Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for December, 2014

ApoList – November 2014

Posted by cris on December 3, 2014

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Bcl-2 family members
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Structural Model of Active Bax at the Membrane
Stephanie Bleicken, Gunnar Jeschke, Carolin Stegmueller, Raquel Salvador-Gallego, Ana J. García-Sáez, Enrica Bordignon
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00779-5

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1
Richard G. Carroll, Emilie Hollville, Seamus J. Martin
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00915-2

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function
S B Ma, T N Nguyen, I Tan, R Ninnis, S Iyer, D A Stroud, M Menard, R M Kluck, M T Ryan and G Dewson
http://www.nature.com/cdd/journal/v21/n12/abs/cdd2014119a.html?WT.ec_id=CDD-201412

The Functional Differences of Pro-survival and Pro-apoptotic B cell lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in their Bcl-2 Homology 3 (BH3) Domains
Erinna F. Lee, Grant Dewson, Marco Evangelista, Anne Pettikiriarachchi, Haoran Zhu, Peter M. Colman, and W. Douglas Fairlie
http://www.jbc.org/content/early/2014/11/03/jbc.M114.610758.abstract

Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells
K S R Sastry, M A Al-Muftah, Pu Li, M K Al-Kowari, E Wang, A Ismail Chouchane, D Kizhakayil, G Kulik, F M Marincola, A Haoudi and L Chouchane
http://www.nature.com/cdd/journal/v21/n12/abs/cdd2014140a.html?WT.ec_id=CDD-201412

Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer
A Zeuner, F Francescangeli, P Contavalli, G Zapparelli, T Apuzzo, A Eramo, M Baiocchi, M L De Angelis, M Biffoni, G Sette, M Todaro, G Stassi and R De Maria
http://www.nature.com/cdd/journal/v21/n12/abs/cdd2014105a.html?WT.ec_id=CDD-201412

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice
M J Herold, R Stuchbery, D Mérino, T Willson, A Strasser, D Hildeman and P Bouillet
http://www.nature.com/cddis/journal/v5/n10/abs/cddis2014409a.html?WT.ec_id=CDDIS-201410

Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation
H Huang, K Shah, N A Bradbury, C Li and C White
http://www.nature.com/cddis/journal/v5/n10/abs/cddis2014419a.html?WT.ec_id=CDDIS-201410

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Death receptors
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CD95 and CD95L promote and protect cancer stem cells
Paolo Ceppi, Abbas Hadji, Frederick J. Kohlhapp, Abhinandan Pattanayak, Annika Hau, Xia Liu, Huiping Liu, Andrea E. Murmann and Marcus E. Peter
http://www.nature.com/ncomms/2014/141104/ncomms6238/full/ncomms6238.html?WT.ec_id=NCOMMS-20141105

PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript
Tanya Todorova, Florian J. Bock and Paul Chang
http://www.nature.com/ncomms/2014/141110/ncomms6362/full/ncomms6362.html?WT.ec_id=NCOMMS-20141112

DICER1/Alu RNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration
Younghee Kim, Valeria Tarallo, Nagaraj Kerur, Tetsuhiro Yasuma, Bradley D. Gelfand, Ana Bastos-Carvalho, Yoshio Hirano, Reo Yasuma, Takeshi Mizutani, Benjamin J. Fowler, Shengjian Li, Hiroki Kaneko, Sasha Bogdanovich, Balamurali K. Ambati, David R. Hinton, William W. Hauswirth, Razqallah Hakem, Charles Wright, and Jayakrishna Ambati
http://www.pnas.org/content/111/45/16082.abstract.html?etoc

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Caspases
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Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome
Qi Hu, Di Wu, Wen Chen, Zhen Yan, Chuangye Yan, Tianxi He, Qionglin Liang, and Yigong Shi
http://www.pnas.org/content/111/46/16254.full

Metabolic control of Ca2+/Calmodulin-dependent protein kinase II (CaMKII)-mediated Caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A)
Bofu Huang, Chih-Sheng Yang, Jeffrey Wojton, Nai-Jia Huang, Chen Chen, Erik J. Soderblom, Liguo Zhang, and Sally Kornbluth
http://www.jbc.org/content/early/2014/11/04/jbc.M114.585844.abstract

Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns
S Yoon, S J Park, J H Han, J H Kang, J-h Kim, J Lee, S Park, H-J Shin, K Kim, M Yun and Y-J Chwae
http://www.nature.com/cddis/journal/v5/n10/abs/cddis2014450a.html?WT.ec_id=CDDIS-201410

Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells
Syeda Khadija , Rajakrishnan Veluthakal , Vaibhav Sidarala & Anjaneyulu Kowluru
http://link.springer.com/article/10.1007/s10495-014-1038-4?wt_mc=alerts.TOCjournals

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IAPs
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Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase
A Hamacher-Brady, S C Choe, J Krijnse-Locker and N R Brady
http://www.nature.com/cdd/journal/v21/n12/abs/cdd2014101a.html?WT.ec_id=CDD-201412

Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila
Q Huang, X Tang, G Wang, Y Fan, L Ray, A Bergmann, T Y Belenkaya, X Ling, D Yan, Y Lin, X Ye, W Shi, X Zhou, F Lu, J Qu and X Lin
http://www.nature.com/cdd/journal/v21/n12/abs/cdd2014115a.html?WT.ec_id=CDD-201412

cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation
A Marivin, J Berthelet, J Cartier, C Paul, S Gemble, A Morizot, W Boireau, M Saleh, J Bertoglio, E Solary and L Dubrez
http://www.nature.com/onc/journal/v33/n48/abs/onc2013499a.html?WT.ec_id=ONC-201411

