Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for May, 2016

ApoList – April 2016

Posted by cris on May 3, 2016

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Cell death and inflammation
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Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells
Jennifer Martinez, Larissa D. Cunha, Sunmin Park, Mao Yang, Qun Lu, Robert Orchard, Quan-Zhen Li, Mei Yan, Laura Janke, Cliff Guy, Andreas Linkermann, Herbert W. Virgin & Douglas R. Green
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature17950.html

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo
Chang Sup Lee, Kristen K. Penberthy, Karen M. Wheeler, Ignacio J. Juncadella, Peter Vandenabeele, Jeffrey J. Lysiak, Kodi S. Ravichandran
http://www.cell.com/immunity/fulltext/S1074-7613(16)30020-6

PGE2 induced in and released by dying cells functions as an inhibitory DAMP
Sho Hangai, Tomoka Ao, Yoshitaka Kimura, Kosuke Matsuki, Takeshi Kawamura, Hideo Negishi, Junko Nishio, Tatsuhiko Kodama, Tadatsugu Taniguchi, and Hideyuki Yanai
http://www.pnas.org/content/113/14/3844.abstract.html?etoc

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity
Tania Løve Aaes, Agnieszka Kaczmarek, Tinneke Delvaeye, Bram De Craene, Stefaan De Koker, Liesbeth Heyndrickx, Iris Delrue, Joachim Taminau, Bartosz Wiernicki, Philippe De Groote, Abhishek D. Garg, Luc Leybaert, Johan Grooten, Mathieu J.M. Bertrand, Patrizia Agostinis, Geert Berx, Wim Declercq, Peter Vandenabeele, Dmitri V. Krysko
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30293-5

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression
Lena Seifert, Gregor Werba, Shaun Tiwari, Nancy Ngoc Giao Ly, Sara Alothman, Dalia Alqunaibit, Antonina Avanzi, Rocky Barilla, Donnele Daley, Stephanie H. Greco, Alejandro Torres-Hernandez, Matthew Pergamo, Atsuo Ochi, Constantinos P. Zambirinis, Mridul Pansari, Mauricio Rendon, Daniel Tippens, Mautin Hundeyin, Vishnu R. Mani, Cristina Hajdu, Dannielle Engle & George Miller
http://www.nature.com/nature/journal/v532/n7598/full/nature17403.html

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Bcl-2 family proteins
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Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane
Katelyn L. O’Neill, Kai Huang, Jingjing Zhang, Yi Chen, and Xu Luo
http://genesdev.cshlp.org/content/30/8/973.abstract?etoc

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
Reut Yosef, Noam Pilpel, Ronit Tokarsky-Amiel, Anat Biran, Yossi Ovadya, Snir Cohen, Ezra Vadai, Liat Dassa, Elisheva Shahar, Reba Condiotti, Ittai Ben-Porath and Valery Krizhanovsky
http://www.nature.com/ncomms/2016/160406/ncomms11190/full/ncomms11190.html

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury.
D’Orsi B, Engel T, Pfeiffer S, Nandi S, Kaufmann T, Henshall DC, Prehn JH.
http://www.jneurosci.org/content/36/16/4564.long

The Stability and Expression Level of Bok is Governed by Binding to Inositol 1,4,5-trisphosphate Receptors
Jacqualyn J. Schulman, Forrest A.. Wright, Xiaobing Han, Eric J. Zluhan, Laura M. Szczesniak, and Richard J. H. Wojcikiewicz
http://www.jbc.org/content/early/2016/04/06/jbc.M115.711242.abstract

Prolyl Hydroxylase 3 Attenuates MCL-1–Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells
Praveenkumar Radhakrishnan, Nadine Ruh, Jonathan M. Harnoss, Judit Kiss, Martin Mollenhauer, Anna-Lena Scherr, Lisa K. Platzer, Thomas Schmidt, Klaus Podar, Joseph T. Opferman, Juergen Weitz, Henning Schulze-Bergkamen, Bruno C. Koehler, Alexis Ulrich, and Martin Schneider
http://cancerres.aacrjournals.org/content/76/8/2219.abstract?etoc

Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate Bid during TRAIL-induced Apoptosis
Kai Huang, Jingjing Zhang, Katelyn L. O’Neill, Channabasavaiah B. Gurumurthy, Rolen M. Quadros, and Xu Luo
http://www.jbc.org/content/early/2016/04/06/jbc.M115.711051.abstract

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis
S Grabow, G L Kelly, A R D Delbridge, P N Kelly, P Bouillet, J M Adams and A Strasser
http://www.nature.com/cddis/journal/v7/n3/abs/cddis201643a.html

AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells
P. Antonietti, F. Gessler, H. Düssmann, C. Reimertz, M. Mittelbronn, J.H.M. Prehn, D. Kögel
http://www.sciencedirect.com/science/article/pii/S0167488915004371

Orphan Nuclear Receptor NR4A1 binds a novel protein interaction site on anti-apoptotic B-cell lymphoma gene-2 family proteins
Paulo H. C. Godoi, Rachel P. Wilkie-Grantham, Asami Hishiki, Renata Sano, Yasuko Matsuzawa, Hiroko Yanagi, Claudia E. Munte, Ya Chen, Yong Yao, Francesca M. Marassi, Hans R. Kalbitzer, Shu-ichi Matsuzawa, and John C. Reed
http://www.jbc.org/content/early/2016/04/19/jbc.M116.715235.abstract

Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak
J Megyesi, A Tarcsafalvi, NSHL Seng, R Hodeify & PM Price
http://www.nature.com/articles/cddiscovery201566

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Death receptors
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The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response
Neha Agrawal, Renald Delanoue, Alessandra Mauri, Davide Basco, Matthieu Pasco, Bernard Thorens, Pierre Léopold
http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30106-1

Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure
A P Komarov, E A Komarova, K Green, L R Novototskaya, P S Baker, A Eroshkin, A L Osterman, A A Chenchick, C Frangou and A V Gudkov
http://www.nature.com/cddis/journal/v7/n3/abs/cddis201645a.html

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells
M Drachsler, S Kleber, A Mateos, K Volk, N Mohr, S Chen, B Cirovic, J Tüttenberg, C Gieffers, J Sykora, C R Wirtz, W Mueller, M Synowitz and A Martin-Villalba
http://www.nature.com/cddis/journal/v7/n4/abs/cddis2016102a.html

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Caspases
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Human Monocytes Engage an Alternative Inflammasome Pathway
[FADD, Caspase-8]
Moritz M. Gaidt, Thomas S. Ebert, Dhruv Chauhan, Tobias Schmidt, Jonathan L. Schmid-Burgk, Francesca Rapino, Avril A.B. Robertson, Matthew A. Cooper, Thomas Graf, Veit Hornung
http://www.cell.com/immunity/fulltext/S1074-7613(16)00037-6

Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src
Jennifer LY Tsang, Song Hui Jia, Jean Parodo, Pamela Plant, Monika Lodyga, Emmanuel Charbonney, Katalin Szaszi, Andras Kapus, John C. Marshall
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153946

Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death
R Martin, C Desponds, R O Eren, M Quadroni, M Thome & N Fasel
http://www.nature.com/articles/cddiscovery201624

Overexpression of caspase 7 is ERα dependent to affect proliferation and cell growth in breast cancer cells by targeting p21Cip
S Chaudhary, B Madhukrishna, A K Adhya, S Keshari and S K Mishra
http://www.nature.com/oncsis/journal/v5/n4/abs/oncsis201612a.html

A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation
Lior Aram, Tslil Braun, Carmel Braverman, Yosef Kaplan, Liat Ravid, Smadar Levin-Zaidman, Eli Arama
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30080-6

