ApoList – December 2016

Bcl-2 Family Proteins

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes
Vicente Andreu-Fernández, Mónica Sancho, Ainhoa Genovés, Estefanía Lucendo, Franziska Todt, Joachim Lauterwasser, Kathrin Funk, Günther Jahreis, Enrique Pérez-Payá, Ismael Mingarro, Frank Edlich and Mar Orzáez

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance
Jessie Pécot, Laurent Maillet, Janic Le Pen, Céline Vuillier, Sophie de Carné Trécesson, Aurélie Fétiveau, Kristopher A. Sarosiek, Florian J. Bock, Frédérique Braun, Anthony Letai, Stephen W.G. Tait, Fabien Gautier, Philippe P. Juin

Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling
Victor Peperzak, Erik Slinger, Johanna Ter Burg and Eric Eldering

Caspase-3–dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells
Ioulia Vardaki, Claire Sanchez, Pedro Fonseca, Magnus Olsson, Dimitrios Chioureas, George Rassidakis, Anders Ullén, Boris Zhivotovsky, MagnusBjörkholm, and Theocharis Panaretakis

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact
Benjamin Bonneau, Hideaki Ando, Katsuhiro Kawaai, Matsumi Hirose, Hiromi Takahashi-Iwanaga and Katsuhiko Mikoshiba

Targeted Inactivation of Bax Reveals a Subtype-Specific Mechanism of Cajal-Retzius Neuron Death in the Postnatal Cerebral Cortex
Fanny Ledonne, David Orduz, Judith Mercier, Lisa Vigier, Elisabeth A. Grove, Fadel Tissir, Maria Cecilia Angulo, Alessandra Pierani, Eva Coppola

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation
Grace R. Anderson , Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley, Peter S. Winter, Elizabeth K. Zieser-Misenheimer, Holly M. Alley, Alexander Yllanes, Victoria Haney, Kimberly L. Blackwell, Shannon J. McCall, Donald P. McDonnell, Kris C. Wood

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability
Casey Ah-Cann, Maximilien Tailler, Andrew J Kueh, Marco J Herold, Joseph T Opferman, Marie-Liesse Asselin-Labat and Philippe Bouillet

Mature neurons dynamically restrict apoptosis via redundant premitochondrial brakes
Ryan P. Annis, Vijay Swahari, Ayumi Nakamura, Alison X. Xie, Scott M. Hammond and Mohanish Deshmukh

Death receptors and FLIP

Hepatitis B virus–triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response
Gu-Choul Shin, Hong Seok Kang, Ah Ram Lee & Kyun-Hwan Kim

hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma
Karianne G Fleten, Vivi Ann Flørenes, Lina Prasmickaite, Oliver Hill, Jaromir Sykora, Gunhild M Mælandsmo & Birgit Engesæter

C-FLIPL modulated Wnt/beta-catenin activation via association with TIP49 protein
Jing Zhang, Heng-yi Jiang, Lin-kai Zhang, Wen-ling Xu, Yi-ting Qiao, Xu-guo Zhu, Wan Liu, Qian-qian Zheng, and Zi-Chun Hua

Necroptosis and necrosis

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
M Cristina de Almagro, Tatiana Goncharov, Anita Izrael-Tomasevic, Stefanie Duttler, Matthias Kist, Eugene Varfolomeev, Xiumin Wu, Wyne P Lee, Jeremy Murray, Joshua D Webster, Kebing Yu, Donald S Kirkpatrick, Kim Newton and Domagoj Vucic

A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis
Katharina Rohde, Lara Kleinesudeik, Stefanie Roesler, Oliver Löwe, Juliana Heidler, Katrin Schröder, Ilka Wittig, Stefan Dröse and Simone Fulda

TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade
Piotr T. Filipczak, Cindy Thomas, Wenshu Chen, Andrew Salzman, Jacob D.
McDonald, Yong Lin, and Steven A. Belinsky


Bcl-2-Ome – a database and interactive web service for dissecting the Bcl-2 interactome
Annika Hantusch, Thomas Brunner, Tancred Frickey and Markus Rehm

