ApoList – August 2014

Bcl-2 family proteins

Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy
Emilie Hollville, Richard G. Carroll, Sean P. Cullen, Seamus J. Martin

BH3 Mimetics Demonstrate Differential Activities Dependent Upon the Functional Repertoire of Pro- and Anti-Apoptotic BCL-2 Family Proteins
Thibaud Thierry Renault, Rana Elkholi, Archana Bharti, and Jerry Edward Chipuk

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells
Priyanka Sathe, Rebecca B. Delconte, Fernando Souza-Fonseca-Guimaraes, Cyril Seillet, Michael Chopin, Cassandra J. Vandenberg, Lucille C. Rankin, Lisa A. Mielke, Ingela Vikstrom, Tatiana B. Kolesnik, Sandra E. Nicholson, Eric Vivier, Mark J. Smyth, Stephen L. Nutt, Stefan P. Glaser, Andreas Strasser, Gabrielle T. Belz, Sebastian Carotta and Nicholas D. Huntington

Bim is a crucial regulator of apoptosis induced by Mycobacterium tuberculosis
N Aguiló, S Uranga, D Marinova, C Martín and J Pardo

Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin
R A Charan, B N Johnson, S Zaganelli, J D Nardozzi and M J LaVoie

Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S
Hengyou Weng, Huilin Huang, Bowen Dong, Panpan Zhao, Hui Zhou, and Lianghu Qu

Estrogen Regulation of Anti-Apoptotic Bcl-2 Family Member Mcl-1 Expression in Breast Cancer Cells
Jennifer L. Schacter, Elizabeth S. Henson, Spencer B. Gibson

Clinical Profiling of BCL-2 Family Members in the Setting of BRAF Inhibition Offers a Rationale for Targeting De Novo Resistance Using BH3 Mimetics
Dennie T. Frederick, Roberto A. Salas Fragomeni, Aislyn Schalck, Isabel Ferreiro-Neira, Taylor Hoff, Zachary A. Cooper, Rizwan Haq, David J. Panka, Lawrence N. Kwong, Michael A. Davies, James C. Cusack, Keith T. Flaherty, David E. Fisher, James W. Mier, Jennifer A. Wargo, Ryan J. Sullivan

Death receptors

D-Cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and Its Ligand FasL
Yoon Jong Choi, Borja Saez, Lars Anders, Per Hydbring, Joanna Stefano, Nickolas A. Bacon, Colleen Cook, Ilona Kalaszczynska, Sabina Signoretti, Richard A. Young, David T. Scadden, Piotr Sicinski

Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity
Jonathan D. Graves, Jennifer J. Kordich, Tzu-Hsuan Huang, Julia Piasecki, Tammy L. Bush, Timothy Sullivan, Ian N. Foltz, Wesley Chang, Heather Douangpanya, Thu Dang, Jason W. O’Neill, Rommel Mallari, Xiaoning Zhao, Daniel G. Branstetter, John M. Rossi, Alexander M. Long, Xin Huang, Pamela M. Holland

Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ
C Bersani, L-D Xu, A Vilborg, W-O Lui and K G Wiman


Ubiquitin‐dependent regulation of MEKK2/3‐MEK5‐ERK5 signaling module by XIAP and cIAP1
Armelle‐Natsuo Takeda, Tripat Kaur Oberoi‐Khanuja, Gabor Glatz, KatharinaSchulenburg, Rolf‐Peter Scholz, Alejandro Carpy, Boris Macek, Attila Remenyi, and Krishnaraj Rajalingam

FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis
Rana S. Moubarak, Laura Planells-Ferrer, Jorge Urresti, Stéphanie Reix, Miguel F. Segura, Paulina Carriba, Fernando Marqués-Fernàndez, Carme Sole, Nuria Llecha-Cano, Joaquin Lopez-Soriano, Daniel Sanchis, Victor J. Yuste, and Joan X. Comella

The Ubiquitin-Associated Domain of Cellular Inhibitor of Apoptosis Proteins Facilitates Ubiquitylation
Rhesa Budhidarmo and Catherine L. Day

Non-Canonical Roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in Epithelial Tube Size Control
Renée M. Robbins, Samantha C. Gbur, Greg J. Beitel


A systems biological analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation
Maximilian Ludwig Würstle and Markus Rehm

Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates
M Poreba, P Kasperkiewicz, S J Snipas, D Fasci, G S Salvesen and M Drag

Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response
Ting Liu, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Koichi Shikada, Mai Yamagishi, Katsuaki Hoshino, Tsuneyasu Kaisho, Kiwamu Takemoto, Toshihiko Suzuki, Erina Kuranaga, Osamu Ohara, Masayuki Miura

Inflammatory caspases are innate immune receptors for intracellular LPS
Jianjin Shi, Yue Zhao, Yupeng Wang, Wenqing Gao, Jingjin Ding, Peng Li, Liyan Hu & Feng Shao

