ApoList – June 2015

Bcl-2 family proteins

Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
Bingshe Han, Dongkyoo Park, Rui Li, Maohua Xie, Taofeek K. Owonikoko, Guojing Zhang, Gabriel L. Sica, Chunyong Ding, Jia Zhou, Andrew T. Magis, Zhuo G. Chen, Dong M. Shin, Suresh S. Ramalingam, Fadlo R. Khuri, Walter J. Curran, Xingming Deng

Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB–induced Bcl-xL for inhibition of apoptosis
Christian Schwartz, Ralf Willebrand, Silke Huber, Rudolf A. Rupec, DavinaWu, Richard Locksley, and David Voehringer

mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation
Junghui Koo, Ping Yue, Xingming Deng, Fadlo R. Khuri, and Shi-Yong Sun

miR-326 Targets Antiapoptotic Bcl-xL and Mediates Apoptosis in Human Platelets
Shifang Yu, Huicong Huang, Gang Deng, Zuoting Xie, Yincai Ye, Ruide Guo, Xuejiao Cai, Junying Hong, Dingliang Qian, Xiangjing Zhou, Zhihua Tao, Bile Chen, Qiang Li

The Pro-Apoptotic BH3-Only Protein Bim Interacts with Components of the Translocase of the Outer Mitochondrial Membrane (TOM)
Daniel O. Frank, Jörn Dengjel, Florian Wilfling, Vera Kozjak-Pavlovic, Georg Häcker, Arnim Weber

BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress
Marcos A. Carpio, Michael Michaud, Wenping Zhou, Jill K. Fisher, Loren D. Walensky, and Samuel G. Katz

Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells
Emanuela Papaianni, Souhayla El Maadidi, Andrea Schejtman, Simon Neumann, Ulrich Maurer, Francesca Marino-Merlo, Antonio Mastino, Christoph Borner

Death receptors and ligands

CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma
M Teodorczyk, S Kleber, D Wollny, J P Sefrin, B Aykut, A Mateos, P Herhaus, I Sancho-Martinez, O Hill, C Gieffers, J Sykora, W Weichert, C Eisen, A Trumpp, M R Sprick, F Bergmann, T Welsch and A Martin-Villalba

Molecular mechanism of ER stress-induced gene expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in macrophages
Yan Huang, Yarui Wang, Xiaofeng Li, Zhaolin Chen, Xiaohui Li, Huan Wang, Mingming Ni and Jun Li

A Humanized Leucine Zipper-TRAIL Hybrid Induces Apoptosis of Tumors both In Vitro and In Vivo
Dmitri Rozanov, Paul Spellman, Alexei Savinov, Alex Y. Strongin

A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer
Young-Jun Jeon, Justin Middleton, Taewan Kim, Alessandro Laganà, Claudia Piovan, Paola Secchiero, Gerard J. Nuovo, Ri Cui, Pooja Joshi, Giulia Romano, Gianpiero Di Leva, Bum-Kyu Lee, Hui-Lung Sun, Yonghwan Kim, Paolo Fadda, Hansjuerg Alder, Michela Garofalo, and Carlo M. Croce

TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response
Dmitri Rozanov, Anton Cheltsov, Eduard Sergienko, Stefan Vasile, Vladislav Golubkov, Alexander E. Aleshin, Trevor Levin, Elie Traer, Byron Hann, Julia Freimuth, Nikita Alexeev, Max A. Alekseyev, Sergey P. Budko, Hans Peter Bächinger, Paul Spellman

Caspases and FLIP

The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons
Lingfeng Meng, Ben Mulcahy, Steven J. Cook, Marianna Neubauer, Airong Wan, Yishi Jin, Dong Yan

An Inhibitor of PIDDosome Formation
Ruth Thompson, Richa B. Shah, Peter H. Liu, Yogesh K. Gupta, Kiyohiro Ando, Aneel K. Aggarwal, Samuel Sidi

Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death
C-S Yang, K Matsuura, N-J Huang, A C Robeson, B Huang, L Zhang and S Kornbluth

Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation
Xiaoou Zhou, Gianpietro Dotti, Robert A. Krance, Caridad A. Martinez, Swati Naik, Rammurti T. Kamble, April G. Durett, Olga Dakhova, Barbara Savoldo, Antonio Di Stasi, David M. Spencer, Yu-Feng Lin, Hao Liu, Bambi J. Grilley, Adrian P. Gee, Cliona M. Rooney, Helen E. Heslop, and Malcolm K. Brenner

RasGAP shields Akt from deactivating phosphatases in fibroblast growth factor signaling but loses this ability once cleaved by caspase-3
Katia Cailliau, Arlette Lescuyer, Anne-Françoise Burnol, Álvaro Cuesta-Marbán, Christian Widmann, and Edith Browaeys-Poly

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
Christina Antonopoulos, Hana M. Russo, Caroline El Sanadi, Bradley N. Martin, Xiaoxia Li, William J. Kaiser, Edward S. Mocarski, and George R. Dubyak

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria
E S Marini, C Giampietri, S Petrungaro, S Conti, A Filippini, L Scorrano and E Ziparo

Non-apoptotic cell death

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis
Sean P. Cullen, Conor J. Kearney, Danielle M. Clancy, Seamus J. Martin

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death
Jason Karch, Onur Kanisicak, Matthew J. Brody, Michelle A. Sargent, Demetria M. Michael, Jeffery D. Molkentin


RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis
Tohru Yonekawa, Graciela Gamez, Jihye Kim, Aik Choon Tan, Jackie Thorburn, Jacob Gump, Andrew Thorburn, and Michael J Morgan

pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205
Longxing Cao, Xiangyi Shi, Haishuang Chang, Qinfen Zhang, and Yongning He

Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis
Emilie Hangen, Olivier Féraud, Sylvie Lachkar, Haiwei Mou, Nunzianna Doti, Gian Maria Fimia, Ngoc-vy Lam, Changlian Zhu, Isabelle Godin, Kevin Muller, Afroditi Chatzi, Esther Nuebel, Fabiola Ciccosanti, Stéphane Flamant, Paule Bénit, Jean-Luc Perfettini, Allan Sauvat, Annelise Bennaceur-Griscelli, Karine Ser-Le Roux, Patrick Gonin, Kostas Tokatlidis, Pierre Rustin, Mauro Piacentini, Menotti Ruvo, Klas Blomgren, Guido Kroemer, Nazanine Modjtahedi

Apoptosis Inducing Factor (AIF) and its Family Member, AMID, are Rotenone-Sensitive NADH:ubiquinone Oxidoreductases (NDH-2)
Mahmoud M. Elguindy and Eiko Nakamaru-Ogiso

Autophagy regulates tissue overgrowth in a context-dependent manner
E Pérez, G Das, A Bergmann and E H Baehrecke

Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress
B Gole, C Baumann, E Mian, C I Ireno and L Wiesmüller

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage
Tatiana Varanita, Maria Eugenia Soriano, Vanina Romanello, Tania Zaglia, Rubén Quintana-Cabrera, Martina Semenzato, Roberta Menabò, Veronica Costa, Gabriele Civiletto, Paola Pesce, Carlo Viscomi, Massimo Zeviani, Fabio Di Lisa, Marco Mongillo, Marco Sandri, Luca Scorrano


The BCL-2 protein family, BH3-mimetics and cancer therapy
A R D Delbridge and A Strasser

The diverse role of RIP kinases in necroptosis and inflammation
John Silke, James A Rickard and Motti Gerlic

The Importance of Being Dead: Cell Death Mechanisms Assessment in Anti-Sarcoma Therapy
Santiago Rello-Varona, David Herrero-Martín, Laura Lagares-Tena, Roser López-Alemany, Nuria Mulet-Margalef, Juan Huertas-Martínez, Silvia García-Monclús, Javier García del Muro, Cristina Muñoz-Pinedo, and Oscar M Tirado

