ApoList – June 2018

—————————-
Death receptors
—————————-

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
Palak Amin, Marcus Florez, Ayaz Najafov, Heling Pan, Jiefei Geng, Dimitry Ofengeim, Slawomir A. Dziedzic, Huibing Wang, Vica Jean Barrett, Yasushi Ito, Matthew J. LaVoie, and Junying Yuan
http://www.pnas.org/content/115/26/E5944?etoc=

A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation
Geert de Vreede, Holly A. Morrison, Alexandra M. Houser, Ryan M. Boileau, Ditte Andersen, Julien Colombani, David Bilder
https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30369-1

TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia
Jun Yang, Francis R. LeBlanc, Shubha A. Dighe, Cait E. Hamele, Thomas L. Olson, David J. Feith and Thomas P. Loughran Jr
http://bloodjournal.org/content/131/25/2803.abstract?etoc

Monocyte chemotactic protein-induced protein-1 enhances DR5 degradation and negatively regulates DR5 activation-induced apoptosis through its deubiquitinase function
You-Take Oh, Guoqing Qian, Jiusheng Deng & Shi-Yong Sun
https://www.nature.com/articles/s41388-018-0200-9?

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment
Jessica Wagner, C. Leah Kline, Lanlan Zhou, Kerry S. Campbell, Alexander W. MacFarlane, Anthony J. Olszanski, Kathy Q. Cai, Harvey H. Hensley, Eric A. Ross, Marie D. Ralff, Andrew Zloza, Charles B. Chesson, Jenna H. Newman, Howard Kaufman, Joseph Bertino, Mark Stein, and Wafik S. El-Deiry
https://www.jci.org/articles/view/96711

CONSTRUCTION AND CHARACTERIZATION OF A NEW TRAIL SOLUBLE FORM, ACTIVE AT PICOMOLAR CONCENTRATIONS
Matias Eliseo Melendez, Renato José Silva-Oliveira, Anna Luiza Silva Almeida Vicente, Lidia Maria Rebolho Batista Arantes, Ana Carolina de Carvalho, Alberto Luis Epstein, Rui Manuel Reis, and André Lopes Carvalho
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=25519&path%5B%5D=79903

Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells
Zunyue Zhang, Guohong Lin, Yujing Yan, Xiang Li, Yibing Hu, Jing Wang, Bingjiao Yin, Yaqun Wu, Zhuoya Li & Xiang-Ping Yang
https://www.nature.com/articles/s41388-018-0221-4

OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Klaus Heger, Katherine E. Wickliffe, Ada Ndoja, Juan Zhang, Aditya Murthy, Debra L. Dugger, Allie Maltzman, Felipe de Sousa e Melo, Jeffrey Hung, Yi Zeng, Erik Verschueren, Donald S. Kirkpatrick, Domagoj Vucic, Wyne P. Lee, Merone Roose-Girma, Robert J. Newman, Søren Warming, Yi-Chun Hsiao, László G. Kőműves, Joshua D. Webster, Kim Newton & Vishva M. Dixit
https://www.nature.com/articles/s41586-018-0256-2

Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation
Purvi Mande, Bahar Zirak, Wei-Che Ko, Keyon Taravati, Karen L. Bride, Tia Y. Brodeur, April Deng, Karen Dresser, Zhaozhao Jiang, Rachel Ettinger, Katherine A. Fitzgerald, Michael D. Rosenblum, John E. Harris, and Ann Marshak-Rothstein
https://www.jci.org/articles/view/98219

———————————-
Caspases and IAPs
———————————-

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3
Tae-Bong Kang, Ju-Seong Jeong, Seung-Hoon Yang, Andrew Kovalenko & David Wallach
https://www.nature.com/articles/s41418-018-0104-9

Phosphorylation by protein kinase A disassembles the caspase-9 core
Banyuhay P. Serrano & Jeanne A. Hardy
https://www.nature.com/articles/s41418-017-0052-9