IAP antagonists induce anti-tumor immunity in multiple myeloma
Marta Chesi, Noweeda N Mirza, Victoria M Garbitt, Meaghen E Sharik, Amylou C Dueck, Yan W Asmann, Ilseyar Akhmetzyanova, Heidi E Kosiorek, Arianna Calcinotto, Daniel L Riggs, Niamh Keane, Gregory J Ahmann, Kevin M Morrison, Rafael Fonseca, Martha Q Lacy, David Dingli, Shaji K Kumar, Sikander Ailawadhi, Angela Dispenzieri, Francis Buadi, Morie A Gertz, Craig B Reeder, Yi Lin, Asher A Chanan-Khan, A Keith Stewart, David Fooksman & P Leif Bergsagel

Robust high-throughput kinetic analysis of apoptosis with real-time high-content live-cell imaging
Jesse D Gelles and Jerry Edward Chipuk

Reviews and Comments

Necroptosis in development, inflammation and disease
Ricardo Weinlich, Andrew Oberst, Helen M. Beere & Douglas R. Green

S63845, an MCL-1 Selective BH3 Mimetic: Another Arrow in Our Quiver
Anthony Letai

Roles of Caspases in Necrotic Cell Death
Junying Yuan, Ayaz Najafov, Bénédicte F. Py

Doxorubicin-induced chronic dilated cardiomyopathy—the apoptosis hypothesis revisited
Cynthia Kankeu, Kylie Clarke, Egle Passante, Heinrich J. Huber

Questions and controversies: the role of necroptosis in liver disease
Lily Dara, Zhang-Xu Liu & Neil Kaplowitz

MCL1 Can Be Targeted to Induce Apoptosis in Multiple Cancer Types


ApoList – November 2016


Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs
Ryan J. Cummings, Gaetan Barbet, Gerold Bongers, Boris M. Hartmann, Kyle Gettler, Luciana Muniz, Glaucia C. Furtado, Judy Cho, Sergio A. Lira & J. Magarian Blander

Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205
Longxing Cao, Haishuang Chang, Xiangyi Shi, Chao Peng, and Yongning He

Bcl-2 family proteins

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery and David Baker

Low carbohydrate diet prevents Mcl-1-mediated resistance to BH3-mimetics
Camila Rubio-Patiño, Jozef P. Bossowski, Elodie Villa, Laura Mondragón, Barbara Zunino, Emma Proïcs, Johanna Chiche, Frédéric Bost, Els Verhoeyen,  and  Jean-Ehrland Ricci

Enhanced Stabilization of MCL1 by the Human T-Cell Leukemia Virus Type 1
bZIP Factor Is Modulated by Blocking the Recruitment of Cullin 1 to the SCF Complex
Risa Mukai and Takayuki Ohshima

FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma
Y Li, M N Bouchlaka, J Wolff, K M Grindle, L Lu, S Qian, X Zhong, N Pflum, P Jobin, B S Kahl, J C Eickhoff, S M Wuerzberger-Davis, S Miyamoto, C J Thomas, D T Yang, C M Capitini and L Rui

Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified
Rong Chu, Sarah E. Alford, Katherine Hart, Anisha Kothari, Samuel G. Mackintosh, Matthew R. Kovak,  and  Timothy C. Chambers

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins
Katharine J. Goodall, Megan L. Finch-Edmondson, Joanne van Vuuren, George C. Yeoh, Ian E. Gentle, James E. Vince, Paul G. Ekert, David L. Vaux, Bernard A. Callus

Caspases and caspase substrates

Caspase-2 cleavage of tau reversibly impairs memory
Xiaohui Zhao, Linda A Kotilinek, Benjamin Smith, Chris Hlynialuk, Kathleen Zahs, Martin Ramsden, James Cleary & Karen H Ashe

The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
Chu-Chiao Wu, Sunhee Lee, Srinivas Malladi, Miao-Der Chen, Nicholas J. Mastrandrea, Zhiwen Zhang and Shawn B. Bratton

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
Teresa L. M. Thurston, Sophie A. Matthews, Elliott Jennings, Eric Alix, Feng Shao, Avinash R. Shenoy, Mark A. Birrell and David W. Holden

Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31
Donghyun Joo, Yong Tang, Marzenna Blonska, Jianping Jin, Xueqiang Zhao, and Xin Lin

Death receptors and FLIP

Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand
Michelle L. Ols, Jaime L. Cullen, Adriana Turqueti-Neves, Josephine Giles, Mark J. Shlomchik

