Apoptosis and cell death

Apolist: monthly literature updates for researchers

ApoList – January 2018

Posted by cris on February 5, 2018

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Bcl-2 family proteins
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Measurement of BH3-only protein tolerance
Haiming Dai, Husheng Ding, Kevin L Peterson, X Wei Meng, Paula A Schneider, Katherine L B Knorr & Scott H Kaufmann
http://www.nature.com/articles/cdd2017156

E2F1 interacts with BCL‐xL and regulates its subcellular localization dynamics to trigger cell death
Céline Vuillier, Steven Lohard, Aurélie Fétiveau, Jennifer Allègre, Cémile Kayaci, Louise E King, Frédérique Braun, Sophie Barillé‐Nion, Fabien Gautier, Laurence Dubrez, Andrew P Gilmore, Philippe P Juin and Laurent Maillet
http://EMBOr.embopress.org/content/19/2/234?etoc

Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.
Lucantoni F, Lindner AU, O’Donovan N, Düssmann H, Prehn JHM.
https://www.nature.com/articles/s41419-017-0039-y

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di & Guanglei Zhuang
https://www.nature.com/articles/s41467-017-02693-9

Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor
Edward P. Harvey, Hyuk-Soo Seo, Rachel M. Guerra, Gregory H. Bird, Sirano Dhe-Paganon, Loren D. Walensky
https://www.nature.com/articles/nri.2017.9

The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma
A. Esteve-Arenys, J. G. Valero, A. Chamorro-Jorganes, D. Gonzalez, V. Rodriguez, I. Dlouhy, I. Salaverria, E. Campo, D. Colomer, A. Martinez, G. Rymkiewicz, P. Pérez-Galán, A. Lopez-Guillermo & G. Roué
https://www.nature.com/articles/s41388-017-0111-1

Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2 double-hit B cell lymphoma
Micol Ravà, Aleco D’Andrea, Paola Nicoli, Ilaria Gritti, Giulio Donati, Mirko Doni, Marco Giorgio, Daniela Olivero and Bruno Amati
http://stm.sciencemag.org/content/10/426/eaan8723?utm_campaign=toc_stm_2018-01-31&et_rid=33946976&et_cid=1822874

A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function
Giovanni Monaco, Rita La Rovere, Spyridoula Karamanou, Kirsten Welkenhuyzen, Hristina Ivanova, Elien Vandermarliere, Marta Di Martile, Donatella Del Bufalo, Humbert De Smedt, Jan B. Parys, Anastassios Economou and Geert Bultynck
http://onlinelibrary.wiley.com/doi/10.1111/febs.14324/abstract

Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells
Raheleh Rezaei Araghi, Gregory H. Bird, Jeremy A. Ryan, Justin M. Jenson, Marina Godes, Jonathan R. Pritz, Robert A. Grant, Anthony Letai, Loren D. Walensky, and Amy E. Keating
https://www.nature.com/articles/onc2017299

Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy
Guo Chen, Andrew T. Magis, Ke Xu, Dongkyoo Park, David S. Yu, Taofeek K. Owonikoko, Gabriel L. Sica, Sarah W. Satola, Suresh S. Ramalingam, Walter J. Curran, Paul W. Doetsch, and Xingming Deng
https://www.jci.org/articles/view/92742

Caspase cleavage of Mcl-1 impairs its anti-apoptotic activity and proteasomal degradation in non-small lung cancer cells
Ting Wang, Zhiwei Yang, Yimeng Zhang, Xiang Zhang, Lei Wang, Shengli Zhang & Lintao Jia
https://link.springer.com/article/10.1007/s10495-017-1436-5

Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis
Qi Sun, Jacqueline Lesperance, Hiromi Wettersten, Elaine Luterstein, Yoko S. DeRose, Alana Welm, David A. Cheresh, and Jay S. Desgrosellier
https://www.jci.org/articles/view/93707

Coordinated repression of BIM and PUMA by Epstein–Barr virus latent genes maintains the survival of Burkitt lymphoma cells
Leah Fitzsimmons, Andrew J Boyce, Wenbin Wei, Catherine Chang, Deborah Croom-Carter et al.
https://www.nature.com/articles/cdd2017150

Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling
Martin Grundy, Claire Seedhouse, Thomas Jones, Liban Elmi, Michael Hall, Adam Graham, Nigel Russell, Monica Pallis
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190682

