ApoList – September 2014

Bcl-2 family proteins

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane
Dana Westphal, Grant Dewson, Marie Menard, Paul Frederick, Sweta Iyer, Ray Bartolo, Leonie Gibson, Peter E. Czabotar, Brian J. Smith, Jerry M. Adams, and Ruth M. Kluck

BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues
Nathiya Muthalagu, Melissa R. Junttila, Katrin E. Wiese, Elmar Wolf, Jennifer Morton, Barbara Bauer, Gerard I. Evan, Martin Eilers, Daniel J. Murphy

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers
Jason M. Brouwer, Dana Westphal, Grant Dewson, Adeline Y. Robin, Rachel T. Uren, Ray Bartolo, Geoff V. Thompson, Peter M. Colman, Ruth M. Kluck, Peter E. Czabotar

MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM
Barbara Pernaute, Thomas Spruce, Kimberley M. Smith, Juan Miguel Sánchez-Nieto, Miguel Manzanares, Bradley Cobb, and Tristan A. Rodríguez

Small-molecule Bax agonists for cancer therapy
Meiguo Xin, Rui Li, Maohua Xie, Dongkyoo Park, Taofeek K. Owonikoko, Gabriel L. Sica, Patrick E. Corsino, Jia Zhou, Chunyong Ding, Mark A. White, Andrew T. Magis, Suresh S. Ramalingam, Walter J. Curran, Fadlo R. Khuri and Xingming Deng

T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity
Megan L Burger, Kenneth K Leung, Margaux J Bennett, Astar Winoto

Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199
Triona Ni Chonghaile, Justine E. Roderick, Cian Glenfield, Jeremy Ryan, Stephen E. Sallan, Lewis B. Silverman, Mignon L. Loh, Stephen P. Hunger,Brent Wood, Daniel J. DeAngelo, Richard Stone, Marian Harris, Alejandro Gutierrez, Michelle A. Kelliher, and Anthony Letai

The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin
P Geserick, J Wang, M Feoktistova and M Leverkus

Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer
Y Loriot, P Mordant, D Dugue, O Geneste, A Gombos, P Opolon, J Guegan, J-L Perfettini, A Pierre, L K Berthier, G Kroemer, J C Soria, S Depil and E Deutsch

Syk Interacts with and Phosphorylates Nucleolin To Stabilize Bcl-xL mRNA and Promote Cell Survival
Wen-Horng Wang, Michael O. Childress, and Robert L. Geahlen

The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the β-TrCP homologue slimb
Jessie Colin , Julie Garibal , Amandine Clavier , Aurore Rincheval-Arnold , Sébastien Gaumer , Bernard Mignotte & Isabelle Guénal

Genome‐wide siRNA screen reveals coupling between mitotic apoptosis and adaptation
Laura A Díaz‐Martínez, Zemfira N Karamysheva, Ross Warrington, Bing Li,  Shuguang Wei, Xian‐Jin Xie, Michael G Roth, and Hongtao Yu

RIP kinases

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
Nozomi Takahashi, Lars Vereecke, Mathieu J. M. Bertrand, Linde Duprez, Scott B. Berger, Tatyana Divert, Amanda Gonçalves, Mozes Sze, Barbara Gilbert, Stephanie Kourula, Vera Goossens, Sylvie Lefebvre, Claudia Günther, Christoph Becker, John Bertin, Peter J. Gough, Wim Declercq, Geert van Loo & Peter Vandenabeele

RIPK1- and RIPK3-induced cell death mode is determined by target availability
W D Cook, D M Moujalled, T J Ralph, P Lock, S N Young, J M Murphy and D L Vaux

RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage
A-L Nugues, H El Bouazzati, D Hétuin, C Berthon, A Loyens, E Bertrand, N Jouy, T Idziorek and B Quesnel

Death receptors

TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells
M H Tuthill, A Montinaro, J Zinngrebe, K Prieske, P Draber, S Prieske, T Newsom-Davis, S von Karstedt, J Graves and H Walczak

NF-κB-inducing Kinase (NIK) Contains an Amino Terminal Inhibitor of Apoptosis (IAP) Binding Motif (IBM) that Potentiates NIK Degradation by c-IAP1
Sunhee Lee, Madhavi Challa-Malladi, Shawn B. Bratton, and Casey W. Wright