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IAPs
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Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma
Yibin Yang, Priscilla Kelly, Arthur L. Shaffer, Roland Schmitz, Hee Min Yoo, Xinyue Liu, Da Wei Huang, Daniel Webster, Ryan M. Young, Masao Nakagawa, Michele Ceribelli, George W. Wright, Yandan Yang, Hong Zhao, Xin Yu, Weihong Xu, Wing C. Chan, Elaine S. Jaffe, Randy D. Gascoyne, Elias Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa Rimsza, Louis M. Staudt
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30088-5

The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock
A C West, B P Martin, D A Andrews, S J Hogg, A Banerjee, G Grigoriadis, R W Johnstone and J Shortt
http://www.nature.com/oncsis/journal/v5/n4/abs/oncsis201626a.html

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Miscellaneous
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Key roles of necroptotic factors in promoting tumor growth
Xinjian Liu, Min Zhou, Ling Mei, Jiaying Ruan, Qian Hu, Jing Peng, Hang Su, Hong Liao, Shanling Liu, WeiPing Liu, He Wang, Qian Huang, Fang Li, and Chuan-Yuan Li
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=7924

T-cell development of resistance to apoptosis is driven by a metabolic shift in carbon source and altered activation of death pathways
C D Bortner, A B Scoltock, D W Cain and J A Cidlowski
http://www.nature.com/cdd/journal/v23/n5/abs/cdd2015156a.html

GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death
Nir Qvit, Amit U. Joshi, Anna D. Cunningham, Julio C.B. Ferreira, and Daria Mochly-Rosen
http://www.jbc.org/content/early/2016/04/27/jbc.M115.711630.abstract

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Reviews
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Onto better TRAILs for cancer treatment
D de Miguel, J Lemke, A Anel, H Walczak and L Martinez-Lostao
http://www.nature.com/cdd/journal/v23/n5/abs/cdd2015174a.html

Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer
D Merino, S W Lok, J E Visvader and G J Lindeman
http://www.nature.com/onc/journal/v35/n15/abs/onc2015287a.html

Necroptosis in acute kidney injury: a shedding light
S Wang, C Zhang, L Hu and C Yang
http://www.nature.com/cddis/journal/v7/n3/abs/cddis201637a.html

Cancer therapy in the necroptosis era
Z Su, Z Yang, L Xie, J P DeWitt and Y Chen
http://www.nature.com/cdd/journal/v23/n5/abs/cdd20168a.html

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Comments
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MOMP in the absence of BH3-only proteins
Ana J. García Sáez and Andreas Villunger
http://genesdev.cshlp.org/content/30/8/878.abstract?etoc

Killing Lymphoma with Smac-Mimetics: As Easy as ABC?
Ueli Nachbur, John Silke
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30101-5

Krebs Cycle Moonlights in Caspase Regulation
Adi Minis, Hermann Steller
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30161-7

Influenza leaves a TRAIL to pulmonary edema
Rena Brauer, Peter Chen
http://www.jci.org/articles/view/86802

Heat shock protein 90 regulates necroptosis by modulating multiple signaling effectors
C K Yang and S D He
http://www.nature.com/cddis/journal/v7/n3/full/cddis201625a.html

Another DRAM involved in autophagy and cell death
Michaela Mrschtik & Kevin M. Ryan
http://www.tandfonline.com/doi/full/10.1080/15548627.2015.1137412

Death by a thousand knives: Multiple BH3-only proteins are required for maximal apoptosis triggered through the BCR
Matthew J. Carter & Mark S. Cragg
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1084444

Spatially restricting caspase activation
http://stke.sciencemag.org/content/9/423/ec86.abstract

Inhibition of p38 or MK2 Increases SMAC-Mimetic Efficacy against AML
http://cancerdiscovery.aacrjournals.org/content/6/4/OF9.abstract?etoc

BCL-2 and Aurora A Inhibitors Suppress MYCN-Amplified Neuroblastomas
http://cancerdiscovery.aacrjournals.org/content/6/4/OF12.abstract?etoc

Blebbishield emergency program: an apoptotic route to cellular transformation
G G Jinesh and A M Kamat
http://www.nature.com/cdd/journal/v23/n5/full/cdd201626a.html




 

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