Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for July, 2015

ApoList – July 2015

Posted by cris on July 31, 2015

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Bcl-2 family proteins
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Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation
[Bcl-L-rambo]
Tomokazu Murakawa, Osamu Yamaguchi, Ayako Hashimoto, Shungo Hikoso, Toshihiro Takeda, Takafumi Oka, Hiroki Yasui, Hiromichi Ueda, Yasuhiro Akazawa, Hiroyuki Nakayama, Manabu Taneike, Tomofumi Misaka, Shigemiki Omiya, Ajay M. Shah, Akitsugu Yamamoto, Kazuhiko Nishida, Yoshinori Ohsumi, Koji Okamoto, Yasushi Sakata and Kinya Otsu
http://www.nature.com/ncomms/2015/150706/ncomms8527/full/ncomms8527.html

Oxidative Modification of miR-184 Enables It to Target Bcl-xL and Bcl-w
Jian-Xun Wang, Jie Gao, Su-Ling Ding, Kun Wang, Jian-Qin Jiao, Yin Wang, Teng Sun, Lu-Yu Zhou, Bo Long, Xiao-Jie Zhang, Qian Li, Jin-Ping Liu, Chang Feng, Jia Liu, Ying Gong, Zhixia Zhou, Pei-Feng Li
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00339-1

Structure-Function Analysis of Mcl-1 Identifies a Novel Senescence Regulating Domain
Abeba Demelash, Lukas W. Pfannenstiel, Charles S. Tannenbaum, Xiaoxia Li, Matthew F. Kalady, Jennifer DeVecchio, and Brian R. Gastman
http://www.jbc.org/content/early/2015/07/23/jbc.M115.663898.abstract

Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2
D Merino, S A Best, M-L Asselin-Labat, F Vaillant, B Pal, R A Dickins, R L Anderson, A Strasser, P Bouillet, G J Lindeman and J E Visvader
http://www.nature.com/onc/journal/v34/n30/abs/onc2014313a.html

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction
A Y Robin, K Krishna Kumar, D Westphal, A Z Wardak, G V Thompson, G Dewson, P M Colman and P E Czabotar
http://www.nature.com/cddis/journal/v6/n7/abs/cddis2015141a.html

Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration
C L Buchheit, B L Angarola, A Steiner, K J Weigel and Z T Schafer
http://www.nature.com/cdd/journal/v22/n8/abs/cdd2014209a.html

Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain
J-S Kim, B Ku, T-G Woo, A-Y Oh, Y-S Jung, Y-M Soh, J-H Yeom, K Lee, B-J Park, B-H Oh and N-C Ha
http://www.nature.com/cddis/journal/v6/n7/abs/cddis2015118a.html

Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic–Ischemic Brain Damage in Neonatal Rats
Deyuan Li, Xihong Li, Jinlin Wu, Jinhui Li, Li Zhang, Tao Xiong, Jun Tang, Yi Qu, Dezhi Mu, Wei-Qing Wang, Shu-Jun Liu, Ian Max Møller, Song-Quan Song
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132998

Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation
A Brockmann, A Bluwstein, A Kögel, S May, A Marx, M P Tschan and T Brunner
http://www.nature.com/cddis/journal/v6/n6/abs/cddis2015137a.html

Bcl-2high mantle cell lymphoma cells are sensitized to acadesine with ABT-199
Arnau Montraveta, Sílvia Xargay-Torrent, Laia Rosich, Mònica López-Guerra, Jocabed Roldán, Vanina Rodríguez, Eriong Lee-Vergés, Mercè de Frías, Clara Campàs, Elias Campo, Gaël Roué and Dolors Colomer
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=4230

Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia
Rongqing Pan, Vivian R. Ruvolo, Jun Wei, Marina Konopleva, John C. Reed, Maurizio Pellecchia, Michael Andreeff, and Peter P. Ruvolo
http://bloodjournal.org/content/126/3/363.abstract?etoc

Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin
D Escobar, M I Hepp, C Farkas, T Campos, N M Sodir, M Morales, C I Álvarez, L Swigart, G I Evan, J L Gutiérrez, R Nishinakamura, A F Castro and R Pincheira
http://www.nature.com/cddis/journal/v6/n7/abs/cddis2015165a.html

Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF)
B S Tan, K H Tiong, H L Choo, F Fei-Lei Chung, L-W Hii, S H Tan, I KS Yap, S Pani, N TW Khor, S F Wong, R Rosli, S-K Cheong and C-O Leong
http://www.nature.com/cddis/journal/v6/n7/abs/cddis2015191a.html

