ApoList – March 2014

Bcl-2 family proteins

Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism
Lauren A. Barclay, Thomas E. Wales, Thomas P. Garner, Franziska Wachter, Susan Lee, Rachel M. Guerra, Michelle L. Stewart, Craig R. Braun, Gregory H. Bird, Evripidis Gavathiotis, John R. Engen, Loren D. Walensky

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Joel D. Leverson, Darren C. Phillips, Michael J. Mitten, Erwin R. Boghaert, Dolores Diaz, Stephen K. Tahir, Lisa D. Belmont, Paul Nimmer, Yu Xiao, Xiaoju M. Ma, Kym N. Lowes, Peter Kovar, Jun Chen, Sha Jin, Morey Smith, John Xue, Haichao Zhang, Anatol Oleksijew, Terrance J. Magoc, Kedar S. Vaidya, Daniel H. Albert, Jacqueline M. Tarrant, Nghi La, Le Wang, Zhi-Fu Tao, Michael D. Wendt, Deepak Sampath, Saul H. Rosenberg, Chris Tse, Huang, Wayne J. Fairbrother, Steven W. Elmore, Andrew J. Souers

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer
Anthony C. Faber, Anna F. Farago, Carlotta Costa, Anahita Dastur, Maria Gomez-Caraballo, Rebecca Robbins, Bethany L. Wagner, William M. Rideout III, Charles T. Jakubik, Jungoh Ham, Elena J. Edelman, Hiromichi Ebi, Alan T. Yeo, Aaron N. Hata, Youngchul Song, Neha U. Patel, Ryan J. March, Ah Ting Tam, Randy J. Milano, Jessica L. Boisvert, Mark A. Hicks, Sarah Elmiligy, Scott E. Malstrom, Miguel N. Rivera, Hisashi Harada, Brad E. Windle, Sridhar Ramaswamy, Cyril H. Benes, Tyler Jacks, and Jeffrey A. Engelman

Overexpression of Mcl-1L Splice Variant Is Associated with Poor Prognosis and Chemoresistance in Oral Cancers
Vinayak Palve, Sanchita Mallick, Gauri Ghaisas, Sadhana Kannan, Tanuja Teni

Group VIA phospholipase A2 (iPLA2β) modulates Bcl-x 5′ splice site selection and suppresses anti-apoptotic Bcl-x(L) in β-cells
Suzanne E. Barbour, Phuong T. Nguyen, Margaret Park, Bhargavi Emani, Xiaoyong Lei, Mamatha Kambalapalli, Jacqueline C. Shultz, Dayanjan Wijesinghe, Charles E. Chalfant, and Sasanka Ramanadham

JAK2V617F Drives Mcl-1 Expression and Sensitizes Hematologic Cell Lines to Dual Inhibition of JAK2 and Bcl-xL
Jun Guo, Lisa Roberts, Zhui Chen, Philip J. Merta, Keith B. Glaser, O. Jameel Shah

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival
Nai Yang Fu, Anne C. Rios, Bhupinder Pal, Rina Soetanto, Aaron T. L. Lun, Kevin Liu, Tamara Beck, Sarah A. Best, François Vaillant, Philippe Bouillet, Andreas Strasser, Thomas Preiss, Gordon K. Smyth, Geoffrey J. Lindeman & Jane E. Visvader

Death receptors

Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability
A Rossin, J Durivault, T Chakhtoura-Feghali, N Lounnas, L Gagnoux-Palacios and A-O Hueber

Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia
Fatih M. Uckun, Dorothea E. Myers, Sanjive Qazi, Zahide Ozer, Rebecca Rose, Osmond J. D’Cruz, Hong Ma

The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis
Jeny Shklover, Flonia Levy-Adam, Estee Kurant

NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells
Kritarth Singh, Anastasia Poteryakhina, Andrei Zheltukhin, Khyati Bhatelia, Paresh Prajapati, Lakshmi Sripada, Dhanendra Tomar, Rochika Singh, Arun K. Singh, Peter M. Chumakov, Rajesh Singh

Inhibition of Methyltransferases Accelerates Degradation of cFLIP and Sensitizes B-Cell Lymphoma Cells to TRAIL-Induced Apoptosis
Frank K. Braun, Rohit Mathur, Lalit Sehgal, Rachel Wilkie-Grantham, Joya Chandra, Zuzana Berkova, Felipe Samaniego

