Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for October, 2016

ApoList – September 2016

Posted by cris on October 10, 2016

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Death receptors and RIP kinases
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SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
Paul R. Elliott, Derek Leske, Matous Hrdinka, Katrin Bagola, Berthe K. Fiil, Stephen H. McLaughlin, Jane Wagstaff, Norbert Volkmar, John C. Christianson, Benedikt M. Kessler, Stefan M.V. Freund, David Komander, Mads Gyrd-Hansen
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30415-4

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
Silvia Alvarez-Diaz, Christopher P. Dillon, Najoua Lalaoui, Maria C. Tanzer, Diego A. Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C. Josefsson, Lorraine A. O’Reilly, John Silke, Warren S. Alexander, Douglas R. Green, Andreas Strasser
http://www.cell.com/immunity/abstract/S1074-7613(16)30289-8

Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality
Cunxian Fan, Wenjuan Pu, Xiaoxia Wu, Xixi Zhang, Lingjuan He, Bin Zhou and Haibing Zhang
http://www.nature.com/cddis/journal/v7/n9/full/cddis2016251a.html

Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis
Daniela Siegmund, Juliane Kums, Martin Ehrenschwender and Harald Wajant
http://www.nature.com/cddis/journal/v7/n9/abs/cddis2016285a.html

Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas
Sinyi Kong, Yi Yang, Yuanming Xu, Yajun Wang, Yusi Zhang, Johanna Melo-Cardenas, Xiangping Xu, Beixue Gao, Edward B. Thorp, Donna D. Zhang, Bin Zhang, Jianxun Song, Kezhong Zhang, Jianning Zhang, Jinping Zhang, Huabin Li, and Deyu Fang
http://www.pnas.org/content/113/37/10394.abstract.html?etoc

MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome
Xixi Zhang, Cunxian Fan, Haiwei Zhang, Qun Zhao, Yongbo Liu, Chengxian Xu, Qun Xie, Xiaoxia Wu, Xianjun Yu, Jianke Zhang, Haibing Zhang
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30925-1

Expression of death receptor 4 is positively regulated by MEK/ERK/AP-1 signaling and suppressed upon MEK inhibition
Weilong Yao, You-Take Oh, Jiusheng Deng, Ping Yue, Liang Deng, Henry Huang, Wei Zhou, and Shi-Yong Sun
http://www.jbc.org/content/early/2016/08/30/jbc.M116.738302.abstract

Keratin impact on PKCδ- and ASMase-mediated regulation of hepatocyte lipid raft size – implication for FasR-associated apoptosis
Stéphane Gilbert, Anne Loranger, M. Bishr Omary, and Normand Marceau
http://jcs.biologists.org/content/129/17/3262?etoc

Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis
Ryan M Carr, Guilin Qiao, Jianzhong Qin, Sundararajan Jayaraman, Bellur S Prabhakar et al.
http://www.nature.com/articles/cddiscovery201667

Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation
John P Dowling, Yubo Cai, John Bertin, Peter J Gough and Jianke Zhang
http://www.nature.com/cddis/journal/v7/n9/abs/cddis2016307a.html

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Necroptosis
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An evolutionary perspective on the necroptotic pathway
Yves Dondelinger, Paco Hulpiau, Yvan Saeys, Mathieu J.M. Bertrand, Peter Vandenabeele
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(16)30075-7

Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells
Justyna Sosna, Stephan Philipp, Johaiber Fuchslocher Chico, Carina Saggau, Jürgen Fritsch, Alexandra Föll, Johannes Plenge, Christoph Arenz,Thomas Pinkert, Holger Kalthoff, Anna Trauzold, Ingo Schmitz, Stefan Schütze, and Dieter Adam
http://mcb.asm.org/content/36/20/2626.abstract?etoc

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
Silvia Alvarez-Diaz, Christopher P. Dillon, Najoua Lalaoui, Maria C. Tanzer, Diego A. Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C. Josefsson, Lorraine A. O’Reilly, John Silke, Warren S. Alexander, Douglas R. Green, Andreas Strasser
http://www.cell.com/immunity/abstract/S1074-7613(16)30289-8

K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo
B Shutinoski, N A Alturki, D Rijal, J Bertin, P J Gough, M G Schlossmacher and S Sad
http://www.nature.com/cdd/journal/v23/n10/abs/cdd201651a.html

