ApoList – January 2014


Bcl-2 family proteins

Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD
Alfredo Giménez-Cassina, Luisa Garcia-Haro, Cheol Soo Choi, Mayowa A. Osundiji, Elizabeth A. Lane, Hu Huang, Muhammed A. Yildirim, Benjamin Szlyk, Jill K. Fisher, Klaudia Polak, Elaura Patton, Jessica Wiwczar, Marina Godes, Dae Ho Lee, Kirsten Robertson, Sheene Kim, Ameya Kulkarni, Alberto Distefano, Varman Samuel, Gary Cline, Young-Bum Kim, Gerald I. Shulman, Nika N. Danial

Increased leukocyte survival and accelerated onset of lymphoma in absence of MCL-1 S159-phosphorylation
Lindner SE, Wissler M, Gründer A, Aumann K, Ottina E, Peintner L, Brauns-Schubert P, Preiss F, Herzog S, Borner C, Charvet C, Villunger A, Pahl HL, Maurer U.

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
Gemma L. Kelly, Stephanie Grabow, Stefan P. Glaser, Leah Fitzsimmons, Brandon J. Aubrey, Toru Okamoto, Liz J. Valente, Mikara Robati, Lin Tai, W. Douglas Fairlie, Erinna F. Lee, Mikael S. Lindstrom, Klas G. Wiman, David C.S. Huang, Philippe Bouillet, Martin Rowe, Alan B. Rickinson, Marco J. Herold, and Andreas Strasser

mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1
Anthony C. Faber, Erin M. Coffee, Carlotta Costa, Anahita Dastur, Hiromichi Ebi, Aaron N. Hata, Alan T. Yeo, Elena J. Edelman, Youngchul Song, Ah Ting Tam, Jessica L. Boisvert, Randy J. Milano, Jatin Roper, David P. Kodack, Rakesh K. Jain, Ryan B. Corcoran, Miguel N. Rivera, Sridhar Ramaswamy, Kenneth E. Hung, Cyril H. Benes, and Jeffrey A. Engelman

The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA
Ryan Soderquist , Alexandre A. Pletnev , Alexey V. Danilov & Alan Eastman

MiR-98 is involved in rat embryo implantation by targeting Bcl-xl
Hong-Fei Xia, Xiao-Hua Jin, Zong-Fu Cao, Tian Shi, Xu Ma

Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase
Maohua Xie, Yun Yen, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri, Walter J. Curran, Paul W. Doetsch, and Xingming Deng

Caspase-8 and FLIP

A Novel Mitochondrial MAVS/Caspase-8 Platform Links RNA Virus-Induced Innate Antiviral Signaling to Bax/Bak-Independent Apoptosis.
El Maadidi S, Faletti L, Berg B, Wenzl C, Wieland K, Chen ZJ, Maurer U, Borner C.

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes.
Prajwal Gurung, Paras K Anand, R K Subbarao Malireddi, Lieselotte Vande Walle, Nina Van Opdenbosch, Christopher P Dillon, Ricardo Weinlich, Douglas R Green, Mohamed Lamkanfi, Thirumala-Devi Kanneganti

C-terminal domain of c-FLIPL inhibits the interaction of caspase-8 prodomain with RIP1 death domain and regulates caspase-8-dependent NF-κB activation
Iyo Matsuda, Kentaro Matsuo, Yuka Matsushita, Yasushi Haruna, Masamitsu Niwa, and Takao Kataoka

Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
J S Riley, R Hutchinson, D G McArt, N Crawford, C Holohan, I Paul, S Van Schaeybroeck, M Salto-Tellez, P G Johnston, D A Fennell, K Gately, K O’Byrne, R Cummins, E Kay, P Hamilton, I Stasik and D B Longley

Involvement of caspase-8 and c-FLIPL in proangiogenic effects of the Tumor Necrosis Factor Related Apoptosis Inducing Ligand
Giuseppina Cantarella, Giulia Di Benedetto, Domenico Ribatti, Gloria Saccani-Jotti and Renato Bernardini