A Microplate-Based Nonradioactive Protein Synthesis Assay: Application to TRAIL Sensitization by Protein Synthesis Inhibitors
Henrich, CJ

Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery
Xinyi Jiang, Sergio Fitch, Christine Wang, Christy Wilson, Jianfeng Li, Gerald A. Grant, and Fan Yang

Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells
Ian R. Logan, Urszula L. McClurg, Dominic L. Jones, Daniel J. O’Neill, Fadhel S. Shaheen, John Lunec, Luke Gaughan,  and  Craig N. Robson

TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death
Jürgen Fritsch, Ricarda Fickers, Jan Klawitter, Vinzenz Särchen, Philipp Zingler, Dieter Adam, Ottmar Janssen, Eberhard Krause,  and  Stefan Schütze

RIP kinases, necroptosis

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
Juan Lin, Snehlata Kumari, Chun Kim, Trieu-My Van, Laurens Wachsmuth,Apostolos Polykratis& Manolis Pasparakis

RIPK1 inhibits ZBP1-driven necroptosis during development.
Kim Newton, Katherine E. Wickliffe, Allie Maltzman, Debra L. Dugger, Andreas Strasser, Victoria C. Pham, Jennie R. Lill, Merone Roose-Girma, Søren Warming, Margaret Solon, Hai Ngu, Joshua D. Webster & Vishva M. Dixit

Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis
Hongyu Jie, Yi He, Xuechan Huang, Qingyou Zhou, Yanping Han, Xing Li, Yongkun Bai and Erwei Sun

Dynamic quantitative proteomics characterization of TNF-α-induced necroptosis
Yang Wang, Zhi-Hao Huang, Yang-Jia Li, Gui-Wei He, Ru-Yuan Yu, Jie Yang, Wan-Ting Liu, Bin Li & Qing-Yu He

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis
Claudia Günther, Gui-Wei He, Andreas E. Kremer, James M. Murphy, Emma J. Petrie, Kerstin Amann, Peter Vandenabeele, Andreas Linkermann, Christopher Poremba, Ulrike Schleicher, Christin Dewitz, Stefan Krautwald, Markus F. Neurath, Christoph Becker, Stefan Wirtz

RIPK1 protects from TNF-α-mediated liver damage during hepatitis
Aveline Filliol, Claire Piquet-Pellorce, Jacques Le Seyec, Muhammad Farooq, Valentine Genet, Catherine Lucas-Clerc, John Bertin, Peter J Gough, Marie-Thérèse Dimanche-Boitrel, Peter Vandenabeele, Mathieu JM Bertrand and Michel Samson


ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Sebastian Doll, Bettina Proneth,Yulia Y Tyurina, Elena Panzilius, Sho Kobayashi, Irina Ingold,Martin Irmler, Johannes Beckers, Michaela Aichler, Axel Walch, Holger Prokisch, Dietrich Trümbach, Gaowei Mao,Feng Qu, Hulya Bayir,Joachim Füllekrug, Christina H Scheel, Wolfgang Wurst, Joel A Schick, Valerian E Kagan, José Pedro Friedmann Angeli & Marcus Conrad

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses
Yang Ou, Shang-Jui Wang, Dawei Li, Bo Chu, and Wei Gu


TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression
Xian Zhang, Chien-Feng Li, Ling Zhang, Ching-Yuan Wu, Lixia Han, Guoxiang Jin, Abdol Hossein Rezaeian, Fei Han, Chunfang Liu, Chuan Xu, Xiaohong Xu, Chih-Yang Huang, Fuu-Jen Tsai, Chang-Hai Tsai, Kounosuke Watabe, Hui-Kuan Lin

Reviews, comments / other

Physiological and Pharmacological Control of BAK, BAX, and Beyond
Mark P.A. Luna-Vargas, Jerry Edward Chipuk

Ironing out how p53 regulates ferroptosis
Maureen E. Murphy

Suzanne Cory: Life-and-Death Switches: the Rise of BH3 Mimetics

Caspase-2 and tau—a toxic partnership?
Carol M Troy and Michael L Shelanski

Caspase-2: Divide and conquer [Alzheimer]

Dual Inhibition of MDM2 and XIAP Induces Cancer Cell Apoptosis

The killer protein Gasdermin D
John A Wright and Clare E Bryant