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Non-apoptotic cell death
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Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production
C J Kearney, S P Cullen, G A Tynan, C M Henry, D Clancy, E C Lavelle and S J Martin
http://www.nature.com/cdd/journal/v22/n8/abs/cdd2014222a.html

An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death
Merce Garcia-Belinchon, Maria Sanchez-Osuna, Laura Martinez-Escardo, Carla Granados-Colomina, Sonia Pascual-Guiral, Victoria Iglesias-Guimarais, Elisenda Casanelles, Judit Ribas, and Victor J. Yuste
http://www.jbc.org/content/early/2015/06/29/jbc.M115.644179.abstract

Glutaminolysis and Transferrin Regulate Ferroptosis
Minghui Gao, Prashant Monian, Nosirudeen Quadri, Ravichandran Ramasamy, Xuejun Jiang
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00450-5

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Death receptors
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Blocking Tumor Necrosis Factor α Enhances CD8 T-cell–Dependent Immunity in Experimental Melanoma
Florie Bertrand, Julia Rochotte, Céline Colacios, Anne Montfort, Anne-Françoise Tilkin-Mariamé, Christian Touriol, Philippe Rochaix, Isabelle Lajoie-Mazenc, Nathalie Andrieu-Abadie, Thierry Levade, Hervé Benoist, and Bruno Ségui
http://cancerres.aacrjournals.org/content/75/13/2619.abstract?etoc

MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC
Pooja Joshi, Young-Jun Jeon, Alessandro Laganà, Justin Middleton, Paola Secchiero, Michela Garofalo, and Carlo M. Croce
http://www.pnas.org/content/112/28/8650.abstract.html?etoc

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis
L Boutaffala, M J M Bertrand, C Remouchamps, G Seleznik, F Reisinger, M Janas, C Bénézech, M T Fernandes, S Marchetti, F Mair, C Ganeff, A Hupalowska, J-E Ricci, B Becher, J Piette, P Knolle, J Caamano, P Vandenabeele, M Heikenwalder and E Dejardin
http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd201569a.html

TRAIL-Troglitazone-induced apoptosis in prostate Cancer Cells involve AMP-activated protein kinase
Sreevidya Santha, Navin Viswakarma, Subhasis Das, Ajay Rana, and Basabi Rana
http://www.jbc.org/content/early/2015/07/21/jbc.M115.663526.abstract

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IAPs, necroptosis
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Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination
M C de Almagro, T Goncharov, K Newton and D Vucic
http://www.nature.com/cddis/journal/v6/n6/abs/cddis2015158a.html

Bax/Bak-Dependent, Drp1-Independent Targeting of XIAP into Inner-Mitochondrial Compartments Counteracts Smac-Dependent Effector Caspase Activation
Anne Hamacher-Brady and Nathan Ryan Brady
http://www.jbc.org/content/early/2015/07/01/jbc.M115.643064.abstract

Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death
H Schoeneberger, K Belz, B Schenk and S Fulda
http://www.nature.com/onc/journal/v34/n31/abs/onc2014338a.html

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Caspases
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Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes
M G Sanders, M J Parsons, A G A Howard, J Liu, S R Fassio, J A Martinez and L Bouchier-Hayes
http://www.nature.com/cddis/journal/v6/n7/abs/cddis2015186a.html

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
Seokwon Kang, Teresa Fernandes-Alnemri, Corey Rogers, Lindsey Mayes, Ying Wang, Christopher Dillon, Linda Roback, William Kaiser, Andrew Oberst, Junji Sagara, Katherine A. Fitzgerald, Douglas R. Green, Jianke Zhang, Edward S. Mocarski and Emad S. Alnemri
http://www.nature.com/ncomms/2015/150624/ncomms8515/full/ncomms8515.html

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Cell-cell communication
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Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
Kyoung Wan Yoon, Sanguine Byun, Eunjeong Kwon, So-Young Hwang, Kiki Chu, Masatsugu Hiraki, Seung-Hee Jo, Astrid Weins, Samy Hakroush, Angelika Cebulla, David B. Sykes, Anna Greka, Peter Mundel, David E. Fisher, Anna Mandinova, Sam W. Lee
http://www.sciencemag.org/content/349/6247/1261669.full

Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms
[in C. elegans]
Zao Li, Victor Venegas, Yuji Nagaoka, Eri Morino, Prashant Raghavan, Anjon Audhya, Yoshinobu Nakanishi, Zheng Zhou
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005285

Apoptotic cells activate AMPK and inhibit epithelial cell growth without change in intracellular energy stores
Vimal A. Patel, Donald Massenburg, Snezana Vujicic, Lanfei Feng, Meiyi Tang, Natalia Litbarg, Angelika Antoni, Joyce Rauch, Wilfred Lieberthal, and Jerrold S. Levine
http://www.jbc.org/content/early/2015/07/16/jbc.M115.667345.abstract

