Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for June, 2016

ApoList – May 2016

Posted by cris on June 7, 2016

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Bcl-2 family proteins
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Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
Sweta Iyer, Khatira Anwari, Amber E. Alsop, Wai Shan Yuen, David C. S. Huang, John Carroll, Nicholas A. Smith, Brian J. Smith, Grant Dewson and Ruth M. Kluck
http://www.nature.com/ncomms/2016/160524/ncomms11734/full/ncomms11734.html

Physiological restraint of Bak by Bcl-xL is essential for cell survival
Erinna F. Lee, Stephanie Grabow, Stephane Chappaz, Grant Dewson, Colin Hockings, Ruth M. Kluck, Marlyse A. Debrincat, Daniel H. Gray, Matthew T.Witkowski, Marco Evangelista, Anne Pettikiriarachchi, Philippe Bouillet, Rachael M. Lane, Peter E. Czabotar, Peter M. Colman, Brian J. Smith, Benjamin T. Kile, and W. Douglas Fairlie
http://genesdev.cshlp.org/content/30/10/1240.abstract?etoc

MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure
Xiang Hong Li, Cam T. Ha & Mang Xiao
http://link.springer.com/article/10.1007/s10495-016-1238-1

The deubiquitinase Usp27x stabilizes the BH3‐only protein Bim and enhances apoptosis
Arnim Weber, Melanie Heinlein, Jörn Dengjel, Claudia Alber, Prafull KumarSingh, and Georg Häcker
http://EMBOr.embopress.org/content/17/5/724?etoc

BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth
Jiusheng Deng, Dongkyoo Park, Mengchang Wang, Ajay Nooka, Qiaoya Deng, Shannon Matulis, Jonathan Kaufman, Sagar Lonial, Lawrence H. Boise, Jacques Galipeau, and Xingming Deng
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=8513

High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition
Laurel T. Bate-Eya, Ilona J.M. den Hartog, Ida van der Ploeg, Linda Schild, Jan Koster, Evan E. Santo, Ellen M. Westerhout, Rogier Versteeg, Huib N. Caron, Jan J. Molenaar,  and  M. Emmy M. Dolman
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=8547

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia
A A Guirguis, C I Slape, L M Failla, J Saw, C S Tremblay, D R Powell, F Rossello, A Wei, A Strasser and D J Curtis
http://www.nature.com/cdd/journal/v23/n6/abs/cdd2015159a.html

The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells
María J. Ruiz-Magaña, Rocío Martínez-Aguilar, Estefanía Lucendo, Diana Campillo-Davo, Klaus Schulze-Osthoff, Carmen Ruiz-Ruiz
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=7871&pubmed-linkout=1

DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress
Björn Oettinghaus, Donato D’Alonzo, Elisa Barbieri, Lisa Michelle Restelli, Claudia Savoia, Maria Licci, Markus Tolnay, Stephan Frank, Luca Scorrano
http://www.sciencedirect.com/science/article/pii/S0005272816300639

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Death receptors
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The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
Luigi Tortola, Roberto Nitsch, Mathieu J.M. Bertrand, Melanie Kogler, Younes Redouane, Ivona Kozieradzki, Iris Uribesalgo, Lilian M. Fennell, Mads Daugaard, Helene Klug, Gerald Wirnsberger, Reiner Wimmer, Thomas Perlot, Renu Sarao, Shuan Rao, Toshikatsu Hanada, Nozomi Takahashi, Elisabeth Kernbauer, Duygu Demiröz, Giulio Superti-Furga, Thomas Decker, Andrea Pichler, Fumiyo Ikeda, Guido Kroemer, Peter Vandenabeele, Poul H. Sorensen, Josef M. Penninger
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30445-4

Opposing roles of TGF-β and EGF in the regulation of TRAIL-induced apoptosis in human breast epithelial cells
Ana Cano-González, Abelardo López-Rivas
http://www.sciencedirect.com/science/article/pii/S0167488916301550

Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death
Carriba P, Jimenez S, Navarro V, Moreno-Gonzalez I, Barneda-Zahonero B, Moubarak RS, Lopez-Soriano J, Gutierrez A, Vitorica J, Comella JX
http://www.nature.com/cddis/journal/v6/n2/full/cddis20156a.html

RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis
Peter Brünker, Katharina Wartha, Thomas Friess, Sandra Grau-Richards, Inja Waldhauer, Claudia Ferrara Koller, (…) Pablo Umaña
http://mct.aacrjournals.org/content/15/5/946.full

Characterization of MUDENG, a novel anti-apoptotic protein
J-H Choi, J-B Lim, D D Wickramanayake, Y Wagley, J Kim, H-C Lee, H G Seo, T-H Kim and J-W Oh
http://www.nature.com/oncsis/journal/v5/n5/abs/oncsis201630a.html

TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas.
Galenkamp KM, Carriba P, Urresti J, Planells-Ferrer L, Coccia E, Lopez-Soriano J, Barneda-Zahonero B, Moubarak RS, Segura MF, Comella JX.
http://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-015-0329-x

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Non-apoptotic cell death
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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
Gabriela Brumatti , Chunyan Ma, Najoua Lalaoui, Nhu-Y Nguyen, Mario Navarro, Maria C. Tanzer, Jennifer Richmond, Margherita Ghisi, Jessica M. Salmon, Natasha Silke, Giovanna Pomilio, Stefan P. Glaser, Elisha de Valle, Raffi Gugasyan, Mark A. Gurthridge, Stephen M. Condon, Ricky W. Johnstone, Richard Lock, Guy Salvesen, Andrew Wei, David L. Vaux, Paul G. Ekert, John Silke
http://stm.sciencemag.org/content/8/339/339ra69

