ApoList – January 2016

Bcl-2 family proteins

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Jianhui Chang, Yingying Wang, Lijian Shao, Remi-Martin Laberge, Marco Demaria, Judith Campisi, Krishnamurthy Janakiraman, Norman E Sharpless, Sheng Ding, Wei Feng, Yi Luo, Xiaoyan Wang, Nukhet Aykin-Burns,  Kimberly Krager, Usha Ponnappan, Martin Hauer-Jensen, Aimin Meng & Daohong Zhou

Bcl-xL promotes metastasis independent of its anti-apoptotic activity
Soyoung Choi, Zhengming Chen, Laura H. Tang, Yuanzhang Fang, Sandra J. Shin, Nicole C. Panarelli, Yao-Tseng Chen, Yi Li, Xuejun Jiang and Yi-Chieh Nancy Du

BH3‐in‐groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes
Zhi Zhang, Sabareesh Subramaniam, Justin Kale, Chenyi Liao, Bo Huang, Hetal Brahmbhatt, Samson GF Condon, Suzanne M Lapolla, Franklin A Hays, Jingzhen Ding, Feng He, Xuejun C Zhang, Jianing Li, Alessandro Senes, David W Andrews, and Jialing Lin

Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX
Paolo Mattiolo, Ares Barbero-Farran, Josep Amigó, Marta Ripamonti, Judit Ribas, Jacint Boix

Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia
B T Gaudette, B Dwivedi, K S Chitta, S Poulain, D Powell, P Vertino, X Leleu, S Lonial, A A Chanan-Khan, J Kowalski and L H Boise

TNF superfamily

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase-1
Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekra, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur and John Silke

Binding studies of TNF receptor superfamily (TNFRSF) receptors on intact cells
Isabell Lang, Simone Füllsack, Agnes Wyzgol, Andrea Fick, Johannes Trebing, Viktoria Schäfer, Daniela Weisenberger, and Harald Wajant

Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction
Wenshu Lu, Qiongyu Chen, Songmin Ying, Xiaobing Xia, Zhanru Yu, Yuan Lui,George Tranter, Boquan Jin, Chaojun Song, Leonard W. Seymour, and ShisongJiang

Inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs response of cancer cells to DR5-mediated apoptosis and T cell-induced killing
Y-T Oh, J Deng, P Yue, T K Owonikoko, F R Khuri and S-Y Sun

γ-secretase activity is required for regulated intramembrane proteolysis of tumor necrosis factor (TNF) receptor 1 and TNF-mediated pro-apoptotic signaling
Jyoti Chhibber-Goel, Caroline Coleman-Vaughan, Vishal Agrawal, Neha Sawhney, Emer Hickey, James C. Powell, and Justin V. McCarthy

Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to TRAIL-mediated Cell Death
Roslyn N. Crowder, David T. Dicker, and Wafik S. El-Deiry

Non-apoptotic cell death

Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it
S Yoon, K Bogdanov, A Kovalenko and D Wallach

Regulation of RIPK3 and RHIM-dependent necroptosis by the proteasome
Kenta Moriwaki and Francis Ka-Ming Chan

Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification
L Potze, S Di Franco, C Grandela, M L Pras-Raves, D I Picavet, H A van Veen, H van Lenthe, F B Mullauer, N N van der Wel, A Luyf, A H C van Kampen, S Kemp, V Everts, J H Kessler, F M Vaz and J P Medema

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
Özge Canli, Yasemin B. Alankuş, Sasker Grootjans, Naidu Vegi, Lothar Hültner, Philipp S. Hoppe, Timm Schroeder, Peter Vandenabeele, Georg W. Bornkamm, and Florian R. Greten

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
A V Jacobsen, K N Lowes, M C Tanzer, I S Lucet, J M Hildebrand, E J Petrie, M F van Delft, Z Liu, S A Conos, J-G Zhang, D C S Huang, J Silke, G Lessene and J M Murphy

MicroRNA-7 regulates the function of mitochondrial permeability transition pore by targeting VDAC1
Amrita Datta Chaudhuri, Doo Chul Choi, Savan Kabaria, Alan Tran, and Eunsung Junn

Auto Poisoning of the Respiratory Chain by a Quorum-Sensing-Regulated Molecule Favors Biofilm Formation and Antibiotic Tolerance
Ronen Hazan, Yok Ai Que, Damien Maura, Benjamin Strobel, Paul Anthony Majcherczyk, Laura Rose Hopper, David J. Wilbur, Teri N. Hreha, Blanca Barquera, Laurence G. Rahme


Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function
Sandra Milasta, Christopher P. Dillon, Oliver E. Sturm, Katherine C. Verbist, Taylor L. Brewer, Giovanni Quarato, Scott A. Brown, Sharon Frase, Laura J. Janke, S. Scott Perry, Paul G. Thomas, Douglas R. Green

X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity
M K Evans, S J Sauer, S Nath, T J Robinson, M A Morse and G R Devi


Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
Alex R. D. Delbridge, Stephanie Grabow, Andreas Strasser & David L. Vaux

Inhibitor of apoptosis proteins as intracellular signaling intermediates
Andrew J. Kocab and Colin S. Duckett

Necroptosis: a potential, promising target and switch in acute pancreatitis
Gang Wang, Feng-Zhi Qu, Le Li, Jia-Chen Lv & Bei Sun

Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?
S Baig, I Seevasant, J Mohamad, A Mukheem, H Z Huri and T Kamarul


AIF Is “Always In Fashion” for T Cells
Marc O. Johnson, Jeffrey C. Rathmell

Unconventional cell death in erythroid cells
Lesley J. Bruce and David J. Anstee

Caspase 8 expression may determine the survival of women with ovarian cancer
M Kim, L Hernandez and C M Annunziata