ApoList – May 2017

Death receptors

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M. Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier

CNS Macrophages Control Neurovascular Development via CD95L
Si Chen, Nathalie Tisch, Marcel Kegel, Rosario Yerbes, Robert Hermann, Hannes Hudalla, Cecilia Zuliani, Gülce Sila Gülcüler, Klara Zwadlo, Jakob von Engelhardt, Carmen Ruiz de Almodóvar, Ana Martin-Villalba

The linear ubiquitin chain assembly complex regulates TRAIL‐induced gene activation and cell death
Elodie Lafont, Chahrazade Kantari‐Mimoun, Peter Draber, Diego De Miguel, Torsten Hartwig, Matthias Reichert, Sebastian Kupka, Yutaka Shimizu, Lucia Taraborrelli, Maureen Spit, Martin R Sprick, and Henning Walczak

The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis inducing ligand
Shan-zhong Yang, Fei Xu, Tong Zhou, Xinyang Zhao, Jay M McDonald, and Yabing Chen

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis
Jason A Glab, Marcel Doerflinger, Christina Nedeva, Irvin Jose, George W Mbogo, James C Paton, Adrienne W Paton, Andrew J Kueh, Marco J Herold, David CS Huang, David Segal, Gabriella Brumatti and Hamsa Puthalakath

Necroptosis and RIPK1

When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157
Diego Rojas-Rivera, Tinneke Delvaeye, Ria Roelandt, Wim Nerinckx, Koen Augustyns, Peter Vandenabeele and Mathieu J M Bertrand

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter
Zhentao Yang, Bin Jiang, Yan Wang, Hengxiao Ni, Jia Zhang, Jinmei Xia, Minggang Shi, Li-Man Hung, Jingsong Ruan, Tak Wah Mak, Qinxi Li, Jiahuai Han


Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2
Gergely Imre, Jean Berthelet, Jan Heering, Sebastian Kehrloesser, Inga Maria Melzer, Byung Il Lee, Bernd Thiede, Volker Dötsch, and Krishnaraj Rajalingam

Caspase-2-mediated cell death is required for deleting aneuploid cells
S Dawar, Y Lim, J Puccini, M White, P Thomas, L Bouchier-Hayes, D R Green, L Dorstyn and S Kumar

Caspase-3 controls AML1-ETO–driven leukemogenesis via autophagy modulation in a ULK1-dependent manner
Na Man, Yurong Tan, Xiao-Jian Sun, Fan Liu, Guoyan Cheng, Sarah M. Greenblatt, Camilo Martinez, Daniel L. Karl, Koji Ando, Ming Sun, Dan Hou, Bingyi Chen, Mingjiang Xu, Feng-Chun Yang, Zhu Chen, Saijuan Chen, Stephen D. Nimer, and Lan Wang

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a Gasdermin
Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang & Feng Shao


Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin–specific clinical impact
Daisuke Ennishi, Anja Mottok, Susana Ben-Neriah, Hennady P. Shulha, PedroFarinha, Fong Chun Chan, Barbara Meissner, Merrill Boyle, Christoffer Hother, Robert Kridel, Daniel Lai, Saeed Saberi, Ali Bashashati, Sohrab P. Shah, Ryan D. Morin, Marco A. Marra, Kerry J. Savage, Laurie H. Sehn, Christian Steidl, Joseph M. Connors, Randy D. Gascoyne, and David W. Scott

BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma
Chiaki Tsuge Ishida, Elena Bianchetti, Chang Shu, Marc-Eric Halatsch, M. Andrew Westhoff, Georg Karpel-Massler and Markus D. Siegelin

Endoplasmic Reticulum Stress-induced Degradation of DNAJB12 Stimulates BOK Accumulation and Primes Cancer Cells for Apoptosis
Pattarawut Sopha, Hong Yu Ren, Diane E. Grove, and Douglas M Cyr

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo
Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David CS Huang, Andreas Strasser, Suzanne Cory, Marco J Herold and Andrew M Lew


Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing
Abhishek D Garg, Lien Vandenberk, Shentong Fang, Tekele Fasche, Sofie Van Eygen, Jan Maes, Matthias Van Woensel, Carolien Koks, Niels Vanthillo, Norbert Graf, Peter de Witte, Stefaan Van Gool, Petri Salven and Patrizia Agostinis

Modulation of macrophage antitumor potential by apoptotic lymphoma cells
Jorine J L P Voss, Catriona A Ford, Sofia Petrova, Lynsey Melville, Margaret Paterson, John D Pound, Pam Holland, Bruno Giotti, Tom C Freeman and Christopher D Gregory


Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis
Yasmin M. Ramdzan, Mikhail M. Trubetskov, Angelique R. Ormsby, Estella A. Newcombe, Xiaojing Sui, Mark J. Tobin, Marie N. Bongiovanni, Sally L. Gras, Grant Dewson, Jason M.L. Miller, Steven Finkbeiner, Nagaraj S. Moily, Jonathan Niclis, Clare L. Parish, Anthony W. Purcell, Michael J. Baker, Jacqueline A. Wilce, Saboora Waris, Diana Stojanovski, Till Böcking, Ching-Seng Ang, David B. Ascher, Gavin E. Reid, Danny M. Hatters

ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment
M Pérez-Alea, K McGrail, S Sánchez-Redondo, B Ferrer, G Fournet, J Cortés, E Muñoz, J Hernandez-Losa, S Tenbaum, G Martin, R Costello,I Ceylan, V Garcia-Patos and J A Recio

Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection
Alexander M Price, Joanne Dai, Quentin Bazot, Luv Patel, Pavel A Nikitin, Reza Djavadian, Peter S Winter, Cristina A Salinas, Ashley Perkins Barry, Kris C Wood, Eric C Johannsen, Anthony Letai, Martin J Allday and Micah A Luftig


Plant life needs cell death, but does plant cell death need Cys proteases?
Daniela J. Sueldo and Renier A. L. van der Hoorn

Caspases rule the intracellular trafficking cartel
Catherine Duclos, Christine Lavoie and Jean-Bernard Denault

Immunological Reviews Special issue:
Molecular Mechanisms of Cell Death

– Caspase-8: regulating life and death
Bart Tummers, Douglas R. Green
– RIPK3 in cell death and inflammation: the good, the bad, and the ugly
Susana Orozco and Andrew Oberst
– The in vivo evidence for regulated necrosis
Wulf Tonnus and Andreas Linkermann
– The many ways tissue phagocytes respond to dying cells
J. Magarian Blander
… and many more.

Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
Silvia von Karstedt, Antonella Montinaro & Henning Walczak


TRAIL‐ and TNF‐induced signaling complexes—so similar yet so different
Harald Wajant

Old and Novel Functions of Caspase-2
M.A. Miles, T. Kitevska-Ilioski, C.J. Hawkins

Intercellular cannibalism fuels tumor growth
Ernesto Pérez and Andreas Bergmann

BAK regulates catalase release from peroxisomes
Yukio Fujiki , Non Miyata, Satoru Mukai, Kanji Okumoto & Emily H. Cheng

Caspase 2 in mitotic catastrophe: The terminator of aneuploid and tetraploid cells
Ilio Vitale, Gwenola Manic, Maria Castedo & Guido Kroemer

A Different Path for Harnessing TRAIL

Cell death: ESCRTing dying cells back to life

RNA decay: The anti-apoptotic function of ADAR1