ApoList – August 2015

Bcl-2 family proteins

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species
Yamunadevi Subburaj, Katia Cosentino, Markus Axmann, Esteban Pedrueza-Villalmanzo, Eduard Hermann, Stephanie Bleicken, Joachim Spatz and Ana J. García-Sáez

Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis
Ariele Viacava Follis, Fabien Llambi, Parker Merritt, Jerry E. Chipuk, Douglas R. Green, Richard W. Kriwacki

Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice
C Woess, S Tuzlak, V Labi, M Drach, D Bertele, P Schneider and A Villunger

CHIP buffers heterogeneous Bcl-2 expression levels to prevent augmentation of anticancer drug-resistant cell population
M Tsuchiya, Y Nakajima, T Waku, H Hiyoshi, T Morishita, R Furumai, Y Hayashi, H Kishimoto, K Kimura and J Yanagisawa

Mutant KRAS Upregulates BCL-XL via STAT3 to Confer Apoptosis Resistance that is Reversed by BIM Induction and BCL-XL Antagonism
Aziz Zaanan, Koichi Okamoto, Hisato Kawakami, Khashayarsha Khazaie, Shengbing Huang, and Frank A. Sinicrope

BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.
Akhtar RS1, Geng Y, Klocke BJ, Latham CB, Villunger A, Michalak EM, Strasser A, Carroll SL, Roth KA.

The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis
Amandine Clavier, Vincent Ruby, Aurore Rincheval-Arnold, Bernard Mignotte, and Isabelle Guénal

Death receptors and ligands

e-Blood: Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells
Alexandra C. Vrazo, Adrianne E. Hontz, Sarah K. Figueira, Braeden L. Butler, Julie M. Ferrell, Brock F. Binkowski, Jinzhu Li, and Kimberly A. Risma

In vivo Effects in Melanoma of ROCK Inhibition-Induced FasL Overexpression
Iotefa Teiti, Florie Bertrand, Christine Pich, Rémi Gence, Isabelle Lajoie-Mazenc, Philippe Rochaix, Gilles Favre, and Anne-Françoise Tilkin-Mariamé

IAPs / caspases / FLIP

USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics
E-W Lee, D Seong, J Seo, M Jeong, H-K Lee and J Song

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion.
Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC.

cFLIP is critical for oligodendrocyte protection from inflammation
D C Tanner, A Campbell, K M O’Banion, M Noble and M Mayer-Pröschel

Non-apoptotic cell death

Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death
Christina Schott, Ulrike Graab, Nicole Cuvelier, Heidi Hahn, and Simone Fulda

CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells
X Qiu, C Klausen, J-C Cheng and P C K Leung


The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity
Buvana Ravishankar, Haiyun Liu, Rahul Shinde, Kapil Chaudhary, Wei Xiao, Jillian Bradley, Marianne Koritzinsky, Michael P. Madaio, and Tracy L. McGaha

Reviews / comments

Phagocytosis of apoptotic cells in homeostasis
Sanja Arandjelovic and Kodi S Ravichandran

DED or alive: assembly and regulation of the death effector domain complexes
J S Riley, A Malik, C Holohan and D B Longley

Cell Death Identification in Anticancer Therapy—Letter
J. Martin Brown, Bradly G. Wouters, and David G. Kirsch

Cell Death Identification in Anticancer Therapy—Response
Santiago Rello-Varona, David Herrero-Martín, Roser López-Alemany, and Oscar M. Tirado

Bcl-2 family proteins, Drp1 and mitochondrial dynamics in apoptosis