ApoList – October 2017

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Bcl-2 family proteins
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BCL-XL directly modulates RAS signalling to favour cancer cell stemness
Sophie de Carné Trécesson, Frédérique Souazé, Agnès Basseville, Anne-Charlotte Bernard, Jessie Pécot, Jonathan Lopez, Margaux Bessou, Kristopher A. Sarosiek, Anthony Letai, Sophie Barillé-Nion, Isabelle Valo, Olivier Coqueret, Catherine Guette, Mario Campone, Fabien Gautier & Philippe Paul Juin
https://www.nature.com/articles/s41467-017-01079-1

MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
Kyung-min Lee, Jennifer M. Giltnane, Justin M. Balko, Luis J. Schwarz, Angel L. Guerrero-Zotano, Katherine E. Hutchinson, Mellissa J. Nixon, Mónica V. Estrada, Violeta Sánchez, Melinda E. Sanders, Taekyu Lee, Henry Gómez, Ana Lluch, J. Alejandro Pérez-Fidalgo, Melissa Magdalene Wolf, Gabriela Andrejeva, Jeffrey C. Rathmell, Stephen W. Fesik, Carlos L. Arteaga
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30560-0

Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis
Prafull Kumar Singh, Aristomenis Roukounakis, Daniel O. Frank, Susanne Kirschnek, Kushal Kumar Das, Simon Neumann, Josef Madl, Winfried Römer, Carina Zorzin, Christoph Borner, Aladin Haimovici, Ana Garcia-Saez, Arnim Weber and Georg Häcker
http://genesdev.cshlp.org/content/31/17/1754.abstract?etoc

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
Denis E. Reyna, Thomas P. Garner, Andrea Lopez, Felix Kopp, Gaurav S. Choudhary, Ashwin Sridharan, Swathi-Rao Narayanagari, Kelly Mitchell, Baoxia Dong, Boris A. Bartholdy, Loren D. Walensky, Amit Verma, Ulrich Steidl, Evripidis Gavathiotis
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30364-1

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
Yohannes A. Mebratu, Ivan Leyva-Baca, Marc G. Wathelet, Neal Lacey, Hitendra S. Chand, Augustine M. K. Choi & Yohannes Tesfaigzi
https://www.nature.com/articles/s41467-017-00975-w

Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity
Han-A Park, Pawel Licznerski, Nelli Mnatsakanyan, Yulong Niu, Silvio Sacchetti, Jing Wu, Brian M Polster, Kambiz N Alavian and Elizabeth A Jonas
http://www.nature.com/cdd/journal/v24/n11/abs/cdd2017123a.html

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
Georg Karpel-Massler, Chiaki Tsuge Ishida, Elena Bianchetti, Yiru Zhang, Chang Shu, Takashi Tsujiuchi, Matei A. Banu, Franklin Garcia, Kevin A. Roth, Jeffrey N. Bruce, Peter Canoll & Markus D. Siegelin
https://www.nature.com/articles/s41467-017-00984-9

Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis
Natalia Edison, Yael Curtz, Nicole Paland, Dana Mamriev, Nicolas Chorubczyk, Tali Haviv-Reingewertz, Nir Kfir, David Morgenstern, Meital Kupervaser, Juliana Kagan, Hyoung Tae Kim, Sarit Larisch
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31342-6

Loss of BIM augments resistance of ATM-deficient thymocytes to DNA damage-induced apoptosis but does not accelerate lymphoma development
Alex RD Delbridge, Stephanie Grabow and Andreas Strasser
http://www.nature.com/cdd/journal/v24/n11/full/cdd2017138a.html

NOVEL POST-TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF PRO-APOPTOTIC PROTEIN BOK AND ANTI-APOPTOTIC PROTEIN MCL-1 DETERMINE THE FATE OF BREAST CANCER CELLS TO SURVIVE OR DIE
Benjamin Onyeagucha, Panneerdoss Subbarayalu, Nourhan Abdelfattah, Subapriya Rajamanickam, Santosh Timilsina, Rosa Guzman, Vijay Eedunuri, Sanjay Bansal, Tabrez Mohammad, Yidong Chen, Ratna K. Vadlamudi, and  Manjeet K. Rao
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=20841&path%5B%5D=66379

