ApoList – August 2016

Bcl-2 family proteins

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway
Thomas P. Garner, Denis E. Reyna, Amit Priyadarshi, Hui-Chen Chen, Sheng Li, Yang Wu, Yogesh Tengarai Ganesan, Vladimir N. Malashkevich, Steve S. Almo, Emily H. Cheng, Evripidis Gavathiotis

MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs
C David Wood, Hildegonda Veenstra, Sarika Khasnis, Andrea Gunnell, Helen M Webb, Claire Shannon-Lowe Simon Andrews, Cameron S Osborne, Michelle J West

BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice
Mohamed-Amine Hamouda, Arnaud Jacquel, Guillaume Robert, Alexandre Puissant, Valentine Richez, Romeo Cassel, Nina Fenouille, Sandrine Roulland, Jerome Gilleron, Emmanuel Griessinger, Alix Dubois, Beatrice Bailly-Maitre, Diogo Goncalves, Aude Mallavialle, Pascal Colosetti, Sandrine Marchetti, Martine Amiot, Patricia Gomez-Bougie, Nathalie Rochet, Marcel Deckert, Herve Avet-Loiseau, Paul Hofman, Jean-Michel Karsenti, Pierre-Yves Jeandel, Claudine Blin-Wakkach, Bertrand Nadel, Thomas Cluzeau, Kenneth C. Anderson, Jean-Gabriel Fuzibet, Patrick Auberger, and Frederic Luciano

Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation
Christine B. Karim, L. Michel Espinoza-Fonseca, Zachary M. James, Eric A. Hanse, Jeffrey S. Gaynes, David D. Thomas, and Ameeta Kelekar

The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition
Hristina Ivanova, Abigael Ritane, Larry Wagner, Tomas Luyten, George Shapovalov, Kirsten Welkenhuyzen, Bruno Seitaj, Giovanni Monaco, Humbert De Smedt, Natalia Prevarskaya, David I. Yule, Jan B. Parys,  and  Geert Bultynck

Selective Impairment of TH17-Differentiation and Protection against Autoimmune Arthritis after Overexpression of BCL2A1 in T Lymphocytes
Marcos Iglesias, Juan Jesús Augustin, Pilar Alvarez, Inés Santiuste, Jorge Postigo, Jesús Merino, Ramón Merino

Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancer
M Hornsveld, M Tenhagen, R A van de Ven, A M M Smits, M H van Triest, M van Amersfoort, D E A Kloet, T B Dansen, B M Burgering and P W B Derksen

Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport
Juliana Velez, Rongqing Pan, Jason T.C. Lee, Leonardo Enciso, Marta Suarez, Jorge Eduardo Duque, Daniel Jaramillo, Catalina Lopez, Ludis Morales, William Bornmann, Marina Konopleva, Gerald Krystal, Michael Andreeff,  and  Ismael Samudio

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L
Victoria E Pedanou, Stéphane Gobeil, Sébastien Tabariès, Tessa M Simone, Lihua Julie Zhu, Peter M Siegel and Michael R Green

Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism
Radhika Kandaswamy, Georgina P. Sava, Helen E. Speedy, Sílvia Beà, José I. Martín-Subero, James B. Studd, Gabriele Migliorini, Philip J. Law, Xose S. Puente, David Martín-García, Itziar Salaverria, Jesús Gutiérrez-Abril, Carlos López-Otín, Daniel Catovsky, James M. Allan, Elías Campo, Richard S. Houlston

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL
Ingela B Vikström, Anne Slomp, Emma M Carrington, Laura M Moesbergen, Catherine Chang, Gemma L Kelly, Stefan P Glaser, J H Marco Jansen, Jeanette H W Leusen, Andreas Strasser, David C S Huang, Andrew M Lew, Victor Peperzak and David M Tarlinton

BNIP3 Suppresses PINK1 Proteolytic Cleavage to Promote Mitophagy
Tongmei Zhang, Liang Xue, Li Li, Chengyuan Tang, Zhengqing Wan, Ruoxi Wang, Jieqiong Tan, Ya Tan, Hailong Han, Runyi Tian, Timothy R. Billiar, W. Andy Tao, and Zhuohua Zhang

