ApoList – June 2014

Bcl-2 family proteins

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak
Lisa M. Lindqvist, Melanie Heinlein, David C. S. Huang, and David L. Vaux

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
Erik Procko, Geoffrey Y. Berguig, Betty W. Shen, Yifan Song, Shani Frayo, Anthony J. Convertine, Daciana Margineantu, Garrett Booth, Bruno E. Correia, Yuanhua Cheng, William R. Schief, David M. Hockenbery, Oliver W. Press, Barry L. Stoddard, Patrick S. Stayton, David Baker

Bcl-2 binds to and inhibits ryanodine receptors
Tim Vervliet, Elke Decrock, Jordi Molgó, Vincenzo Sorrentino, Ludwig Missiaen, Luc Leybaert, Humbert De Smedt, Nael Nadif Kasri, Jan B. Parys,and Geert Bultynck

Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma
Vicente Fresquet, Melissa Rieger, Carlo Carolis, Maria J. García-Barchino, and Jose A. Martinez-Climent

Bcl-xL controls a switch between cell death modes during mitotic arrest
N Bah, L Maillet, J Ryan, S Dubreil, F Gautier, A Letai, P Juin and S Barillé-Nion

Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein
J Galindo-Moreno, R Iurlaro, N El Mjiyad, J Díez-Pérez, T Gabaldón and C Muñoz-Pinedo

APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction
Lixin Wan, Mingjia Tan, Jie Yang, Hiroyuki Inuzuka, Xiangpeng Dai, Tao Wu, Jia Liu, Shavali Shaik, Guoan Chen, Jing Deng, Marcos Malumbres, Anthony Letai, Marc W. Kirschner, Yi Sun, Wenyi Wei

LIN-35/Rb Causes Starvation-Induced Germ Cell Apoptosis via CED-9/Bcl2 Downregulation in Caenorhabditis elegans
L. I. Láscarez-Lagunas, C. G. Silva-García, T. D. Dinkova, and R. E. Navarro

Novel Polymeric Nanoparticles for Intracellular Delivery of Peptide Cargos: Antitumor Efficacy of the BCL-2 Conversion Peptide NuBCP-9
Manoj Kumar, Dikshi Gupta, Gurpal Singh, Sapna Sharma, Madhusudan Bhat, C.K. Prashant, A.K. Dinda, Surender Kharbanda, Donald Kufe, and Harpal Singh

Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection
Gundula Min-Oo, Natalie A. Bezman, Sharline Madera, Joseph C. Sun, and Lewis L. Lanier

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid
A Shamas-Din, D Satsoura, O Khan, W Zhu, B Leber, C Fradin and D W Andrews

Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis
B Wang, M Xie, R Li, T K Owonikoko, S S Ramalingam, F R Khuri, W J Curran, Y Wang and X Deng

Inhibition of PP2A Prevents Mcl-1 Dephosphorylation at the Thr-163/Ser-159 Phosphodegron, Dramatically Reducing Expression in Mcl-1-Amplified Lymphoma Cells
Shanna K. Nifoussi, Nora R. Ratcliffe, Deborah L. Ornstein, Gary Kasof, Stefan Strack, and Ruth W. Craig

Non-apoptotic cell death, IAPs

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
Monica Yabal, Nicole Müller, Heiko Adler, Nathalie Knies, Christina J. Groß, Rune Busk Damgaard, Hirokazu Kanegane, Marc Ringelhan, Thomas Kaufmann, Mathias Heikenwälder, Andreas Strasser, Olaf Groß, Jürgen Ruland, Christian Peschel, Mads Gyrd-Hansen, Philipp J. Jost

Autophagy and apoptosis: parent-of-origin genome-dependent mechanisms of cellular self-destruction
Grazyna E. Ptak, Paola Toschi, Antonella Fidanza, Marta Czernik, Federica Zacchini, Jacek A. Modlinski and Pasqualino Loi

A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy
W He, Q Wang, B Srinivasan, J Xu, M T Padilla, Z Li, X Wang, Y Liu, X Gou, H-M Shen, C Xing and Y Lin

