ApoList – February 2018

 
 
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Bcl-2 family proteins
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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
Kate McArthur, Lachlan W. Whitehead, John M. Heddleston, Lucy Li, Benjamin S. Padman, Viola Oorschot, Niall D. Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M. Lane, Marija Dramicanin, Tahnee L. Saunders, Canny Sugiana, Romina Lessene, Laura D. Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, Guillaume Lessene, Michael T. Ryan, Kelly L. Rogers, Mark F. van Delft, Benjamin T. Kile
 
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD
Silvia Escudero, Elma Zaganjor, Susan Lee, Christopher P. Mill, Ann M. Morgan, Emily B. Crawford, Jiahao Chen, Thomas E. Wales, Rida Mourtada, James Luccarelli, Gregory H. Bird, Ulrich Steidl, John R. Engen, Marcia C. Haigis, Joseph T. Opferman, Loren D. Walensky
 
Targeting CDK6 and BCL2 Exploits the “MYB Addiction” of Ph+ Acute Lymphoblastic Leukemia
Marco De Dominici, Patrizia Porazzi, Angela Rachele Soliera, Samanta A. Mariani, Sankar Addya, Paolo Fortina, Luke F. Peterson, Orietta Spinelli, Alessandro Rambaldi, Giovanni Martinelli, Anna Ferrari, Ilaria Iacobucci and Bruno Calabretta
 
B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2’s apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors
Karl L. Banta, Xinyue Wang, Phani Das and Astar Winoto
 
Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer
Haolong Li, Lei Liu, Haocai Chang, Zhengzhi Zou & Da Xing
 
The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer
Steven Carberry, Beatrice D’Orsi, Naser Monsefi, Manuela Salvucci, Orna Bacon, Joanna Fay, Markus Rehm, Deborah McNamara, Elaine W. Kay & Jochen M. H. Prehn
 
MCL-1 is a prognostic indicator and drug target in breast cancer
Kirsteen J. Campbell, Sandeep Dhayade, Nicola Ferrari, Andrew H. Sims, Emma Johnson, Susan M. Mason, Ashley Dickson, Kevin M. Ryan, Gabriela Kalna, Joanne Edwards, Stephen W. G. Tait & Karen Blyth
 
Grouper Iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim
Suresh Banjara, Jiahao Mao, Timothy M. Ryan, Sofia Caria and Marc Kvansakul
 
 
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Caspases
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Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
Dave Boucher, Mercedes Monteleone, Rebecca C. Coll, Kaiwen W. Chen, Connie M. Ross, Jessica L. Teo, Guillermo A. Gomez, Caroline L. Holley, Damien Bierschenk, Katryn J. Stacey, Alpha S. Yap, Jelena S. Bezbradica, Kate Schroder
 
Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1
Monica L Gonzalez Ramirez, Marcin Poreba, Scott J Snipas, Katarzyna Groborz, Marcin Drag and Guy S Salvesen
 
Modifications to a common phosphorylation network provide individualized control in caspases
Melvin E Thomas, Robert Grinshpon, Paul Swartz and A Clay Clark
 
A caspase-2-RFXANK interaction and its implication for MHC class II expression
Jeremy Forsberg, Xinge Li, Birce Akpinar, Roger Salvatori, Martin Ott, Boris Zhivotovsky & Magnus Olsson
 
Glycolysis promotes caspase-3 activation in lipid rafts in T cells
Michael A. Secinaro, Karen A. Fortner, Oliver Dienz, Angela Logan, Michael P. Murphy, Vikas Anathy, Jonathan E. Boyson & Ralph C. Budd
 
ATP-COMPETITIVE PLK1 INHIBITORS INDUCE CASPASE 3-MEDIATED PLK1 CLEAVAGE AND ACTIVATION IN HEMATOPOIETIC CELL LINES
Maeva Dufies, Damien Ambrosetti, Sonia Boulakirba, Anne Calleja, Coline Savy, Nathan Furstoss, Marwa Zerhouni, Julien Parola, Lazaro Aira-Diaz, Sandrine Marchetti, Francois Orange, Sandra Lacas-Gervais, Frederic Luciano, Arnaud Jacquel, Guillaume Robert, Gilles Pagès, and Patrick Auberger
 
Rare mutations inapoptosis related genes APAF1, CASP9, and CASP3 contribute to human neural tube defects
Xiangyu Zhou, Weijia Zeng, Huili Li, Haitao Chen, Gang Wei, Xueyan Yang, Ting Zhang & Hongyan Wang
 
 
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Death receptors and FLIP
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Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure Mohammed Al-Saeedi, Niels Steinebrunner, Hassan Kudsi, Niels Halama, Carolin Mogler, Markus W. Büchler, Peter H. Krammer, Peter Schemmer & Martina Müller
 
c-FLIP is a target of the E3 ligase deltex1 in gastric cancer
Tzu-Sheng Hsu, Shu-Ting Mo, Ping-Ning Hsu & Ming-Zong Lai
 
Impairment of Fas-ligand–caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death
Xenia A. Glukhova, Julia A. Trizna, Olga V. Proussakova, Vladimir Gogvadze & Igor P. Beletsky
 
