ApoList – January 2015

Bcl-2 family proteins

Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis
Thibaud T. Renault, Konstantinos V. Floros, Rana Elkholi, Kelly-Ann Corrigan, Yulia Kushnareva, Shira Y. Wieder, Claudia Lindtner, Madhavika N. Serasinghe, James J. Asciolla, Christoph Buettner, Donald D. Newmeyer, Jerry E. Chipuk

Differential retrotranslocation of mitochondrial Bax and Bak
Franziska Todt, Zeynep Cakir, Frank Reichenbach, Frederic Emschermann, Joachim Lauterwasser, Andrea Kaiser, Gabriel Ichim, Stephen WG Tait, Stephan Frank, Harald F Langer, and Frank Edlich

Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes
Laura A Gillies, Han Du, Bjoern Peters, C. Michael Knudson, Donald D. Newmeyer, and Tomomi Kuwana

The BH3-only protein Bad is dispensable for TNF-mediated cell death
E Ottina, M Sochalska, R Sgonc and A Villunger

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells
Duohui Jing, Vivek A. Bhadri, Dominik Beck, Julie A. I. Thoms, Nurul A. Yakob, Jason W. H. Wong, Kathy Knezevic, John E. Pimanda, and Richard B. Lock

Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim dependent fashion
Elena Catalán, Paula Jaime-Sánchez, Nacho Aguiló, Markus M. Simon, Christopher J. Froelich, and Julián Pardo

BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma
Cristina Correia, Paula A. Schneider, Haiming Dai, Ahmet Dogan, Matthew J. Maurer, Amy K. Church, Anne J. Novak, Andrew L. Feldman, Xiaosheng Wu,Husheng Ding, X. Wei Meng, James R. Cerhan, Susan L. Slager, William R. Macon, Thomas M. Habermann, Judith E. Karp, Steven D. Gore, Neil E. Kay, Diane F. Jelinek, Thomas E. Witzig, Grzegorz S. Nowakowski, and Scott H. Kaufmann

Characterisation of a novel A1-specific monoclonal antibody
M J Lang, M S Brennan, L A O’Reilly, E Ottina, P E Czabotar, E Whitlock, W D Fairlie, L Tai, A Strasser and M J Herold

MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies
G S Choudhary, S Al-harbi, S Mazumder, B T Hill, M R Smith, J Bodo, E D Hsi and A Almasan

DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX
J-J Guan, X-D Zhang, W Sun, L Qi, J-C Wu and Z-H Qin

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
J D Leverson, H Zhang, J Chen, S K Tahir, D C Phillips, J Xue, P Nimmer, S Jin, M Smith, Y Xiao, P Kovar, A Tanaka, M Bruncko, G S Sheppard, L Wang, S Gierke, L Kategaya, D J Anderson, C Wong, J Eastham-Anderson, M J C Ludlam, D Sampath, W J Fairbrother, I Wertz, S H Rosenberg, C Tse, S W Elmore and A J Souers

Death receptors and FADD

Delaying mitotic exit downregulates FLIP expression and strongly sensitizes tumor cells to TRAIL
T Sánchez-Pérez, R H Medema and A López-Rivas

Genome-Wide Identification of Fas/CD95 Alternative Splicing Regulators Reveals Links with Iron Homeostasis
J. Ramón Tejedor, Panagiotis Papasaikas, Juan Valcárcel

Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer
Brittany M. Bowman, Katrina A. Sebolt, Benjamin A. Hoff, Jennifer L. Boes, Danette L. Daniels, Kevin A. Heist, Craig J. Galbán, Rajiv M. Patel, Jianke Zhang, David G. Beer, Brian D. Ross, Alnawaz Rehemtulla, and Stefanie Galbán

Non-apoptotic cell death/caspase-8

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells
S Saveljeva, S L Mc Laughlin, P Vandenabeele, A Samali and M J M Bertrand

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions
Y Estornes, M A Aguileta, C Dubuisson, J De Keyser, V Goossens, K Kersse, A Samali, P Vandenabeele and M J M Bertrand

RIP1-dependent Bid cleavage mediates TNFα-induced but Caspase-3-independent cell death in L929 fibroblastoma cells
Guozhu Chen , Xiang Cheng , Ming Zhao , Song Lin , Jiangyang Lu , Jiarui Kang & Xiaodan Yu

A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing
Kenta Moriwaki, John Bertin, Peter J. Gough and Francis Ka-Ming Chan

Caspases and IAPs

Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment.
Varfolomeev E, Izrael-Tomasevic A, Yu K, Bustos D, Goncharov T, Belmont LD, Masselot A, Bakalarski CE, Kirkpatrick DS, Vucic D.

Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response
I Eckhardt, A Weigert and S Fulda

XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis
M Ehrenschwender, S Bittner, K Seibold and H Wajant

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia
E Kavanagh, J Rodhe, M A Burguillos, J L Venero and B Joseph

Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice
C H Wilson, S Shalini, A Filipovska, T R Richman, S Davies, S D Martin, S L McGee, J Puccini, A Nikolic, L Dorstyn and S Kumar

Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate
A Aries, J Whitcomb, W Shao, H Komati, M Saleh and M Nemer

Phagocytosis and other consequences

Apico-basal forces exerted by apoptotic cells drive epithelium folding
Bruno Monier, Melanie Gettings, Guillaume Gay, Thomas Mangeat, Sonia Schott, Ana Guarner & Magali Suzanne

A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells
Hengwen Yang, Yu-Zen Chen, Yi Zhang, Xiaohui Wang, Xiang Zhao, James I. Godfroy, Qian Liang, Man Zhang, Tianying Zhang, Quan Yuan, Mary Ann Royal, Monica Driscoll, Ning-Shao Xia, Hang Yin and Ding Xue


Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity
Martina Haller, Andreas K Hock, Evangelos Giampazolias, Andrew Oberst, Douglas R Green, Jayanta Debnath, Kevin M Ryan, Karen H Vousden & Stephen W G Tait

GRIM REAPER peptide binds to receptor kinase PRK5 to trigger cell death in Arabidopsis
Michael Wrzaczek, Julia P Vainonen, Simon Stael, Liana Tsiatsiani, Hanna Help‐Rinta‐Rahko, Adrien Gauthier, David Kaufholdt, Benjamin Bollhöner, Airi Lamminmäki, An Staes, Kris Gevaert, Hannele Tuominen, Frank Van Breusegem, Ykä Helariutta, and Jaakko Kangasjärvi

EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway
Brent Neumann, Sean Coakley, Rosina Giordano-Santini, Casey Linton, Eui Seung Lee, Akihisa Nakagawa, Ding Xue & Massimo A. Hilliard


Necroptosis and its role in inflammation
Manolis Pasparakis, Peter Vandenabeele

Programmed necrosis and necroptosis signalling
Maria Feoktistova and Martin Leverkus

RIP kinases: key decision makers in cell death and innate immunity
F Humphries, S Yang, B Wang and P N Moynagh

Die for the community: an overview of programmed cell death in bacteria
N Allocati, M Masulli, C Di Ilio and V De Laurenzi

Autophagy as a pro-death pathway
Donna Denton, Tianqi Xu and Sharad Kumar

TMBIM protein family: ancestral regulators of cell death
D Rojas-Rivera and C Hetz

The domains of apoptosis and inflammation
Hyun Ho Park

Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
Yu-Chih Lo , Su-Chang Lin , Chao-Yu Yang & Jung-Yu Tung

The Bcl-2 family: structures, interactions and targets for drug discovery
Marc Kvansakul & Mark G. Hinds

The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling
Wen-Pin Kao , Chao-Yu Yang , Tsung-Wei Su , Yin-Ting Wang , Yu-Chih Lo & Su-Chang Lin

Structural basis of cell apoptosis and necrosis in TNFR signaling
Jing Huang , Shaoning Yu , Chaoneng Ji & Jixi Li

Hijacking of death receptor signaling by bacterial pathogen effectors
Jie Luo , Jiaqingzi Hu , Yong Zhang , Qing Hu & Shan Li

Death effecter domain for the assembly of death-inducing signaling complex
Jin Kuk Yang

Methods, comments, other

Imaging-based methods for assessing caspase activity in single cells.
Parsons MJ, Rehm M, Bouchier-Hayes L.

Measuring caspase activity by förster resonance energy transfer.
Rehm M, Parsons MJ, Bouchier-Hayes L.

Measuring initiator caspase activation by bimolecular fluorescence complementation.
Parsons MJ, Bouchier-Hayes L.

Cell biology: Death drags down the neighbourhood
Claudia G. Vasquez & Adam C. Martin

Stefan Grimm, 1963–2014, a tragic loss for the scientific community
A-L Mahul-Mellier, L Huc, A Lemarié, S Irshad, M Hwang, C Datler and E Pazarentzos