Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for March, 2016

ApoList – February 2016

Posted by cris on March 6, 2016

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Bcl-2 family proteins
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Mito-priming as a method to engineer Bcl-2 addiction
Jonathan Lopez, Margaux Bessou, Joel S. Riley, Evangelos Giampazolias, Franziska Todt, Tony Rochegüe, Andrew Oberst, Douglas R. Green, Frank Edlich, Gabriel Ichim and Stephen W. G. Tait
http://www.nature.com/ncomms/2016/160202/ncomms10538/full/ncomms10538.html

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores
Raquel Salvador‐Gallego, Markus Mund, Katia Cosentino, Jale Schneider, Joseph Unsay, Ulrich Schraermeyer, Johann Engelhardt, Jonas Ries, and Ana J García‐Sáez
http://EMBOJ.embopress.org/content/35/4/389?etoc

Bax assembles into large ring‐like structures remodeling the mitochondrial outer membrane in apoptosis
Lena Große, Christian A Wurm, Christian Brüser, Daniel Neumann, Daniel C Jans, and Stefan Jakobs
http://EMBOJ.embopress.org/content/35/4/402?etoc

cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities
S Bleicken, G Hofhaus, B Ugarte-Uribe, R Schröder and A J García-Sáez
http://www.nature.com/cddis/journal/v7/n2/abs/cddis201634a.html

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination
Jungoh Ham, Carlotta Costa, Renata Sano, Timothy L. Lochmann, Erin M. Sennott, Neha U. Patel, Anahita Dastur, Maria Gomez-Caraballo, Kateryna Krytska, Aaron N. Hata, Konstantinos V. Floros, Mark T. Hughes, Charles T. Jakubik, Daniel A.R. Heisey, Justin T. Ferrell, Molly L. Bristol, Ryan J. March, Craig Yates, Mark A. Hicks, Wataru Nakajima, Madhu Gowda, Brad E. Windle, Mikhail G. Dozmorov, Mathew J. Garnett, Ultan McDermott, Hisashi Harada, Shirley M. Taylor, Iain M. Morgan, Cyril H. Benes, Jeffrey A. Engelman, Yael P. Mossé, Anthony C. Faber
http://www.cell.com/cancer-cell/abstract/S1535-6108(16)00031-3

Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx
Tianyu Jiang, Minhao Liu, Jianping Wu, and Yigong Shi
http://www.pnas.org/content/113/8/2074.abstract.html?etoc

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL
J Le Pen, M Laurent, K Sarosiek, C Vuillier, F Gautier, S Montessuit, J C Martinou, A Letaï, F Braun and P P Juin
http://www.nature.com/cddis/journal/v7/n2/abs/cddis2015400a.html

Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein
D Trisciuoglio, M Desideri, V Farini, T De Luca, M Di Martile, M G Tupone, A Urbani, S D’Aguanno and D Del Bufalo
http://www.nature.com/cddis/journal/v7/n2/abs/cddis2015357a.html

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Death receptors
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Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor
Qingshan Fu, Tian-Min Fu, Anthony C. Cruz, Prabuddha Sengupta, Stacy K. Thomas, Shuqing Wang, Richard M. Siegel, Hao Wu, James J. Chou
http://www.cell.com/molecular-cell/abstract/S1097-2765(16)00010-1

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekera, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur and John Silke
http://elifesciences.org/content/4/e10592v2

Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity
Niklas K. Finnberg, Prashanth Gokare, Arunasalam Navaraj, Krystle A. LangKuhs, George Cerniglia, Hideo Yagita, Kazuyoshi Takeda, Noboru Motoyama, and Wafik S. El-Deiry
http://cancerres.aacrjournals.org/content/76/3/700.abstract?etoc

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IAPs
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Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
Najoua Lalaoui, Kay Hänggi, Gabriela Brumatti, Diep Chau, Nhu-Y.N. Nguyen, Lazaros Vasilikos, Lisanne M. Spilgies, Denise A. Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M. Salmon, Geoffrey M. Matthews, Elisha de Valle, Donia M. Moujalled, Manoj B. Menon, Sukhdeep Kaur Spall, Stefan P. Glaser, Jennifer Richmond, Richard B. Lock, Stephen M. Condon, Raffi Gugasyan, Matthias Gaestel, Mark Guthridge, Ricky W. Johnstone, Lenka Munoz, Andrew Wei, Paul G. Ekert, David L. Vaux, W. Wei-Lynn Wong, John Silke
http://www.cell.com/cancer-cell/abstract/S1535-6108(16)00035-0

Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway
Sreerangam N. C. V. L. Pushpavalli, Arpita Sarkar, M. Janaki Ramaiah, G. Koteswara Rao, Indira Bag, Utpal Bhadra & Manika Pal-Bhadra
http://link.springer.com/article/10.1007/s10495-015-1206-1

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Caspases and FLIP
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Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo
Daniel R. Ram, Vladimir Ilyukha, Tatyana Volkova, Anton Buzdin, Albert Tai, Irina Smirnova, and Alexander Poltorak
http://www.pnas.org/content/113/6/1606.abstract.html?etoc

Distinct activation mechanisms of NF-κB regulator IKK by isoforms of the cell death regulator cFLIP
Mehdi Baratchian, Christopher A. Davis, Akira Shimizu, David Escors, Claire Bagneris, Tracey Barrett, and Mary K. Collins
http://www.jbc.org/content/early/2016/02/10/jbc.M116.718122.abstract

Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach
L Flanagan, M Meyer, J Fay, S Curry, O Bacon, H Duessmann, K John, K C Boland, D A McNamara, E W Kay, H Bantel, H Schulze-Bergkamen and J H M Prehn
http://www.nature.com/cddis/journal/v7/n2/abs/cddis20167a.html

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Non-apoptotic cell death
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Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis
Giovanni Quarato, Cliff S. Guy, Christy R. Grace, Fabien Llambi, Amanda Nourse, Diego A. Rodriguez, Randall Wakefield, Sharon Frase, Tudor Moldoveanu, Douglas R. Green
http://www.cell.com/molecular-cell/abstract/S1097-2765(16)00012-5

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3
Jinho Seo, Eun-Woo Lee, Hyerim Sung, Daehyeon Seong, Yves Dondelinger, Jihye Shin, Manhyung Jeong, Hae-Kyung Lee, Jung-Hoon Kim, Su Yeon Han, Cheolju Lee, Je Kyung Seong, Peter Vandenabeele & Jaewhan Song
http://www.nature.com/ncb/journal/v18/n3/full/ncb3314.html

Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis
X M Zhao, Z Chen, J B Zhao, P P Zhang, Y F Pu, S H Jiang, J J Hou, Y M Cui, X L Jia and S Q Zhang
http://www.nature.com/cddis/journal/v7/n2/abs/cddis2015390a.html

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis
Ting Zhang, Yan Zhang, Mingyao Cui, Li Jin, Yimei Wang
http://www.nature.com/nm/journal/v22/n2/full/nm.4017.html

Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis
Wei Lu, Junhui Sun, Jeong Seon Yoon, Yan Zhang, Lixin Zheng, Elizabeth Murphy, Mark P. Mattson, Michael J. Lenardo
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147792

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
Shrikant R. Mulay, Jyaysi Desai, Santhosh V. Kumar, Jonathan N. Eberhard, Dana Thomasova, Simone Romoli, Melissa Grigorescu, Onkar P. Kulkarni, Bastian Popper, Volker Vielhauer, Gabriele Zuchtriegel, Christoph Reichel, Jan Hinrich Bräsen, Paola Romagnani, Rostyslav Bilyy, Luis E. Munoz, Martin Herrmann, Helen Liapis, Stefan Krautwald, Andreas Linkermann & Hans-Joachim Anders
http://www.nature.com/ncomms/2016/160128/ncomms10274/full/ncomms10274.html

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Miscellaneous
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The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons
Annika L.A. Nichols, Ellen Meelkop, Casey Linton, Rosina Giordano-Santini, Robert K. Sullivan, Alessandra Donato, Cara Nolan, David H. Hall, Ding Xue, Brent Neumann, Massimo A. Hilliard
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30028-6

Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling
David J. Simon, Jason Pitts, Nicholas T. Hertz, Jing Yang, Yuya Yamagishi, Olav Olsen, Milica Tešić Mark, Henrik Molina, Marc Tessier-Lavigne
http://www.cell.com/cell/fulltext/S0092-8674(16)30046-0

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry
Angela Logan, Victoria R. Pell, Karl J. Shaffer, Cameron Evans, Nathan J. Stanley, Ellen L. Robb, Tracy A. Prime, Edward T. Chouchani, Helena M. Cochemé, Ian M. Fearnley, Sara Vidoni, Andrew M. James, Carolyn M. Porteous, Linda Partridge, Thomas Krieg, Robin A.J. Smith, Michael P. Murphy
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00615-4

