Apoptosis and cell death

Apolist: monthly literature updates for researchers

ApoList – August 2017

Posted by cris on September 4, 2017

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Bcl-2 family and MOMP
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Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency
Evangelos Giampazolias, Barbara Zunino, Sandeep Dhayade, Florian Bock, Catherine Cloix, Kai Cao, Alba Roca, Jonathan Lopez, Gabriel Ichim, Emma Proïcs, Camila Rubio-Patiño, Loic Fort, Nader Yatim, Emma Woodham, Susana Orozco, Lucia Taraborrelli, Nieves Peltzer, Daniele Lecis, Laura Machesky, Henning Walczak, Matthew L. Albert, Simon Milling, Andrew Oberst,
Jean-Ehrland Ricci, Kevin M. Ryan, Karen Blyth & Stephen W. G. Tait
http://www.nature.com/ncb/journal/v19/n9/full/ncb3596.html

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
Delphine Merino , James R. Whittle, François Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maïa Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Gräsel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J. Herold, David C. S. Huang, Gordon K. Smyth, Olivier Geneste, Guillaume Lessene, Jane E. Visvader, Geoffrey J. Lindeman
http://stm.sciencemag.org/content/9/401/eaam7049

Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response
Ioannis K. Zervantonakis, Claudia Iavarone, Hsing-Yu Chen, Laura M. Selfors, Sangeetha Palakurthi, Joyce F. Liu, Ronny Drapkin, Ursula Matulonis, Joel D. Leverson, Deepak Sampath, Gordon B. Mills & Joan S. Brugge
https://www.nature.com/articles/s41467-017-00263-7

Apoptotic resistance of human skin mast cells is mediated by Mcl-1
Tarek Hazzan, Jürgen Eberle, Margitta Worm & Magda Babina
https://www.nature.com/articles/cddiscovery201748

Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins
A Antignani, D Segal, N Simon, R J Kreitman, D Huang and D J FitzGerald
http://www.nature.com/onc/journal/v36/n35/abs/onc2017111a.html

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis
Donna Kennedy, Katarzyna Mnich, Deepu Oommen, Reka Chakravarthy, Leonardo Almeida-Souza, Michiel Krols, Svetlana Saveljeva, Karen Doyle, Sanjeev Gupta, Vincent Timmerman, Sophie Janssens, Adrienne M Gorman and Afshin Samali
http://www.nature.com/cddis/journal/v8/n8/abs/cddis2017408a.html

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL
Alex RD Delbridge, Brandon J Aubrey, Craig Hyland, Jonathan P Bernardini, Ladina Di Rago, Jean-Marc Garnier, Guillaume Lessene, Andreas Strasser, Warren S Alexander and Stephanie Grabow
http://www.nature.com/cddis/journal/v8/n7/abs/cddis2017304a.html

PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
Saw-See Hong, Hubert Marotte, Guillaume Courbon, Gary S. Firestein, Pierre Boulanger & Pierre Miossec
https://www.nature.com/articles/s41467-017-00142-1

TARGETING THE APOPTOTIC MCL-1-PUMA INTERFACE WITH A DUAL-ACTING COMPOUND
Jiyuan Liu, Zhen Tian, Nan Zhou, Xueying Liu, Chenyi Liao, Beilei Lei, Jianing Li, Shengyong Zhang, and Hui Chen
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=17294&path%5B%5D=55350

The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF
Seng H Liew, Quynh-Nhu Nguyen, Andreas Strasser, Jock K Findlay and Karla J Hutt
http://www.nature.com/cddis/journal/v8/n8/abs/cddis2017361a.html

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Death receptors
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JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells
Q Wang, Q Chen, L Zhu, M Chen, W Xu, S Panday, Z Wang, A Li, O D Røe, R Chen, S Wang, R Zhang and J Zhou
http://www.nature.com/oncsis/journal/v6/n7/abs/oncsis201757a.html

p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa
María Platón-Corchado, Pablo F Barcelona, Sean Jmaeff, Miguel Marchena, Alberto M Hernández-Pinto, Catalina Hernández-Sánchez, H Uri Saragovi and Enrique J de la Rosa
http://www.nature.com/cddis/journal/v8/n7/abs/cddis2017306a.html

Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells
Yelyzaveta Shlyakhtina, Valeria Pavet and Hinrich Gronemeyer
http://www.nature.com/cddis/journal/v8/n8/abs/cddis2017423a.html

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Necroptosis / DAI
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RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system
Dianrong Li, Lingjun Meng, Tao Xu, Yaning Su, Xiao Liu, Zhiyuan Zhang and Xiaodong Wang
https://elifesciences.org/articles/27692

RIP3 attenuates the pancreatic damage induced by deletion of ATG7
Xiaodong Zhou, Li Xie, Leizhou Xia, Frank Bergmann, Markus W Büchler, Guido Kroemer, Thilo Hackert and Franco Fortunato
http://www.nature.com/cddis/journal/v8/n7/abs/cddis2017313a.html

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira & Junying Yuan
https://www.nature.com/articles/s41467-017-00406-w

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death
Sannula Kesavardhana, Teneema Kuriakose, Clifford S. Guy, Parimal Samir, R.K. Subbarao Malireddi, Ashutosh Mishra, and Thirumala-Devi Kanneganti
http://jem.rupress.org/content/214/8/2217?etoc

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis
Jonathan Maelfait, Layal Liverpool, Anne Bridgeman, Katherine B Ragan, Jason W Upton and Jan Rehwinkel
http://EMBOJ.embopress.org/content/36/17/2529?etoc

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Caspases and IAPs
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Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis
Ian M Cartwright, Xinjian Liu, Min Zhou, Fang Li and Chuan-Yuan Li
https://elifesciences.org/articles/26371

A mutation in keratin 18 that causes caspase-digestion resistance protects homozygous transgenic mice from hepatic apoptosis and injury
Han-Na Yoon, Sung-Yeon Yoon, Jin-Hyuck Hong, and Nam-On Ku
http://jcs.biologists.org/content/130/15/2541?etoc

IAPs protect host target tissues from graft-versus-host disease in mice
Tomomi Toubai, Corinne Rossi, Katherine Oravecz-Wilson, Chen Liu, CynthiaZajac, Shin-Rong Julia Wu, Yaping Sun, Hideaki Fujiwara, Hiroya Tamaki, Daniel Peltier, Mary Riwes, Israel Henig, Stuart Brabbs, Colin S. Duckett, Shaomeng Wang, and Pavan Reddy
http://www.bloodadvances.org/content/1/19/1517.abstract?etoc

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer
Ryan A Hutchinson, Helen G Coleman, Kathy Gately, Vincent Young, Siobhan Nicholson et al.
https://www.nature.com/articles/cddiscovery201750

Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
Dae-Sun Kim, Himika Dastidar, Chunfen Zhang, Franz J. Zemp, Keith Lau, Matthias Ernst, Andrea Rakic, Saif Sikdar, Jahanara Rajwani, Victor Naumenko, Dale R. Balce, Ben W. Ewanchuk, Pankaj Taylor, Robin M. Yates, Craig Jenne, Chris Gafuik & Douglas J. Mahoney
https://www.nature.com/articles/s41467-017-00324-x

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Efferocytosis and corpse degradation
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Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis
Yuichi Yanagihashi, Katsumori Segawa, Ryota Maeda, Yo-ichi Nabeshima, and Shigekazu Nagata
http://www.pnas.org/content/114/33/8800.abstract.html?etoc

Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in Caenorhabditis elegans
Kaitlin Driscoll, Gillian M. Stanfield, Rita Droste, and H. Robert Horvitz
http://www.pnas.org/content/114/33/8806.abstract.html?etoc

