice Schuler-Thurner, Patrick Neubert, Jonathan Jantsch, Harald Wajant & Martin Ehrenschwender

https://www.nature.com/articles/s41388-018-0265-5

 

Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation – Sara R. Oliveira, Pedro A. Dionísio, Hugo Brito, Lídia Franco, Catarina A. B. Rodrigues, Rita C. Guedes, Carlos A. M. Afonso, Joana D. Amaral & Cecília M. P. Rodrigues

https://www.nature.com/articles/s41420-018-0067-0


Caspases and IAPs


Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock – Pratyusha Mandal, Yanjun Feng, John D. Lyons, Scott B. Berger, Shunsuke Otani, Alexandra DeLaney, Gregory K. Tharp, Kristal Maner-Smith, Eileen M. Burd, Michelle Schaeffer, Sandra Hoffman, Carol Capriotti, Linda Roback, Cedrick B. Young, Zhe Liang, Eric A. Ortlund, Nelson C. DiPaolo, Steven Bosinger, John Bertin, Peter J. Gough, Igor E. Brodsky, Craig M. Coopersmith, Dmitry M. Shayakhmetov, Edward S. Mocarski

https://www.cell.com/immunity/fulltext/S1074-7613(18)30293-0

 

Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activators – Alexander C Robeson, Kelly R Lindblom, Jeffrey Wojton, Sally Kornbluth and Kenkyo Matsuura

http://EMBOJ.embopress.org/content/37/14/e97072?etoc

 

Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6 – Anastasia Noël, Libin Zhou, Bénédicte Foveau, P. Jesper Sjöström & Andréa C. LeBlanc

https://www.nature.com/articles/s41418-017-0043-x

 

Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity – Steven M. Chirieleison, Joseph K. Rathkey, Derek W. Abbott

http://stke.sciencemag.org/content/11/539/eaao3964

 

XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis – Seong-In Jeong, Jung-Wook Kim, Kyung-Phil Ko, Byung-Kyu Ryu, Min-Goo Lee

https://www.nature.com/articles/s41419-018-0867-4

 

Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers – Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.

https://link.springer.com/article/10.1007%2Fs00109-018-1675-0


Execution phase and post-mortem


Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors – Marat S. Pavlyukov, Hai Yu, Soniya Bastola, Mutsuko Minata, Victoria O. Shender, Yeri Lee, Suojun Zhang, Jia Wang, Svetlana Komarova, Jun Wang, Shinobu Yamaguchi, Heba Allah Alsheikh, Junfeng Shi, Dongquan Chen, Ahmed Mohyeldin, Sung-Hak Kim, Yong Jae Shin, Ksenia Anufrieva, Evgeniy G. Evtushenko, Nadezhda V. Antipova, Georgij P. Arapidi, Vadim Govorun, Nikolay B. Pestov, Mikhail I. Shakhparonov, L. James Lee, Do-Hyun Nam, Ichiro Nakano

https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30226-5

 

Staurosporine-induced apoptotic water loss is cell- and attachment-specific – Michael A. Model, Nathan J. Mudrak, Priyanka S. Rana, Robert J. Clements

https://link.springer.com/article/10.1007/s10495-018-1471-x

 

Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology – Alice Tsuboi, Shizue Ohsawa, Daiki Umetsu, Yukari Sando, Erina Kuranaga, Tatsushi Igaki, Koichi Fujimoto

https://www.cell.com/current-biology/fulltext/S0960-9822(18)30631-6


Necroptosis


NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis – David Pajuelo, Norberto Gonzalez-Juarbe, Uday Tak, Jim Sun, Carlos J. Orihuela, Michael Niederweis

https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30952-5

 

Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance – Sheng-Yen Lin, Sung-Yuan Hsieh, Yi-Ting Fan, Wen-Chi Wei, Pei-Wen Hsiao, Dai-Hua Tsai, Tzong-Shoon Wu & Ning-Sun Yang

https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1386359

 

Activated platelets induce MLKL-driven neutrophil necroptosis and release of neutrophil extracellular traps in venous thrombosis – Daigo Nakazawa, Jyaysi Desai, Stefanie Steiger, Susanne Müller, Satish Kumar Devarapu,   Shrikant R. Mulay, Takamasa Iwakura & Hans-Joachim Anders

https://www.nature.com/articles/s41420-018-0073-2

 

Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation – Sara R. Oliveira, Pedro A. Dionísio, Hugo Brito, Lídia Franco, Catarina A. B. Rodrigues, Rita C. Guedes, Carlos A. M. Afonso, Joana D. Amaral & Cecília M. P. Rodrigues

https://www.nature.com/articles/s41420-018-0067-0


Miscellanous


Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma – Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, Feng Qu, Simon Van Herck, Yulia Y. Tyurina, Hülya Bayır, Behnaz A. Abhari, Jose Pedro Friedmann Angeli, Sze Men Choi, Eline Meul, Karen Heyninck, Ken Declerck, Chandra Sekhar Chirumamilla, Maija Lahtela-Kakkonen, Guy Van Camp, Dmitri V. Krysko, Paul G. Ekert, Simone Fulda, Bruno G. De Geest, Marcus Conrad, Valerian E. Kagan, Wim Vanden Berghe, Peter Vandenabeele, and Tom Vanden Berghe

https://www.jci.org/articles/view/99032

 

Mechanism of membrane pore formation by human gasdermin‐D – Estefania Mulvihill, Lorenzo Sborgi, Stefania A Mari, Moritz Pfreundschuh, Sebastian Hiller and Daniel J Müller

http://EMBOJ.embopress.org/content/37/14/e98321?etoc

 

Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” – Abdel Aouacheria,  Kyle W. Cunningham, J. Marie Hardwick, Zdena Palková, Ted Powers, Fedor F. Severin, Libuše Váchová

http://science.sciencemag.org/content/360/6395/eaar6910

 

Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” – Neta Shlezinger, Henriette Irmer, Sourabh Dhingra, Sarah R. Beattie, Robert A. Cramer, Gerhard H. Braus, Amir Sharon, Tobias M. Hohl

http://science.sciencemag.org/content/360/6395/eaas9457


Reviews


Programmed Cell Death in Immune Defense: Knowledge and Presumptions – David Wallach, Tae-Bong Kang

https://www.cell.com/immunity/abstract/S1074-7613(18)30301-7

 

New insights into apoptosome structure and function – Loretta Dorstyn, Christopher W. Akey & Sharad Kumar

https://www.nature.com/articles/s41418-017-0025-z

 

Do Fungi Undergo Apoptosis-Like Programmed Cell Death? – J. Marie Hardwick

http://mbio.asm.org/content/9/4/e00948-18.full


Comments / other


Gut check: dead cell samples leads to tolerant examples – Thomas H Oguin III & Jennifer Martinez

https://www.nature.com/articles/cdd201745

 

Growing a gasdermin pore in membranes of pyroptotic cells – Jingjin Ding and Feng Shao

http://EMBOJ.embopress.org/content/37/15/e100067?etoc

 

Q & A – Karen Vousden

https://www.cell.com/current-biology/fulltext/S0960-9822(18)30675-4

 

Finding clues in the p53 maze: an interview with Karen Vousden

http://dmm.biologists.org/content/11/8/dmm035675

 

Jerry Chipuk: A powerhouse for mitochondrial biology

http://jcb.rupress.org/content/early/2018/07/09/jcb.201807034

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