Apoptosis and cell death

Apolist: monthly literature updates for researchers

ApoList – November 2017

Posted by cris on December 4, 2017

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Bcl-2 family proteins
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The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice
Kerstin Brinkmann, Stephanie Grabow, Craig D Hyland, Charis E Teh, Warren S Alexander, Marco J Herold and Andreas Strasser
https://www.nature.com/articles/cdd2017125

Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL+ B-Lineage Acute Lymphoblastic Leukemia
Amit Budhraja, Meghan E Turnis, Michelle L Churchman, Anisha Kothari, Xue Yang, Haiyan Xu, Ewa Kaminska, John C Panetta, David Finkelstein, Charles G. Mullighan and Joseph T Opferman
http://clincancerres.aacrjournals.org/content/early/2017/10/03/1078-0432.CCR-17-1231

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Jason Karch, Tobias G Schips, Bryan D Maliken, Matthew J Brody, Michelle A Sargent, Onur Kanisciak and Jeffery D Molkentin
https://elifesciences.org/articles/30543

Venetoclax is effective in small cell lung cancers with high BCL-2 expression
Timothy L Lochmann, Konstantinos V Floros, Mitra Naseri, Krista M Powell, Wade Cook, Ryan J March, Giovanna T Stein, Patricia Greninger, Yuki Kato Maves, Laura R Saunders, Scott J. Dylla, Carlotta Costa, Sosipatros A Boikos, Joel D. Leverson, Andrew J. Souers, Geoffrey W Krystal, Hisashi Harada, Cyril H. Benes and Anthony C. Faber
http://clincancerres.aacrjournals.org/content/early/2017/11/08/1078-0432.CCR-17-1606

BCL-2 system analysis identifies high-risk colorectal cancer patients.
Lindner AU, Salvucci M, Morgan C, Monsefi N, Resler AJ, Cremona M, Curry S, Toomey S, O’Byrne R, Bacon O, Stühler M, Flanagan L, Wilson R, Johnston PG, Salto-Tellez M, Camilleri-Broët S, McNamara DA, Kay EW, Hennessy BT, Laurent-Puig P, Van Schaeybroeck S, Prehn JHM.
http://gut.bmj.com/content/66/12/2141.long

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c-FLIP / caspases
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PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP
Huibing Wang, Huyan Meng, Xingyan Li, Kezhou Zhu, Kangyun Dong, Adnan K. Mookhtiar, Huiting Wei, Ying Li, Shao-Cong Sun, and Junying Yuan
http://www.pnas.org/content/114/45/11944.abstract.html

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis
Rosa Martín-Pérez, Rosario Yerbes, Rocío Mora-Molina, Ana Cano-González, Joaquín Arribas, Massimiliano Mazzone, Abelardo López-Rivas and Carmen Palacios
http://oncotarget.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21458

CFLIP CRITICALLY MODULATES APOPTOTIC RESISTANCE IN EPITHELIAL-TO-MESENCHYMAL TRANSITION
Chandrasekhar Padmanabhan, Eric J. Rellinger, Jing Zhu, Hanbing An, Luke G. Woodbury, Dai H. Chung, Alex G. Waterson, Craig W. Lindsley, Anna L. Means, and  R. Daniel Beauchamp
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=19557&path%5B%5D=62500

Active-site adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9
Banyuhay P. Serrano, Hannah S. Szydlo, Dominique R. Alfandari and Jeanne A. Hardy
http://www.jbc.org/content/early/2017/10/24/jbc.M117.811976.abstract

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Death receptors
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Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
Jingjing Zhu, Céline G. Powis de Tenbossche, Stefania Cané, Didier Colau, Nicolas van Baren, Christophe Lurquin, Anne-Marie Schmitt-Verhulst, Peter Liljeström, Catherine Uyttenhove & Benoit J. Van den Eynde
https://www.nature.com/articles/s41467-017-00784-1

TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects
Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Ryota Amachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Keiichiro Watanabe, Masami Iwasa, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Kimiko Sogabe, Shingen Nakamura, Hirokazu Miki, Kiyoe Kurahashi, Sumiko Yoshida, Kenichi Aihara, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe
http://www.bloodadvances.org/content/1/24/2124.abstract?etoc

A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell.
Akira Hashiramoto, Yoshitake Konishi, Koichi Maruyama, Hiroki Kawasaki, Kosuke Yoshida, Ken Tsumiyama, Kimie Tanaka, Masaru Mizuhara, Toshio Shiotsuki, Hitomi Kitamura, Koichiro Komai, Tomoatsu Kimura, Hideo Yagita, Kazuko Shiozawa and Shunichi Shiozawa
http://www.jbc.org/content/early/2017/11/27/jbc.M117.798884.abstract

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RIPK1, necroptosis
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RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense
Lance W. Peterson, Naomi H. Philip, Alexandra DeLaney, Meghan A. Wynosky-Dolfi, Kendra Asklof, Falon Gray, Ruth Choa, Elisabet Bjanes, Elisabeth L. Buza, Baofeng Hu, Christopher P. Dillon, Douglas R. Green, Scott B. Berger, Peter J. Gough, John Bertin and Igor E. Brodsky
http://jem.rupress.org/content/214/11/3171?etoc