Caspases and IAPs

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome
C Manzl, L L Fava, G Krumschnabel, L Peintner, M C Tanzer, C Soratroi, F J Bock, F Schuler, B Luef, S Geley and A Villunger

Cellular Inhibitor of Apoptosis Protein cIAP2 Protects against Pulmonary Tissue Necrosis during Influenza Virus Infection to Promote Host Survival
Ian Gaël Rodrigue-Gervais, Katherine Labbé, Maryse Dagenais, Jeremy Dupaul-Chicoine, Claudia Champagne, Alexandre Morizot, Alexander Skeldon, Erik L. Brincks, Silvia M. Vidal, Thomas S. Griffith, Maya Saleh

Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death
H Vakifahmetoglu-Norberg, E Norberg, A B Perdomo, M Olsson, F Ciccosanti, S Orrenius, G M Fimia, M Piacentini and B Zhivotovsky

Reduced cellular Ca2 + availability enhances TDP-43 cleavage by apoptotic caspases
Giovanni De Marco, Annarosa Lomartire, Giorgia Mandili, Elisa Lupino, Barbara Buccinnà, Cristina Ramondetti, Cristina Moglia, Francesco Novelli, Marco Piccinini, Michael Mostert, Maria Teresa Rinaudo, Adriano Chiò, Andrea Calvo

Amyloid β binds procaspase-9 to inhibit assembly of Apaf-1 apoptosome and intrinsic apoptosis pathway
Md. Golam Sharoar, Md. Imamul Islam, Md. Shahnawaz, Song Yub Shin, Il-Seon Park

Receptor-interacting protein 1 increases chemoresistance by maintaining inhibitor of apoptosis protein levels and reducing reactive oxygen species through a microRNA-146a-mediated catalase pathway
Qiong Wang, Wenshu Chen, Lang Bai, Wenjie Chen, Mabel T. Padilla, Amy S. Lin, Shaoqing Shi, Xia Wang, and Yong Lin

Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice
Ian E. Gentle, Isabel Moelter, Nadja Lechler, Sarah Bambach, Smiljka Vucikuja, Georg Häcker, and Peter Aichele

Death Receptor pathway

Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus
Crystal M. H. Randall, Sunetra Biswas, Catherine V. Selen, and Joanna L. Shisler

Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment
Rui Hu, Qiumei Du, Xiangyun Yin, Jingyun Li, Tingting Wang, Liguo Zhang

Epigenetic regulation of microRNA-128a expression contributes to the apoptosis-resistance of human T-cell leukaemia Jurkat cells by modulating expression of Fas-associated protein with death domain (FADD)
Nami Yamada, Shunsuke Noguchi, Minami Kumazaki, Haruka Shinohara, Kohei Miki, Tomoki Naoe, Yukihiro Akao

Self-renewal and Differentiation of Muscle Satellite Cells is Regulated by Fas-associated Death Domain
Wei Cheng, Lu Wang, Bingya Yang, Rong Zhang, Chun Yao, Liangqiang He, Zexu Liu, Pan Du, Kahina Hammache, Juan Wen, Huang Li, Qiang Xu, and Zichun Hua

TNF/TNF-R1 pathway is involved in doxorubicin-induced acute sterile inflammation
A Kaczmarek, O Krysko, L Heyndrickx, T Løve Aaes, T Delvaeye, C Bachert, L Leybaert, P Vandenabeele and D V Krysko

TRAIL-coated leukocytes that kill cancer cells in the circulation
Michael J. Mitchell, Elizabeth Wayne, Kuldeepsinh Rana, Chris B. Schaffer, and Michael R. King

Non-apoptotic cell death

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis
Q Remijsen, V Goossens, S Grootjans, C Van den Haute, N Vanlangenakker, Y Dondelinger, R Roelandt, I Bruggeman, A Goncalves, M J M Bertrand, V Baekelandt, N Takahashi, T V Berghe and P Vandenabeele

