ApoList – November 2014

Bcl-2 family members

Structural Model of Active Bax at the Membrane
Stephanie Bleicken, Gunnar Jeschke, Carolin Stegmueller, Raquel Salvador-Gallego, Ana J. García-Sáez, Enrica Bordignon

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1
Richard G. Carroll, Emilie Hollville, Seamus J. Martin

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function
S B Ma, T N Nguyen, I Tan, R Ninnis, S Iyer, D A Stroud, M Menard, R M Kluck, M T Ryan and G Dewson

The Functional Differences of Pro-survival and Pro-apoptotic B cell lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in their Bcl-2 Homology 3 (BH3) Domains
Erinna F. Lee, Grant Dewson, Marco Evangelista, Anne Pettikiriarachchi, Haoran Zhu, Peter M. Colman, and W. Douglas Fairlie

Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells
K S R Sastry, M A Al-Muftah, Pu Li, M K Al-Kowari, E Wang, A Ismail Chouchane, D Kizhakayil, G Kulik, F M Marincola, A Haoudi and L Chouchane

Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer
A Zeuner, F Francescangeli, P Contavalli, G Zapparelli, T Apuzzo, A Eramo, M Baiocchi, M L De Angelis, M Biffoni, G Sette, M Todaro, G Stassi and R De Maria

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice
M J Herold, R Stuchbery, D Mérino, T Willson, A Strasser, D Hildeman and P Bouillet

Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation
H Huang, K Shah, N A Bradbury, C Li and C White

Death receptors

CD95 and CD95L promote and protect cancer stem cells
Paolo Ceppi, Abbas Hadji, Frederick J. Kohlhapp, Abhinandan Pattanayak, Annika Hau, Xia Liu, Huiping Liu, Andrea E. Murmann and Marcus E. Peter

PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript
Tanya Todorova, Florian J. Bock and Paul Chang

DICER1/Alu RNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration
Younghee Kim, Valeria Tarallo, Nagaraj Kerur, Tetsuhiro Yasuma, Bradley D. Gelfand, Ana Bastos-Carvalho, Yoshio Hirano, Reo Yasuma, Takeshi Mizutani, Benjamin J. Fowler, Shengjian Li, Hiroki Kaneko, Sasha Bogdanovich, Balamurali K. Ambati, David R. Hinton, William W. Hauswirth, Razqallah Hakem, Charles Wright, and Jayakrishna Ambati


Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome
Qi Hu, Di Wu, Wen Chen, Zhen Yan, Chuangye Yan, Tianxi He, Qionglin Liang, and Yigong Shi

Metabolic control of Ca2+/Calmodulin-dependent protein kinase II (CaMKII)-mediated Caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A)
Bofu Huang, Chih-Sheng Yang, Jeffrey Wojton, Nai-Jia Huang, Chen Chen, Erik J. Soderblom, Liguo Zhang, and Sally Kornbluth

Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns
S Yoon, S J Park, J H Han, J H Kang, J-h Kim, J Lee, S Park, H-J Shin, K Kim, M Yun and Y-J Chwae

Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells
Syeda Khadija , Rajakrishnan Veluthakal , Vaibhav Sidarala & Anjaneyulu Kowluru


Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase
A Hamacher-Brady, S C Choe, J Krijnse-Locker and N R Brady

Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila
Q Huang, X Tang, G Wang, Y Fan, L Ray, A Bergmann, T Y Belenkaya, X Ling, D Yan, Y Lin, X Ye, W Shi, X Zhou, F Lu, J Qu and X Lin

cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation
A Marivin, J Berthelet, J Cartier, C Paul, S Gemble, A Morizot, W Boireau, M Saleh, J Bertoglio, E Solary and L Dubrez

Non-apoptotic cell death

Synchronized renal tubular cell death involves ferroptosis
Andreas Linkermann, Rachid Skouta, Nina Himmerkus, Shrikant R. Mulay, Christin Dewitz, Federica De Zen, Agnes Prokai, Gabriele Zuchtriegel, Fritz Krombach, Patrick-Simon Welz, Ricardo Weinlich, Tom Vanden Berghe, Peter Vandenabeele, Manolis Pasparakis, Markus Bleich, Joel M. Weinberg, Christoph A. Reichel, Jan Hinrich Bräsen, Ulrich Kunzendorf, Hans-Joachim Anders, Brent R. Stockwell, Douglas R. Green, and Stefan Krautwald

Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells
V Derangère, A Chevriaux, F Courtaut, M Bruchard, H Berger, F Chalmin, S Z Causse, E Limagne, F Végran, S Ladoire, B Simon, W Boireau, A Hichami, L Apetoh, G Mignot, F Ghiringhelli and C Rébé

TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis
I Karl, M Jossberger-Werner, N Schmidt, S Horn, M Goebeler, M Leverkus, H Wajant and T Giner

Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma
K E McCabe, K Bacos, D Lu, J R Delaney, J Axelrod, M D Potter, M Vamos, V Wong, N D P Cosford, R Xiang and D G Stupack


RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Pratyusha Mandal, Scott B. Berger, Sirika Pillay, Kenta Moriwaki, Chunzi Huang, Hongyan Guo, John D. Lich, Joshua Finger, Viera Kasparcova, Bart Votta, Michael Ouellette, Bryan W. King, David Wisnoski, Ami S. Lakdawala, Michael P. DeMartino, Linda N. Casillas, Pamela A. Haile, Clark A. Sehon, Robert W. Marquis, Jason Upton, Lisa P. Daley-Bauer, Linda Roback, Nancy Ramia, Cole M. Dovey, Jan E. Carette, Francis Ka-Ming Chan, John Bertin, Peter J. Gough, Edward S. Mocarski, William J. Kaiser

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
Xiaqiong Wang, Wei Jiang, Yiqing Yan, Tao Gong, Jiahuai Han, Zhigang Tian & Rongbin Zhou

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8+ T cells
P Duewell, A Steger, H Lohr, H Bourhis, H Hoelz, S V Kirchleitner, M R Stieg, S Grassmann, S Kobold, J T Siveke, S Endres and M Schnurr

IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF‐κB retention
Evangelos Pazarentzos, Anne‐Laure Mahul‐Mellier, Christoph Datler, Wanwisa Chaisaklert, Ming‐Shih Hwang, Jan Kroon, Ding Qize, Foy Osborne, Abdullah Al‐Rubaish, Amein Al‐Ali, Nicholas D Mazarakis, Eric O Aboagye, and Stefan Grimm

Reviews / previews

The Two Faces of Receptor Interacting Protein Kinase-1
Ricardo Weinlich, Douglas R. Green

A new kind of cell suicide: mechanisms and functions of programmed necrosis
Liming Sun, Xiaodong Wang

Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
Elkholi  R, Renault  TT, Serasinghe  MN, Chipuk  JE

Regulated cell death and inflammation: an auto-amplification loop causes organ failure.
Linkermann A, Stockwell BR, Krautwald S, Anders HJ.

Senescence and apoptosis: dueling or complementary cell fates?
Bennett G Childs, Darren J Baker, James L Kirkland, Judith Campisi, and Jan M van Deursen

Revisiting caspases in sepsis
M Aziz, A Jacob and P Wang

Pores of No Return
David W. Andrews

The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3
Manira Rayamajhi and Edward A Miao