ApoList – October 2014

Bcl-2 family proteins

Blm-s, a BH3-Only Protein Enriched in Postmitotic Immature Neurons, Is Transcriptionally Upregulated by p53 during DNA Damage
Wei-Wen Liu, Shih-Yu Chen, Chia-Hsien Cheng, Hwai-Jong Cheng, Pei-Hsin Huang

Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis
Xian Jiang, Hui Jiang, Zhirong Shen, and Xiaodong Wang

Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury.
Pfeiffer S, Anilkumar U, Chen G, Ramírez-Peinado S, Galindo-Moreno J, Muñoz-Pinedo C, Prehn JH

Interaction of Leukocyte Elastase Inhibitor/L-DNase II with BCL-2 and BAX
Imène Jaadane, Atf Nagbou, Francine Behar-Cohen, Alicia Torriglia

Conformational Rearrangements in the Pro-Apoptotic Protein, Bax, as it inserts into mitochondria: A Cellular Death Switch
Robert F. Gahl, Yi He, Shiqin Yu, and Nico Tjandra

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3
M N Koenig, E Naik, L Rohrbeck, M J Herold, E Trounson, P Bouillet, T Thomas, A K Voss, A Strasser and L Coultas

A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis
Shuang Chen, Yu Zhang, Liang Zhou, Yun Leng, Hui Lin, Maciej Kmieciak, Xin-Yan Pei, Richard Jones, Robert Z. Orlowski, Yun Dai, and Steven Grant

Hsp27 binding to the 3′UTR of bim mRNA prevents neuronal death during oxidative stress–induced injury: a novel cytoprotective mechanism
David Dávila, Eva M. Jiménez-Mateos, Claire M. Mooney, Guillermo Velasco, David C. Henshall, and Jochen H. M. Prehn

Bim regulation miRrors microRNA 17~92 cluster expression in endothelial cells in vivo
X W Meng and S H Kaufmann

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity
Ivan Cherh Chiet Low, Thomas Loh, Yiqing Huang, David M. Virshup, and Shazib Pervaiz

Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice
L Gangoda, M Doerflinger, R Srivastava, N Narayan, L E Edgington, J Orian, C Hawkins, L A O’Reilly, H Gu, M Bogyo, P Ekert, A Strasser and H Puthalakath

Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation
S E Lindner, M Wissler, A Gründer, K Aumann, E Ottina, L Peintner, P Brauns-Schubert, F Preiss, S Herzog, C Borner, C Charvet, A Villunger, H L Pahl and U Maurer

Death receptors and FADD

HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death
Nieves Peltzer, Eva Rieser, Lucia Taraborrelli, Peter Draber, Maurice Darding, Barbara Pernaute, Yutaka Shimizu, Aida Sarr, Helena Draberova, Antonella Montinaro, Juan Pedro Martinez-Barbera, John Silke, Tristan A. Rodriguez, Henning Walczak

Piwil2 Inhibits Keratin 8 Degradation through Promoting p38-Induced Phosphorylation To Resist Fas-Mediated Apoptosis
Siyuan Jiang, Lianfang Zhao, Yilu Lu, Meiling Wang, Yuan Chen, Dachang Tao, Yunqiang Liu, Huaqin Sun, Sizhong Zhang, and Yongxin Ma

DAPK2 is a novel modulator of TRAIL-induced apoptosis
C R Schlegel, A-V Fonseca, S Stöcker, M L Georgiou, M B Misterek, C E Munro, C R Carmo, M J Seckl and A P Costa-Pereira

Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout
H Ehlken, S Krishna-Subramanian, L Ochoa-Callejero, V Kondylis, N E Nadi, B K Straub, P Schirmacher, H Walczak, G Kollias and M Pasparakis


RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis
Conor J. Kearney, Sean P. Cullen, Danielle Clancy and Seamus J. Martin