Acetylation of p53 at lysine 120 upregulates Apaf-1 and sensitizes mitochondrial apoptotic pathway
Tao Yun, Kaiwen Yu, ShuangShuang Yang, Yifan Cui, Zixi Wang, Huiyu Ren, She Chen, Lin Li, Xiaoyun Liu, Min Fang, and Xuejun Jiang
http://www.jbc.org/content/early/2016/02/05/jbc.M115.706341.abstract

Stage-Specific Changes in the Water, Na+, Cl- and K+ Contents of Organelles during Apoptosis, Demonstrated by a Targeted Cryo Correlative Analytical Approach
Frédérique Nolin, Jean Michel, Laurence Wortham, Pavel Tchelidze, Vincent Banchet, Nathalie Lalun, Christine Terryn, Dominique Ploton
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148727

A HSP60-targeting peptide for cell apoptosis imaging
S Yang, J Meng, Y Yang, H Liu, C Wang, J Liu, Y Zhang, C Wang and H Xu
http://www.nature.com/oncsis/journal/v5/n2/abs/oncsis201614a.html

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Correspondence
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Is BOK required for apoptosis induced by endoplasmic reticulum stress?
Yuniel Fernandez-Marrero, Francine Ke, Nohemy Echeverry, Philippe Bouillet, Daniel Bachmann, Andreas Strasser, and Thomas Kaufmann
http://www.pnas.org/content/113/5/E492.extract.html?etoc

Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation
Marcos A. Carpio, Michael Michaud, Wenping Zhou, Jill K. Fisher, Loren D. Walensky, and Samuel G. Katz
http://www.pnas.org/content/113/5/E494.extract.html?etoc

Expression of Concern: Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. Nataly Shulga, Robin Wilson-Smith, John G. Pastorino. J Cell Sci doi: 10.1242/jcs.061846
Michael Way
http://jcs.biologists.org/content/129/4/868?etoc

Expression of Concern: GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis. Nataly Shulga, John G. Pastorino. J Cell Sci doi: 10.1242/jcs.103093
Michael Way
http://jcs.biologists.org/content/129/4/870?etoc

Expression of Concern: Sirtuin-3 modulates Bak- and Bax-dependent apoptosis. Manish Verma, Nataly Shulga, John G. Pastorino. J Cell Sci  doi: 10.1242/jcs.115188
Michael Way
http://jcs.biologists.org/content/129/4/871?etoc

Expression of Concern: Mitoneet mediates TNFα-induced necroptosis promoted by exposure to fructose and ethanol. Nataly Shulga, John G. Pastorino. J Cell Sci doi: 10.1242/jcs.140764
Michael Way
http://jcs.biologists.org/content/129/4/872?etoc

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Reviews
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Cell Death Signaling
Douglas R. Green and Fabien Llambi
http://cshperspectives.cshlp.org/content/7/12/a006080.long

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
Nieves Peltzer, Maurice Darding, Henning Walczak
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(16)00012-X

Ferroptosis: Death by Lipid Peroxidation
Wan Seok Yang, Brent R. Stockwell
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(15)00216-0

Caspases Connect Cell-Death Signaling to Organismal Homeostasis
Lorenzo Galluzzi, Alejandro López-Soto, Sharad Kumar, Guido Kroemer
http://www.cell.com/immunity/abstract/S1074-7613(16)30007-3

Ferroptosis: process and function
Y Xie, W Hou, X Song, Y Yu, J Huang, X Sun, R Kang and D Tang
http://www.nature.com/cdd/journal/v23/n3/abs/cdd2015158a.html

Apoptosis in Drosophila: which role for mitochondria?
Amandine Clavier, Aurore Rincheval-Arnold, Jessie Colin, Bernard Mignotte & Isabelle Guénal
http://link.springer.com/article/10.1007/s10495-015-1209-y

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Previews
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Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage’s Appetite for Apoptotic Cells
Joseph P. Kolb, Jennifer Martinez
http://www.cell.com/immunity/abstract/S1074-7613(16)30010-3

Doughnuts, daisy chains and crescent moons: the quest for the elusive apoptotic pore
Grant Dewson
http://EMBOJ.embopress.org/content/35/4/371?etoc

TNFα-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38α MAPK Pathway
Nomeda Girnius, Roger J. Davis
http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30002-2

BIM-EL localization: The key to understanding anoikis resistance in inflammatory breast cancer cells |
Cassandra L Buchheit & Zachary T Schafer
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1011474

The double life of RIPK1
Lei Jin, Jiezhong Chen, Xiao Ying Liu, Chen Chen Jiang & Xu Dong Zhang
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1035690

Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors |
Joel D. Leverson
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1050155

Reassessing the role of NAD as a prosurvival factor |
Nicolas Preyat & Oberdan Leo
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1062591
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