Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for October, 2017

ApoList – September 2017

Posted by cris on October 2, 2017

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Bcl-2 family proteins
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Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation
Matthias Kollek, Gesina Voigt, Christian Molnar, Fabronia Murad, Daniela Bertele, Christopher Felix Krombholz, Sheila Bohler, Verena Labi, Stefan Schiller, Mirjam Kunze, Stephan Geley, Charlotte M. Niemeyer, Ana Garcia-Saez, Miriam Erlacher
http://jem.rupress.org/content/early/2017/09/06/jem.20161721.long

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor
Xiaofeng Wu, Li-shu Zhang, Jason Toombs, Yi-Chun Kuo, John Tyler Piazza, Rubina Tuladhar, Quinn Barrett, Chih-wei Fan, Xuewu Zhang, Loren D. Walensky, Marcel Kool, Steven Y. Cheng, Rolf Brekken, Joseph T. Opferman, Douglas R. Green, Tudor Moldoveanu & Lawrence Lum
http://www.nature.com/ncb/journal/v19/n10/full/ncb3616.html

Parkin promotes proteasomal degradation of misregulated BAX
Zeynep Cakir, Kathrin Funk, Joachim Lauterwasser, Franziska Todt, Ralf M. Zerbes, Aline Oelgeklaus, Atsushi Tanaka, Martin van der Laan and Frank Edlich
http://jcs.biologists.org/content/130/17/2903?etoc

The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer’s disease
Kumar Nikhil and Kavita Shah
http://jcs.biologists.org/content/130/18/3023?etoc

Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis
Margaret E. Maes, Cassandra L. Schlamp, Robert W. Nickells
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184434

ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death
Nicola J. Darling , Kathryn Balmanno, Simon J. Cook
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184907

p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress
Ignacio López, Anne-Sophie Tournillon, Rodrigo Prado Martins, Konstantinos Karakostis, Laurence Malbert-Colas, Karin Nylander and Robin Fåhraeus
http://www.nature.com/cdd/journal/v24/n10/abs/cdd201796a.html

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Death receptors and IAPs
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MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Yves Dondelinger, Tom Delanghe, Diego Rojas-Rivera, Dario Priem, Tinneke Delvaeye, Inge Bruggeman, Franky Van Herreweghe, Peter Vandenabeele & Mathieu J. M. Bertrand
http://www.nature.com/ncb/journal/v19/n10/full/ncb3608.html

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection
Manoj B. Menon, Julia Gropengießer, Jessica Fischer, Lena Novikova, Anne Deuretzbacher, Juri Lafera, Hanna Schimmeck, Nicole Czymmeck, Natalia Ronkina, Alexey Kotlyarov, Martin Aepfelbacher, Matthias Gaestel & Klaus Ruckdeschel
http://www.nature.com/ncb/journal/v19/n10/full/ncb3614.html

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).
Nichollas E Scott, Cristina Giogha, Georgina L Pollock, Catherine L Kennedy, Andrew I Webb, Nicholas A Williamson, Jaclyn S Pearson and Elizabeth L Hartland
http://www.jbc.org/content/early/2017/08/31/jbc.M117.805036.abstract

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF
Conor J Kearney, Najoua Lalaoui, Andrew J Freeman, Kelly M Ramsbottom, John Silke and Jane Oliaro
http://www.nature.com/cdd/journal/v24/n10/abs/cdd201794a.html

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Necroptosis
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Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis
Eduardo Reynoso, Hua Liu, Lin Li, Anthony L. Yuan, She Chen and Zhigao Wang
http://www.jbc.org/content/early/2017/09/06/jbc.M117.799353.abstract

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis
Shuzhen Liu, Hua Liu, Andrea Johnston, Sarah Hanna-Addams, Eduardo Reynoso, Yougui Xiang, and Zhigao Wang
http://www.pnas.org/content/114/36/E7450.abstract.html?etoc

Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis
Fabienne Le Cann, Claire Delehouzé, Sabrina Leverrier-Penna, Aveline Filliol, Arnaud Comte, Olivier Delalande, Nathalie Desban, Blandine Baratte, Isabelle Gallais, Claire Piquet-Pellorce, Florence Faurez, Marion Bonnet, Yvette Mettey, Peter Goekjian, Michel Samson, Peter Vandenabeele, Stéphane Bach, Marie-Thérèse Dimanche-Boitrel
http://onlinelibrary.wiley.com/doi/10.1111/febs.14176/abstract