Pigment epithelial-derived factor(PEDF)-triggered lung cancer cell apoptosis relies on a p53-driven Fas-L up-regulation and Fas cell surface translocation
Lei Li, Ya-Chao Yao, Shu-Huan Fang, Cai-Qi Ma, Yi Cen, Zu-Min Xu, Zhi-Yu Dai, Cen Li, Shuai Li, Ting Zhang, Hong-Hai Hong, Wei-Wei Qi, Ti Zhou, Chao-Yang Li, Xia Yang, and Guo-Quan Gao


Glucose metabolism is inhibited by caspases upon the induction of apoptosis
L A Pradelli, E Villa, B Zunino, S Marchetti and J-E Ricci

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming
Ramanjaneyulu Allam, Kate E Lawlor, Eric Chi‐Wang Yu, Alison L Mildenhall, Donia M Moujalled, Rowena S Lewis, Francine Ke, Kylie D Mason, Michael J White, Katryn J Stacey, Andreas Strasser, Lorraine A O’Reilly, Warren Alexander, Benjamin T Kile, David L Vaux, and James E Vince

A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8–induced IL-1
Matija Hedl and Clara Abraham

An unexpected role for caspase-2 in neuroblastoma
L Dorstyn, J Puccini, A Nikolic, S Shalini, C H Wilson, M D Norris, M Haber and S Kumar

Non-apoptotic functions of caspase-7 during osteogenesis
E Svandova, H Lesot, T Vanden Berghe, A S Tucker, P T Sharpe, P Vandenabeele and E Matalova

FANCD2 is a target for caspase 3 during DNA damage-induced apoptosis
Wataru Sakai, Kaoru Sugasawa


Neuronal necrosis is regulated by a conserved chromatin-modifying cascade
Kai Liu, Lianggong Ding, Yuhong Li, Hui Yang, Chunyue Zhao, Ye Lei, Shuting Han, Wei Tao, Dengshun Miao, Hermann Steller, Michael J. Welsh, and Lei Liu

A cell suicide module: Auxin-induced rapid degradation of Inhibitor of Caspase Activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation and cell death
Kumiko Samejima, Hiromi Ogawa, Alexander V. Ageichik, Kevin L Peterson, Scott H. Kaufmann, Masato T. Kanemaki, and William C. Earnshaw

Stabilization of apoptotic cells: generation of zombie cells
M Oropesa-Ávila, Y Andrade-Talavera, J Garrido-Maraver, M D Cordero, M de la Mata, D Cotán, M V Paz, A D Pavón, E Alcocer-Gómez, I de Lavera, R Lema, A P Zaderenko, A Rodríguez-Moreno and J A Sánchez-Alcázar

Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models
Mareike Florek, Emanuela I. Sega, Dennis B. Leveson-Gower, Jeanette Baker, Antonia M. S. Müller, Dominik Schneidawind, Everett Meyer, and Robert S. Negrin

Exposure of phosphatidylserine by Xk-related protein family members during apoptosis
Jun Suzuki, Eiichi Imanishi, and Shigekazu Nagata


Metabolic control of cell death
Douglas R. Green, Lorenzo Galluzzi, Guido Kroemer

X-Linked Inhibitor of Apoptosis Protein – A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer Therapy
Petra Obexer and Michael J. Ausserlechner

Autophagy as initiator or executioner of cell death
[in plants]
Elena A. Minina, Peter V. Bozhkov, Daniel Hofius

Compartmentalization of TNF-related apoptosis-inducing ligand (TRAIL) death receptor functions: emerging role of nuclear TRAIL-R2
U Bertsch, C Röder, H Kalthoff and A Trauzold

Previews / other

Stop competing, start talking!
Luca L Fava and Andreas Villunger

What Makes You Can also Break You, Part III: Mitochondrial Permeability Transition Pore Formation by an Uncoupling Channel within the C-Subunit Ring of the F1FO ATP Synthase?
Christos Chinopoulos and Gyorgy Szabadkai

The C Ring of the F1Fo ATP Synthase Forms the Mitochondrial Permeability Transition Pore: A Critical Appraisal
Andrew Philip Halestrap

RIP kinase 3 in necroptosis: does it take two or more to kill?
C Kim and M Pasparakis

ABT-199 Shows Effectiveness in CLL