 
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IAPs
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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Tatiana Goncharov, Stefanie Hedayati, Melinda M. Mulvihill, Anita Izrael-Tomasevic, Kerry Zobel, Surinder Jeet, Anna V. Fedorova, Celine Eidenschenk, Jason deVoss, Kebing Yu, Andrey S. Shaw, Donald S. Kirkpatrick, Wayne J. Fairbrother, Kurt Deshayes, Domagoj Vucic
 
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
Alessandro Annibaldi, Sidonie Wicky John, Tom Vanden Berghe, Kirby N. Swatek, Jianbin Ruan, Gianmaria Liccardi, Katiuscia Bianchi, Paul R. Elliott, Sze Men Choi, Samya Van Coillie, John Bertin, Hao Wu, David Komander, Peter Vandenabeele, John Silke, Pascal Meier
 
The IAP family member BRUCE regulates autophagosome–lysosome fusion
Petra Ebner, Isabella Poetsch, Luiza Deszcz, Thomas Hoffmann, Johannes Zuber & Fumiyo Ikeda
 
IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans
Che A. Stafford, Kate E. Lawlor, Valentin J. Heim, Aleksandra Bankovacki, Jonathan P. Bernardini, John Silke, Ueli Nachbur
 
 
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Necroptosis
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Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis
Huyan Meng, Zhen Liu, Xingyan Li, Huibing Wang, Taijie Jin, Guowei Wu, Bing Shan, Dana E. Christofferson, Chunting Qi, Qiang Yu, Ying Li and Junying Yuan
 
RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism
Wenjing Liu, Binbin Chen, Yang Wang, Chenling Meng, Huihui Huang, Xiao-Ru Huang, Jinzhong Qin, Shrikant R. Mulay, Hans-Joachim Anders, Andong Qiu, Baoxue Yang, Gordon J. Freeman, Hua Jenny Lu, Herbert Y. Lin, Zhi-Hua Zheng, Hui-Yao Lan, Yu Huang, and Yin Xia
 
Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models
Angelo Iannielli, Simone Bido, Lucrezia Folladori, Alice Segnali, Cinzia Cancellieri, Alessandra Maresca, Luca Massimino, Alicia Rubio, Giuseppe Morabito, Leonardo Caporali, Francesca Tagliavini, Olimpia Musumeci, Giuliana Gregato, Erwan Bezard, Valerio Carelli, Valeria Tiranti, Vania Broccoli
 
Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination
Xiaolan Liu, Yueshuo Li, Songling Peng, Xinfang Yu, Wei Li, Feng Shi, Xiangjian Luo, Min Tang, Zheqiong Tan, A. M. Bode & Ya Cao
 
 
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Other non apoptotic cell death
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RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells
Mark A. Hawk, Cassandra L. Gorsuch, Patrick Fagan, Chan Lee, Sung Eun Kim, Jens C. Hamann, Joshua A. Mason, Kelsey J. Weigel, Matyas Abel Tsegaye, Luqun Shen, Sydney Shuff, Junjun Zuo, Stephan Hu, Lei Jiang, Sarah Chapman, W. Matthew Leevy, Ralph J. DeBerardinis, Michael Overholtzer & Zachary T. Schafer
 
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function
Tomokazu Yamaguchi , Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M. Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba
 
 
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Reviews
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Bax, Bak and beyond — mitochondrial performance in apoptosis
Aida Peña-Blanco and Ana J. García-Sáez
 
Pyroptosis: an inflammatory link between NAFLD and NASH with potential therapeutic implications
Juliane I. Beier, Jesus M. Banales
 
Apoptosis in megakaryocytes and platelets: the life and death of a lineage
Kate McArthur, Stephane Chappaz and Benjamin T. Kile
 
A matter of life and death: stem cell survival in tissue regeneration and tumour formation
Despina Soteriou & Yaron Fuchs
 
Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies
Ali Razaghi, Kirsten Heimann, Patrick M. Schaeffer & Spencer B. Gibson
 
Immunological consequences of kidney cell death
Maysa Sarhan, Anne von Mässenhausen, Christian Hugo, Rainer Oberbauer & Andreas Linkermann
 
Cell death-based treatment of glioblastoma
Simone Fulda
 
Necroptosis and neutrophil-associated disorders
Xiaoliang Wang, Shida Yousefi & Hans-Uwe Simon
 
Cell death-based approaches in treatment of the urinary tract-associated diseases: a fight for survival in the killing fields
Diego Martin-Sanchez, Miguel Fontecha-Barriuso, Maria Dolores Sanchez-Niño, Adrian M. Ramos, Ramiro Cabello, Carmen Gonzalez-Enguita, Andreas Linkermann, Ana Belén Sanz & Alberto Ortiz
 
Cell death-based treatment of neuroblastoma
Kadri Valter, Boris Zhivotovsky & Vladimir Gogvadze
 
 
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Comments
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Cell-in-cell phenomena, cannibalism, and autophagy: is there a relationship?
Stefano Fais & Michael Overholtzer
 
LEVERAGING THE IRON-STARVATION RESPONSE TO PROMOTE FERROPTOSIS
Samantha W. Alvarez,  and  Richard Possemato
 
MK2 puts an additional brake on RIPK1 cytotoxic potential
Yves Dondelinger, Tom Delanghe & Mathieu M. J. Bertrand
 
Inflammation NODs to Antagonists of RIP2-XIAP Interaction
Shiyu Xia, Tian-Min Fu, Hao Wu
 
Condemned by metabolism – The kinase RIP3 increases aerobic flux to produce reactive oxygen species
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