Non-apoptotic cell death

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3
Wanze Chen, Jianfeng Wu, Lisheng Li, Zhengmao Zhang, Junming Ren, Yaoji Liang, Fenfang Chen, Chao Yang, Zhenru Zhou, Sheng Sean Su, Xinru Zheng,Zhirong Zhang, Chuan-Qi Zhong,  Haoqiang Wan, Mu Xiao, Xia Lin, Xin-Hua Feng & Jiahuai Han

Activation of Necroptosis in Multiple Sclerosis
Dimitry Ofengeim, Yasushi Ito, Ayaz Najafov, Yaoyang Zhang, Bing Shan, Judy Park DeWitt, Juanying Ye, Xumin Zhang, Ansi Chang, Helin Vakifahmetoglu-Norberg, Jiefei Geng, Benedicte Py, Wen Zhou, Palak Amin, Jonilson Berlink Lima, Chunting Qi, Qiang Yu, Bruce Trapp, Junying Yuan

Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1
Malek Najjar, Chalada Suebsuwong, Soumya S. Ray, Roshan J. Thapa, Jenny L. Maki, Shoko Nogusa, Saumil Shah, Danish Saleh, Peter J. Gough, John Bertin, Junying Yuan, Siddharth Balachandran, Gregory D. Cuny, Alexei Degterev

Ferroptosis as a p53-mediated activity during tumour suppression
Le Jiang, Ning Kon, Tongyuan Li, Shang-Jui Wang, Tao Su, Hanina Hibshoosh, Richard Baer & Wei Gu

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus
Shinya Omoto, Hongyan Guo, Ganesh R. Talekar, Linda Roback, William J. Kaiser, and Edward Mocarski

IAPs and caspases

S-nitrosylation of XIAP at Cys 213 of BIR2 domain impairs XIAP’s anti-caspase 3 activity and anti-apoptotic function
Weiwei Wu, Oi Wan Wan & Kenny K. K. Chung

IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1
M D Faye, S T Beug, T E Graber, N Earl, X Xiang, B Wild, S Langlois, J Michaud, K N Cowan, R G Korneluk and M Holcik

Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells
Ivana Bulatovic, Cristian Ibarra, Cecilia Österholm, Heng Wang, Antonio Beltrán-Rodríguez, Manuel Varas-Godoy, Agneta Månsson-Broberg, Per Uhlén, András Simon, Karl-Henrik Grinnemo

Preclinical Studies Identify Non-Apoptotic Low-Level Caspase-3 as Therapeutic Target in Pemphigus Vulgaris
Camille Luyet, Katja Schulze, Beyza S. Sayar, Denise Howald, Eliane J. Müller, Arnaud Galichet


Necroptosis: Fifty shades of RIPKs
Gabriel Ichim & Stephen WG Tait

Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy
Maja Sochalska, Selma Tuzlak, Alexander Egle and Andreas Villunger

Old, new and emerging functions of caspases
S Shalini, L Dorstyn, S Dawar and S Kumar

Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins
Alfredo Giménez-Cassina, Nika N. Danial

The role of CD95 and CD95 ligand in cancer
M E Peter, A Hadji, A E Murmann, S Brockway, W Putzbach, A Pattanayak and P Ceppi

Comparative structural analysis of the caspase family with other clan CD cysteine peptidases
Karen McLuskey and Jeremy Mottram

BH3-only proteins: a 20-year stock-take
Marcel Doerflinger, Jason A. Glab and Hamsa Puthalakath

Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition
M Bonora, M R Wieckowski, C Chinopoulos, O Kepp, G Kroemer, L Galluzzi and P Pinton

Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling
Consuelo Gajate & Faustino Mollinedo

Glycosphingolipids and cell death: one aim, many ways
Carmen Garcia-Ruiz, Albert Morales & José C. Fernández-Checa

Role of mitochondrial raft-like microdomains in the regulation of cell apoptosis
Tina Garofalo, Valeria Manganelli, Maria Grasso, Vincenzo Mattei, Alberto Ferri, Roberta Misasi & Maurizio Sorice


BIM’s up first
Daniel J. Murphy & Nathiya Muthalagu

BCL2 Is Synthetic Lethal to IDH1/2 Mutations in AML

Epithelial Morphogenesis: Apoptotic Forces Drive Cell Shape Changes
Daniel P. Kiehart