Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for January, 2018

ApoList – December 2017

Posted by cris on January 2, 2018

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Bcl-2 family proteins
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Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
David Lagares , Alba Santos, Paula E. Grasberger, Fei Liu, Clemens K. Probst, Rod A. Rahimi, Norihiko Sakai, Tobias Kuehl, Jeremy Ryan, Patrick Bhola, Joan Montero, Mohit Kapoor, Murray Baron, Xaralabos Varelas, Daniel J. Tschumperlin, Anthony Letai, Andrew M. Tager
http://stm.sciencemag.org/content/9/420/eaal3765

BOK promotes chemical-induced hepatocarcinogenesis in mice
Tatiana Rabachini, Yuniel Fernandez-Marrero, Matteo Montani, Giulio Loforese, Valentina Sladky, Zhaoyue He, Daniel Bachmann, Simone Wicki, Andreas Villunger, Deborah Stroka & Thomas Kaufmann
https://www.nature.com/articles/s41418-017-0008-0

First-in-human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia
Bernd Boidol, Christoph Kornauth, Emiel van der Kouwe, Nicole Prutsch, Lukas Kazianka, Sinan Gültekin, Gregor Hoermann, Marius E. Mayerhoefer, Georg Hopfinger, Alexander Hauswirth, Michael Panny, Marie-Bernadette Aretin, Bernadette Hilgarth, Wolfgang R. Sperr, Peter Valent, Ingrid Simonitsch-Klupp, Richard Moriggl, Olaf Merkel, Lukas Kenner, Ulrich Jäger, Stefan Kubicek and Philipp B. Staber
http://bloodjournal.org/content/130/23/2499.abstract?etoc

Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D. Leverson, Gwen Nichols, John C. Reed, Marina Konopleva, Michael Andreeff
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30502-0

RECIPROCAL SENSITIVITY OF DIFFUSE LARGE B-CELL LYMPHOMA CELLS TO BCL-2 INHIBITORS BIRD-2 VERSUS VENETOCLAX
Tamara Vervloessem, Haidar Akl, Thomas Tousseyn, Humbert De Smedt, Jan B. Parys,  and  Geert Bultynck
https://doi.org/10.18632/oncotarget.22898

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
Reema Jain, Julie M. Sheridan, Antonia Policheni, Melanie Heinlein, Luke C. Gandolfo, Grant Dewson, Gordon K. Smyth, Stephen N. Sansom, Nai Yang Fu, Jane E. Visvader, Georg A. Holländer, Andreas Strasser and Daniel H. D. Gray
http://bloodjournal.org/content/130/23/2504.abstract?etoc

MCL-1 INHIBITOR SUPPRESSES TUMOR GROWTH OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA IN A MOUSE MODEL
Jianqing Lin, Deqiang Fu, Yijun Dai, Jianguang Lin,  and  Tianwen Xu
https://doi.org/10.18632/oncotarget.18772

Golgi stress–induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing
Jan Baumann, Tatiana I. Ignashkova, Sridhar R. Chirasani, Silvia Ramírez-Peinado, Hamed Alborzinia, Mathieu Gendarme, Kyra Kuhnigk, Valentin Kramer, Ralph K. Lindemann and Jan H. Reiling
http://www.molbiolcell.org/content/29/1/42.abstract?etoc

Involvement of proapoptotic genes in autophagic cell death induced by irradiation
Jianrui Song, Xue Zhao, Yi Feng, Sheng Xu, Yanling Zhang & Lixin Wei
https://www.nature.com/articles/cddiscovery201768

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Death receptors / cFLIP
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A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell.
Akira Hashiramoto, Yoshitake Konishi, Koichi Murayama, Hiroki Kawasaki, Kosuke Yoshida, Ken Tsumiyama, Kimie Tanaka, Masaru Mizuhara, Toshio Shiotsuki, Hitomi Kitamura, Koichiro Komai, Tomoatsu Kimura, Hideo Yagita, Kazuko Shiozawa and Shunichi Shiozawa
http://www.jbc.org/content/early/2017/12/05/jbc.M117.798884.abstract