Activation of necroptosis in human and experimental cholestasis
Marta B Afonso, Pedro M Rodrigues, André L Simão, Dimitry Ofengeim, Tânia Carvalho, Joana D Amaral, Maria M Gaspar, Helena Cortez-Pinto, Rui E Castro, Junying Yuan and Cecília M P Rodrigues
http://www.nature.com/cddis/journal/v7/n9/abs/cddis2016280a.html

TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints
Xiaoyun Guo, Haifeng Yin, Yi Chen, Lei Li, Jing Li and Qinghang Liu
http://www.nature.com/cddis/journal/v7/n9/abs/cddis2016294a.html

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Bcl-2 family proteins
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The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
Jonathan J. Kotzin, Sean P. Spencer, Sam J. McCright, Dinesh B. Uthaya Kumar, Magalie A. Collet, Walter K. Mowel, Ellen N. Elliott, Asli Uyar, Michelle A. Makiya, Margaret C. Dunagin, Christian C. D. Harman, Anthony T. Virtue, Stella Zhu, Will Bailis, Judith Stein, Cynthia Hughes, Arjun Rak, E. John Wherry, Loyal A. Goff, Amy D. Klion, John L. Rinn,  Adam Williams, Richard A. Flavell, Jorge Henao-Mejia
http://www.nature.com/nature/journal/v537/n7619/full/nature19346.html

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury.
D’Orsi B, Engel T, Pfeiffer S, Nandi S, Kaufmann T, Henshall DC, Prehn JH.
http://www.jneurosci.org/content/36/16/4564.long

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells
Bing Z. Carter, Po Yee Mak, Hong Mu, Hongsheng Zhou, Duncan H. Mak, Wendy Schober, Joel D. Leverson, Bin Zhang, Ravi Bhatia, Xuelin Huang, Jorge Cortes, Hagop Kantarjian, Marina Konopleva and Michael Andreeff
http://stm.sciencemag.org/content/8/355/355ra117

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain
Divyaanka Iyer, Supriya V. Vartak, Archita Mishra, Gunaseelan Goldsmith, Sujeet Kumar, Mrinal Srivastava, Mahesh Hegde, Vidya Gopalakrishnan, Mark Glenn, Mahesh Velusamy, Bibha Choudhary, Nagesh Kalakonda, Subhas S. Karki, Avadhesha Surolia and Sathees C. Raghavan
http://onlinelibrary.wiley.com/doi/10.1111/febs.13815/full

BCL-2 system analysis identifies high-risk colorectal cancer patients.
Lindner AU, Salvucci M, Morgan C, Monsefi N, Resler AJ, Cremona M, Curry S, Toomey S, O’Byrne R, Bacon O, Stühler M, Flanagan L, Wilson R, Johnston PG, Salto-Tellez M, Camilleri-Broët S, McNamara DA, Kay EW, Hennessy BT, Laurent-Puig P, Van Schaeybroeck S, Prehn JH.
http://gut.bmj.com/content/early/2016/09/23/gutjnl-2016-312287.long

Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice
Rebecca A Bilardi, Natasha S Anstee, Stefan P Glaser, Mikara Robati, Cassandra J Vandenberg and Suzanne Cory
http://www.nature.com/cddis/journal/v7/n9/abs/cddis2016258a.html

A potential molecular model for studying apoptosis enhanced by the interaction of BCL-G with JAB1 in swine
Pengfei Jiang, Xingye Wang, Xiaolin Chen, Yaping Wang, Zhanzhan Kang, Jingna Wang,  and  Deli Zhang
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=11230

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Caspases
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Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1–Dependent Apoptosis in Cancer Cells
Annahita Sallmyr, Yoshihiro Matsumoto, Vera Roginskaya, Bennett Van Houten, and Alan E. Tomkinson
http://cancerres.aacrjournals.org/content/76/18/5431.abstract?etoc

Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage
Kazuhiro Sakamaki, Takahiro M. Ishii, Toshiya Sakata, Kiwamu Takemoto, Chiyo Takagi, Ayako Takeuchi, Ryo Morishita, Hirotaka Takahashi, Akira Nozawa, Hajime Shinoda, Kumiko Chiba, Haruyo Sugimoto, Akiko Saito, Shuhei Tamate, Yutaka Satou, Sang-Kee Jung, Satoshi Matsuoka, Koji Koyamada, Tatsuya Sawasaki, Takeharu Nagai, Naoto Ueno
http://www.sciencedirect.com/science/article/pii/S0167488916302154

Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues
J E Seaman, O Julien, P S Lee, T J Rettenmaier, N D Thomsen and J A Wells
http://www.nature.com/cdd/journal/v23/n10/abs/cdd201662a.html

Caspase-2 deficiency accelerates chemically induced liver cancer in mice
S Shalini, A Nikolic, C H Wilson, J Puccini, N Sladojevic, J Finnie, L Dorstyn and S Kumar
http://www.nature.com/cdd/journal/v23/n10/abs/cdd201681a.html

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Miscellaneous
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The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca2+ flux from the endoplasmic reticulum to mitochondria
A Fouqué, E Lepvrier, L Debure, Y Gouriou, M Malleter, V Delcroix, M Ovize, T Ducret, C Li, M Hammadi, P Vacher and P Legembre
http://www.nature.com/cdd/journal/v23/n10/abs/cdd201661a.html

A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress
M A Aguileta, D Rojas-Rivera, V Goossens, Y Estornes, G Van Isterdael, P Vandenabeele and M J M Bertrand
http://www.nature.com/cdd/journal/v23/n10/abs/cdd201659a.html

Functional inhibition of Hsp70 by Pifithrin-μ switches Gambogic acid induced caspase dependent cell death to caspase independent cell death in human bladder cancer cells
Mohammad Ishaq, Rani Ojha, Kapil Sharma, Gaurav Sharma, Shrawan K. Singh, Sekhar Majumdar,
http://www.sciencedirect.com/science/article/pii/S016748891630180X

JAK/STAT signalling mediates cell survival in response to tissue stress
Marco La Fortezza, Madlin Schenk, Andrea Cosolo, Addie Kolybaba, Isabelle Grass, Anne-Kathrin Classen
http://dev.biologists.org/content/143/16/2907

Inhibition of autophagy by chloroquine induces apoptosis in primary effusion lymphoma in vitro and in vivo through induction of endoplasmic reticulum stress
Md. Masud Alam, Ryusho Kariya, Azusa Kawaguchi, Kouki Matsuda, Eriko Kudo & Seiji Okada
http://link.springer.com/article/10.1007/s10495-016-1277-7

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Reviews
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Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics – recent successes, current challenges and future promise
Kristopher A. Sarosiek and Anthony Letai
http://onlinelibrary.wiley.com/doi/10.1111/febs.13714/full

Targeting BCL-2-like Proteins to Kill Cancer Cells
Suzanne Cory, Andrew W. Roberts, Peter M. Colman, Jerry M. Adams
http://www.cell.com/trends/cancer/fulltext/S2405-8033(16)30080-2

Bcl-2 proteins and calcium signaling: complexity beneath the surface
T Vervliet, J B Parys and G Bultynck
http://www.nature.com/onc/journal/v35/n39/abs/onc201631a.html

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Comments
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BCL2 Inhibition by Venetoclax: Targeting the Achilles’ Heel of the Acute Myeloid Leukemia Stem Cell?
Vinod A. Pullarkat and Edward M. Newman
http://cancerdiscovery.aacrjournals.org/content/6/10/1082.abstract?etoc

The gasdermin-D pore: Executor of pyroptotic cell death
Sebastian Rühl,  and  Petr Broz
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=11421

Cotargeting BCL-2 and BCL-XL for maximal efficacy in ALL
Naval Daver and Marina Konopleva
http://bloodjournal.org/content/128/10/1316?etoc

RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs
Ulrike Höckendorf, Monica Yabal,  and  Philipp J. Jost
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=11195

Death Receptor 6–Mediated Endothelial Necroptosis Drives Metastasis
http://cancerdiscovery.aacrjournals.org/content/6/10/OF12.abstract?etoc

RIPK3 Induces Leukemia-Initiating Cell Death and Differentiation
http://cancerdiscovery.aacrjournals.org/content/6/9/OF10.abstract?etoc

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Roger Y. Tsien (1952–2016)
Stephen J. Lippard
http://science.sciencemag.org/content/354/6308/41




 

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