ApoList – January 2017

Bcl-2 Family Proteins

Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics
Kristopher A. Sarosiek, Cameron Fraser, Nathiya Muthalagu, Patrick D. Bhola, Weiting Chang, Samuel K. McBrayer, Adam Cantlon, Sudeshna Fisch, Gail Golomb-Mello, Jeremy A. Ryan, Jing Deng, Brian Jian, Chris Corbett, Marti Goldenberg, Joseph R. Madsen, Ronglih Liao, Dominic Walsh, John Sedivy, Daniel J. Murphy, Daniel Ruben Carrasco, Shenandoah Robinson, Javid Moslehi, Anthony Letai

Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5–dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics
Edward Cherok, Shan Xu, Sunan Li, Shweta Das, W. Alex Meltzer, Michal Zalzman, Chunxin Wang, and Mariusz Karbowski

Dual modulation of MCL-1 and mTOR determines the response to sunitinib
Mohamed Elgendy, Amal Kamal Abdel-Aziz, Salvatore Lorenzo Renne, Viviana Bornaghi, Giuseppe Procopio, Maurizio Colecchia, Ravindran Kanesvaran, Chee Keong Toh, Daniela Bossi, Isabella Pallavicini, Jose Luis Perez-Gracia, Maria Dolores Lozano, Valeria Giandomenico, Ciro Mercurio, Luisa Lanfrancone, Nicola Fazio, Franco Nole, Bin Tean Teh, Giuseppe Renne, Saverio Minucci

MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks
Abid R. Mattoo, Raj K. Pandita, Sharmistha Chakraborty, Vijaya Charaka, Kalpana Mujoo, Clayton R. Hunt, and Tej K. Pandita

Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice
Naoki Ichikawa, Mariana Alves, Shona Pfeiffer, Elena Langa, Yasmina E Hernández-Santana, Hidenori Suzuki, Jochen HM Prehn, Tobias Engel and David C Henshall

Structural insight into an evolutionarily ancient programmed cell death regulator – the crystal structure of marine sponge BHP2 bound to LB-Bak-2
Sofia Caria, Mark G Hinds and Marc Kvansakul

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis
Mateus Milani, Dominic P Byrne, Georgia Greaves, Michael Butterworth, Gerald M Cohen, Patrick A Eyers and Shankar Varadarajan

Death receptors

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction
Anthony C. Cruz, Madhu Ramaswamy, Claudia Ouyang, Christopher A. Klebanoff, Prabuddha Sengupta, Tori N. Yamamoto, Françoise Meylan, Stacy K. Thomas, Nathan Richoz, Robert Eil, Susan Price, Rafael Casellas, V. Koneti Rao, Jennifer Lippincott-Schwartz, Nicholas P. Restifo and Richard M. Siegel

TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation
Carlos R. Reis, Ping-Hung Chen, Nawal Bendris, and Sandra L. Schmid

c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity
Carlos Plaza-Sirvent, Marc Schuster, Yvonne Neumann, Ulrike Heise, Marina C. Pils, Klaus Schulze-Osthoff, Ingo Schmitz

Death receptor 6 contributes to autoimmunity in lupus-prone mice
Daisuke Fujikura, Masahiro Ikesue, Tsutomu Endo, Satoko Chiba, Hideaki Higashi and Toshimitsu Uede

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs
Heather Torrey , John Butterworth, Toshiyuki Mera, Yoshiaki Okubo, Limei Wang, Danielle Baum, Audrey Defusco, Sara Plager, Sarah Warden, Daniel Huang, Eva Vanamee, Rosemary Foster, Denise L. Faustman

TNF-induced chronic inflammation does not affect tumorigenesis driven by p53 loss
Derek Lacey, Andreas Strasser and Philippe Bouillet

Caspases and execution phase

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani and Emad S. Alnemri

SUMO-Modified FADD Recruits Cytosolic Drp1 and Caspase-10 to Mitochondria for Regulated Necrosis
Seon-Guk Choi, Hyunjoo Kim, Eun Il Jeong, Ho-June Lee, Sungwoo Park, Song-Yi Lee, Hyeon-Jeong Lee, Seong Won Lee, Chin Ha Chung, and Yong-Keun Jung

