ApoList – December 2016

Bcl-2 Family Proteins

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes
Vicente Andreu-Fernández, Mónica Sancho, Ainhoa Genovés, Estefanía Lucendo, Franziska Todt, Joachim Lauterwasser, Kathrin Funk, Günther Jahreis, Enrique Pérez-Payá, Ismael Mingarro, Frank Edlich and Mar Orzáez

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance
Jessie Pécot, Laurent Maillet, Janic Le Pen, Céline Vuillier, Sophie de Carné Trécesson, Aurélie Fétiveau, Kristopher A. Sarosiek, Florian J. Bock, Frédérique Braun, Anthony Letai, Stephen W.G. Tait, Fabien Gautier, Philippe P. Juin

Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling
Victor Peperzak, Erik Slinger, Johanna Ter Burg and Eric Eldering

Caspase-3–dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells
Ioulia Vardaki, Claire Sanchez, Pedro Fonseca, Magnus Olsson, Dimitrios Chioureas, George Rassidakis, Anders Ullén, Boris Zhivotovsky, MagnusBjörkholm, and Theocharis Panaretakis

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact
Benjamin Bonneau, Hideaki Ando, Katsuhiro Kawaai, Matsumi Hirose, Hiromi Takahashi-Iwanaga and Katsuhiko Mikoshiba

Targeted Inactivation of Bax Reveals a Subtype-Specific Mechanism of Cajal-Retzius Neuron Death in the Postnatal Cerebral Cortex
Fanny Ledonne, David Orduz, Judith Mercier, Lisa Vigier, Elisabeth A. Grove, Fadel Tissir, Maria Cecilia Angulo, Alessandra Pierani, Eva Coppola

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation
Grace R. Anderson , Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley, Peter S. Winter, Elizabeth K. Zieser-Misenheimer, Holly M. Alley, Alexander Yllanes, Victoria Haney, Kimberly L. Blackwell, Shannon J. McCall, Donald P. McDonnell, Kris C. Wood

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability
Casey Ah-Cann, Maximilien Tailler, Andrew J Kueh, Marco J Herold, Joseph T Opferman, Marie-Liesse Asselin-Labat and Philippe Bouillet

Mature neurons dynamically restrict apoptosis via redundant premitochondrial brakes
Ryan P. Annis, Vijay Swahari, Ayumi Nakamura, Alison X. Xie, Scott M. Hammond and Mohanish Deshmukh

Death receptors and FLIP

Hepatitis B virus–triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response
Gu-Choul Shin, Hong Seok Kang, Ah Ram Lee & Kyun-Hwan Kim

hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma
Karianne G Fleten, Vivi Ann Flørenes, Lina Prasmickaite, Oliver Hill, Jaromir Sykora, Gunhild M Mælandsmo & Birgit Engesæter

C-FLIPL modulated Wnt/beta-catenin activation via association with TIP49 protein
Jing Zhang, Heng-yi Jiang, Lin-kai Zhang, Wen-ling Xu, Yi-ting Qiao, Xu-guo Zhu, Wan Liu, Qian-qian Zheng, and Zi-Chun Hua

Necroptosis and necrosis

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
M Cristina de Almagro, Tatiana Goncharov, Anita Izrael-Tomasevic, Stefanie Duttler, Matthias Kist, Eugene Varfolomeev, Xiumin Wu, Wyne P Lee, Jeremy Murray, Joshua D Webster, Kebing Yu, Donald S Kirkpatrick, Kim Newton and Domagoj Vucic

A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis
Katharina Rohde, Lara Kleinesudeik, Stefanie Roesler, Oliver Löwe, Juliana Heidler, Katrin Schröder, Ilka Wittig, Stefan Dröse and Simone Fulda

TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade
Piotr T. Filipczak, Cindy Thomas, Wenshu Chen, Andrew Salzman, Jacob D.
McDonald, Yong Lin, and Steven A. Belinsky


Bcl-2-Ome – a database and interactive web service for dissecting the Bcl-2 interactome
Annika Hantusch, Thomas Brunner, Tancred Frickey and Markus Rehm

IAP antagonists induce anti-tumor immunity in multiple myeloma
Marta Chesi, Noweeda N Mirza, Victoria M Garbitt, Meaghen E Sharik, Amylou C Dueck, Yan W Asmann, Ilseyar Akhmetzyanova, Heidi E Kosiorek, Arianna Calcinotto, Daniel L Riggs, Niamh Keane, Gregory J Ahmann, Kevin M Morrison, Rafael Fonseca, Martha Q Lacy, David Dingli, Shaji K Kumar, Sikander Ailawadhi, Angela Dispenzieri, Francis Buadi, Morie A Gertz, Craig B Reeder, Yi Lin, Asher A Chanan-Khan, A Keith Stewart, David Fooksman & P Leif Bergsagel

Robust high-throughput kinetic analysis of apoptosis with real-time high-content live-cell imaging
Jesse D Gelles and Jerry Edward Chipuk

Reviews and Comments

Necroptosis in development, inflammation and disease
Ricardo Weinlich, Andrew Oberst, Helen M. Beere & Douglas R. Green

S63845, an MCL-1 Selective BH3 Mimetic: Another Arrow in Our Quiver
Anthony Letai

Roles of Caspases in Necrotic Cell Death
Junying Yuan, Ayaz Najafov, Bénédicte F. Py

Doxorubicin-induced chronic dilated cardiomyopathy—the apoptosis hypothesis revisited
Cynthia Kankeu, Kylie Clarke, Egle Passante, Heinrich J. Huber

Questions and controversies: the role of necroptosis in liver disease
Lily Dara, Zhang-Xu Liu & Neil Kaplowitz

MCL1 Can Be Targeted to Induce Apoptosis in Multiple Cancer Types


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