Death receptor signaling

E-Cadherin Couples Death Receptors to the Cytoskeleton to Regulate Apoptosis
Min Lu, Scot Marsters, Xiaofen Ye, Elizabeth Luis, Lino Gonzalez, Avi Ashkenazi

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
Gregory T Motz, Stephen P Santoro, Li-Ping Wang, Tom Garrabrant, Ricardo R Lastra, Ian S Hagemann, Priti Lal, Michael D Feldman, Fabian Benencia & George Coukos

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis
Thomas Condamine, Vinit Kumar, Indu R. Ramachandran, Je-In Youn, Esteban Celis, Niklas Finnberg, Wafik S. El-Deiry, Rafael Winograd, Robert H. Vonderheide, Nickolas R. English, Stella C. Knight, Hideo Yagita, Judith C. McCaffrey, Scott Antonia, Neil Hockstein, Robert Witt, Gregory Masters, Thomas Bauer, Dmitry I. Gabrilovich

Role of ATF3 for ER Stress-induced Sensitization of p53-deficient Human Colon Cancer Cells to TRAIL-mediated Apoptosis Through Upregulation of DR5 by Zerumbone and Celecoxib
Makoto Edagawa, Junya Kawauchi, Manabu Hirata, Hiroto Goshima, Makoto Inoue, Tatsuro Okamoto, Akira Murakami, Yoshihiko Maehara, and Shigetaka Kitajima

Poly(ADP-Ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-Mediated Apoptosis by Enhancing Death Receptor Expression
X. Wei Meng, Brian D. Koh, Jin-San Zhang, Karen S. Flatten, Paula A. Schneider, Daniel D. Billadeau, Allan D. Hess, B. Douglas Smith, Judith E. Karp, and Scott H. Kaufmann

Loss of the death receptor CD95 (Fas) expression by dendritic cells protects from a chronic viral infection
Vineeth Varanasi, Aly Azeem Khan, and Alexander V. Chervonsky

FADD regulates thymocyte development at the β-selection checkpoint by modulating Notch signaling
X Zhang, X Dong, H Wang, J Li, B Yang, J Zhang and Z-C Hua

Caspases and downstream

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
Katsumori Segawa, Sachiko Kurata, Yuichi Yanagihashi, Thijn R. Brummelkamp, Fumihiko Matsuda, Shigekazu Nagata

A nonapoptotic role for CASP2/caspase 2: Modulation of autophagy
Meenakshi Tiwari, Lokendra K Sharma, Difernando Vanegas, Danielle A Callaway, Yidong Bai, James D Lechleiter and Brian Herman

The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35
Chan-Hee Kim, Donggi Paik, Florentina Rus, and Neal Silverman

Caspase-Activated DNase is necessary and sufficient for oligonucleosomal DNA breakdown, but not for chromatin disassembly during caspase-dependent apoptosis of LN-18 glioblastoma cells
Maria Sanchez-Osuna, Merce Garcia-Belinchon, Victoria Iglesias-Guimarais, Estel Gil-Guinon, Elisenda Casanelles, and Victor J. Yuste


Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae
Sandra Malmgren Hill, Xinxin Hao, Beidong Liu, Thomas Nyström

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress
Mridusmita Saikia, Raul Jobava, Marc Parisien, Andrea Putnam, Dawid Krokowski, Xing-Huang Gao, Bo-Jhih Guan, Yiyuan Yuan, Eckhard Jankowsky, Zhaoyang Feng, Guo-fu Hu, Marianne Pusztai-Carey, Madhavi Gorla, Naresh Babu V. Sepuri, Tao Pan, and Maria Hatzoglou

RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis
W Chen, Q Wang, L Bai, W Chen, X Wang, C S Tellez, S Leng, M T Padilla, T Nyunoya, S A Belinsky and Y Lin

Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo
Xing Guo, Hiromi Sesaki and Xin Qi

Reviews / Comments

A cell death avenue evolved from a life-saving path
Harm H. Kampinga

Designer Proteins to Trigger Cell Death
Wayne J. Fairbrother, Avi Ashkenazi

Yeast Metacaspase: Grim Reaper or Savior?

More than apoptosis: Bcl-2 at ryanodine receptor channels