Comments, other

Another face of RIPK1
Douglas R Green

Necrosis: Linking the Inflammasome to Inflammation
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Guido Kroemer

Paradise revealed II: Top science, sunny beach, tropical fruits and caipirinhas….
Meeting report
G P Amarante-Mendes, S Adjemian, B P Mello, E D Hottz and P E Marques

A conversation with Craig Thompson


MetaboList – May 2015

Cancer Metabolism

Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations
Bradley A. Webb, Farhad Forouhar, Fu-En Szu, Jayaraman Seetharaman, Liang Tong & Diane L. Barber

Aerobic glycolysis tunes YAP/TAZ transcriptional activity
Elena Enzo, Giulia Santinon, Arianna Pocaterra, Mariaceleste Aragona, Silvia Bresolin, Mattia Forcato, Daniela Grifoni, Annalisa Pession, Francesca Zanconato, Giulia Guzzo, Silvio Bicciato, and Sirio Dupont

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
Emelyn H. Shroff, Livia S. Eberlin, Vanessa M. Dang, Arvin M. Gouw, Meital Gabay, Stacey J. Adam, David I. Bellovin, Phuoc T. Tran, William M. Philbrick, Adolfo Garcia-Ocana, Stephanie C. Casey, Yulin Li, Chi V. Dang, Richard N. Zare, and Dean W. Felsher

ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence
Katherine M. Aird, Andrew J. Worth, Nathaniel W. Snyder, Joyce V. Lee, Sharanya Sivanand, Qin Liu, Ian A. Blair, Kathryn E. Wellen, Rugang Zhang

Brief Report: Stromal cell–mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling
Regina Jitschin, Martina Braun, Mirjeta Qorraj, Domenica Saul, Katarina Le Blanc, Thorsten Zenz, and Dimitrios Mougiakakos

IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia
Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, and Issay Kitabayashi

Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma
Patricia Maiso, Daisy Huynh, Michele Moschetta, Antonio Sacco, Yosra Aljawai, Yuji Mishima, John M. Asara, Aldo M. Roccaro, Alec C. Kimmelman,and Irene M. Ghobrial

Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs
M Saqcena, S Mukhopadhyay, C Hosny, A Alhamed, A Chatterjee and D A Foster

Polymorphism in one-carbon metabolism pathway affects survival of gastric cancer patients: Large and comprehensive study
Zhao T, Gu D, Xu Z, Huo X, Shen L, Wang C, Tang Y, Wu P, He J, Gong W, He ML, Chen J

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions
Linchong Sun, Libing Song, Qianfen Wan, Gongwei Wu, Xinghua Li, Yinghui Wang, Jin Wang, Zhaoji Liu, Xiuying Zhong, Xiaoping He, Shengqi Shen, Xin Pan, Ailing Li, Yulan Wang, Ping Gao, Huiru Tang and Huafeng Zhang

MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect
L Lin, H Huang, W Liao, H Ma, J Liu, L Wang, N Huang, Y Liao and W Liao

Analyses of the Transcriptome and Metabolome Demonstrate That HIF1α Mediates Altered Tumor Metabolism in Clear Cell Renal Cell Carcinoma
Denise R. Minton, Leiping Fu, Qiuying Chen, Brian D. Robinson, Steven S. Gross, David M. Nanus, Lorraine J. Gudas

Comprehensive Analysis of Glycolytic Enzymes as Therapeutic Targets in the Treatment of Glioblastoma
Morgane Sanzey, Siti Aminah Abdul Rahim, Anais Oudin, Anne Dirkse, Tony Kaoma, Laurent Vallar, Christel Herold-Mende, Rolf Bjerkvig, Anna Golebiewska, Simone P. Niclou

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/ Mammalian Target of Rapamycin (mTOR) Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma
Hideki Makinoshima, Masahiro Takita, Koichi Saruwatari, Shigeki Umemura, Yuuki Obata, Genichiro Ishii, Shingo Matsumoto, Eri Sugiyama, Atsushi Ochiai, Ryo Abe, Koichi Goto, Hiroyasu Esumi, and Katsuya Tsuchihara


AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of ras-transformed fibroblasts
Joffrey Pelletier, Danièle Roux, Benoit Viollet, Nathalie M. Mazure,  and  Jacques Pouysségur

Glucose-Based Regulation of miR-451/AMPK Signaling Depends on the OCT1 Transcription Factor
Khairul I. Ansari, Daisuke Ogawa, Arun K. Rooj, Sean E. Lawler, Anna M. Krichevsky, Mark D. Johnson, E. Antonio Chiocca, Agnieszka Bronisz, Jakub Godlewski

5′-AMP-activated protein kinase alpha regulates stress granule biogenesis
Hicham Mahboubi, Ramla Barise, Ursula Stochaj

Enhanced amino acid utilization sustains growth of cells lacking Snf1/AMPK
Raffaele Nicastro, Farida Tripodi, Cinzia Guzzi, Veronica Reghellin, Sakda Khoomrung, Claudia Capusoni, Concetta Compagno, Cristina Airoldi, Jens Nielsen, Lilia Alberghina, Paola Coccetti

Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in Saccharomyces cerevisiae
Jofre Ferrer Dalmau, Francisca Randez Gil, Maribel Marquina, José A. Prieto and Antonio Casamayor

Polarized activities of AMPK and BRSK in primary hippocampal neurons
Vedangi Sample, Santosh Ramamurthy, Kirill Gorshkov, Gabriele V. Ronnett, and Jin Zhang

Anti-metabolic drugs, starvation

Dose-dependent Effect of 2-Deoxy-D-Glucose on Glycoprotein Mannosylation in Cancer Cells
Ahadova, A; Gebert, J; Doeberitz, MV; Kopitz, J; Kloor, M

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
Giovanna Bianchi, Roberto Martella, Silvia Ravera, Cecilia Marini, Selene Capitanio, Annamaria Orengo, Laura Emionite, Chiara Lavarello, Adriana Amaro, Andrea Petretto, Ulrich Pfeffer, Gianmario Sambuceti, Vito Pistoia, Lizzia Raffaghello,  and  Valter D. Longo


The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
Thomas R. Cox, Robin M. H. Rumney, Erwin M. Schoof, Lara Perryman, Anette M. Høye, Ankita Agrawal, Demelza Bird, Norain Ab Latif, Hamish Forrest, Holly R. Evans, Iain D. Huggins, Georgina Lang, Rune Linding, Alison Gartland & Janine T. Erler

EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination
L Gómez-Maldonado, M Tiana, O Roche, A Prado-Cabrero, L Jensen, A Fernandez-Barral, I Guijarro-Muñoz, E Favaro, G Moreno-Bueno, L Sanz, J Aragones, A Harris, O Volpert, B Jimenez and L del Peso

Snail is a Direct Target of HIF1α in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells
Xingbo Xu, Xiaoying Tan, Bjoern Tampe, Elisa Sanchez, Michael Zeisberg, and Elisabeth M. Zeisberg

Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis
X-D Liu, J Yao, D N Tripathi, Z Ding, Y Xu, M Sun, J Zhang, S Bai, P German, A Hoang, L Zhou, D Jonasch, X Zhang, C J Conti, E Efstathiou, N M Tannir, N T Eissa, G B Mills, C L Walker and E Jonasch

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression
Joshua C. Black, Elnaz Atabakhsh, Jaegil Kim, Kelly M. Biette, Capucine Van Rechem, Brendon Ladd, Paul d. Burrowes, Carlos Donado, Hamid Mattoo, Benjamin P. Kleinstiver, Bing Song, Grasiella Andriani, J. Keith Joung, Othon Iliopoulos, Cristina Montagna, Shiv Pillai, Gad Getz, and JohnathanR. Whetstine


SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents
Yuzheng Zhao, Qingxun Hu, Feixiong Cheng, Ni Su, Aoxue Wang, Yejun Zou, Hanyang Hu, Xianjun Chen, Hai-Meng Zhou, Xinzhi Huang, Kai Yang, Qian Zhu, Xue Wang, Jing Yi, Linyong Zhu, Xuhong Qian, Lixin Chen, Yun Tang, Joseph Loscalzo, Yi Yang

Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry
Sabine Guenther, Laura J. Muirhead, Abigail V.M. Speller, Ottmar Golf, Nicole Strittmatter, Rathi Ramakrishnan, Robert D. Goldin, Emrys Jones, Kirill Veselkov, Jeremy Nicholson, Ara Darzi, and Zoltan Takats

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis
Hiroshi Tsugawa, Tomas Cajka, Tobias Kind, Yan Ma, Brendan Higgins, Kazutaka Ikeda, Mitsuhiro Kanazawa, Jean VanderGheynst, Oliver Fiehn & Masanori Arita

New method to assess mitophagy flux by flow cytometry
Marta Mauro-Lizcano, Lorena Esteban-Martínez, Esther Seco, Ana Serrano-Puebla, Lucia Garcia-Ledo, Cláudia Figueiredo-Pereira, Helena L A Vieira & Patricia Boya

Quantification of folate metabolism using transient metabolic flux analysis
Tedeschi  PM, Johnson-Farley  N, Lin  H, Shelton  LM, Ooga  T, Mackay  G, Van Den Broek  N, Bertino  JR, Vazquez  A


Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis
Najate Aït-Ali, Ram Fridlich, Géraldine Millet-Puel, Emmanuelle Clérin, François Delalande, Céline Jaillard, Frédéric Blond, Ludivine Perrocheau, Sacha Reichman, Leah C. Byrne, Anne Olivier-Bandini, Jacques Bellalou, Emmanuel Moyse, Frédéric Bouillaud, Xavier Nicol, Deniz Dalkara, Alain van Dorsselaer, José-Alain Sahel, Thierry Léveillard

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity
Guoliang Cui, Matthew M. Staron, Simon M. Gray, Ping-Chih Ho, Robert A. Amezquita, Jingxia Wu, Susan M. Kaech

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
Susmita Kaushik and Ana Maria Cuervo


Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs
Yangzom D. Bhutia, Ellappan Babu, Sabarish Ramachandran, and Vadivel Ganapathy

Role of tumor hypoxia in acquisition of resistance to microtubule-stabilizing drugs
Viswanath Das, Jana Stepankova, Marian Hajduch, John H. Miller

Targeting the 5′-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer.
Popovics P, Frigo DE, Schally AV, Rick FG

Defining the Metabolome: Size, Flux, and Regulation
Nicola Zamboni, Alan Saghatelian, Gary J. Patti

Pyruvate kinase M2 at a glance
Weiwei Yang and Zhimin Lu


Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK
Reuben J. Shaw

Paving the way for therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide
Paolo E Porporato & Pierre Sonveaux

Endothelial cells and cancer cells: metabolic partners in crime?
Zecchin A, Borgers G, Carmeliet P:

Targeting the Warburg effect for leukemia therapy: Magnitude matters
Ying-Hua Wang & David T Scadden

Chronic lymphocytic leukemia and the Warburg effect
Carol Moreno

Nutrient stress revamps cancer cell metabolism
Moscat J, Richardson A, Diaz-Meco MT.

Metabolic signals in the hypoxic response

Improving PET Evaluation of Brain Tumors

How inhibition of TORC1 stimulates gene expression

ApoList – May 2015

Bcl-2 family proteins

The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest
Manuel D. Haschka, Claudia Soratroi, Susanne Kirschnek, Georg Häcker, Richard Hilbe, Stephan Geley, Andreas Villunger and Luca L. Fava

Minimalist model systems reveal similarities and differences between membrane interaction modes of MCL1 and BAK
Olatz Landeta, Ane Landajuela, Ana Garcia-Saez, and Gorka Basañez

CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation
Y Liu, H V Clegg, P L Leslie, J Di, L A Tollini, Y He, T-H Kim, A Jin, L M Graves, J Zheng and Y Zhang

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress
Alex R. D. Delbridge, Joseph T. Opferman, Stephanie Grabow, and Andreas Strasser

Mcl-1 is a key regulator of the ovarian reserve
S Omari, M Waters, T Naranian, K Kim, A L Perumalsamy, M Chi, E Greenblatt, K H Moley, J T Opferman and A Jurisicova

A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1
Matthew C. Clifton, David M. Dranow, Alison Leed, Ben Fulroth, James W. Fairman, Jan Abendroth, Kateri A. Atkins, Ellen Wallace, Dazhong Fan, Guoping Xu, Z. J. Ni, Doug Daniels, John Van Drie, Guo Wei, Alex B. Burgin, Todd R. Golub, Brian K. Hubbard, Michael H. Serrano-Wu

TNF family members

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production
Danyal Butt, Tyani D. Chan, Katherine Bourne, Jana R. Hermes, Akira Nguyen, Aaron Statham, Lorraine A. O’Reilly, Andreas Strasser, Susan Price, Peter Schofield, Daniel Christ, Antony Basten, Cindy S. Ma, Stuart G. Tangye, Tri Giang Phan, V. Koneti Rao, Robert Brink

Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display
Pradeep M. Nair, Heather Flores, Alvin Gogineni, Scot Marsters, David A. Lawrence, Robert F. Kelley, Hai Ngu, Meredith Sagolla, Laszlo Komuves, Richard Bourgon, Jeffrey Settleman, and Avi Ashkenazi

Decoy Receptor DcR1 Is Induced in a p50/Bcl3–Dependent Manner and Attenuates the Efficacy of Temozolomide
Nassir M. Mansour, Giovanna M. Bernal, Longtao Wu, Clayton D. Crawley, Kirk E. Cahill, David J. Voce, Irina V. Balyasnikova, Wei Zhang, Ruben Spretz, Luis Nunez, Gustavo F. Larsen, Ralph R. Weichselbaum, and Bakhtiar Yamini

Comparative biochemical and functional analysis of viral and human secreted TNF decoy receptors
Sergio M. Pontejo, Ali Alejo, and Antonio Alcami

The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis
Noritaka Yamaguchi, Naoto Yamaguchi

Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Zhiping Zeng, Zhe Sun, Mingfeng Huang, Weidong Zhang, Jie Liu, Liqun Chen, Fan Chen, Yuqi Zhou, Jiacheng Lin, Fengyu Huang, Lin Xu, Zixing Zhuang, Shangjie Guo, Gulimiran Alitongbieke, Guobin Xie, Yang Xu, Bingzhen Lin, Xihua Cao, Ying Su, Xiao-kun Zhang, and Hu Zhou

The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells
Min Zhang, Nanae Harashima, Tamami Moritani, Weidong Huang, Mamoru Harada

Death Receptor-Induced Apoptosis Signalling Regulation by Ezrin Is Cell Type Dependent and Occurs in a DISC-Independent Manner in Colon Cancer Cells
Elisabetta Iessi, Luciana Zischler, Aurélie Etringer, Marion Bergeret, Aymeric Morlé, Guillaume Jacquemin, Alexandre Morizot, Sarah Shirley, Najoua Lalaoui, Selene L. Elifio-Esposito, Stefano Fais, Carmen Garrido, Eric Solary, Olivier Micheau

The Gβ5 protein regulates sensitivity to TRAIL-induced cell death in colon carcinoma
D Fuchs, M Metzig, M Bickeböller, C Brandel and W Roth

Caspases and IAPs

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus
Gregor Ebert, Simon Preston, Cody Allison, James Cooney, Jesse G. Toe, Michael D. Stutz, Samar Ojaimi, Hamish W. Scott, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, Ruth Chin, Danielle Colledge, Xin Li, Nadia Warner, Peter Revill, Scott Bowden, John Silke, C. Glenn Begley, and Marc Pellegrini