Cellular FLIP long isoform (cFLIPL)-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression.
Lauren T Gates-Tanzer and Joanna L Shisler
http://www.jbc.org/content/early/2017/12/08/jbc.RA117.000541.abstract

ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor
Andrew T. Holdbrooks, Colleen M. Britain and Susan L. Bellis
http://www.jbc.org/content/early/2017/12/12/jbc.M117.801480.abstract

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Necroptosis / ferroptosis
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Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis
Laura R. Parisi, Nas Li, G. Ekin Atilla-Gokcumen
https://www.sciencedirect.com/science/article/pii/S2451945617303240

ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival
Gary X. Wang, Ho-Chou Tu, Yiyu Dong, Anders Jacobsen Skanderup, Yufeng Wang, Shugaku Takeda, Yogesh Tengarai Ganesan, Song Han, Han Liu, James J. Hsieh, Emily H. Cheng
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31667-4

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Inflammasome / apoptosis or pyroptosis
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The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity
Katharina S. Schneider, Christina J. Groß, Roland F. Dreier, Benedikt S. Saller, Ritu Mishra, Oliver Gorka, Rosalie Heilig, Etienne Meunier, Mathias S. Dick, Tamara Ćiković, Jan Sodenkamp, Guillaume Médard, Ronald Naumann, Jürgen Ruland, Bernhard Kuster, Petr Broz, Olaf Groß
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31814-4

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4
Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, Pedro H.V. Saavedra, Nathalia M. de Vasconcelos, Amanda Gonçalves, Lieselotte Vande Walle, Dieter Demon, Magdalena Matusiak, Filip Van Hauwermeiren, Jinke D’Hont, Tino Hochepied, Stefan Krautwald, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
http://www.cell.com/cell-reports/abstract/S2211-1247(17)31755-2

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice
Bing Xua , Mingzuo Jianga , Yi Chua , Weijie Wanga , Di Chen , Xiaowei Li , Zhao Zhang , Di Zhang , Daiming Fan , Yongzhan Nie , Feng Shao , Kaichun Wu, Jie Liang
http://www.journal-of-hepatology.eu/article/S0168-8278(17)32494-7/fulltext

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Miscellaneous
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X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Client of Heat Shock Protein 70 (Hsp70) and a Biomarker of its Inhibition
Laura C Cesa, Hao Shao, Sharan R Srinivasan, Eric Tse, Chetali Jain, Erik R.P. Zuiderweg, Daniel R Southworth, Anna K Mapp and Jason E Gestwicki
http://www.jbc.org/content/early/2017/12/18/jbc.RA117.000634.abstract

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Reviews
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Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax
Joel D. Leverson, Deepak Sampath, Andrew J. Souers, Saul H. Rosenberg, Wayne J. Fairbrother, Martine Amiot, Marina Konopleva and Anthony Letai
http://cancerdiscovery.aacrjournals.org/content/7/12/1376

Paving TRAIL’s Path with Ubiquitin
Elodie Lafont, Torsten Hartwig, Henning Walczak
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(17)30204-9

Sphingolipid metabolism in cancer signalling and therapy
Besim Ogretmen
https://www.nature.com/articles/nrc.2017.96

Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling
Simon J. Cook, Kate Stuart, Rebecca Gilley, Matthew J. Sale
http://onlinelibrary.wiley.com/doi/10.1111/febs.14122/abstract

Therapeutic opportunities based on caspase modulation.
Simone Fulda
http://www.sciencedirect.com/science/article/pii/S1084952117305256

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Comments
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T-PLL: another check on the venetoclax list?
Prithviraj Bose and Marina Y. Konopleva
http://bloodjournal.org/content/130/23/2447?etoc

MCL-1 keeps a charming home for thymocytes
Xuguang Tai
http://bloodjournal.org/content/130/23/2448?etoc

BTSA1 Activates BAX to Promote Apoptosis in Acute Myeloid Leukemia
http://cancerdiscovery.aacrjournals.org/content/7/12/1363.2

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