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis
Adrian Schreiber, Anthony Rousselle, Jan Ulrich Becker, Anne von Mässenhausen, Andreas Linkermann, and Ralph Kettritz
http://www.pnas.org/content/114/45/E9618.abstract.html?etoc

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Non apoptotic cell death
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Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury
Kwong Tai Cheng, Shiqin Xiong, Zhiming Ye, Zhigang Hong, Anke Di, Kit Man Tsang, Xiaopei Gao, Shejuan An, Manish Mittal, Stephen M. Vogel, Edward A. Miao, Jalees Rehman, Asrar B. Malik
https://www.jci.org/articles/view/94495

Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway
Kazuki Hattori, Hiroyuki Ishikawa, Chihiro Sakauchi, Saki Takayanagi, Isao Naguro and Hidenori Ichijo
http://EMBOr.embopress.org/content/18/11/2067?etoc

Cell death and cell lysis are separable events during pyroptosis
Lucian DiPeso, Daisy X Ji, Russell E Vance & Jordan V Price
https://www.nature.com/articles/cddiscovery201770

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Miscellaneous
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Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells
Allison W. Roberts, Bettina L. Lee, Jacques Deguine, Shinu John, Mark J. Shlomchik, Gregory M. Barton
http://www.cell.com/immunity/fulltext/S1074-7613(17)30437-5

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation
Antonio Galleu , Yanira Riffo-Vasquez, Cristina Trento, Cara Lomas, Luigi Dolcetti, Tik Shing Cheung, Malte von Bonin, Laura Barbieri, Krishma Halai, Sophie Ward, Ling Weng, Ronjon Chakraverty, Giovanna Lombardi, Fiona M. Watt, Kim Orchard, David I. Marks, Jane Apperley, Martin Bornhauser, Henning Walczak, Clare Bennett, Francesco Dazzi
http://stm.sciencemag.org/content/9/416/eaam7828

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma
Wilson X Mai, Laura Gosa, Veerle W Daniels, Lisa Ta, Jonathan E Tsang, Brian Higgins, W Blake Gilmore, Nicholas A Bayley, Mitra Dehghan Harati, Jason T Lee, William H Yong, Harley I Kornblum, Steven J Bensinger, Paul S Mischel, P Nagesh Rao, Peter M Clark, Timothy F Cloughesy, Anthony Letai & David A Nathanson
https://www.nature.com/articles/nm.4418

Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform
Ujval Anilkumar, Petronela Weisova, Jasmin Schmid, Tytus Bernas, Heinrich J. Huber, Heiko Düssmann, Niamh M. C. Connolly, Jochen H. M. Prehn
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188343

Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program
Farokh Dotiwala, Sumit Sen Santara, Andres Ariel Binker-Cosen, Bo Li, Sriram Chandrasekaran, Judy Lieberman
http://www.cell.com/cell/fulltext/S0092-8674(17)31188-1

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Reviews
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How do we fit ferroptosis in the family of regulated cell death?
Howard O Fearnhead, Peter Vandenabeele and Tom Vanden Berghe
https://www.nature.com/articles/cdd2017149

The resurrection of the PIDDosome – emerging roles in the DNA-damage response and centrosome surveillanc
Valentina Sladky, Fabian Schuler, Luca L. Fava and Andreas Villunger
http://jcs.biologists.org/content/130/22/3779?etoc

Q&A: Cellular near death experiences—what is anastasis?
Gongping Sun and Denise J. Montell
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0441-z

Inhibitors of apoptosis: clinical implications in cancer
Mervat S. Mohamed, Mai K. Bishr, Fahad M. Almutairi & Ayat G. Ali
https://link.springer.com/article/10.1007/s10495-017-1429-4

Conserved nucleolar stress at the onset of cell death
Pierre Golstein
http://onlinelibrary.wiley.com/doi/10.1111/febs.14095/abstract

Inflammasome activation and assembly at a glance
Ankit Malik and Thirumala-Devi Kanneganti
http://jcs.biologists.org/content/130/23/3955?etoc

Special issue in “Cell Calcium” on Ca++ and cell death
– Preface: Ca2+ signaling and cell death: Focus on the role of Ca2+ signals in the regulation of cell death & survival processes in health, disease and therapy
https://www.sciencedirect.com/science/journal/aip/01434160
– Editorial:Ca2+ signaling and cell death: Focus on Ca2+-transport systems and their implication in cell death and survival
Jan B. Parys, Geert Bultynck
https://www.sciencedirect.com/science/article/pii/S0143416017301756

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Comments / other
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Apoptotic debris goes in the Bim
Lack of Bim expression in myeloid cells induces lupus nephritis in mice
http://stm.sciencemag.org/content/9/417/eaar2440

The Silent Undertakers: Macrophages Programmed for Efferocytosis
Judith E. Allen, Dominik Rückerl
http://www.cell.com/immunity/fulltext/S1074-7613(17)30464-8

Caspase-independent cell death: an anti-cancer double-whammy
Evangelos Giampazolias & Stephen W.G. Tait
http://www.tandfonline.com/doi/abs/10.1080/15384101.2017.1408229#.WhvXWEFadZM.facebook

The Ferrous Awakens
Andrew J. Rennekamp
http://www.cell.com/cell/fulltext/S0092-8674(17)31380-6

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