Melanoma differentiation associated gene 7/IL-24 exerts cytotoxic effects by altering the alternative splicing of Bcl-x pre-mRNA via the SRC/PKCδ signaling axis.
Brian A. Shapiro, Ngoc T. Vu, Michael D. Shultz, Jacqueline C. Shultz, Jennifer A. Mietla, Mazen M. Gouda, Adly Yacoub, Paul Dent, Paul B. Fisher, Margaret A. Park, and Charles E. Chalfant


Anti-apoptotic Bcl-XL but not Mcl-1 contributes to protection against virus-induced apoptosis
Michaela Ohmer, Arnim Weber, Gerd Sutter, Katrin Ehrhardt, Albert Zimmermann and Georg Häcker

Bcl-xL is an oncogenic driver in colorectal cancer
Anna-Lena Scherr, Georg Gdynia, Mariam Salou, Praveen Radhakrishnan, Katarina Duglova, Anette Heller, Sophia Keim, Nicole Kautz, Adam Jassowicz, Christin Elssner, You-Wen He, Dirk Jaeger, Mathias Heikenwalder, Martin Schneider, Achim Weber, Wilfried Roth, Henning Schulze-Bergkamen and Bruno Christian Koehler

PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage
J Barroso-González, S Auclair, S Luan, L Thomas, K M Atkins, J E Aslan, L L Thomas, J Zhao, Y Zhao and G Thomas

Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts
Prasamit Saurav Baruah, Myriam Beauchemin, Josée Hébert, Richard Bertrand

Death receptors

SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
Lisa Schlicher, Manuela Wissler, Florian Preiss, Prisca Brauns- Schubert, Celia Jakob, Veronica Dumit, Christoph Borner, Joern Dengjel, Ulrich Maurer

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes
Sebastian Kupka, Diego De Miguel, Peter Draber, Luigi Martino, Silvia Surinova, Katrin Rittinger, Henning Walczak

SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes
Sebastian A Wagner, Shankha Satpathy, Petra Beli, Chunaram Choudhary

NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II
Alessandra Pescatore, Elio Esposito, Peter Draber, Henning Walczak and Matilde Valeria Ursini

Antitherapeutic antibody-mediated hepatotoxicity of recombinant human Apo2L/TRAIL in the cynomolgus monkey
Christina L Zuch de Zafra, Avi Ashkenazi, Walter C Darbonne, Melissa Cheu, Klara Totpal, Shirley Ortega, Heather Flores, Mark D Walker, Bruce Kabakoff, Bert L Lum, Barbara J Mounho-Zamora, Scot A Marsters and Noël O Dybdal

Caspases and IAPs

The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila
T V Lee, H E Kamber Kaya, R Simin, E H Baehrecke and A Bergmann

Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152
A Tchoghandjian, A Soubéran, E Tabouret, C Colin, E Denicolaï, C Jiguet-Jiglaire, A El-Battari, C Villard, N Baeza-Kallee and D Figarella-Branger

Caspases uncouple p27Kip1 from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion
S R Podmirseg, H Jäkel, G D Ranches, M K Kullmann, B Sohm, A Villunger, H Lindner and L Hengst


RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
Yasushi Ito , Dimitry Ofengeim, Ayaz Najafov, Sudeshna Das, Shahram Saberi, Ying Li, Junichi Hitomi, Hong Zhu, Hongbo Chen, Lior Mayo, Jiefei Geng, Palak Amin, Judy Park DeWitt, Adnan Kasim Mookhtiar, Marcus Florez, Amanda Tomie Ouchida, Jian-bing Fan, Manolis Pasparakis, Michelle A. Kelliher, John Ravits, Junying Yuan

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
M Cristina de Almagro, Tatiana Goncharov, Anita Izrael-Tomasevic, Stefanie Duttler, Matthias Kist, Eugene Varfolomeev, Xiumin Wu, Wyne P Lee, Jeremy Murray, Joshua D Webster, Kebing Yu, Donald S Kirkpatrick, Kim Newton and Domagoj Vucic

