ApoList – April 2018

Bcl-2 family proteins

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
Dongshi Chen, Jingshan Tong, Liheng Yang, Liang Wei, Donna B. Stolz, Jian Yu, Jianke Zhang, and Lin Zhang

Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation
Sinéad Kinsella, Michael Fichtner, Orla Watters, Hans-Georg König and Jochen H. M. Prehn

The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim
Lazaro E. Aira, Elodie Villa, Pascal Colosetti, Parvati Gamas, Laurie Signetti, Sandrine Obba, Emma Proics, Fabien Gautier, Béatrice Bailly-Maitre, Arnaud Jacquel, Guillaume Robert, Frédéric Luciano, Philippe P. Juin, Jean-Ehrland Ricci, Patrick Auberger & Sandrine Marchetti

Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance
Annika Hantusch, Kushal K. Das, Ana J. García-Sáez, Thomas Brunner & Markus Rehm

Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins
Michael D. Crabtree, Carolina A. T. F. Mendonça, Quenton R. Bubb and Jane Clarke

Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling
Florian Schubert, Juliane Rapp, Prisca Brauns-Schubert, Lisa Schlicher, Kerstin Stock, Manuela Wissler, Martina Weiß, Céline Charvet, Christoph Borner & Ulrich Maurer

Venetoclax for patients with chronic lymphocytic leukemia who progressed during or after idelalisib therapy
Steven Coutre, Michael Choi, Richard R. Furman, Herbert Eradat, Leonard Heffner, Jeffrey A. Jones, Brenda Chyla, Lang Zhou, Suresh Agarwal, Tina Waskiewicz, Maria Verdugo, Rod A. Humerickhouse, Jalaja Potluri, William G. Wierda and Matthew S. Davids

Veronika Reidel, Johanna Kauschinger, Richard T. Hauch, Catharina Müller-Thomas, Niroshan Nadarajah, Rainer Burgkart, Burkhard Schmidt, Dirk Hempel, Anne Jacob, Julia Slotta-Huspenina, Ulrike Höckendorf, Christian Peschel, Wolfgang Kern, Torsten Haferlach, Katharina S. Götze, Stefanie Jilg, and Philipp J. Jost

Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer
Özge Saatci, Simone Borgoni, Özge Akbulut, Selvi Durmus, Umar Raza , Erol Eyüpoğlu , Can Alkan , Aytekin Akyol , Özgür Kütük, Stefan Wiemann & Özgür Şahin

Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt’s lymphoma cells
Justine Debernardi, Emilie Hollville, Marc Lipinski, Joëlle Wiels & Aude Robert

Death receptors

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L. Haas, Yutaka Shimizu, Charlotta Böiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T. Ashworth, Allison Beal, Tariq Enver, John Bertin, William Kaiser, Andreas Strasser, John Silke, Philippe Bouillet & Henning Walczak

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential
Rebecca Feltham, Kunzah Jamal, Tencho Tenev, Gianmaria Liccardi, Isabel Jaco, Celia Monteiro Domingues, Otto Morris, Sidonie Wicky John, Alessandro Annibaldi, Marcella Widya, Conor J. Kearney, Danielle Clancy, Paul R. Elliott, Timo Glatter, Qi Qiao, Andrew J. Thompson, Alexey Nesvizhskii, Alexander Schmidt, David Komander, Hao Wu, Seamus Martin, Pascal Meier

S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death
Sabrina Romagny, Sarra Bouaouiche, Géraldine Lucchi, Patrick Ducoroy, Jean B. Bertoldo, Hernan Terenzi, Ali Bettaieb and Stéphanie Plenchette

Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
Violet R. Mukaro, Alex Quach, Michelle E. Gahan, Bernadette Boog, Zhi H. Huang, Xiuhui Gao, Carol Haddad, Suresh Mahalingam, Charles S. Hii & Antonio Ferrante

Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis
William P. Bozza, Yaqin Zhang,  and  Baolin Zhang

