ApoList – July 2016


Just So Stories about the Evolution of Apoptosis
Douglas R. Green, Patrick Fitzgerald

Cell death and inflammation: the case for IL‐1 family cytokines as the canonical DAMPs of the immune system
Seamus J. Martin

Protease signaling in animal and plant-regulated cell death
Guy S. Salvesen, Anne Hempel and Nuria S. Coll

The deadly landscape of pro‐apoptotic BCL‐2 proteins in the outer mitochondrial membrane
Mark P.A. Luna‐Vargas, Jerry E. Chipuk

Discoveries and controversies in BCL‐2 protein‐mediated apoptosis
Janet H. Zheng, Ariele Viacava Follis, Richard W. Kriwacki, Tudor Moldoveanu

Death in the fast lane: what’s next for necroptosis?
Andrew Oberst

Formation and removal of poly‐ubiquitin chains in the regulation of tumor necrosis factor‐induced gene activation and cell death
Sebastian Kupka, Matthias Reichert, Peter Draber, Henning Walczak

Cell death induced by endoplasmic reticulum stress
Raffaella Iurlaro, Cristina Muñoz‐Pinedo

How does metabolism affect cell death in cancer?
Elodie Villa, Jean‐Ehrland Ricci

Attacking cancer’s Achilles heel: antagonism of anti‐apoptotic BCL‐2 family members
Joseph T. Opferman

The Dynamics of Apoptotic Cell Clearance
Michael R. Elliott, Kodi S. Ravichandran

Lieselotte Vande Walle, Mohamed Lamkanfi

Programmed Cell Death and Complexity in Microbial Systems
Pierre M. Durand, Stuart Sym, Richard E. Michod

Programmed Cell Death in Unicellular Phytoplankton
Kay D. Bidle

Pathogen Tactics to Manipulate Plant Cell Death
M. Shahid Mukhtar, Maggie E. McCormack, Cristiana T. Argueso, Karolina M. Pajerowska-Mukhtar

Cell death at the intestinal epithelial front line
Maria Eugenia Delgado, Thomas Grabinger, Thomas Brunner

Death in the intestinal epithelium—basic biology and implications for inflammatory bowel disease
J. Magarian Blander

Comments / other

The cell’s dilemma, or the story of cell death: an entertainment in three acts (pages 2568–2576)
Douglas R. Green

Special Issue on Cell Death: Murder, mystery (and a little bit of mayhem) in Manhattan
Jerry E. Chipuk and Seamus J. Martin

RIPK3 Slams the Brake on Leukemogenesis
Francis Ka-Ming Chan

The Highway to Hell: A RIP Kinase-Directed Shortcut to Inflammatory Cytokine Production
Joanne M. Hildebrand, James M. Murphy

Life after death: RIP1 and RIP3 move beyond necroptosis
SB Berger, J Bertin & PJ Gough

Precambrian origins of the TNFR superfamily
S D Quistad & N Traylor-Knowles

Pore-forming death signal

Bcl-2 family proteins

Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53
L J Valente, S Grabow, C J Vandenberg, A Strasser and A Janic

Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1
E C Watson, L Whitehead, R H Adams, G Dewson and L Coultas

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux
Boris Reljic, Stephanie Conos, Erinna F. Lee, Jean-Marc Garnier, Li Dong, Guillaume Lessene, W. Douglas Fairlie, David L. Vaux & Lisa M. Lindqvist

A functional BH3 domain in an aquaporin from Leishmania infantum
C M Genes, H de Lucio, V M González, P A Sánchez-Murcia, E Rico, F Gago, N Fasel & A Jiménez-Ruiz

Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax
R Bajpai, S M Matulis, C Wei, A K Nooka, H E Von Hollen, S Lonial, L H Boise and M Shanmugam

The Human Bcl-2 Family Member Bcl-rambo Localizes to Mitochondria and Induces Apoptosis and Morphological Aberrations in Drosophila
Mako Nakazawa, Hisanori Matsubara, Yuka Matsushita, Megumi Watanabe, Nicole Vo, Hideki Yoshida, Masamitsu Yamaguchi, Takao Kataoka

Critical role of mitochondria-mediated apoptosis for JNJ-26481585-induced antitumor activity in rhabdomyosarcoma
U Heinicke, J Kupka, I Fichter and S Fulda

Death receptors

NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis
H Chung, A Vilaysane, A Lau, M Stahl, V Morampudi, A Bondzi-Simpson, J M Platnich, N A Bracey, M-C French, P L Beck, J Chun, B A Vallance and D A Muruve

CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice
Amanda Poissonnier, Doriane Sanséau, Matthieu Le Gallo, Marine Malleter, Nicolas Levoin, Roselyne Viel, Lucie Morere, Aubin Penna, Patrick Blanco, Alain Dupuy, Florence Poizeau, Alain Fautrel, Julien Seneschal, Florence Jouan, Jerome Ritz, Edouard Forcade, Nathalie Rioux, Cécile Contin-Bordes, Thomas Ducret, Anne-Marie Vacher, Paul A. Barrow, Robin J. Flynn, Pierre Vacher, Patrick Legembre

Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy
Gertrud Knoll, Sebastian Bittner, Maria Kurz, Jonathan Jantsch,  and  Martin Ehrenschwender


The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator
Lucia Dunajová, Emily Cash, Robert Markus, Sophie Rochette, Amelia R. Townley, and Sally P. Wheatley

The Strica Homolog AaCASPS16 Is Involved in Apoptosis in the Yellow Fever Vector, Aedes albopictus
Kun Meng, Xiaomei Li, Shengya Wang, Chunyan Zhong, Zhouning Yang, Lingyan Feng, Qingzhen Liu

Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination
Yoon Kyung Jeon, Chung Kwon Kim, Jaemoon Koh, Doo Hyun Chung,  and  Geun-Hyoung Ha

Enzymatically inactive procaspase-1 stabilizes the ASC-pyroptosome and supports pyroptosome spreading during cell division
Robert Stein, Franz Kapplusch, Michael Christian Heymann, Susanne Russ, Wolfgang Staroske, Christian Michael Hedrich, Angela Rösen-Wolff, and Sigrun Ruth Hofmann

Necroptosis and RIP kinases

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells
Ulrike Höckendorf, Monica Yabal, Tobias Herold, Enkhtsetseg Munkhbaatar, Stephanie Rott, Stefanie Jilg, Johanna Kauschinger, Giovanni Magnani, Florian Reisinger, Michael Heuser, Hans Kreipe, Karl Sotlar, Thomas Engleitner, Roland Rad, Wilko Weichert, Christian Peschel, Jürgen Ruland, Mathias Heikenwalder, Karsten Spiekermann, Julia Slotta-Huspenina, Olaf Groß, Philipp J. Jost

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4
Malek Najjar, Danish Saleh, Matija Zelic, Shoko Nogusa, Saumil Shah, Albert Tai, Joshua N. Finger, Apostolos Polykratis, Peter J. Gough, John Bertin, Michael J. Whalen, Manolis Pasparakis, Siddharth Balachandran, Michelle Kelliher, Alexander Poltorak, Alexei Degterev

Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma
F Radogna, C Cerella, A Gaigneaux, C Christov, M Dicato and M Diederich

The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873
K Wang, F Liu, C-Y Liu, T An, J Zhang, L-Y Zhou, M Wang, Y-H Dong, N Li, J-N Gao, Y-F Zhao and P-F Li

Other forms of cell death

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman

Pore-forming activity and structural autoinhibition of the gasdermin family
Jingjin Ding, Kun Wang, Wang Liu, Yang She, Qi Sun, Jianjin Shi, Hanzi Sun, Da-Cheng Wang, Feng Shao

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
Robin A. Aglietti, Alberto Estevez, Aaron Gupta, Monica Gonzalez Ramirez, Peter S. Liu, Nobuhiko Kayagaki, Claudio Ciferri, Vishva M. Dixit, and Erin C. Dueber

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, Joka Pipercevic, Rosalie Heilig, Henning Stahlberg, Christopher J Farady, Daniel J Müller, Petr Broz, Sebastian Hiller

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells
S Ma, E S Henson, Y Chen and S B Gibson

Autophagy promotes ferroptosis by degradation of ferritin
Wen Hou, Yangchun Xie, Xinxin Song, Xiaofang Sun, Michael T. Lotze, Herbert J. Zeh III, Rui Kang & Daolin Tang


A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway
Xian Jiang, Li Li, Zhengxin Ying, Chenjie Pan, Shaoqiang Huang, Lin Li, Miaomiao Dai, Bo Yan, Ming Li, Hui Jiang, She Chen, Zhiyuan Zhang, Xiaodong Wang

Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G
Jason L.J. Lin, Akihisa Nakagawa, Riley Skeen-Gaar, Wei-Zen Yang, Pei Zhao, Zhe Zhang, Xiao Ge, Shohei Mitani, Ding Xue, Hanna S. Yuan