Apoptosis and cell death

Apolist: monthly literature updates for researchers

ApoList – March 2018

Posted by cris on April 3, 2018

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Bcl-2 family proteins
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Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins
Colin Hockings, Amber E. Alsop, Stephanie C. Fennell, Erinna F. Lee, W. Douglas Fairlie, Grant Dewson & Ruth M. Kluck
https://www.nature.com/articles/s41418-017-0010-6

Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10
Adrien Nougarede, Nikolay Popgeorgiev, Loay Kassem, Soleilmane Omarjee, Stephane Borel, Ivan Mikaelian, Jonathan Lopez, Rudy Gadet, Olivier Marcillat, Isabelle Treilleux, Bruno O. Villoutreix, Ruth Rimokh and Germain Gillet
http://cancerres.aacrjournals.org/content/78/6/1404

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells
Mark Mensink, Natasha S. Anstee, Mikara Robati, Robyn L. Schenk, Marco J. Herold, Suzanne Cory & Cassandra J. Vandenberg
https://www.nature.com/articles/s41418-017-0045-8

Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL
Yanfang Wu, Xia Li, Junying Jia, Yanpeng Zhang, Jing Li, Zhengmao Zhu, Huaqing Wang, Jie Tang, and Junjie Hu
http://www.pnas.org/content/115/12/E2762

ANTIAPOPTOTIC BCL-2 PROTEINS DETERMINE SORAFENIB/REGORAFENIB RESISTANCE AND BH3-MIMETIC EFFICACY IN HEPATOCELLULAR CARCINOMA
Anna Tutusaus, Milica Stefanovic, Loreto Boix, Blanca Cucarull, Aynara Zamora, Laura Blasco, Pablo García de Frutos, Maria Reig, Jose C. Fernandez-Checa, Montserrat Marí, Anna Colell, Jordi Bruix,  and  Albert Morales
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24673&path%5B%5D=77402

BCL-XL AS A POOR PROGNOSTIC BIOMARKER AND PREDICTOR OF RESPONSE TO ADJUVANT CHEMOTHERAPY SPECIFICALLY IN BRAF-MUTANT STAGE II AND III COLON CANCER
Philip D. Dunne, Helen G. Coleman, Peter Bankhead, Matthew Alderdice, Ronan T. Gray, Stephen McQuaid,Victoria Bingham, Maurice B. Loughrey, Jacqueline A. James, Amy M. B. McCorry, Alan Gilmore, Caitriona Holohan,Dirk Klingbiel, Sabine Tejpar, Patrick G. Johnston, Darragh G. McArt, Federica Di Nicolantonio, Daniel B. Longley, and  Mark Lawler
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24481&path%5B%5D=76870

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Death receptors
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Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
Gerd Meyer zu Horste, Dariusz Przybylski, Markus A. Schramm, Chao Wang, Alexandra Schnell, Youjin Lee, Raymond Sobel, Aviv Regev, Vijay K. Kuchroo
http://www.cell.com/immunity/fulltext/S1074-7613(18)30084-0

The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing
Xiaoxing Kou , Xingtian Xu, Chider Chen, Maria Laura Sanmillan, Tao Cai, Yanheng Zhou, Claudio Giraudo, Anh Le, Songtao Shi
http://stm.sciencemag.org/content/10/432/eaai8524

DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells
Joo-Young Im, Bo-Kyung Kim, Ji-Young Lee, Seung-Ho Park, Hyun Seung BanKyeong Eun Jung &
Misun Won
https://www.nature.com/articles/s41388-017-0025-y

Glycogen synthase kinase-3ß inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma
Na Zhang, Xiaojia Liu, Lu Liu, Zhesong Deng, Qingxuan Zeng, Weiqiang Pang, Yang Liu, Danqing Song & Hongbin Deng
https://www.nature.com/articles/s41419-018-0309-3

Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells
Marta Mauro-Lizcano & Abelardo López-Rivas
https://www.nature.com/articles/s41419-018-0263-0

STAT5 INHIBITION INDUCES TRAIL/DR4 DEPENDENT APOPTOSIS IN PERIPHERAL T-CELL LYMPHOMA
Haley M. Simpson, Aki Furusawa, Kavitha Sadashivaiah, Curt I. Civin, and Arnob Banerjee
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24698&path%5B%5D=77475

INTERFERON BETA INDUCES APOPTOSIS IN NASOPHARYNGEAL CARCINOMA CELLS VIA THE TRAIL-SIGNALING PATHWAY
Anna Makowska, Lora Wahab, Till Braunschweig, Nikiforos-Ioannis Kapetanakis, Christian Vokuhl, Bernd Denecke,Lian Shen, Pierre Busson, and Udo Kontny
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24479&path%5B%5D=76864