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
Jianrong Wang, Nanhai He, Na Zhang, Dexian Quan, Shuo Zhang, Caroline Zhang, Ruth T. Yu, Annette R. Atkins, Ruihong Zhu, Chunhui Yang, Ying Cui, Christopher Liddle, Michael Downes, Hui Xiao, Ye Zheng, Johan Auwerx, Ronald M. Evans & Qibin Leng
https://www.nature.com/articles/s41467-017-00931-8

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.
T-C Teh, N-Y Nguyen, D M Moujalled, D Segal, G Pomilio, S Rijal, A Jabbour, K Cummins, K Lackovic, P Blombery, E Thompson, P G Ekert, G Lessene, S P Glaser, D C S Huang, A W Roberts, M A Guthridge &A H Wei
http://dx.doi.org/10.1038/leu.2017.243

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Death receptors
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Secretory stressors induce intracellular death receptor accumulation to control apoptosis
Bram J van Raam, Tamara Lacina, Ralph K Lindemann and Jan H Reiling
https://www.nature.com/cddis/journal/v8/n10/full/cddis2017466a.html

Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.
Mark A Miles and Christine J Hawkins
https://www.nature.com/cddis/journal/v8/n10/full/cddis2017454a.html

The Btk-dependent PIP5K1γ lipid kinase activation by Fas counteracts FasL-induced cell death
Aurélie Rossin, Nadia Lounnas, Jérôme Durivault, Giorgia Miloro, Laurent Gagnoux-Palacios & Anne-Odile Hueber
https://link.springer.com/article/10.1007/s10495-017-1415-x

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism
William Putzbach, Quan Q Gao, Monal Patel, Stijn van Dongen, Ashley Haluck-Kangas, Aishe A Sarshad, Elizabeth T Bartom, Kwang-Youn A Kim, Denise M Scholtens, Markus Hafner, Jonathan C Zhao, Andrea E Murmann and Marcus E Peter
https://elifesciences.org/articles/29702

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Caspases and IAPs
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Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity
Claire H Wilson, Andrej Nikolic, Stephen J Kentish, Marianne Keller, George Hatzinikolas, Loretta Dorstyn, Amanda J Page and Sharad Kumar
http://www.nature.com/cddis/journal/v8/n10/abs/cddis2017518a.html

Mass Cytometric Analysis Reveals Viable Activated Caspase-3+ Luminal Progenitors in the Normal Adult Human Mammary Gland
David J.H.F. Knapp, Nagarajan Kannan, Davide Pellacani, Connie J. Eaves
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31416-X

Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation
Guillermo García-Laínez, Mónica Sancho, Vanessa García-Bayarri & Mar Orzáez
https://link.springer.com/article/10.1007/s10495-017-1405-z

Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
Zhiyuan Niu, Qian Shi, Wenlong Zhang, Yuxin Shu, Nanfei Yang, Bing Chen, Qingsong Wang, Xuyang Zhao, Jiajia Chen, Nan Cheng, Xiujing Feng, Zichun Hua, Jianguo Ji & Pingping Shen
https://www.nature.com/articles/s41467-017-00523-6

Modulation of apoptotic response by LAR family phosphatases–cIAP1 signaling during urinary tract morphogenesis
Katherine Stewart, You Chi Tang, Maxwell E. R. Shafer, Adda-Lee Graham-Paquin, and Maxime Bouchard
http://www.pnas.org/content/114/43/E9016.abstract.html?etoc

Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice
Fengjie Hao, Francisco Javier Cubero, Pierluigi Ramadori, Lijun Liao, Ute Haas, Daniela Lambertz, Roland Sonntag, Jörg- Martin Bangen, Nikolaus Gassler, Mareike Hoss, Konrad L Streetz, Johanna Reissing, Henning W Zimmermann, Christian Trautwein, Christian Liedtke and Yulia A Nevzorova
http://www.nature.com/cddis/journal/v8/n10/abs/cddis2017532a.html

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Non-apoptotic cell death
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PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals
Sally E. Wenzel, Yulia Y. Tyurina, Jinming Zhao, Claudette M. St. Croix, Haider H. Dar, Gaowei Mao, Vladimir A. Tyurin, Tamil S. Anthonymuthu, Alexandr A. Kapralov, Andrew A. Amoscato, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Elizabeth M. Kenny, Qin Yang, Joel C. Rosenbaum, Louis J. Sparvero, David R. Emlet, Xiaoyan Wen, Yoshinori Minami, Feng Qu, Simon C. Watkins, Theodore R. Holman, Andrew P. VanDemark, John A. Kellum, Ivet Bahar, Hülya Bayır, Valerian E. Kagan
http://www.cell.com/cell/fulltext/S0092-8674(17)31138-8

p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis
Francesco Napoletano, Benjamin Gibert, Keren Yacobi-Sharon, Stéphane Vincent, Clémentine Favrot, Patrick Mehlen, Victor Girard, Margaux Teil, Gilles Chatelain, Ludivine Walter, Eli Arama, Bertrand Mollereau
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007024

