Apoptosis and cell death

Apolist: monthly literature updates for researchers

ApoList – February 2017

Posted by cris on March 3, 2017

Death receptors

Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation
Conor M. Henry, Seamus J. Martin

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2
Torsten Hartwig, Antonella Montinaro, Silvia von Karstedt, Alexandra Sevko, Silvia Surinova, Ankur Chakravarthy, Lucia Taraborrelli, Peter Draber, Elodie Lafont, Frederick Arce Vargas, Mona A. El-Bahrawy, Sergio A. Quezada, Henning Walczak

Glucose deprivation induces ATF4-mediated apoptosis through TRAIL death receptors
Raffaella Iurlaro, Franziska Püschel, Clara Lucía León-Annicchiarico, Hazel O’Connor, Seamus J. Martin, Daniel Palou-Gramón, Estefanía Lucendo and Cristina Muñoz-Pinedo

N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.
Dufour F, Rattier T, Shirley S, Picarda G, Constantinescu AA, Morlé A, Zakaria AB, Marcion G, Causse S, Szegezdi E, Zajonc DM, Seigneuric R, Guichard G, Gharbi T, Picaud F, Herlem G, Garrido C, Schneider P, Benedict CA, Micheau O.

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress
Florent Dufour, Thibault Rattier, Andrei Alexandru Constantinescu, Luciana Zischler, Aymeric Morlé, Hazem Ben Mabrouk, Etienne Humblin, Guillaume Jacquemin, Eva Szegezdi, Fabien Delacote, Naziha Marrakchi, Gilles Guichard, Catherine Pellat-Deceunynck, Pierre Vacher, Patrick Legembre, Carmen Garrido, and Olivier Micheau

Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling
Cristian R Smulski, Marion Decossas, Neila Chekkat, Julien Beyrath, Laure Willen, Gilles Guichard, Raquel Lorenzetti, Marta Rizzi, Hermann Eibel, Pascal Schneider and Sylvie Fournel

Bcl-2 family proteins

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax
Joan Montero, Jason Stephansky, Tianyu Cai, Gabriel K. Griffin, Lucia Cabal-Hierro, Katsuhiro Togami, Leah J. Hogdal, Ilene Galinsky, Elizabeth A. Morgan, Jon C. Aster, Matthew S. Davids, Nicole R. LeBoeuf, Richard M. Stone, Marina Konopleva, Naveen Pemmaraju, Anthony Letai and Andrew A. Lane

Disordered clusters of Bak dimers rupture mitochondria during apoptosis
Rachel T Uren, Martin O’Hely, Sweta Iyer, Ray Bartolo, Melissa X Shi, Jason M Brouwer, Amber E Alsop, Grant Dewson and Ruth M Kluck

BCL-W has a fundamental role in B cell survival and lymphomagenesis
Clare M. Adams, Annette S. Kim, Ramkrishna Mitra, John K. Choi, Jerald Z. Gong, Christine M. Eischen

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection
Selma Tuzlak, Robyn L Schenk, Ajithkumar Vasanthakumar, Simon P Preston, Manuel D Haschka, Dimitra Zotos, Axel Kallies, Andreas Strasser, Andreas Villunger and Marco J Herold

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment
Robyn L Schenk, Selma Tuzlak, Emma M Carrington, Yifan Zhan, Susanne Heinzel, Charis E Teh, Daniel H Gray, Lin Tai, Andrew M Lew, Andreas Villunger, Andreas Strasser and Marco J Herold

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival
Charlotte Viant, Sophie Guia, Robert J. Hennessy, Jai Rautela, Kim Pham, Claire Bernat, Wilford Goh, Yuhao Jiao, Rebecca Delconte, Michael Roger, Vanina Simon, Fernando Souza-Fonseca-Guimaraes, Stephanie Grabow, Gabrielle T. Belz, Benjamin T. Kile, Andreas Strasser, Daniel Gray, Phillip D. Hodgkin, Bruce Beutler, Eric Vivier, Sophie Ugolini, and Nicholas D. Huntington

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation
J Tong, S Tan, F Zou, J Yu and L Zhang

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice
Natasha S Anstee, Cassandra J Vandenberg, Kirsteen J Campbell, Peter D Hughes, Lorraine A O’Reilly and Suzanne Cory

miRNAs cooperate in apoptosis regulation during C. elegans development
Ryan Sherrard, Sebastian Luehr, Heinke Holzkamp, Katherine McJunkin, Nadin Memar, and Barbara Conradt

BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells
Christopher D. Graham, Niroop Kaza, Hawley C. Pruitt, Lauren M. Gibson, Barbara J. Klocke, Lalita A. Shevde, Steven L. Carroll, and Kevin A. Roth

Necroptosis and RIP kinases

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function
Kay Hänggi, Lazaros Vasilikos, Aida Freire Valls, Rosario Yerbes, Janin Knop, Lisanne M Spilgies, Kristy Rieck, Tvisha Misra, John Bertin, Peter J Gough, Thomas Schmidt, Carmen Ruiz de Almodòvar and W Wei-Lynn Wong

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu and Jiahuai Han

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D
Kimberley D. Gutierrez, Michael A. Davis, Brian P. Daniels, Tayla M. Olsen, Pooja Ralli-Jain, Stephen W. G. Tait, Michael Gale and Andrew Oberst

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
Stephanie A. Conos, Kaiwen W. Chen, Dominic De Nardo, Hideki Hara, Lachlan Whitehead, Gabriel Núñez, Seth L. Masters, James M. Murphy, Kate Schroder, David L. Vaux, Kate E. Lawlor, Lisa M. Lindqvist, and James E. Vince

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT1, Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A1, Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J.