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis
Boris Strilic, Lida Yang, Julián Albarrán-Juárez, Laurens Wachsmuth, Kang Han, Ulrike C. Müller, Manolis Pasparakis, Stefan Offermanns

MiR-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts
Dongze Qin, Xiaohong Wang, Yutian Li, Liwang Yang, Ruitao Wang, Jiangtong Peng, Kobina Essandoh, Xingjiang Mu, Tianqing Peng, Qinghua Han, Kai-Jiang Yu, and Guo-Chang Fan

RIPK3-Mediated Necroptosis and Apoptosis Contributes to Renal Tubular Cell Progressive Loss and Chronic Kidney Disease Progression in Rats
Yongjun Zhu, Hongwang Cui, Yunfeng Xia, Hua Gan

Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling
Kipyegon Kitur, Sarah Wachtel, Armand Brown, Matthew Wickersham, Franklin Paulino, Hernán F. Peñaloza, Grace Soong, Susan Bueno, Dane Parker, Alice Prince

Other forms of cell death

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, Joka Pipercevic, Rosalie Heilig, Henning Stahlberg, Christopher J Farady, Daniel J Müller,Petr Broz, and Sebastian Hiller

Necrotic pyknosis is a morphologically and biochemically distinct event from apoptotic pyknosis
Lin Hou, Kai Liu, Yuhong Li, Shuang Ma, Xunming Ji, Lei Liu

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
Wan Seok Yang, Katherine J. Kim, Michael M. Gaschler, Milesh Patel, Mikhail S. Shchepinov, and Brent R. Stockwell


Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure
Jun Suzuki, Eiichi Imanishi, and Shigekazu Nagata

Targeting prohibitins induces apoptosis in acute myeloid leukemia cells
Helena Pomares, Claudia M Palmeri, Daniel Iglesias-Serret, Cristina Moncunill-Massaguer, José Saura-Esteller, Sonia Núñez-Vázquez, Enric Gamundi, Montserrat Arnan, Sara Preciado, Fernando Albericio, Rodolfo Lavilla, Gabriel Pons, Eva M González-Barca, Ana M Cosialls, Joan Gil

Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis
Y Ge, Y-M Cai, L Bonneau, V Rotari, A Danon, E A McKenzie, H McLellan, L Mach and P Gallois

Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor‐dependent apoptosis
Mauro Corrado, Francesca R Mariotti, Laura Trapani, Lucia Taraborrelli, Francesca Nazio, Valentina Cianfanelli, Maria Eugenia Soriano, Emilie Schrepfer, Francesco Cecconi, Luca Scorrano, and Silvia Campello

Paracrine effect of carbon monoxide – astrocytes promote neuroprotection through purinergic signaling in mice
Cláudia S. F. Queiroga, Raquel M. A. Alves, Sílvia V. Conde, Paula M. Alves, and Helena L. A. Vieira


A fate worse than death: apoptosis as an oncogenic process
Gabriel Ichim & Stephen W. G. Tait

Bcl-2 proteins in development, health, and disease of the hematopoietic system
Matthias Kollek, Alexandra Müller, Alexander Egle and Miriam Erlacher

Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties
Valentina Izzo, José Manuel Bravo-San Pedro, Valentina Sica, Guido Kroemer, Lorenzo Galluzzi

Post-translational modifications as key regulators of TNF-induced necroptosis
X Liu, F Shi, Y Li, X Yu, S Peng, W Li, X Luo and Y Cao

Regulatory non-coding RNA: new instruments in the orchestration of cell death
Ye Su, Haijiang Wu, Alexander Pavlosky, Ling-Lin Zou, Xinna Deng, Zhu-Xu Zhang and Anthony M Jevnikar

Revisiting autophagy addiction of tumor cells
Beat Nyfeler & Christina H. Eng


SPATA2 – Keeping the TNF signal short and sweet
Rebecca Feltham, Andrew I Webb, and John Silke

Autophagy complexes cell death by necroptosis
Megan L. Goodall, Scott D. Cramer, and  Andrew Thorburn

Cytosolic BAX Can Form Autoinhibited Dimers to Suppress Apoptosis

RIP endothelial cells
Anna Dart