The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells
Karen Legler, Charlotte Hauser, Jan-Hendrik Egberts, Anna Willms, Carola Heneweer, Susann Boretius, Christoph Röcken, Claus-Christian Glüer, Thomas Becker, Michael Kluge, Oliver Hill, Christian Gieffers, Harald Fricke, Holger Kalthoff, Johannes Lemke & Anna Trauzold


Caspase-9 CARD : core domain interactions require a properly formed active site
Kristen L. Huber, Banyuhay P. Serrano and Jeanne A. Hardy

Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation
Giulia Allavena, Francesca Cuomo, Georg Baumgartner, Tadeja Bele, Alexander Yarar Sellgren, Kyaw Soe Oo, Kaylee Johnson, Vladimir Gogvadze, Boris Zhivotovsky & Vitaliy O Kaminskyy


TWEAK and RIPK1 mediate a second wave of cell death during AKI
Diego Martin-Sanchez, Miguel Fontecha-Barriuso, Susana Carrasco, Maria Dolores Sanchez-Niño, Anne von Mässenhausen, Andreas Linkermann, Pablo Cannata-Ortiz, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz, and Ana Belen Sanz

Phenytoin inhibits necroptosis
Anne von Mässenhausen, Wulf Tonnus, Nina Himmerkus, Simon Parmentier, Danish Saleh, Diego Rodriguez, Jiraporn Ousingsawat, Rosalind L. Ang, Joel M. Weinberg, Ana B. Sanz, Alberto Ortiz, Adrian Zierleyn, Jan Ulrich Becker, Blandine Baratte, Nathalie Desban, Stéphane Bach, Ina Maria Schiessl, Shoko Nogusa, Siddharth Balachandran, Hans Joachim Anders, Adrian T. Ting, Markus Bleich, Alexei Degterev, Karl Kunzelmann, Stefan R. Bornstein, Douglas R. Green, Christian Hugo & Andreas Linkermann

Proteasome inhibition blocks necroptosis by attenuating death complex aggregation
Mohammad Ali & Edward S. Mocarski

RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome
Matija Zelic, Justine E. Roderick, Joanne A. O’Donnell, Jesse Lehman, Sung Eun Lim, Harish P. Janardhan, Chinmay M. Trivedi, Manolis Pasparakis, and Michelle A. Kelliher

Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression
Kezhou Zhu, Wei Liang, Zaijun Ma, Daichao Xu, Shuangyi Cao, Xiaojuan Lu, Nan Liu, Bing Shan, Lihui Qian & Junying Yuanhttps://www.nature.com/articles/s41419-018-0524-y

Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis
Shuo Liu, Yun Li, Harry M. C. Choi, Chinmoy Sarkar, Eugene Y. Koh Junfang Wu & Marta M. Lipinski


Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift
Jane A Armstrong, Nicole J Cash, Yulin Ouyang, Jack C Morton, Michael Chvanov, Diane Latawiec, Muhammad Awais, Alexei V Tepikin, Robert Sutton and David N Criddle

Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition
Carlos A. Elena-Real, Antonio Díaz-Quintana, Katiuska González-Arzola, Adrián Velázquez-Campoy, Mar Orzáez, Abelardo López-Rivas, Sergio Gil-Caballero, Miguel Á. De la Rosa & Irene Díaz-Moreno


Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer
Daniele Bano,  Jochen H.M. Prehn

Neuronal Cell Death
Michael Fricker, Aviva M. Tolkovsky, Vilmante Borutaite , Michael Coleman, and Guy C. Brown

Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation
Olivier Micheau

Comments / other

Caspase substrates won’t be defined by a four-letter code
Paul J. Baker and Seth L. Masters

BAX and BAK at the Gates of Innate Immunity
Lorenzo Galluzzi, Claire Vanpouille-Box

Evolution of an allosteric “off switch” in apoptotic caspases
Andrew B. Herr

Venetoclax after idelalisib: relevant progress for CLL
Francesc Bosch and Michael Hallek

Selenium and iron, two elemental rivals in the ferroptotic death process
Irina Ingold and Marcus Conrad

John Sulston (1942–2018)
Martin Chalfie


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