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Non-apoptotic cell death
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Synchronized renal tubular cell death involves ferroptosis
Andreas Linkermann, Rachid Skouta, Nina Himmerkus, Shrikant R. Mulay, Christin Dewitz, Federica De Zen, Agnes Prokai, Gabriele Zuchtriegel, Fritz Krombach, Patrick-Simon Welz, Ricardo Weinlich, Tom Vanden Berghe, Peter Vandenabeele, Manolis Pasparakis, Markus Bleich, Joel M. Weinberg, Christoph A. Reichel, Jan Hinrich Bräsen, Ulrich Kunzendorf, Hans-Joachim Anders, Brent R. Stockwell, Douglas R. Green, and Stefan Krautwald
http://www.pnas.org/content/111/47/16836.abstract.html?etoc

Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells
V Derangère, A Chevriaux, F Courtaut, M Bruchard, H Berger, F Chalmin, S Z Causse, E Limagne, F Végran, S Ladoire, B Simon, W Boireau, A Hichami, L Apetoh, G Mignot, F Ghiringhelli and C Rébé
http://www.nature.com/cdd/journal/v21/n12/abs/cdd2014117a.html?WT.ec_id=CDD-201412

TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis
I Karl, M Jossberger-Werner, N Schmidt, S Horn, M Goebeler, M Leverkus, H Wajant and T Giner
http://www.nature.com/cddis/journal/v5/n10/abs/cddis2014404a.html?WT.ec_id=CDDIS-201410

Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma
K E McCabe, K Bacos, D Lu, J R Delaney, J Axelrod, M D Potter, M Vamos, V Wong, N D P Cosford, R Xiang and D G Stupack
http://www.nature.com/cddis/journal/v5/n10/abs/cddis2014448a.html?WT.ec_id=CDDIS-201410

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Miscellaneous
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RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Pratyusha Mandal, Scott B. Berger, Sirika Pillay, Kenta Moriwaki, Chunzi Huang, Hongyan Guo, John D. Lich, Joshua Finger, Viera Kasparcova, Bart Votta, Michael Ouellette, Bryan W. King, David Wisnoski, Ami S. Lakdawala, Michael P. DeMartino, Linda N. Casillas, Pamela A. Haile, Clark A. Sehon, Robert W. Marquis, Jason Upton, Lisa P. Daley-Bauer, Linda Roback, Nancy Ramia, Cole M. Dovey, Jan E. Carette, Francis Ka-Ming Chan, John Bertin, Peter J. Gough, Edward S. Mocarski, William J. Kaiser
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00831-4

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
Xiaqiong Wang, Wei Jiang, Yiqing Yan, Tao Gong, Jiahuai Han, Zhigang Tian & Rongbin Zhou
http://www.nature.com/ni/journal/v15/n12/full/ni.3015.html?WT.ec_id=NI-201412#close

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8+ T cells
P Duewell, A Steger, H Lohr, H Bourhis, H Hoelz, S V Kirchleitner, M R Stieg, S Grassmann, S Kobold, J T Siveke, S Endres and M Schnurr
http://www.nature.com/cdd/journal/v21/n12/abs/cdd201496a.html?WT.ec_id=CDD-201412

IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF‐κB retention
Evangelos Pazarentzos, Anne‐Laure Mahul‐Mellier, Christoph Datler, Wanwisa Chaisaklert, Ming‐Shih Hwang, Jan Kroon, Ding Qize, Foy Osborne, Abdullah Al‐Rubaish, Amein Al‐Ali, Nicholas D Mazarakis, Eric O Aboagye, and Stefan Grimm
http://EMBOJ.embopress.org/content/33/23/2814?etoc

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Reviews / previews
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The Two Faces of Receptor Interacting Protein Kinase-1
Ricardo Weinlich, Douglas R. Green
http://www.cell.com/molecular-cell/fulltext/S1097-2765(14)00866-1

A new kind of cell suicide: mechanisms and functions of programmed necrosis
Liming Sun, Xiaodong Wang
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(14)00185-6

Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
Elkholi  R, Renault  TT, Serasinghe  MN, Chipuk  JE
http://www.cancerandmetabolism.com/content/2/1/16

Regulated cell death and inflammation: an auto-amplification loop causes organ failure.
Linkermann A, Stockwell BR, Krautwald S, Anders HJ.
http://www.nature.com/nri/journal/v14/n11/full/nri3743.html

Senescence and apoptosis: dueling or complementary cell fates?
Bennett G Childs, Darren J Baker, James L Kirkland, Judith Campisi, and Jan M van Deursen
http://embor.embopress.org/content/15/11/1139?etoc

Revisiting caspases in sepsis
M Aziz, A Jacob and P Wang
http://www.nature.com/cddis/journal/v5/n11/abs/cddis2014488a.html?WT.ec_id=CDDIS-201411

Pores of No Return
David W. Andrews
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00870-3

The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3
Manira Rayamajhi and Edward A Miao
http://www.nature.com/ni/journal/v15/n12/full/ni.3030.html?WT.ec_id=NI-201412

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