T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node
Myriam Baratin, Léa Simon, Audrey Jorquera, Clément Ghigo, Doulaye Dembele, Jonathan Nowak, Rebecca Gentek, Stephan Wienert, Frederick Klauschen, Bernard Malissen, Marc Dalod, Marc Bajénoff
http://www.cell.com/immunity/fulltext/S1074-7613(17)30326-6

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Ferroptosis
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Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
Z Fan, A-K Wirth, D Chen, C J Wruck, M Rauh, M Buchfelder and N Savaskan
http://www.nature.com/oncsis/journal/v6/n8/abs/oncsis201765a.html

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
Yangchun Xie, Shan Zhu, Xinxin Song, Xiaofang Sun, Yong Fan, Jinbao Liu, Meizuo Zhong, Hua Yuan, Lin Zhang, Timothy R. Billiar, Michael T. Lotze, Herbert J. Zeh III, Rui Kang, Guido Kroemer, Daolin Tang
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31034-3

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Miscellaneous
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Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours
G Itoh, S Chida, K Yanagihara, M Yashiro, N Aiba and M Tanaka
https://www.nature.com/onc/journal/v36/n31/full/onc201749a.html

Aberrant localization of apoptosis protease activating factor-1 in lipid raft sub-domains of diffuse large B cell lymphomas
Jayshree L. Hirpara, Thomas Loh3, Siok Bian Ng4, Wee Joo Chng5 and Shazib Pervaiz
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=13336&path%5B%5D=42329

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase
Jiuya He, Joe Carroll, Shujing Ding, Ian M. Fearnley, and John E. Walker
http://pnas.org/content/114/34/9086.abstract.html?etoc

p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
Reut Yosef, Noam Pilpel, Nurit Papismadov, Hilah Gal, Yossi Ovadya, Ezra Vadai, Stav Miller, Ziv Porat, Shifra Ben‐Dor, and Valery Krizhanovsky
http://EMBOJ.embopress.org/content/36/15/2280?etoc

Amyloid single-cell cytotoxicity assays by nanomotion detection
Francesco S Ruggeri, Anne-Laure Mahul-Mellier, Sandor Kasas, Hilal A Lashuel, Giovanni Longo et al.
https://www.nature.com/articles/cddiscovery201753

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Reviews
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Gasdermins: Effectors of Pyroptosis
Stephen B. Kovacs, Edward A. Miao
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30084-3

BCL2: A promising cancer therapeutic target
Gudapureddy Radha, Sathees C. Raghavan
http://www.sciencedirect.com/science/article/pii/S0304419X17300483

Targeting BCL-2 in B-cell lymphomas
Matthew S. Davids
http://bloodjournal.org/content/130/9/1081.abstract?etoc

The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy
Nicole Rufo, Abhishek D. Garg, Patrizia Agostinis
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30136-X

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Comments / other
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In the Hunger Games, the Winner Takes Everything
Franziska Püschel, Cristina Muñoz-Pinedo
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(17)30151-2

ENTOSIS ENABLES A POPULATION RESPONSE TO STARVATION
Jens C. Hamann, and Michael Overholtzer
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20066&path%5B%5D=64005

A caspase-independent way to kill cancer cells
Brent E. Fitzwalter and Andrew Thorburn
http://www.nature.com/ncb/journal/v19/n9/full/ncb3604.html

Gut check: dead cell samples leads to tolerant examples
Thomas H Oguin, III and Jennifer Martinez
http://www.nature.com/cdd/journal/v24/n9/full/cdd201745a.html

Mitochondrial permeability transition, F1FO‐ATPase and calcium: an enigmatic triangle
Salvatore Nesci
http://embor.embopress.org/content/18/8/1265.full

BAX Can Be Allosterically Sensitized to Promote Apoptosis
http://cancerdiscovery.aacrjournals.org/content/7/9/933.1


Cell scientist to watch – Ana Garcia-Saez
http://jcs.biologists.org/content/130/17/2773?etoc

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