ApoList – December 2013

Bcl-2 family

Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance
Haiming Dai, Husheng Ding, X. Wei Meng, Sun-Hee Lee, Paula A. Schneider, and Scott H. Kaufmann

Organization of the Mitochondrial Apoptotic BAK Pore: Oligomerization of the BAK Homodimers
Sreevidya Aluvila, Tirtha Mandal, Eric Hustedt, Peter Fajer, Jun Yong Choe, and Kyoung Joon Oh

Placental autophagy regulation by the BOK-MCL1 rheostat
Manpreet Kalkat, Julia Garcia, Jessica Ebrahimi, Megan Melland-Smith, Tullia Todros, Martin Post and Isabella Caniggia

Interaction of Bcl-2 with the Autophagy-Related Protein GABARAP — Biophysical Characterization and Functional Implications
Peixiang Ma, Melanie Schwarten, Lars Schneider, Alexandra Boeske, Nadine Henke, Dmitrij Lisak, Stephan Weber, Jeannine Mohrl?der, Matthias Stoldt, Birgit Strodel, Axel Methner, Silke Hoffmann, Oliver H. Weiergr?ber, and Dieter Willbold


Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Zhenyu Cai, Siriporn Jitkaew, Jie Zhao, Hsueh-Cheng Chiang, Swati Choksi, Jie Liu, Yvona Ward, Ling-gang Wu & Zheng-Gang Liu

Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis
Thomas McQuade, YoungSik Cho and Francis Ka‑Ming Chan


Autosis is a Na+,K+-ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia
Yang Liu, Sanae Shoji-Kawata, Rhea M. Sumpter, Jr., Yongjie Wei, Vanessa Ginet, Liying Zhang, Bruce Posner, Khoa A. Tran, Douglas R. Green, Ramnik J. Xavier, Stanley Y. Shaw, Peter G. H. Clarke, Julien Puyal, and Beth Levine

Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation
Bogeon Yun, HeeJung Lee, Moumita Ghosh, Benjamin F. Cravatt, Ku-Lung Hsu, Joseph V. Bonventre, Heather Ewing, Michael H. Gelb, and Christina C. Leslie

Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction
Chen-Tsung Huang, Duen-Yi Huang, Chaur-Jong Hu, Dean Wu, Wan-Wan Lin

Death receptor pathway

Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1
Jacob M. Gump, Leah Staskiewicz, Michael J. Morgan, Alison Bamberg, David W. H. Riches & Andrew Thorburn

Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment
Rui Hu, Qiumei Du, Xiangyun Yin, Jingyun Li, Tingting Wang, Liguo Zhang


Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice
Joseph Puccini, Sonia Shalini, Anne K. Voss, Magtouf Gatei, Claire H. Wilson, Devendra K. Hiwase, Martin F. Lavin, Loretta Dorstyn, and Sharad Kumar

Lysosomal exocytosis and caspase-8-mediated apoptosis in UVA-irradiated keratinocytes
Hanna Appelqvist, Petra Wäster, Ida Eriksson, Inger Rosdahl, and Karin Öllinger

A complex between Atg7 and caspase-9: a novel mechanism of cross-regulation between autophagy and apoptosis
Jie Han, Wen Hou, Leslie A. Goldstein, Donna B. Stolz, Simon C. Watkins, and Hannah Rabinowich

Inhibition of caspases protects mice from radiation induced oral mucositis and abolishes the cleavage of RNA binding protein HuR
Sudha Talwar, Reniqua House, Santhanalakshmi Sundaramurthy, Sundaravadivel Balasubramanian, Hong Yu, and Viswanathan Palanisamy

PLGA-Carbon Nanotube Conjugates for Intercellular Delivery of Caspase-3 into Osteosarcoma Cells
Qingsu Cheng, Marc-Olivier Blais, Greg Harris, Ehsan Jabbarzadeh


Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells
Keiko Nonomura, Yoshifumi Yamaguchi, Misato Hamachi, Masato Koike, Yasuo Uchiyama, Kenichi Nakazato, Atsushi Mochizuki, Asako Sakaue-Sawano, Atsushi Miyawaki, Hiroki Yoshida, Keisuke Kuida, Masayuki Miura

CDK7 Regulates the Mitochondrial Localization of a Tail-Anchored Proapoptotic Protein, Hid
Jun Morishita, Min-Ji Kang, Kevin Fidelin, Hyung Don Ryoo

Autophagy activity contributes to programmed cell death in Caenorhabditis elegans
Haibin Wang, Qun Lu, Shiya Cheng, Xiaochen Wang and Hong Zhang

Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death
S Kook, X Zhan, W M Cleghorn, J L Benovic, V V Gurevich and E V Gurevich

Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs
H A King, L C Cobbold, X Pichon, T Pöyry, L A Wilson, H Booden, R Jukes-Jones, K Cain, K S Lilley, M Bushell and A E Willis

A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death
Raul E. Salinas, Cassandra Ogohara, Monica I. Thomas, Kajal P. Shukla, Samuel I. Miller, and Dennis C. Ko


Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Peter E. Czabotar, Guillaume Lessene, Andreas Strasser & Jerry M. Adams

Concepts of tissue injury and cell death in inflammation: a historical perspective
David Wallach, Tae-Bong Kang & Andrew Kovalenko

Special issue of CDD on immunogenic cell death:
– Killing cancer cells, twice with one shot
M E Bianchi
More reviews and primary papers in the same issue:
– Molecular mechanisms of natural killer cell activation in response to cellular stress
C J Chan, M J Smyth and L Martinet
– Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer
L Bracci, G Schiavoni, A Sistigu and F Belardelli
– Danger signalling during cancer cell death: origins, plasticity and regulation
A D Garg, S Martin, J Golab and P Agostinis
– Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments
H Inoue and K Tani


Autophagy chews Fap to promote apoptosis
Sanket Joshi and Kevin M. Ryan

Dying from within: granzyme B converts entosis to emperitosis
G S Salvesen

Cell death: E2Ffects on mitochondria

Life without the mitochondrial calcium uniporter
[and cell death]
Sebastien Herzig, Kinsey Maundrell and Jean-Claude Martinou