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
Siyun Kuang, Jun Zheng, Hui Yang, Suhua Li, Shuyan Duan, Yanfang Shen, Chaoneng Ji, Jianhua Gan, Xue-Wei Xu, and Jixi Li
http://www.pnas.org/content/114/40/10642.abstract.html?etoc

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
D Chen, Z Fan, M Rauh, M Buchfelder, I Y Eyupoglu and N Savaskan
http://www.nature.com/onc/journal/v36/n40/abs/onc2017146a.html

Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3
Heather Koehler, Samantha Cotsmire, Jeffrey Langland, Karen V. Kibler, Daniel Kalman, Jason W. Upton, Edward S. Mocarski, and Bertram L. Jacobs
http://www.pnas.org/content/114/43/11506.abstract.html?etoc

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Miscellaneous
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Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages
Ying Wang, Manikandan Subramanian, Arif Yurdagul Jr., Valéria C. Barbosa-Lorenzi, Bishuang Cai, Jaime de Juan-Sanz, Timothy A. Ryan, Masatoshi Nomura, Frederick R. Maxfield, Ira Tabas
http://www.cell.com/cell/fulltext/S0092-8674(17)30999-6

The microanatomic segregation of selection by apoptosis in the germinal center
By Christian T. Mayer, Anna Gazumyan, Ervin E. Kara, Alexander D. Gitlin, Jovana Golijanin, Charlotte Viant, Joy Pai, Thiago Y. Oliveira, Qiao Wang, Amelia Escolano, Max Medina-Ramirez, Rogier W. Sanders, Michel C. Nussenzweig
http://science.sciencemag.org/content/358/6360/eaao2602

The Rice Dynamin-Related Protein OsDRP1E Negatively Regulates Programmed Cell Death by Controlling the Release of Cytochrome c from Mitochondria
Zhiqiang Li, Bo Ding , Xueping Zhou, Guo-Liang Wang
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006157

The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage
Katherine Baran, Mao Yang, Christopher P Dillon, Leona L Samson and Douglas R Green
http://www.nature.com/cdd/journal/v24/n11/full/cdd2017116a.html

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease
Dimitry Ofengeim, Sonia Mazzitelli, Yasushi Ito, Judy Park DeWitt, Lauren Mifflin, Chengyu Zou, Sudeshna Das, Xian Adiconis, Hongbo Chen, Hong Zhu, Michelle A. Kelliher, Joshua Z. Levin, and Junying Yuan
http://www.pnas.org/content/114/41/E8788.abstract.html?etoc

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Reviews
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I. Bush, Marcus Conrad, Scott J. Dixon, Simone Fulda, Sergio Gascón, Stavroula K. Hatzios, Valerian E. Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E. Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C. Pagnussat, Jason Park, Qitao Ran, Craig S. Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M. Torti, Suzy V. Torti, Shinya Toyokuni, K.A. Woerpel, Donna D. Zhang
http://www.cell.com/cell/fulltext/S0092-8674(17)31070-X

Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection
Megan H. Orzalli, Jonathan C. Kagan
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30086-7

The immune response to secondary necrotic cells
Monika Sachet, Ying Yu Liang & Rudolf Oehler
https://link.springer.com/article/10.1007/s10495-017-1413-z

CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases
Matthieu Le Gallo, Amanda Poissonnier, Patrick Blanco and Patrick Legembre
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01216/full

Targeting apoptosis in acute myeloid leukaemia
Philippe A Cassier, Marie Castets, Amine Belhabri and Norbert Vey
https://www.nature.com/bjc/journal/v117/n8/full/bjc2017281a.html

Therapeutics targeting Bcl-2 in hematological malignancies
Astrid Ruefli-Brasse and John C. Reed
http://www.biochemj.org/content/474/21/3643?etoc

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Comments
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Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation
Samuel Sidi & Lisa Bouchier-Hayes
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1348325

Apoptosis, Up the Ante
Palaniraja Thandapani, Iannis Aifantis
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30413-0

Cell death: BCL-2 proteins feed their own expression
https://www.nature.com/articles/nrm.2017.106




 

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