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction
Michio Nakaya, Kenji Watari, Mitsuru Tajima, Takeo Nakaya, Shoichi Matsuda, Hiroki Ohara, Hiroaki Nishihara, Hiroshi Yamaguchi, Akiko Hashimoto, Mitsuho Nishida, Akiomi Nagasaka, Yuma Horii, Hiroki Ono, Gentaro Iribe, Ryuji Inoue, Makoto Tsuda, Kazuhide Inoue, Akira Tanaka, Masahiko Kuroda, Shigekazu Nagata, Hitoshi Kurose

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer
Carlos López-García, Laurent Sansregret, Enric Domingo, Nicholas McGranahan, Sebastijan Hobor, Nicolai Juul Birkbak, Stuart Horswell, Eva Grönroos, Francesco Favero, Andrew J. Rowan, Nicholas Matthews, Sharmin Begum, Benjamin Phillimore, Rebecca Burrell, Dahmane Oukrif, Bradley Spencer-Dene, Michal Kovac, Gordon Stamp, Aengus Stewart, Havard Danielsen, Marco Novelli, Ian Tomlinson, Charles Swanton


Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells
Y Mitsuuchi, CA Benetatos, Y Deng, T Haimowitz, SC Beck, MR Arnone, GS Kapoor, ME Seipel, SK Chunduru, MA McKinlay, CG Begley, & SM Condon

Phosphorylation of XIAP by CDK1–cyclin-B1 controls mitotic cell death
Ying Hou, Lindsey A. Allan, and Paul R. Clarke

Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model
Christine C. Dobson, Thet Naing, Shawn T. Beug, Mame D. Faye, Janelle Chabot, Martin St-Jean, Danielle E. Walker, Eric C. LaCasse, David F. Stojdl, Robert G. Korneluk, and Martin Holcik

Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice
Maria Eugenia Guicciardi, Anuradha Krishnan, Steven F Bronk, Petra Hirsova, Thomas S Griffith and Gregory J Gores


The PIDDosome activates p53 in response to supernumerary centrosomes
Luca L. Fava, Fabian Schuler, Valentina Sladky, Manuel D. Haschka, Claudia Soratroi, Lisa Eiterer, Egon Demetz, Guenter Weiss, Stephan Geley, Erich A. Nigg, and Andreas Villunger

Cytochrome c Negatively Regulates NLRP3 Inflammasomes
Chong-Shan Shi, John H. Kehrl

RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer
Anne T. Schneider, Jérémie Gautheron, Maria Feoktistova, Christoph Roderburg, Sven H. Loosen, Sanchari Roy, Fabian Benz, Peter Schemmer, Markus W. Büchler, Ueli Nachbur, Ulf P. Neumann, Rene Tolba, Mark Luedde, Jessica Zucman-Rossi,
Diana Panayotova-Dimitrova, Martin Leverkus, Christian Preisinger, Frank Tacke,mChristian Trautwein, Thomas Longerich, Mihael Vucur, Tom Luedde

Depletion of mitochondria in mammalian cells through enforced mitophagy
Clara Correia-Melo, Gabriel Ichim, Stephen W G Tait & João F Passos


Necroptosis in development, inflammation and disease
Ricardo Weinlich, Andrew Oberst, Helen M. Beere & Douglas R. Green

Disassembly of the Dying: Mechanisms and Functions
Georgia K. Atkin-Smith, Ivan K.H. Poon

Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer
Tariq A. Bhat, Ajay K. Chaudhary, Sandeep Kumar, Jordan O’Malley, Joseph R. Inigo, Rahul Kumar, Neelu Yadav, Dhyan Chandra

Comments / other

Cancer and Apoptosis: Who Is Built to Last?
Douglas R. Green

RIPK1 prevents aberrant ZBP1-initiated necroptosis
Tom Vanden Berghe, and William J. Kaiser

Secondary Necrosis: Accidental No More
Lorenzo Galluzzi, Guido Kroemer

Close encounter of the covalent kind: Inhibiting MCL1’s proapoptotic activity with covalent inhibitors
Guillaune Lessene

How ICE lights the pyroptosis fire
Xing Liu and Judy Lieberman

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer
Xin Chen, Joost J. Oppenheim

Cell death: Pulling the apoptotic trigger for necrosis

IAP Antagonists Promote Phagocytosis of Multiple Myeloma In Vivo

Martin Leverkus, 1965-2016
Henning Walczak & Martin R Sprick