ApoList – May 2016

Bcl-2 family proteins

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
Sweta Iyer, Khatira Anwari, Amber E. Alsop, Wai Shan Yuen, David C. S. Huang, John Carroll, Nicholas A. Smith, Brian J. Smith, Grant Dewson and Ruth M. Kluck

Physiological restraint of Bak by Bcl-xL is essential for cell survival
Erinna F. Lee, Stephanie Grabow, Stephane Chappaz, Grant Dewson, Colin Hockings, Ruth M. Kluck, Marlyse A. Debrincat, Daniel H. Gray, Matthew T.Witkowski, Marco Evangelista, Anne Pettikiriarachchi, Philippe Bouillet, Rachael M. Lane, Peter E. Czabotar, Peter M. Colman, Brian J. Smith, Benjamin T. Kile, and W. Douglas Fairlie

MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure
Xiang Hong Li, Cam T. Ha & Mang Xiao

The deubiquitinase Usp27x stabilizes the BH3‐only protein Bim and enhances apoptosis
Arnim Weber, Melanie Heinlein, Jörn Dengjel, Claudia Alber, Prafull KumarSingh, and Georg Häcker

BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth
Jiusheng Deng, Dongkyoo Park, Mengchang Wang, Ajay Nooka, Qiaoya Deng, Shannon Matulis, Jonathan Kaufman, Sagar Lonial, Lawrence H. Boise, Jacques Galipeau, and Xingming Deng

High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition
Laurel T. Bate-Eya, Ilona J.M. den Hartog, Ida van der Ploeg, Linda Schild, Jan Koster, Evan E. Santo, Ellen M. Westerhout, Rogier Versteeg, Huib N. Caron, Jan J. Molenaar,  and  M. Emmy M. Dolman

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia
A A Guirguis, C I Slape, L M Failla, J Saw, C S Tremblay, D R Powell, F Rossello, A Wei, A Strasser and D J Curtis

The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells
María J. Ruiz-Magaña, Rocío Martínez-Aguilar, Estefanía Lucendo, Diana Campillo-Davo, Klaus Schulze-Osthoff, Carmen Ruiz-Ruiz

DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress
Björn Oettinghaus, Donato D’Alonzo, Elisa Barbieri, Lisa Michelle Restelli, Claudia Savoia, Maria Licci, Markus Tolnay, Stephan Frank, Luca Scorrano

Death receptors

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
Luigi Tortola, Roberto Nitsch, Mathieu J.M. Bertrand, Melanie Kogler, Younes Redouane, Ivona Kozieradzki, Iris Uribesalgo, Lilian M. Fennell, Mads Daugaard, Helene Klug, Gerald Wirnsberger, Reiner Wimmer, Thomas Perlot, Renu Sarao, Shuan Rao, Toshikatsu Hanada, Nozomi Takahashi, Elisabeth Kernbauer, Duygu Demiröz, Giulio Superti-Furga, Thomas Decker, Andrea Pichler, Fumiyo Ikeda, Guido Kroemer, Peter Vandenabeele, Poul H. Sorensen, Josef M. Penninger

Opposing roles of TGF-β and EGF in the regulation of TRAIL-induced apoptosis in human breast epithelial cells
Ana Cano-González, Abelardo López-Rivas

Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death
Carriba P, Jimenez S, Navarro V, Moreno-Gonzalez I, Barneda-Zahonero B, Moubarak RS, Lopez-Soriano J, Gutierrez A, Vitorica J, Comella JX

RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis
Peter Brünker, Katharina Wartha, Thomas Friess, Sandra Grau-Richards, Inja Waldhauer, Claudia Ferrara Koller, (…) Pablo Umaña

Characterization of MUDENG, a novel anti-apoptotic protein
J-H Choi, J-B Lim, D D Wickramanayake, Y Wagley, J Kim, H-C Lee, H G Seo, T-H Kim and J-W Oh

TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas.
Galenkamp KM, Carriba P, Urresti J, Planells-Ferrer L, Coccia E, Lopez-Soriano J, Barneda-Zahonero B, Moubarak RS, Segura MF, Comella JX.