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
Gilad Doitsh, Nicole L. K. Galloway, Xin Geng,  Zhiyuan Yang,  Kathryn M. Monroe,  Orlando Zepeda, Peter W. Hunt, Hiroyu Hatano, Stefanie Sowinski, Isa Muñoz-Arias & Warner C. Greene

Regulation of Ferroptotic Cancer Cell Death by GPX4
Wan Seok Yang, Rohitha SriRamaratnam, Matthew E. Welsch, Kenichi Shimada, Rachid Skouta, Vasanthi S. Viswanathan, Jaime H. Cheah, Paul A. Clemons, Alykhan F. Shamji, Clary B. Clish, Lewis M. Brown, Albert W. Girotti, Virginia W. Cornish, Stuart L. Schreiber, Brent R. Stockwell

Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis
David N. Douda, Lily Yip, Meraj A. Khan, Hartmut Grasemann, and Nades Palaniyar


Altered mitochondria morphology and cell metabolism in apaf1-deficient cells.
Mónica Sancho, Anna Gortat, Andrés E Herrera, Vicente Andreu-Fernández, Elisabetta Ferraro, Francesco Cecconi, Mar Orzáez, Enrique Pérez-Payá

A high-throughput image-based screen for the identification of Bax/Bak-independent caspase activators against drug-resistant cancer cells
Mahendra Seervi , Praveen K. Sobhan , Krupa Ann Mathew , Jeena Joseph , Prakash Rajappan Pillai & T. R. Santhoshkumar

Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis
Fikadu G. Tafesse, Ana M. Vacaru, Elleke F. Bosma, Martin Hermansson, Amrita Jain, Angelika Hilderink, Pentti Somerharju, and Joost C. M. Holthuis

Perturbation of apoptosis upon binding of tRNA to the heme domain of cytochrome c
Madhavi Gorla & Naresh Babu V. Sepuri

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
James M. Murphy, Isabelle S. Lucet, Joanne M. Hildebrand, Maria C. Tanzer, Samuel N. Young, Pooja Sharma, Guillaume Lessene, Warren S. Alexander, Jeffrey J. Babon, John Silke and Peter E. Czabotar

The BCL-2 database, Act 2: moving beyond dualism to diversity and pleiotropy
A Aouacheria


The apoptotic pore on mitochondria: are we breaking through or still stuck?
C Borner and D W Andrews

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis
D Westphal, R M Kluck and G Dewson

Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways
M E Delgado, L Dyck, M A Laussmann and M Rehm

The rheostat in the membrane: BCL-2 family proteins and apoptosis
N Volkmann, F M Marassi, D D Newmeyer and D Hanein

Role of caspase-8 in thymus function
N Pozzesi, A Fierabracci, A M Liberati, M P Martelli, E Ayroldi, C Riccardi and D V Delfino

Viral modulation of programmed necrosis.
Kaiser WJ, Upton JW, Mocarski ES.

Strange attractors: DAMPs and autophagy link tumor cell death and immunity
W Hou, Q Zhang, Z Yan, R Chen, H J Zeh III, R Kang, M T Lotze and D Tang

The role of iron and reactive oxygen species in cell death
Scott J Dixon  & Brent R Stockwell

Apoptosis journal: Special issue
The Universe of DAPK

Comments / other

Caspase-3 and RasGAP: a stress-sensing survival/demise switch
Hadi Khalil, Mathieu J.M. Bertrand, Peter Vandenabeele, Christian Widmann

Is BMF central for anoikis and autophagy?
Monica Delgado and Yohannes Tesfaigzi

TRAIL-Blazing Therapy Against Circulating Tumor Cells
Edward Kai-Hua Chow

Life or Death Decisions
The abundance of a phosphatase that targets a death receptor determines whether autophagy protects cells against apoptosis.