Molecular docking studies of bioactive compounds from Annona muricataLinn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins
Mohamad Norisham Mohamad Rosdi, Shahkila Mohd Arif, Mohamad Hafizi Abu Bakar, Siti Aisyah Razali, Razauden Mohamed Zulkifli & Harisun Ya’akob
https://link.springer.com/article/10.1007/s10495-017-1434-7

Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy
Carmen Aguirre-Hernández, Héctor Maya-Pineda, Julia San Millán, Y. K. Stella Man, Yong-Jie Lu & Gunnel Halldén
https://www.nature.com/articles/s41389-017-0020-8

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes & Francisco J. Iborra
https://www.nature.com/articles/s41467-017-02787-4

BAD and KATP channels regulate neuron excitability and epileptiform activity
Juan Ramón Martínez-François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica L Burnham, Nika N Danial, Gary Yellen
https://elifesciences.org/articles/32721

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Caspases, IAPs
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Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells
Ana Cano-González, Marta Mauro-Lizcano, Daniel Iglesias-Serret, Joan Gil & Abelardo López-Rivas
https://www.nature.com/articles/s41419-017-0164-7

Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment
Andrea Mohr, Laura Deedigan, Sylwia Jencz, Yasamin Mehrabadi, Lily Houlden, Stella-Maris Albarenque & Ralf M Zwacka
https://www.nature.com/articles/cdd2017164

Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts
Hye-Kyoung Jun, Young-Jung Jung, Suk Ji, Sun-Jin An & Bong-Kyu Choi
https://www.nature.com/articles/cdd2017167

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
Wan-Chen Hsieh, Tzu-Sheng Hsu, Ya-Jen Chang & Ming-Zong Lai
https://www.nature.com/articles/s41467-018-02862-4

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Death receptors
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Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes & Francisco J. Iborra
https://www.nature.com/articles/s41467-017-02787-4

CANCER PREVENTIVE EFFECT OF RECOMBINANT TRAIL BY ABLATION OF ONCOGENIC INFLAMMATION IN COLITIS-ASSOCIATED CANCER RATHER THAN ANTICANCER EFFECT
Joo-Young Kim, Young-Mi Kim, Jong-Min Park, Young Min Han, Kang Choon Lee, Ki Baik Hahm,  and  Suntaek Hong
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=23083&path%5B%5D=72802

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RIPK1, necroptosis
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Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis
Ha Yin Lee , Yoko Itahana, Stefan Schuechner, Masahiro Fukuda, H. Shawn Je, Egon Ogris, David M. Virshup, Koji Itahana
http://stke.sciencemag.org/content/11/512/eaam7893

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
Zhentao Yang , Yan Wang ,Yingying Zhang , Xiadi He, Chuan-Qi Zhong ,Hengxiao Ni , Xin Chen , Yaoji Liang , Jianfeng Wu , Shimin Zhao , Dawang Zhou & Jiahuai Han
http://www.nature.com/articles/s41556-017-0022-y

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Post-death
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Resolvins suppress tumor growth and enhance cancer therapy
Megan L. Sulciner, Charles N. Serhan, Molly M. Gilligan, Dayna K. Mudge, Jaimie Chang, Allison Gartung, Kristen A. Lehner, Diane R. Bielenberg, Birgitta Schmidt, Jesmond Dalli, Emily R. Greene, Yael Gus-Brautbar, Julia Piwowarski, Tadanori Mammoto, David Zurakowski, Mauro Perretti, Vikas P. Sukhatme, Arja Kaipainen, Mark W. Kieran, Sui Huang and Dipak Panigrahy
http://jem.rupress.org/content/215/1/115?etoc

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone
Hernan Roca, Jacqueline D. Jones, Marta C. Purica, Savannah Weidner, Amy J. Koh, Robert Kuo, John E. Wilkinson, Yugang Wang, Stephanie Daignault-Newton, Kenneth J. Pienta, Todd M. Morgan, Evan T. Keller, Jacques E. Nör, Lonnie D. Shea, and Laurie K. McCauley
https://www.jci.org/articles/view/92466