Non-apoptotic cell death

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
Gabriela Brumatti , Chunyan Ma, Najoua Lalaoui, Nhu-Y Nguyen, Mario Navarro, Maria C. Tanzer, Jennifer Richmond, Margherita Ghisi, Jessica M. Salmon, Natasha Silke, Giovanna Pomilio, Stefan P. Glaser, Elisha de Valle, Raffi Gugasyan, Mark A. Gurthridge, Stephen M. Condon, Ricky W. Johnstone, Richard Lock, Guy Salvesen, Andrew Wei, David L. Vaux, Paul G. Ekert, John Silke

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL
Scott McComb , Júlia Aguadé-Gorgorió, Lena Harder, Blerim Marovca, Gunnar Cario, Cornelia Eckert, Martin Schrappe, Martin Stanulla, Arend von Stackelberg, Jean-Pierre Bourquin, Beat C. Bornhauser

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis
Megan L. Goodall, Brent E. Fitzwalter, Shadi Zahedi, Min Wu, Diego Rodriguez, Jean M. Mulcahy-Levy, Douglas R. Green, Michael Morgan, Scott D. Cramer, Andrew Thorburn

Hyperglycemic conditions prime cells for RIP1-dependent necroptosis
Timothy J. LaRocca, Sergey A. Sosunov, Nicole L. Shakerley, Vadim S. Ten, and Adam J. Ratner

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis
S Neitemeier, A M Dolga, B Honrath, S S Karuppagounder, I Alim, R R Ratan and C Culmsee

Caspases and IAPs

Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Ngoc T. Vu, Margaret A. Park, Michael D. Shultz, Gamze B. Bulut, Amy C. Ladd, and Charles E. Chalfant

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing
Andrew L. Paek, Julia C. Liu, Alexander Loewer, William C. Forrester, Galit Lahav

Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells
Ana M. Pérez-López, M. Lourdes Soria-Gila, Emma R. Marsden, Annamaria Lilienkampf, Mark Bradley


Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans
Johnsen H, Horvitz H


Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
Nieves Peltzer, Maurice Darding, Henning Walczak

BCL-2 family proteins as regulators of mitochondria metabolism
Atan Gross

Necroptosis: an alternative cell death program defending against cancer
Dongshi Chen, Jian Yu, Lin Zhang

Inflammasome Complexes: Emerging Mechanisms and Effector Functions
Vijay A.K. Rathinam, Katherine A. Fitzgerald

Dying cell recognition shapes the pathophysiology of cell death
G Kroemer

The clearance of dying cells: table for two
D R Green, T H Oguin and J Martinez

Cell death, clearance and immunity in the skeletal muscle
C Sciorati, E Rigamonti, A A Manfredi and P Rovere-Querini

Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation
A D Garg, E Romano, N Rufo and P Agostinis

Exposure of phosphatidylserine on the cell surface
S Nagata, J Suzuki, K Segawa and T Fujii

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
R B Birge, S Boeltz, S Kumar, J Carlson, J Wanderley, D Calianese, M Barcinski, R A Brekken, X Huang, J T Hutchins, B Freimark, C Empig, J Mercer, A J Schroit, G Schett and M Herrmann

Do not let death do us part: ‘find-me’ signals in communication between dying cells and the phagocytes
C B Medina and K S Ravichandran

Exploiting death: apoptotic immunity in microbial pathogenesis
D S Ucker

Amyloid beta, TNFα and FAIM-L; approaching new therapeutic strategies for AD
Paulina Carriba and Joan X. Comella


Autophagy Determines the Path on the TRAIL to Death
Jun-ichi Sakamaki, Kevin M. Ryan

BOK: Oddball of the BCL-2 Family
Elizabeth A. Brem, Anthony Letai

Cell biology: Killer enzymes tethered
Shigekazu Nagata

Turning off the BCL-2 switch to prevent intestinal tumorigenesis
Maartje van der Heijden, Douglas J. Winton, and Louis Vermeulen

Necroptosis DAMPens anti-tumor immunity
K Shibata, Z Omahdi & S Yamasak