Apoptotic-cell-derived membrane microparticles and IFN-α induce an inflammatory immune response
Anna Niessen, Petra Heyder, Stefan Krienke, Norbert Blank, Lars-Oliver Tykocinski, Hanns-Martin Lorenz, and Martin Schiller
http://jcs.biologists.org/content/128/14/2443.abstract?etoc

Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus
Hao Li, Yang-Xin Fu, Qi Wu, Yong Zhou, David K. Crossman, PingAr Yang, Jun Li, Bao Luo, Laurence M. Morel, Janusz H. Kabarowski, Hideo Yagita, Carl F. Ware, Hui-Chen Hsu, John D. Mountz
http://www.jci.org/articles/view/81059

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1
Aaron M. Fond, Chang Sup Lee, Ira G. Schulman, Robert S. Kiss, Kodi S. Ravichandran
http://www.jci.org/articles/view/80300

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Miscellaneous
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A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure
Georgia K. Atkin-Smith, Rochelle Tixeira, Stephanie Paone, Suresh Mathivanan, Christine Collins, Michael Liem, Katharine J. Goodall, Kodi S. Ravichandran, Mark D. Hulett & Ivan K.H. Poon
http://www.nature.com/ncomms/2015/150615/ncomms8439/full/ncomms8439.html

RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy
Qi Luan, Lei Jin, Chen Chen Jiang, Kwang Hong Tay, Fritz Lai, Xiao Ying Liu, Yi Lun Liu, Su Tang Guo, Chun Ying Li, Xu Guang Yan, Hsin-Yi Tseng & Xu Dong Zhang
http://www.tandfonline.com/doi/abs/10.1080/15548627.2015.1049800#.VavOK4SbvDc

MYC Is a Major Determinant of Mitotic Cell Fate
Caroline Topham, Anthony Tighe, Peter Ly, Ailsa Bennett, Olivia Sloss, Louisa Nelson, Rachel A. Ridgway, David Huels, Samantha Littler, Claudia Schandl, Ying Sun, Beatrice Bechi, David J. Procter, Owen J. Sansom, Don W. Cleveland, Stephen S. Taylor
http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00211-1

Mutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis
Linjie Zhao, Tanlin Sun, Jianfeng Pei, and Qi Ouyang
http://www.pnas.org/content/112/30/E4046.abstract.html?etoc

Disruption of cellular homeostasis induces organelle stress and triggers apoptosis like cell-death pathways in malaria parasite
S Rathore, G Datta, I Kaur, P Malhotra and A Mohmmed
http://www.nature.com/cddis/journal/v6/n7/abs/cddis2015142a.html

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Reviews / Comments / other
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Molecular crosstalk between apoptosis, necroptosis, and survival signaling
Tom Vanden Berghe, William J Kaiser, Mathieu JM Bertrand & Peter Vandenabeele
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.975093#.Vbj5XvPtlBc

First MCL-1-selective BH3 mimetics as potential therapeutics for targeted treatment of cancer
S Besbes and C Billard
http://www.nature.com/cddis/journal/v6/n7/full/cddis2015168a.html

Ferroptosis in p53-dependent oncosuppression and organismal homeostasis
L Galluzzi, J M Bravo-San Pedro and G Kroemer
http://www.nature.com/cdd/journal/v22/n8/full/cdd201554a.html

Redox regulation of Smac mimetic-induced cell death
Simone Fulda
http://www.tandfonline.com/doi/abs/10.1080/23723556.2014.1000697#.Vbj4hvPtlBc

Selective Inhibition of BCL2 Shows Antitumor Effects in Lung Cancer
http://cancerdiscovery.aacrjournals.org/content/5/7/OF21.abstract?etoc

A p53-regulated immune checkpoint relevant to cancer
Laurence Zitvogel and Guido Kroemer
http://www.sciencemag.org/content/349/6247/476.summary

Caspase-2 and the oxidative stress response
Sonia Shalini & Sharad Kumar
http://www.tandfonline.com/doi/abs/10.1080/23723556.2015.1004956#.Vbj3tvPtlBc

CHCHD2 connects mitochondrial metabolism to apoptosis
Yong Liu & Yanping Zhang
http://www.tandfonline.com/doi/abs/10.1080/23723556.2015.1004964#.Vbj34vPtlBc


From zero to sixty: cell death signaling in the city that never sleeps
Meeting report
J D Gelles, R Elkholi, M N Serasinghe, M P A Luna-Vargas and J E Chipuk
http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2015194a.html

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