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Miscellaneous
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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Irina Ingold, Carsten Berndt, Sabine Schmitt, Sebastian Doll, Gereon Poschmann, Katalin Buday, Antonella Roveri, Xiaoxiao Peng, Florencio Porto Freitas, Tobias Seibt, Lisa Mehr, Michaela Aichler, Axel Walch, Daniel Lamp, Martin Jastroch, Sayuri Miyamoto, Wolfgang Wurst, Fulvio Ursini, Elias S.J. Arnér, Noelia Fradejas-Villar, Ulrich Schweizer, Hans Zischka, José Pedro Friedmann Angeli, Marcus Conrad
http://www.cell.com/cell/fulltext/S0092-8674(17)31438-1

The unique histidine in OSCP subunit of F‐ATP synthase mediates inhibition of the permeability transition pore by acidic pH
Manuela Antoniel, Kristen Jones, Salvatore Antonucci, Barbara Spolaore, Federico Fogolari, Valeria Petronilli, Valentina Giorgio, Michela Carraro, Fabio Di Lisa, Michael Forte, Ildikó Szabó, Giovanna Lippe and Paolo Bernardi
http://EMBOr.embopress.org/content/19/2/257?etoc

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
Charles L. Evavold, Jianbin Ruan, Yunhao Tan, Shiyu Xia, Hao Wu, Jonathan C. Kagan
http://www.cell.com/immunity/fulltext/S1074-7613(17)30514-9

CDK9‐mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery
Prisca Brauns‐Schubert, Florian Schubert, Manuela Wissler, Martina Weiss,Lisa Schlicher, Simon Bessler, Mariam Safavi, Cornelius Miething, Christoph Borner, Tilman Brummer and Ulrich Maurer
http://EMBOr.embopress.org/content/19/2/244?etoc

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway
Cathleen Holze, Chloé Michaudel, Claire Mackowiak, Darya A. Haas, Christian Benda et al.
https://www.nature.com/articles/s41590-017-0013-y

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Reviews
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi L, et al
https://www.nature.com/articles/s41418-017-0012-4

Structural principles of tumor necrosis factor superfamily signaling
Éva S. Vanamee , Denise L. Faustman
http://stke.sciencemag.org/content/11/511/eaao4910

Evolution of Voltage-Dependent Anion Channel Function: From Molecular Sieve to Governator to Actuator of Ferroptosis
John J. Lemasters
https://www.frontiersin.org/articles/10.3389/fonc.2017.00303/full

Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment
Mark A Hawk and Zachary T Schafer
http://www.jbc.org/content/early/2018/01/16/jbc.TM117.000260.abstract

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Comments
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Bcl-2 proteins: Unraveling the details of a complex and dynamic network
Stephanie Bleicken & Ana J. Garcia-Saez
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1384880

Resolving the dark side of therapy-driven cancer cell death
Eduardo Bonavita, Victoria S. Pelly and Santiago Zelenay
http://jem.rupress.org/content/215/1/9?etoc

An Element of Life
Douglas R. Green
http://www.cell.com/cell/fulltext/S0092-8674(18)30038-2

Apoptotic Regulatory T Cells Retain Suppressive Function through Adenosine
Ulf H. Beier
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30726-X

To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function
Manoj B. Menon, Julia Gropengießer, Klaus Ruckdeschel & Matthias Gaestel
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1396389

Switching from TNF-induced inflammation to death signaling
Qing Xu, Swati Choksi & Zhengang Liu
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1392402

Gasdermin D Flashes an Exit Signal for IL-1
Teneema Kuriakose, Thirumala-Devi Kanneganti
http://www.cell.com/immunity/fulltext/S1074-7613(18)30003-7

Stressed-out ROS take a silent death route
Sannula Kesavardhana & Thirumala-Devi Kanneganti
https://www.nature.com/articles/s41590-017-0034-6

Pulling the BAX trigger for tumor cell death
Denis E. Reyna and Evripidis Gavathiotis
https://doi.org/10.18632/oncotarget.24201

Novel drug combination unleashes apoptosis in AML
http://stm.sciencemag.org/content/10/422/eaar7509


Journal Club: Mitochondria: back to the future
Navdeep S. Chandel
https://www.nature.com/articles/nrm.2017.133

Obituary
Janet A. Houghton, PhD: In Memoriam (1952–2017)
Mark J. Suto
http://cancerres.aacrjournals.org/content/78/1/5

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