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL
Scott McComb , Júlia Aguadé-Gorgorió, Lena Harder, Blerim Marovca, Gunnar Cario, Cornelia Eckert, Martin Schrappe, Martin Stanulla, Arend von Stackelberg, Jean-Pierre Bourquin, Beat C. Bornhauser
http://stm.sciencemag.org/content/8/339/339ra70

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis
Megan L. Goodall, Brent E. Fitzwalter, Shadi Zahedi, Min Wu, Diego Rodriguez, Jean M. Mulcahy-Levy, Douglas R. Green, Michael Morgan, Scott D. Cramer, Andrew Thorburn
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30238-6

Hyperglycemic conditions prime cells for RIP1-dependent necroptosis
Timothy J. LaRocca, Sergey A. Sosunov, Nicole L. Shakerley, Vadim S. Ten, and Adam J. Ratner
http://www.jbc.org/content/early/2016/04/29/jbc.M116.716027.abstract

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis
S Neitemeier, A M Dolga, B Honrath, S S Karuppagounder, I Alim, R R Ratan and C Culmsee
http://www.nature.com/cddis/journal/v7/n5/abs/cddis2016107a.html

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Caspases and IAPs
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Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Ngoc T. Vu, Margaret A. Park, Michael D. Shultz, Gamze B. Bulut, Amy C. Ladd, and Charles E. Chalfant
http://cancerres.aacrjournals.org/content/76/10/2977.abstract?etoc

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing
Andrew L. Paek, Julia C. Liu, Alexander Loewer, William C. Forrester, Galit Lahav
http://www.cell.com/cell/abstract/S0092-8674%2816%2930321-X

Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells
Ana M. Pérez-López, M. Lourdes Soria-Gila, Emma R. Marsden, Annamaria Lilienkampf, Mark Bradley
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153209

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Phagocytosis
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Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans
Johnsen H, Horvitz H
http://bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0262-5

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Reviews
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Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
Nieves Peltzer, Maurice Darding, Henning Walczak
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(16)00012-X

BCL-2 family proteins as regulators of mitochondria metabolism
Atan Gross
http://www.sciencedirect.com/science/article/pii/S0005272816300196

Necroptosis: an alternative cell death program defending against cancer
Dongshi Chen, Jian Yu, Lin Zhang
http://www.sciencedirect.com/science/article/pii/S0304419X16300257

Inflammasome Complexes: Emerging Mechanisms and Effector Functions
Vijay A.K. Rathinam, Katherine A. Fitzgerald
http://www.cell.com/cell/abstract/S0092-8674(16)30344-0

Dying cell recognition shapes the pathophysiology of cell death
G Kroemer
http://www.nature.com/cdd/journal/v23/n6/full/cdd201630a.html

The clearance of dying cells: table for two
D R Green, T H Oguin and J Martinez
http://www.nature.com/cdd/journal/v23/n6/abs/cdd2015172a.html

Cell death, clearance and immunity in the skeletal muscle
C Sciorati, E Rigamonti, A A Manfredi and P Rovere-Querini
http://www.nature.com/cdd/journal/v23/n6/abs/cdd2015171a.html

Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation
A D Garg, E Romano, N Rufo and P Agostinis
http://www.nature.com/cdd/journal/v23/n6/abs/cdd20165a.html

Exposure of phosphatidylserine on the cell surface
S Nagata, J Suzuki, K Segawa and T Fujii
http://www.nature.com/cdd/journal/v23/n6/abs/cdd20167a.html

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
R B Birge, S Boeltz, S Kumar, J Carlson, J Wanderley, D Calianese, M Barcinski, R A Brekken, X Huang, J T Hutchins, B Freimark, C Empig, J Mercer, A J Schroit, G Schett and M Herrmann
http://www.nature.com/cdd/journal/v23/n6/abs/cdd201611a.html

Do not let death do us part: ‘find-me’ signals in communication between dying cells and the phagocytes
C B Medina and K S Ravichandran
http://www.nature.com/cdd/journal/v23/n6/abs/cdd201613a.html

Exploiting death: apoptotic immunity in microbial pathogenesis
D S Ucker
http://www.nature.com/cdd/journal/v23/n6/abs/cdd201617a.html

Amyloid beta, TNFα and FAIM-L; approaching new therapeutic strategies for AD
Paulina Carriba and Joan X. Comella
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270217/

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Comments
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Autophagy Determines the Path on the TRAIL to Death
Jun-ichi Sakamaki, Kevin M. Ryan
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30287-8

BOK: Oddball of the BCL-2 Family
Elizabeth A. Brem, Anthony Letai
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(16)30021-6

Cell biology: Killer enzymes tethered
Shigekazu Nagata
http://www.nature.com/nature/journal/v533/n7604/full/nature18439.html

Turning off the BCL-2 switch to prevent intestinal tumorigenesis
Maartje van der Heijden, Douglas J. Winton, and Louis Vermeulen
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=8757

Necroptosis DAMPens anti-tumor immunity
K Shibata, Z Omahdi & S Yamasak
http://www.nature.com/articles/cddiscovery201633i
 



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