A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate
Yvan Jamilloux, Brice Lagrange, Antonia Di MIcco, Emilie Bourdonnay, Angélina Provost, Rémy Tallant, Thomas Henry and Fabio Martinon
http://www.jbc.org/content/early/2018/06/21/jbc.RA117.000435.abstract

Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-kB activation
Xiaoting Hua, Binbin Li, Liang Song, Cuimei Hu, Xianyang Li, Dandan Wang, Ying Xiong, Ping Zhao, Huawei He, Qingyou xia and Fei Wang
http://www.jbc.org/content/early/2018/06/06/jbc.RA117.000194.abstract

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling
Victoria H. Ng, Brian I. Hang, Leah M. Sawyer, Leif R. Neitzel, Emily E. Crispi, Kristie L. Rose, Tessa M. Popay, Alison Zhong, Laura A. Lee, William P. Tansey, Stacey Huppert and Ethan Lee
http://jcs.biologists.org/content/131/10/jcs210575

Differentiated Macrophages Acquire a Pro-Inflammatory and Cell Death-Resistant Phenotype Due to Increasing XIAP and P38-mediated inhibition of RipK1
Dikchha Rijal, Ardeshir Ariana, Andrew Wight, Kwangsin Kim, Norah A. Alturki, Zoya Aamir, Emmanuelle Ametepe, Robert G. Korneluk, Christopher Tiedje, Manoj B Menon, Matthias Gaestel, Scott McComb and Subash Sad
http://www.jbc.org/content/early/2018/06/13/jbc.RA118.003614.abstract

SURVIVIN ANTAGONIZES CHEMOTHERAPY-INDUCED CELL DEATH OF COLORECTAL CANCER CELLS
Anke Rauch, Annemarie Carlstedt, Claudia Emmerich, Al-Hassan M. Mustafa, Anja Göder, Shirley K. Knauer,Michael Linnebacher, Thorsten Heinzel, and Oliver H. Krämer
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=25600&path%5B%5D=80128

———————————-
Bcl-2 family proteins
———————————-

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL
Kim R. Kampen, Sergey O. Sulima, Benno Verbelen, Tiziana Girardi, Stijn Vereecke, Gianmarco Rinaldi, Jelle Verbeeck, Joyce Op de Beeck, Anne Uyttebroeck, Jules P. P. Meijerink, Anthony V. Moorman, Christine J. Harrison, Pieter Spincemaille, Jan Cools, David Cassiman, Sarah-Maria Fendt, Pieter Vermeersch & Kim De Keersmaecker
https://www.nature.com/articles/s41375-018-0176-z

BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis
Tim Vervliet, Julia V. Gerasimenko, Pawel E. Ferdek, Monika A. Jakubowska, Ole H. Petersen, Oleg V. Gerasimenko & Geert Bultynck
https://www.nature.com/articles/s41420-018-0054-5

miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 [Bim] and BAX Proapoptotic Genes
Tianxiang Hu, Yating Chong, Sumin Lu, Rebecca Wang, Haiyan Qin, Jeane Silva, Eiko Kitamura, Chang-Sheng Chang, LesleyAnn Hawthorn and John K. Cowell
http://cancerres.aacrjournals.org/content/78/13/3522

———————————-
Necroptosis
———————————-

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb & James M. Murphy
https://www.nature.com/articles/s41467-018-04714-7

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
Seung-Won Choi, Han-Hee Park, Soyeon Kim, Jee Min Chung, Hyun-Jin Noh, Sue Kyung Kim, Hyun Kyu Song, Chang-Woo Lee, Michael J. Morgan, Ho Chul Kang, You-Sun Kim
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30390-3

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
Cole M. Dovey, Jonathan Diep, Bradley P. Clarke, Andrew T. Hale, Dan E. McNamara, Hongyan Guo, Nathaniel W. Brown Jr., Jennifer Yinuo Cao, Christy R. Grace, Peter J. Gough, John Bertin, Scott J. Dixon, Dorothea Fiedler, Edward S. Mocarski, William J. Kaiser, Tudor Moldoveanu, John D. York, Jan E. Carette
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30360-5

Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells
Hirotaka Watanabe, Kojiro Ishibashi, Hiroki Mano, Sho Kitamoto, Nanami Sato, Kazuya Hoshiba, Mugihiko Kato, Fumihiko Matsuzawa, Yasuto Takeuchi, Takanobu Shirai, Susumu Ishikawa, Yuka Morioka, Toshiaki Imagawa, Kazuyasu Sakaguchi, Suguru Yonezawa, Shunsuke Kon, Yasuyuki Fujita
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30862-3

Inhibition of Programmed Necrosis Limits Infarct Size through Altered Mitochondrial and Immune Responses in the Aged Female Rat Heart.
Garvin AM1, Jackson MA2, Korzick DH
https://www.ncbi.nlm.nih.gov/pubmed/29957016/

Hyperglycemia potentiates a shift from apoptosis to RIP1-dependent necroptosis
William D. McCaig, Payal S. Patel, Sergey A. Sosunov, Nicole L. Shakerley, Tori A. Smiraglia, Miranda M. Craft, Katharine M. Walker, Matthew A. Deragon, Vadim S. Ten & Timothy J. LaRocca
https://www.nature.com/articles/s41420-018-0058-1

—————————————————————-
Pyroptosis, ferroptosis and other -osis
—————————————————————-

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
Jie Yang, Zhonghua Liu, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis W. Pinkard, Wuxian Shi, Yinghua Chen, George R. Dubyak, Derek W. Abbott, and Tsan Sam Xiao
http://www.pnas.org/content/115/26/6792?etoc=

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever
Apurva Kanneganti, R.K. Subbarao Malireddi, Pedro H.V. Saavedra, Lieselotte Vande Walle, Hanne Van Gorp, Hiroto Kambara, Heather Tillman, Peter Vogel, Hongbo R. Luo, Ramnik J. Xavier, Hongbo Chi and Mohamed Lamkanfi
http://jem.rupress.org/content/215/6/1519?etoc

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
Brienne A. McKenzie, Manmeet K. Mamik, Leina B. Saito, Roobina Boghozian, Maria Chiara Monaco, Eugene O. Major, Jian-Qiang Lu, William G. Branton, and Christopher Power
http://www.pnas.org/content/115/26/E6065?etoc=

Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion
Lyla A. Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P. Weisberg, Brent R. Stockwell, Eldad A. Hod and Steven L. Spitalnik
http://bloodjournal.org/content/131/23/2581.abstract?etoc

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis
Hanke L. Matlung, Liane Babes, Xi Wen Zhao, Michel van Houdt, Louise W. Treffers, Dieke J. van Rees, Katka Franke, Karin Schornagel, Paul Verkuijlen, Hans Janssen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Jeanette H.W. Leusen, Jaap J. Boelens, Ingrid Kuhnle, Jutte van der Werff Ten Bosch, Karl Seeger, Sergio Rutella, Daria Pagliara, Takashi Matozaki, Eiji Suzuki, Catharina Willemien Menke-van der Houven van Oordt, Robin van Bruggen, Dirk Roos, Rene A.W. van Lier, Taco W. Kuijpers, Paul Kubes, Timo K. van den Berg
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30863-5

———————————-
Miscellanous
———————————-

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning
Balázs A. Györffy, Judit Kun, György Török, Éva Bulyáki, Zsolt Borhegyi, Péter Gulyássy, Viktor Kis, Péter Szocsics, András Micsonai, János Matkó, László Drahos, Gábor Juhász, Katalin A. Kékesi, and József Kardos
http://www.pnas.org/content/115/24/6303?etoc=

—————–
Reviews
—————–

XIAP at the crossroads of cell death and inflammation
Domagoj Vucic
https://doi.org/10.18632/oncotarget.25363

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Huizhong Feng, Brent R. Stockwell
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006203

Caspases in metabolic disease and their therapeutic potential
Claire H Wilson & Sharad Kumar
https://www.nature.com/articles/s41418-018-0111-x

Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy
Fei Yi, Nicholas Frazzette, Anthony C. Cruz, Christopher A. Klebanoff, Richard M. Siegel
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30101-1

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s