The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process
Deli Huanga, Xinru Zhenga, Zi-an Wanga, Xin Chena, Wan-ting Hea, Yingying Zhanga, Jin-Gen Xub, Hang Zhaoa, Wenke Shia, Xin Wanga, Yongqun Zhub and Jiahuai Han


Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways
Maria C Tanzer, Nufail Khan, James A Rickard, Nima Etemadi, Najoua Lalaoui, Sukhdeep Kaur Spall, Joanne M Hildebrand, David Segal, Maria Miasari, Diep Chau, WendyWei-Lynn Wong, Mark McKinlay, Srinivas K Chunduru, Christopher A Benetatos, Stephen M Condon, James E Vince, Marco J Herold and John Silke

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme
Yini Li, Mengying Zhou, Qi Hu, Xiao-chen Bai, Weiyun Huang, Sjors H. W. Scheres, and Yigong Shi

AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta
Saul Lema Asqui, Dominique Vercammen, Irene Serrano, Marc Valls, Susana Rivas, Frank van Breusegem, Frank L. Conlon, Jeffery L. Dangl, Núria S. Coll

Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage
Carina de Lima Buzzo, Tiago Medina, Laura M. Branco, Silvia L. Lage, Luís Carlos de Souza Ferreira, Gustavo P. Amarante-Mendes, Michael O. Hottiger, Daniel D. De Carvalho & Karina R. Bortoluci

Caspase-1 promotes monocyte–macrophage differentiation by repressing PPARγ
Zhiyuan Niu, Jiajin Tang, Wenlong Zhang, Yongjun Chen, Yahong Huang, Bing Chen, Jiahong Li and Pingping Shen

Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival
Xuan Pu, Sarah J. Storr, Yimin Zhang, Emad A. Rakha, Andrew R. Green, Ian O. Ellis & Stewart G. Martin

Caspase-6 Undergoes a Distinct Helix-Strand Interconversion Upon Substrate Binding
Kevin B Dagbay, Nicolas Bolik-Coulon, Sergey N Savinov, and Jeanne A Hardy

Palmitoylation of caspase-6 by HIP14 regulates its activation
Niels H Skotte, Shaun S Sanders, Roshni R Singaraja, Dagmar E Ehrnhoefer, Kuljeet Vaid, Xiaofan Qiu, Srinivasaragavan Kannan, Chandra Verma and Michael R Hayden


Bax/Bak-independent mitochondrial depolarization and reactive oxygen species induction by sorafenib overcome resistance to apoptosis in renal cell carcinoma
Bernhard Gillissen, Anja Richter, Antje Richter, Robert Preissner, Klaus Schulze-Osthoff, Frank Essmann, and Peter T Daniel
J. Biol. Chem. published 1 February 2017 doi:10.1074/jbc.M116.754184

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction During Oxidative Stress-Induced Cell Death
Hidemitsu Nakajima, Masanori Itakura, Takeya Kubo, Akihiro Kaneshige, Naoki Harada, Takeshi Izawa, Yasu-Taka Azuma, Mitsuru Kuwamura, Ryouichi Yamaji, and Tadayoshi Takeuchi



Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing
Abhishek D Garg, Lien Vandenberk, Shentong Fang, Tekele Fasche, Sofie Van Eygen, Jan Maes, Matthias Van Woensel, Carolien Koks, Niels Vanthillo, Norbert Graf, Peter de Witte, Stefaan Van Gool, Petri Salven and Patrizia Agostinis

Two coffins and a funeral: early or late caspase activation determines two types of apoptosis induced by DNA damaging agents
Manuel Oropesa-Ávila, Patricia de la Cruz-Ojeda, Jesús Porcuna, Marina Villanueva-Paz, Alejandro Fernández-Vega, Mario de la Mata, Isabel de Lavera, Juan Miguel Suarez Rivero, Raquel Luzón–Hidalgo, Mónica Álvarez-Córdoba, David Cotán, Ana Paula Zaderenko, Mario D. Cordero & José A. Sánchez-Alcázar

Defining the morphologic features and products of cell disassembly during apoptosis
Rochelle Tixeira, Sarah Caruso, Stephanie Paone, Amy A. Baxter, Georgia K. Atkin-Smith, Mark D. Hulett & Ivan K. H. Poon

Synthesis and evaluation of a radiolabeled bis-zinc(II)–cyclen complex as a potential probe for in vivo imaging of cell death
Hongliang Wang, Zhifang Wu, Sijin Li, Kongzhen Hu & Ganghua Tang

Comments / other

Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis
Kelby W. Wegner, Danish Saleh, Alexei Degterev

Application of cryo-electron microscopy for investigation of Bax-induced pores in apoptosis
Tomomi Kuwana
Free access

Multi-parametric imaging of cell heterogeneity in apoptosis analysis
Ivan A. Vorobjev, Natasha S. Barteneva

Jekyll & Hyde: The Other Life of the Death Ligand TRAIL
Najoua Lalaoui, John Silke

Tissues from Young Mice and Patients Are Primed for Apoptosis

Ferroptosis-like cell death in plants

Tumorigenesis: Extra! Extra! Read all about it!
[about the PIDDosome]


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