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Caspases, metacaspases, IAPs
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The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques
Mireille Laforge, Ricardo Silvestre, Vasco Rodrigues, Julie Garibal, Laure Campillo-Gimenez, Shahul Mouhamad, Valérie Monceaux, Marie-Christine Cumont, Henintsoa Rabezanahary, Alain Pruvost, Anabela Cordeiro-da-Silva, Bruno Hurtrel, Guido Silvestri, Anna Senik, and Jérôme Estaquier
https://www.jci.org/articles/view/95127

DNA‐damage inducible protein 1 is a conserved metacaspase substrate that is cleaved and further destabilized in yeast under specific metabolic conditions
León A. Bouvier, Gabriela T. Niemirowicz, Emir Salas‐Sarduy, Juan José Cazzulo, Vanina E. Alvarez
https://febs.onlinelibrary.wiley.com/toc/17424658/285/6?campaign=woletoc

Effect of phosphorylation and single nucleotide polymorphisms on caspase substrates processing
Sonu Kumar & Piotr Cieplak
https://link.springer.com/article/10.1007/s10495-018-1442-2?wt_mc=alerts.TOCjournals

XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype
Myron K. Evans, Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, Gregory M. Palmer, Matthias Gromeier, Herbert Levine, Michael A. Morse, Steven J. Van Laere and Gayathri R. Devi
http://cancerres.aacrjournals.org/content/78/7/1726

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Immunogenicity
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Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion
Lisa M. Lindqvist, Daniel Frank, Kate McArthur, Toby A. Dite, Michael Lazarou, Jonathan S. Oakhill, Benjamin T. Kile & David L. Vaux
https://www.nature.com/articles/s41418-017-0017-z

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Necroptosis, RIPK1
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CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing
Marinella G. Callow, Colin Watanabe, Katherine E. Wickliffe, Russell Bainer, Sarah Kummerfield, Julie Weng, Trinna Cuellar, Vasantharajan Janakiraman, Honglin Chen, Ben Chih, Yuxin Liang, Benjamin Haley, Kim Newton & Michael R. Costa
https://www.nature.com/articles/s41419-018-0301-y

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation
R.K. Subbarao Malireddi, Prajwal Gurung, Jayadev Mavuluri, Tejasvi Krishna Dasari, Jeffery M. Klco, Hongbo Chi, Thirumala-Devi Kanneganti
http://jem.rupress.org/content/215/4/1023?etoc

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Other forms of regulated necrosis
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Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis
Michael M. Gaschler, Fanghao Hu, Huizhong Feng, Andreas Linkermann, Wei Min, and Brent R. Stockwell
https://pubs.acs.org/doi/10.1021/acschembio.8b00199

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death
Hiroto Kambara, Fei Liu, Xiaoyu Zhang, Peng Liu, Besnik Bajrami, Yan Teng, Li Zhao, Shiyi Zhou, Hongbo Yu, Weidong Zhou, Leslie E. Silberstein, Tao Cheng, Mingzhe Han, Yuanfu Xu, Hongbo R. Luo
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30261-4

Contribution of TMEM16F to pyroptotic cell death
Jiraporn Ousingsawat, Podchanart Wanitchakool, Rainer Schreiber & Karl Kunzelmann
https://www.nature.com/articles/s41419-018-0373-8

Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore
Saranya Navaneetha Krishnan, Jesusa L. Rosales & Ki-Young Lee
https://www.nature.com/articles/s41388-017-0103-1

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Miscellaneous
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Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage
Paula Gutierrez-Martinez, Leah Hogdal, Manavi Nagai, Miriama Kruta, Rumani Singh, Kristopher Sarosiek, Andre Nussenzweig, Isabel Beerman, Anthony Letai & Derrick J. Rossi
https://www.nature.com/articles/s41556-018-0054-y

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover
Brent E. Fitzwalter, Christina G. Towers, Kelly D. Sullivan, Zdenek Andrysik, Maria Hoh, Michael Ludwig, Jim O’Prey, Kevin M. Ryan, Joaquin M. Espinosa, Michael J. Morgan, Andrew Thorburn
http://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30109-6

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Reviews / comments
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Perturbing mitosis for anti‐cancer therapy: is cell death the only answer?
Manuel Haschka, Gerlinde Karbon, Luca L Fava and Andreas Villunger
http://EMBOr.embopress.org/content/19/3/e45440?etoc

Nonapoptotic functions of Fas/CD95 in the immune response
Jean-Philippe Guégan and Patrick Legembre
http://onlinelibrary.wiley.com/doi/10.1111/febs.14292/abstract

Necroptosis in development and diseases
Bing Shan, Heling Pan, Ayaz Najafov and Junying Yuan
http://genesdev.cshlp.org/content/32/5-6/327.abstract?etoc

All about the caspase-dependent functions without cell death
Luis Alberto Baena-Lopez
https://www.sciencedirect.com/science/article/pii/S1084952118300028?via%3Dihub

FOXO3a Provides a Quickstep from Autophagy Inhibition to Apoptosis in Cancer Therapy
Patrice Codogno, Etienne Morel
http://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30151-5

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