Chromatin collapse during caspase-dependent apoptotic cell death requires DNA fragmentation factor, 40-kDa subunit-/caspase-activated deoxyribonuclease-mediated 3′-OH single-strand DNA breaks.
Iglesias-Guimarais V1, Gil-Guiñon E, Sánchez-Osuna M, Casanelles E, García-Belinchón M, Comella JX, Yuste VJ


RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
Marius Dannappel, Katerina Vlantis, Snehlata Kumari, Apostolos Polykratis, Chun Kim, Laurens Wachsmuth, Christina Eftychi, Juan Lin, Teresa Corona, Nicole Hermance, Matija Zelic, Petra Kirsch, Marijana Basic, Andre Bleich, Michelle Kelliher & Manolis Pasparakis

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD
Kenji Mizumura, Suzanne M. Cloonan, Kiichi Nakahira, Abhiram R. Bhashyam, Morgan Cervo, Tohru Kitada, Kimberly Glass, Caroline A. Owen, Ashfaq Mahmood, George R. Washko, Shu Hashimoto, Stefan W. Ryter, Augustine M. K. Choi

Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals
A Maeda and B Fadeel

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages
Scott McComb, Erin Cessford, Norah A. Alturki, Julie Joseph, Bojan Shutinoski, Justyna B. Startek, Ana M. Gamero, Karen L. Mossman, and Subash Sad

Non-apoptotic cell death

Transmissible cytotoxicity of multiple myeloma cells by cord blood-derived NK cells is mediated by vesicle trafficking
Beatriz Martin-Antonio, A Najjar, S N Robinson, C Chew, S Li, E Yvon, M W Thomas, I Mc Niece, R Orlowski, C Muñoz-Pinedo, C Bueno, P Menendez, C Fernández de Larrea, A Urbano-Ispizua, E J Shpall and N Shah

A Receptor-interacting Protein 1 (Rip1) Independent Necrotic Death Under The Control Of Protein Phosphatase Pp2a That Involves The Reorganization Of Actin Cytoskeleton And The Action Of Cofilin-1
Andrea Tomasella, Anne Blangy, and Claudio Brancolini

2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53
Paolo Mattiolo, Ares Barbero-Farran, Víctor J. Yuste, Jacint Boix, Judit Ribas


The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: functional linkage with autophagy
Nuria S Coll, A Smidler, M Puigvert, C Popa, M Valls and J L Dangl

Expression of Animal Anti-Apoptotic Gene Ced-9 Enhances Tolerance during Glycine max L.–Bradyrhizobium japonicum Interaction under Saline Stress but Reduces Nodule Formation
Germán Robert, Nacira Muñoz, Mariana Melchiorre, Federico Sánchez, Ramiro Lascano

Discovering Protein-Protein Interactions within the Programmed Cell Death Network Using a Protein-Fragment Complementation Screen
Yuval Gilad, Ruth Shiloh, Yaara Ber, Shani Bialik, Adi Kimchi

Apoptotic Neutrophils Augment the Inflammatory Response to Mycobacterium tuberculosis Infection in Human Macrophages
Henrik Andersson, Blanka Andersson, Daniel Eklund, Eyler Ngoh, Alexander Persson, Kristoffer Svensson, Maria Lerm, Robert Blomgran, Olle Stendahl

Protein C Inhibitor (PCI) Binds to Phosphatidylserine Exposing Cells with Implications in the Phagocytosis of Apoptotic Cells and Activated Platelets
Daniela Rieger, Alice Assinger, Katrin Einfinger, Barbora Sokolikova, Margarethe Geiger

Reviews / editorials

Getting TRAIL back on track for cancer therapy
J Lemke, S von Karstedt, J Zinngrebe and H Walczak

Organelle-specific initiation of cell death  
Lorenzo Galluzzi, Jose Manuel Bravo-San Pedro and Guido Kroemer

Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression
Cassandra L. Buchheit, Kelsey J. Weigel & Zachary T. Schafer

Comments / other

Autosis: a new addition to the cell death tower of babel
Cristina Muñoz-Pinedo and Seamus J Martin

BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy
Lisa M Lindqvist and David L Vaux

Anti-tubulins DEPendably induce apoptosis  
Daniel P. Denning and Takashi Hirose

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA
M J Herold, L A O’Reilly, A Lin, R Srivastava, M Doerflinger, P Bouillet, A Strasser and H Puthalakath

ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade
Aileen M Klein and Melanie H Cobb

A common signalosome for programmed cell death in humans and plants
J Martínez-Fábregas, I Díaz-Moreno, K González-Arzola, A Díaz-Quintana and M A De la Rosa

Caspases Regulate Phosphatidylserine Flippases During Apoptosis

Parkin Can Promote Apoptosis


ApoList – July 2014

Bcl-2 family proteins

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein
Misook Oh, Ji Hoon Lee, Wei Wang, Hui Sun Lee, Woo Sirl Lee, Christopher Burlak, Wonpil Im, Quyen Q. Hoang, and Hyun-Suk Lim

Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis
Seaho Kim, Jiahong Yao, Kimita Suyama, Xia Qian, Bin-Zhi Qian, Sanmay Bandyopadhyay, Olivier Loudig, Carlos De Leon-Rodriguez, Zhen Ni Zhou, Jeffrey Segall, Fernando Macian, Larry Norton, and Rachel B. Hazan

Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage
Kazuya Nakazawa, Nurmaa Dashzeveg and Kiyotsugu Yoshida

Hypoxia-inducible regulation of placental BOK expression
Daochun Luo, Isabella Caniggia and Martin Post

Death Receptors

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
Min Lu1, David A. Lawrence, Scot Marsters, Diego Acosta-Alvear, Philipp Kimmig, Aaron S. Mendez, Adrienne W. Paton, James C. Paton, Peter Walter, Avi Ashkenazi

Evolution of TNF-induced apoptosis reveals 550 My of functional conservation
Steven D. Quistad, Aleksandr Stotland, Katie L. Barott, Cameron A. Smurthwaite, Brett Jameson Hilton, Juris A. Grasis, Roland Wolkowicz, and Forest L. Rohwer

Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis
T He, S Haapa-Paananen, V O Kaminskyy, P Kohonen, V Fey, B Zhivotovsky, O Kallioniemi and M Perälä

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening
Sireesha V Garimella, Kristie Gehlhaus, Jennifer L Dine, Jason J Pitt, Magdalena Grandin, Sirisha Chakka, Marion M Nau, Natasha J Caplen and Stanley Lipkowitz

Caspases and downstream, IAPs

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.
Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O’Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE.

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma
Wei Chi, Fei Li, Hongrui Chen, Yandong Wang, Yingting Zhu, Xuejiao Yang, Jie Zhu, Frances Wu, Hong Ouyang, Jian Ge, Robert N. Weinreb, Kang Zhang, and Yehong Zhuo

Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise
Andreas Flütsch, Rafael Ackermann, Thilo Schroeder, Maria Lukarska, Georg J. Hausammann, Christopher Weinert, Christophe Briand and Markus G. Grütter

Anamorsin, a novel caspase-3 substrate in neurodegeneration
Nuri Yun, Young Mook Lee, Chiho Kim, Hirohiko Shibayama, Akira Tanimura, Yuri Hamanaka, Yuzuru Kanakura, Il-Seon Park, Areum Jo, Joo-Ho Shin, Chung Ju, Won-Ki Kim, and Young J. Oh

Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly
Katharina Belz, Hannah Schoeneberger, Sibylle Wehner, Andreas Weigert, Halvard Bönig, Thomas Klingebiel, Iduna Fichtner, and Simone Fulda


An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore
Kambiz N. Alavian, Gisela Beutner, Emma Lazrove, Silvio Sacchetti, Han-A Park, Pawel Licznerski, Hongmei Li, Panah Nabili, Kathryn Hockensmith, Morven Graham, George A. Porter, Jr., and Elizabeth A. Jonas

Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis
Martinez-Fabregas, J; Diaz-Moreno, I; Gonzalez-Arzola, K; Janocha, S; Navarro, JA; Hervas, M; Bernhardt, R; Velazquez-Campoy, A; Diaz-Quintana, A; De la Rosa, MA

Multiple Mechanisms Modulate Distinct Cellular Susceptibilities toward Apoptosis in the Developing Drosophila Eye
Yun Fan2email, Andreas Bergmann


Regulating cell death at, on, and in membranes
Xiaoke Chi, Justin Kale, Brian Leber, David W. Andrews

At the right distance: ER-mitochondria juxtaposition in cell life and death
Deborah Naon, Luca Scorrano

Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: Potential new target for cancer treatment
Edward F. Greenberg, Andrew R. Lavik, Clark W. Distelhorst

A dual role for the anti-apoptotic Bcl-2 protein in cancer: Mitochondria versus endoplasmic reticulum
Haidar Akl, Tamara Vervloessem, Santeri Kiviluoto, Mart Bittremieux, Jan B. Parys, Humbert De Smedt, Geert Bultynck

SnapShot: Necroptosis
Wen Zhou, Junying Yuan


Killing the Killer: PARC/CUL9 Promotes Cell Survival by Destroying Cytochrome c
Jonathan Lopez and Stephen W. G. Tait

Identifying the components of the elusive mitochondrial permeability transition pore
Jason Karch and Jeffery D. Molkentin

Live Free or Die: Cell-Cell Adhesion Regulates Sensitivity to Trail-Induced Apoptosis
Lisa L. Gallegos, Joan S. Brugge

Expression of FASL in the Tumor Endothelium Limits T-cell Infiltration

Apoptosis: DR5 unfolds ER stress