ApoList – November 2015

Bcl-2 family members

Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation
A Wree, C D Johnson, J Font-Burgada, A Eguchi, D Povero, M Karin and A E Feldstein

Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer
C M Goodwin, O W Rossanese, E T Olejniczak and S W Fesik

Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site
Onyinyechukwu Uchime, Zhou Dai, Nikolaos Biris, David Lee, Sachdev S. Sidhu, Sheng Li, Jonathan R. Lai, and Evripidis Gavathiotis

In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins
D Senft, A Weber, F Saathoff, C Berking, M V Heppt, C Kammerbauer, S Rothenfusser, S Kellner, Z Kurgyis, R Besch and G Häcker

Death receptors

Lifeguard inhibits Fas ligand-mediated endoplasmic reticulum-calcium release mandatory for apoptosis in type II apoptotic cells
Jorge Urresti, Marisol Ruiz-Meana, Elena Coccia, Juan Carlos Arévalo, José Castellano, Celia Fernández-Sanz, Koen M.O. Galenkamp, Laura Planells-Ferrer, Rana S. Moubarak, Núria Llecha-Cano, Stéphanie Reix, David García-Dorado, Bruna Barneda-Zahonero, and Joan X. Comella

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis
L Boutaffala, M J M Bertrand, C Remouchamps, G Seleznik, F Reisinger, M Janas, C Bénézech, M T Fernandes, S Marchetti, F Mair, C Ganeff, A Hupalowska, J-E Ricci, B Becher, J Piette, P Knolle, J Caamano, P Vandenabeele, M Heikenwalder and E Dejardin

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation
K He, X Zheng, M Li, L Zhang and J Yu

Non-apoptotic cell death

Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death
B Schenk and S Fulda

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
Dahai Yang, Yuan He, Raul Muñoz-Planillo, Qin Liu, Gabriel Núñez

Caspases and the apoptosome

Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1
Mengying Zhou, Yini Li, Qi Hu, Xiao-chen Bai, Weiyun Huang,Chuangye Yan, Sjors H.W. Scheres, and Yigong Shi

Apaf1 inhibition promotes cell recovery from apoptosis
Anna Gortat , Mónica Sancho , Laura Mondragón, Àngel Messeguer, Enrique Pérez-Payá, Mar Orzáez

Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke
A P Shabanzadeh, P M D’Onofrio, P P Monnier and P D Koeberle

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
Elena Viganò, Catherine Emma Diamond, Roberto Spreafico, Akhila Balachander, Radoslaw M. Sobota and Alessandra Mortellaro


Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1
E. Vacchelli, Y. Ma, E. E. Baracco, A. Sistigu, D. P. Enot, F. Pietrocola, H. Yang, S. Adjemian, K. Chaba, M. Semeraro, M. Signore, A. De Ninno, V. Lucarini, F. Peschiaroli, L. Businaro, A. Gerardino, G. Manic, T. Ulas, P. Günther, J. L. Schultze, O. Kepp, G. Stoll, C. Lefebvre, C. Mulot, F. Castoldi, S. Rusakiewicz, S. Ladoire, L. Apetoh, J. M. Bravo-San Pedro, M. Lucattelli, C. Delarasse, V. Boige, M. Ducreux, S. Delaloge, C. Borg, F. André, G. Schiavoni, I. Vitale, P. Laurent-Puig, F. Mattei, L. Zitvogel, G. Kroemer

AIF inhibits tumor metastasis by protecting PTEN from oxidation
Shao‐Ming Shen, Meng Guo, Zhong Xiong, Yun Yu, Xu‐Yun Zhao, Fei‐Fei Zhang, and Guo‐Qiang Chen

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis
Vangelis Kondylis, Apostolos Polykratis, Hanno Ehlken, Laura Ochoa-Callejero, Beate Katharina Straub, Santosh Krishna-Subramanian, Trieu-My Van, Harald-Morten Curth, Nicole Heise, Falk Weih, Ulf Klein, Peter Schirmacher, Michelle Kelliher, Manolis Pasparakis

NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance
Feng Li, Xiadi He, Dingwei Ye, Yan Lin, Hongxiu Yu, Cuifang Yao, Lei Huang, Jianong Zhang, Fang Wang, Sha Xu, Xiaohui Wu, Lixia Liu, Chen Yang, Jiaqi Shi, Xiaoyang He, Jie Liu, Yuanyuan Qu, Fushen Guo, Jianyuan Zhao, Wei Xu, Shimin Zhao

Reviews / previews

Cell Death and Cancer Therapy: Don’t Forget to Kill the Cancer Cell!
Letai A.

Phagoptosis – cell death by phagocytosis – plays central roles in physiology, host defense and pathology
Guy C. Brown, Anna Vilalta, MIchael Fricker

Redefining the BH3 Death Domain as a ‘Short Linear Motif’
Abdel Aouacheria, Christophe Combet, Peter Tompa, J. Marie Hardwick

The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival
S Pfeiffer and J H M Prehn

A tale of two domains – a structural perspective of the pseudokinase, MLKL
Peter E. Czabotar and James M. Murphy

Recent insights into cell death and autophagy
Brent E. Fitzwalter and Andrew Thorburn

Role of necroptosis in the pathogenesis of solid organ injury
H Zhao, T Jaffer, S Eguchi, Z Wang, A Linkermann and D Ma

Pyroptosis: Caspase-11 Unlocks the Gates of Death
Aude de Gassart, Fabio Martinon

How dying tumor cells get noticed