ApoList – December 2014

Bcl-2 family members

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner
Mohamed Elgendy, Marco Ciro, Amal Kamal Abdel-Aziz, Giuseppe Belmonte, Roberto Dal Zuffo, Ciro Mercurio, Clelia Miracco, Luisa Lanfrancone, Marco Foiani and Saverio Minucci

Lipid-Dependent Bimodal MCL1 Membrane Activity
Olatz Landeta , Juan Garcia Valero , Hector Flores-Romero , Itsasne Bustillo-Zabalbeitia , Ane Landajuela , Miguel Garcia-Porras , Oihana Terrones , and Gorka Basañez

A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression
Hitendra S. Chand, Gilbert Montano, Xuesong Huang, Scott H. Randell, Yohannes Mebratu, Hans Petersen and Yohannes Tesfaigzi

MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice
Stephanie Grabow, Alex R. D. Delbridge, Liz J. Valente, and Andreas Strasser

Peptides Derived from the Transmembrane Domain of Bcl-2 Proteins as Potential Mitochondrial Priming Tools
Vicente Andreu-Fernández, Ainhoa Genoves , Tzong-Hsien Lee, Matthew Stellato, Federico Lucantoni, Mar Orzáez, Ismael Mingarro, Marie-Isabel Aguilar, and Enrique Pérez-Payá

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis
Peter S. Winter, Kristopher A. Sarosiek, Kevin H. Lin, Manja Meggendorfer,
Susanne Schnittger, Anthony Letai, and Kris C. Wood

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
Sofie Peirs, Filip Matthijssens, Steven Goossens, Inge Van de Walle, Katia Ruggero, Charles E. de Bock, Sandrine Degryse, Kirsten  Canté-Barrett, Delphine Briot, Emmanuelle Clappier, Tim Lammens, Barbara  De Moerloose, Yves Benoit, Bruce Poppe, Jules P. Meijerink, Jan Cools, Jean Soulier, Terence H. Rabbitts, Tom Taghon, Frank Speleman, and Pieter Van Vlierberghe

The Proapoptotic Protein BNIP3 Interacts with VDAC to Induce Mitochondrial Release of Endonuclease G
Xiaosha Zhang, Xiuwu Bian, Jiming Kong

Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling
Rimpy Dhingra, Victoria Margulets, Subir Roy Chowdhury, James Thliveris, Davinder Jassal, Paul Fernyhough, Gerald W. Dorn II, and Lorrie A. Kirshenbaum

Death receptors

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
James A Rickard, Holly Anderton, Nima Etemadi, Ueli Nachbur, Maurice Darding, Nieves Peltzer, Najoua Lalaoui, Kate E Lawlor, Hannah Vanyai, Cathrine Hall, Aleks Bankovacki, Lahiru Gangoda, Wendy Wei-Lynn Wong, Jason Corbin, Chunzi Huang, Edward S Mocarski, James M Murphy, Warren S Alexander, Anne K Voss, David L Vaux, William J Kaiser, Henning Walczak and John Silke

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis
Snehlata Kumari, Younes Redouane, Jaime Lopez-Mosqueda, Ryoko Shiraishi, Malgorzata Romanowska, Stefan Lutzmayer, Jan Kuiper, Conception Martinez, Ivan Dikic, Manolis Pasparakis and Fumiyo Ikeda

Free Fatty Acids shift Insulin-induced Hepatocyte Proliferation towards CD95-dependent Apoptosis
Annika Sommerfeld, Roland Reinehr, and Dieter Häussinger


Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
Michael J. White, Kate McArthur, Donald Metcalf, Rachael M. Lane, John C. Cambier, Marco J. Herold, Mark F. van Delft, Sammy Bedoui, Guillaume Lessene, Matthew E. Ritchie, David C.S. Huang, Benjamin T. Kile

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Anthony Rongvaux, Ruaidhrí Jackson, Christian C.D. Harman, Tuo Li, A. Phillip West, Marcel R. de Zoete, Youtong Wu, Brian Yordy, Saquib A. Lakhani, Chia-Yi Kuan, Tadatsugu Taniguchi, Gerald S. Shadel, Zhijian J. Chen, Akiko Iwasaki, Richard A. Flavell

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions
Shane Deegan, Svetlana Saveljeva, Susan E. Logue, Karolina Pakos-Zebrucka, Sanjeev Gupta, Peter Vandenabeele, Mathieu J.M. Bertrand & Afshin Samali

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice
Elise Peterson Lu, Michael McLellan, Li Ding, Robert Fulton, Elaine R. Mardis, Richard K. Wilson, Christopher A. Miller, Peter Westervelt, John F. DiPersio, Daniel C. Link, Matthew J. Walter, Timothy J. Ley, and Timothy A. Graubert

CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans
Benjamin P Weaver, Rebecca Zabinsky, Yi M Weaver, Eui Seung Lee, Ding Xue and Min Han

A mitochondrial-associated link between an effector caspase and autophagic flux
Lindsay DeVorkin & Sharon M Gorski

Non-apoptotic cell death

Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis
Gaurav D. Gaiha, Kevin J. McKim, Matthew Woods, Thomas Pertel, Janine Rohrbach, Natasha Barteneva, Christopher R. Chin, Dongfang Liu, Damien Z. Soghoian, Kevin Cesa, Shannon Wilton, Michael T. Waring, Adam Chicoine, Travis Doering, E. John Wherry, Daniel E. Kaufmann, Mathias Lichterfeld, Abraham L. Brass, Bruce D. Walker

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Jose Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth, Yulia Y. Tyurina, Vladimir A. Tyurin, Victoria J. Hammond, Nadja Herbach, Michaela Aichler, Axel Walch, Elke Eggenhofer, Devaraj Basavarajappa, Olof Rådmark, Sho Kobayashi, Tobias Seibt, Heike Beck, Frauke Neff, Irene Esposito, Rüdiger Wanke, Heidi Förster, Olena Yefremova, Marc Heinrichmeyer, Georg W. Bornkamm, Edward K. Geissler, Stephen B. Thomas, Brent R. Stockwell, Valerie B. O’Donnell, Valerian E. Kagan, Joel A. Schick  & Marcus Conrad



Myeloid-Derived Suppressor Activity Is Mediated by Monocytic Lineages Maintained by Continuous Inhibition of Extrinsic and Intrinsic Death Pathways
Jessica M. Haverkamp, Amber M. Smith, Ricardo Weinlich, Christopher P. Dillon, Joseph E. Qualls, Geoffrey Neale, Brian Koss, Young Kim, Vincenzo Bronte, Marco J. Herold, Douglas R. Green, Joseph T. Opferman, Peter J. Murray


Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
L Galluzzi, et al

Eaten to death
Charles Nelson and Eric H. Baehrecke

Key regulators of apoptosis execution as biomarker candidates in melanoma
Emilie M Charles & Markus Rehm

The programmed cell death GLuc PCA library – a powerful tool for pathway discovery and drug screening
Yuval Gilad & Adi Kimchi