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Caspases
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Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity
Kimberly E. Anderson, Milton To, James A. Olzmann and Daniel K. Nomura
http://pubs.acs.org/doi/10.1021/acschembio.7b00711#.Wblu2FO10QA.twitter

Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila
Ernesto Pérez, Jillian L Lindblad and Andreas Bergmann
https://elifesciences.org/articles/26747

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
Yannick Boege, Mohsen Malehmir, Marc E. Healy, Kira Bettermann, Anna Lorentzen, Mihael Vucur, Akshay K. Ahuja, Friederike Böhm, Joachim C. Mertens, Yutaka Shimizu, Lukas Frick, Caroline Remouchamps, Karun Mutreja, Thilo Kähne, Devakumar Sundaravinayagam, Monika J. Wolf, Hubert Rehrauer, Christiane Koppe, Tobias Speicher, Susagna Padrissa-Altés, Renaud Maire, Jörn M. Schattenberg, Ju-Seong Jeong, Lei Liu, Stefan Zwirner, Regina Boger, Norbert Hüser, Roger J. Davis, Beat Müllhaupt, Holger Moch, Henning Schulze-Bergkamen, Pierre-Alain Clavien, Sabine Werner, Lubor Borsig, Sanjiv A. Luther, Philipp J. Jost, Ricardo Weinlich, Kristian Unger, Axel Behrens, Laura Hillert, Christopher Dillon, Michela Di Virgilio, David Wallach, Emmanuel Dejardin, Lars Zender, Michael Naumann, Henning Walczak, Douglas R. Green, Massimo Lopes, Inna Lavrik, Tom Luedde, Mathias Heikenwalder, Achim Weber
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30354-9

Engineering a light-activated caspase-3 for precise ablation of neurons in vivo
Ashley D. Smart, Roland A. Pache, Nathan D. Thomsen, Tanja Kortemme, Graeme W. Davis, and James A. Wells
http://pnas.org/content/114/39/E8174.abstract.html?etoc

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Miscellaneous
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Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
Subbarayalu Panneerdoss, Suryavathi Viswanadhapalli, Nourhan Abdelfattah, Benjamin C. Onyeagucha, Santosh Timilsina, Tabrez A. Mohammad, Yidong Chen, Michael Drake, Kristiina Vuori, T. Rajendra Kumar & Manjeet K. Rao
https://www.nature.com/articles/s41467-017-00590-9

Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death
Neta Shlezinger, Henriette Irmer, Sourabh Dhingra, Sarah R. Beattie, Robert A. Cramer, Gerhard H. Braus, Amir Sharon, Tobias M. Hohl
http://science.sciencemag.org/content/357/6355/1037

Germline BAP1 mutations induce a Warburg effect
Angela Bononi, Haining Yang, Carlotta Giorgi, Simone Patergnani, Laura Pellegrini, Mingming Su, Guoxiang Xie, Valentina Signorato, Sandra Pastorino, Paul Morris, Greg Sakamoto, Shafi Kuchay, Giovanni Gaudino, Harvey I Pass, Andrea Napolitano, Paolo Pinton, Wei Jia and Michele Carbone
http://www.nature.com/cdd/journal/v24/n10/abs/cdd201795a.html

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Reviews
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Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer.
Guikema JE, Amiot M, Eldering E.
http://www.tandfonline.com/doi/full/10.1080/14728222.2017.1349754

Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD)
Peintner, L; Borner, C
https://link.springer.com/article/10.1007%2Fs00441-017-2628-6

Cancer: Linking Powerhouses to Suicidal Bags
Laia Martínez-Carreres, Anita Nasrallah, and Lluis Fajas
http://journal.frontiersin.org/article/10.3389/fonc.2017.00204/full

Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands
Greg Lemke
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(17)30110-X

Caspase-2: an orphan enzyme out of the shadows
J Forsberg, B Zhivotovsky and M Olsson
http://www.nature.com/onc/journal/v36/n39/abs/onc2017169a.html

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Comments
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A role for caspase-8 and TRAIL-R2/DR5 in ER-stress-induced apoptosis
Cristina Muñoz-Pinedo and Abelardo López-Rivas
https://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd2017155a.html

Functional precision cancer medicine—moving beyond pure genomics
Anthony Letai
http://www.nature.com/nm/journal/v23/n9/full/nm.4389.html

MK2 balances inflammation and cell death
Andrew Oberst
http://www.nature.com/ncb/journal/v19/n10/full/ncb3619.html

Cdk5 derails Mcl-1’s neuroprotection
http://jcs.biologists.org/content/130/18/e1804?etoc

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