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
Joanne M. Hildebrand, Maria C. Tanzer, Isabelle S. Lucet, Samuel N. Young, Sukhdeep K. Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick C. J. Dobson, Andrew I. Webb, Anne Tripaydonis, Jeffrey J. Babon, Mark D. Mulcair, Martin J. Scanlon, Warren S. Alexander, Andrew F. Wilks, Peter E. Czabotar, Guillaume Lessene, James M. Murphy, and John Silke

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis
Justine E. Roderick, Nicole Hermance, Matija Zelic, Matthew J. Simmons, Apostolos Polykratis, Manolis Pasparakis, and Michelle A. Kelliher

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis
X-N Wu, Z-H Yang, X-K Wang, Y Zhang, H Wan, Y Song, X Chen, J Shao and J Han

Caspases and IAPs

Caspase Cleavage Sites in the Human Proteome: CaspDB, a Database of Predicted Substrates
Sonu Kumar, Bram J. van Raam, Guy S. Salvesen, Piotr Cieplak

Proteinase 3–dependent caspase-3 cleavage modulates neutrophil death and inflammation
Fabien Loison, Haiyan Zhu, Kutay Karatepe, Anongnard Kasorn, Peng Liu, Keqiang Ye, Jiaxi Zhou, Shannan Cao, Haiyan Gong, Dieter E. Jenne, Eileen Remold-O’Donnell, Yuanfu Xu, Hongbo R. Luo

Mitochondrial pro-apoptotic indices do not precede the transient caspase activation associated with myogenesis
Darin Bloemberg, Joe Quadrilatero

HIV-1 Vpu induces caspase-mediated cleavage of IRF3
Sang Yoon Park, Abdul A. Waheed, Zai-Rong Zhang, Eric O. Freed, and Juan S. Bonifacino

BID‐dependent release of mitochondrial SMAC dampens XIAP‐mediated immunity against Shigella
Maria Andree, Jens M Seeger, Stephan Schüll, Oliver Coutelle, Diana  Wagner‐Stippich, Katja Wiegmann, Claudia M Wunderlich, Kerstin Brinkmann, Pia Broxtermann, Axel Witt, Melanie Fritsch, Paola Martinelli, Harald ielig, Tobias Lamkemeyer, Elena I Rugarli, Thomas Kaufmann, Anja Sterner‐Kock, F Thomas Wunderlich, Andreas Villunger, L Miguel Martins, Martin Krönke, Thomas A Kufer, Olaf Utermöhlen, and Hamid Kashkar


An authentic imaging probe to track cell fate from beginning to end
Seung Koo Lee, Luke J. Mortensen, Charles P. Lin and Ching-Hsuan Tung

Mitochondrial Ca2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction
M-S Hwang, C T Schwall, E Pazarentzos, C Datler, N N Alder and S Grimm

CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition
Y Murakami, L Tian, O H Voss, D H Margulies, K Krzewski and J E Coligan

Depletion of the central metabolite NAD leads to oncosis mediated cell death
Christopher Del Nagro, Yang Xiao, Linda Rangell, Mike Reichelt, and Thomas O’Brien

Reviews / previews / other

Regulated Cell Death: Signaling and Mechanisms
Avi Ashkenazi and Guy Salvesen

Mitochondria: from cell death executioners to regulators of cell differentiation
Atsuko Kasahara, Luca Scorrano

Cancer stem cells – important players in tumor therapy resistance
Selcuk Colak and Jan P. Medema

Cell death: RIPK1 protects epithelial cells
Addendum: Cell death: RIPK1 protects epithelial cells

JOURNAL CLUB – The physiological relevance of death receptor-mediated apoptosis
Andreas Strasser describes the first paper to outline a physiological role for apoptosis downstream of the death receptor FAS in lpr mice.

The BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with chronic myeloid leukemia
Xue Chen, Hongxing Liu, Haizhou Xing, Hui Sun and Ping Zhu
Reply: The BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with chronic myeloid leukemia
S Tiong Ong, Charles T H Chuah, Tun Kiat Ko, Axel M Hillmer and Wan-Teck Lim