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis
Gregor Ebert, Cody Allison, Simon Preston, James Cooney, Jesse G. Toe, Michael D. Stutz, Samar Ojaimi, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, John Silke, C. Glenn Begley, and Marc Pellegrini

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens
Cierra N. Casson, Janet Yu, Valeria M. Reyes, Frances O. Taschuk, Anjana Yadav, Alan M. Copenhaver, Hieu T. Nguyen, Ronald G. Collman, and Sunny Shin

Non-apoptotic cell death

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis
D A Rodriguez, R Weinlich, S Brown, C Guy, P Fitzgerald, C P Dillon, A Oberst, G Quarato, J Low, J G Cripps, T Chen and D R Green

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis
Michio Onizawa, Shigeru Oshima, Ulf Schulze-Topphoff, Juan A Oses-Prieto, Timothy Lu, Rita Tavares, Thomas Prodhomme, Bao Duong, Michael I Whang, Rommel Advincula, Alex Agelidis, Julio Barrera, Hao Wu, Alma Burlingame, Barbara A Malynn, Scott S Zamvil & Averil Ma

Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway
Jakub Hanus, Hongmei Zhang, David H. Chen, Qinbo Zhou, Peng Jin, Qinghua Liu, and Shusheng Wang

Phospho-ΔNp63α-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure
Edward A. Ratovitski

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury
M Deutsch, C S Graffeo, R Rokosh, M Pansari, A Ochi, E M Levie, E Van Heerden, D M Tippens, S Greco, R Barilla, L Tomkötter, C P Zambirinis, N Avanzi, R Gulati, H L Pachter, A Torres-Hernandez, A Eisenthal, D Daley and G Miller

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis
A Fauster, M Rebsamen, K V M Huber, J W Bigenzahn, A Stukalov, C-H Lardeau, S Scorzoni, M Bruckner, M Gridling, K Parapatics, J Colinge, K L Bennett, S Kubicek, S Krautwald, A Linkermann and G Superti-Furga


Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3′ Uridylated Intermediates Degraded by DIS3L2
Marshall P. Thomas, Xing Liu, Jennifer Whangbo, Geoffrey McCrossan, Keri B. Sanborn, Emre Basar, Michael Walch, Judy Lieberman

Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters
S K Mungamuri, S Wang, J J Manfredi, W Gu and S A Aaronson

Co-receptors are dispensable for tethering receptor-mediated phagocytosis of apoptotic cells
B Park, J Lee, H Moon, G Lee, D-H Lee, J Hoon Cho and D Park

Apoptotic Cells Induce NF-κB and Inflammasome Negative Signaling
Amir Grau, Adi Tabib, Inna Grau, Inna Reiner, Dror Mevorach


Surviving apoptosis: life–death signaling in single cells
Deborah A. Flusberg, Peter K. Sorger

The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics
Aaron N. Hata, Jeffrey A. Engelman, and Anthony C. Faber

Live to die another way: modes of programmed cell death and the signals emanating from dying cells
Yaron Fuchs & Hermann Steller

Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment
Cristina Correia, Sun-Hee Lee, X. Wei Meng, Nicole D. Vincelette, Katherine L.B. Knorr, Husheng Ding, Grzegorz S. Nowakowski, Haiming Dai, Scott H. Kaufmann

RIPK1 and RIPK3: critical regulators of inflammation and cell death
Kim Newton

Lysosomal proteins in cell death and autophagy (pages 1858–1870)
Michaela Mrschtik and Kevin M. Ryan


Flicking the molecular switch underlying MLKL-mediated necroptosis
Joanne M Hildebrand, Isabelle S Lucet & James M Murphy

A20 is a regulator of necroptosis
Prajwal Gurung, Si Ming Man and Thirumala-Devi Kanneganti

Glutathione peroxidase 4 (Gpx4) and ferroptosis: what’s so special about it?
Marcus Conrad & José Pedro Friedmann Angeli

p53 Promotes Ferroptosis during ROS Stress to Suppress Tumorigenesis