ApoList – November 2013

Non apoptotic cell death

Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis
Stephen W.G. Tait, Andrew Oberst, Giovanni Quarato, Sandra Milasta, Martina Haller, Ruoning Wang, Maria Karvela, Gabriel Ichim, Nader Yatim, Matthew L. Albert, Grahame Kidd, Randall Wakefield, Sharon Frase, Stefan Krautwald, Andreas Linkermann, Douglas R. Green

mTOR regulates phagosome and entotic vacuole fission
Matej Krajcovic, Shefali Krishna, Leila Akkari, Johanna A. Joyce, and Michael Overholtzer

Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase
Tina I. Lam, Angela M. Brennan-Minnella, Seok Joon Won, Yiguo Shen, Colleen Hefner, Yejie Shi, Dandan Sun, and Raymond A. Swanson

Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex
Melissa A. Farrow, Nicole M. Chumbler, Lynne A. Lapierre, Jeffrey L. Franklin, Stacey A. Rutherford, James R. Goldenring, and D. Borden Lacy

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson’s disease
Sabrina Büttner, Lukas Habernig, Filomena Broeskamp, Doris Ruli, F Nora Vögtle, Manolis Vlachos, Francesca Macchi, Victoria Küttner, Didac Carmona-Gutierrez, Tobias Eisenberg, Julia Ring, Maria Markaki, Asli Aras Taskin, Stefan Benke, Christoph Ruckenstuhl, Ralf Braun, Chris Van den Haute, Tine Bammens, Anke van der Perren, Kai-Uwe Fröhlich, Joris Winderickx, Guido Kroemer, Veerle Baekelandt, Nektarios Tavernarakis, Gabor G Kovacs, Jörn Dengjel, Chris Meisinger, Stephan J Sigrist and Frank Madeo

Bcl-2 family proteins

BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis
Kathrin Weber, Nicholas Harper, John Schwabe, Gerald M. Cohen

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors
Michaela Waibel, Vanessa S. Solomon, Deborah A. Knight, Rachael A. Ralli, Sang-Kyu Kim, Kellie-Marie Banks, Eva Vidacs, Clemence Virely, Keith C.S. Sia, Lauryn S. Bracken, Racquel Collins-Underwood, Christina Drenberg, Laura B. Ramsey, Sara C. Meyer, Megumi Takiguchi, Ross A. Dickins, Ross Levine, Jacques Ghysdael, Mark A. Dawson, Richard B. Lock, Charles G. Mullighan, Ricky W. Johnstone

Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B
B van de Kooij, R W Rooswinkel, F Kok, M Herrebout, E de Vries, M Paauwe, G M C Janssen, P A van Veelen and J Borst

Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death
J M Eichhorn, N Sakurikar, S E Alford, R Chu and T C Chambers

Purported Mcl-1 inhibitor marinopyrrole A fails to show selective cytotoxicity for Mcl-1-dependent cell lines
J M Eichhorn, S E Alford, C C Hughes, W Fenical and T C Chambers

Bortezomib antagonizes microtubule-interfering drug-induced apoptosis by inhibiting G2/M transition and MCL-1 degradation
F Rapino, I Naumann and S Fulda

BCL-XL Mediates the Strong Selective Advantage of a 20q11.21 Amplification Commonly Found in Human Embryonic Stem Cell Cultures
S. Avery, A.J. Hirst, D. Baker, C.Y. Lim, S. Alagaratnam, R.I. Skotheim, R.A. Lothe, M.F. Pera, A. Colman, P. Robson, P.W. Andrews, and B.B. Knowles

MCL-1ES Induces MCL-1L-Dependent BAX- and BAK-Independent Mitochondrial Apoptosis
Jae-Hong Kim, Jeehyeon Bae

HER2 Phosphorylates and Destabilizes Pro-Apoptotic PUMA, Leading to Antagonized Apoptosis in Cancer Cells
Richard L. Carpenter, Woody Han, Ivy Paw, Hui-Wen Lo

Evaluation of the BH3-Only Protein Puma as a Direct Bak Activator
Haiming Dai, Yuan-Ping Pang, Marina Ramirez-Alvarado, and Scott H. Kaufmann

Death receptor pathway

CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway inTriple-Negative Breast Cancer
Marine Malleter, Sébastien Tauzin, Alban Bessede, Rémy Castellano, Armelle Goubard, Florence Godey, Jean Levêque, Pascal Jézéquel, Loic Campion, Mario Campone, Thomas Ducret, Gaëtan MacGrogan, Laure Debure, Yves Collette, Pierre Vacher, and Patrick Legembre

Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation
Paolo Gallipoli, Francesca Pellicano, Heather Morrison, Kamilla Laidlaw, Elaine K. Allan, Ravi Bhatia, Mhairi Copland, Heather G. Jørgensen, and Tessa L. Holyoake

Ubiquitination-Deubiquitination by the TRIM27-USP7 Complex Regulates Tumor Necrosis Factor Alpha-Induced Apoptosis
Mohammad Mahabub-Uz Zaman, Teruaki Nomura, Tsuyoshi Takagi, Tomoo Okamura, Wanzhu Jin, Toshie Shinagawa, Yasunori Tanaka, and Shunsuke Ishii

Reduction of Decoy Receptor 3 Enhances TRAIL-Mediated Apoptosis in Pancreatic Cancer
Wei Wang, Mei Zhang, Weimin Sun, Shanmin Yang, Ying Su, Hengshan Zhang, Chaomei Liu, Xinfeng Li, Ling Lin, Sunghee Kim, Paul Okunieff, Zhenhuan Zhang, Lurong Zhang

Decreased affinity of rhTRAIL-D269H/E195R to OPG overcomes TRAIL-resistance mediated by the bone microenvironment
Matthieu C.J. Bosman, Carlos R. Reis, Jan J. Schuringa, Edo Vellenga, and Wim J. Quax

The c-FLIPL cleavage product p43FLIP promotes activation of ERK, NF-κB, caspase-8 and T cell survival
Andreas Koenig, Iwona A. Buskiewicz, Karen A. Fortner, Jennifer Q. Russell, Tomoko Asaoka, You-Wen He, Razqallah Hakem, John E. Eriksson, and Ralph C. Budd

Caspases and downstream / IAPs

Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization
Yu-Zen Chen, James Mapes, Eui-Seung Lee, Riley Robert Skeen-Gaar and Ding Xue

TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death
Dhanendra Tomar, Paresh Prajapati, Lakshmi Sripada, Kritarth Singh, Rochika Singh, Arun Kumar Singh, Rajesh Singh

The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8
Y Li, Y Kong, Z Zhou, H Chen, Z Wang, Y-C Hsieh, D Zhao, X Zhi, J Huang, J Zhang, H Li and C Chen

Expression and Activation of Caspase-6 in Human Fetal and Adult Tissues
Nelly Godefroy, Bénédicte Foveau, Steffen Albrecht, Cynthia G. Goodyer, Andréa C. LeBlanc

A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma
Ning Wang, Yibin Feng, Meifen Zhu, Fung-Ming Siu, Kwan-Ming Ng, Chi-Ming Che

Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis
I Eckhardt, S Roesler and S Fulda

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity
D Lecis, M De Cesare, P Perego, A Conti, E Corna, C Drago, P Seneci, H Walczak, M P Colombo, D Delia and S Sangaletti


Metabolic Activation of CaMKII by Coenzyme A
Francis McCoy, Rashid Darbandi, Hoi Chang Lee, Kavitha Bharatham, Tudor Moldoveanu, Christy R. Grace, Keela Dodd, Wenwei Lin, Si-Ing Chen, Rajendra P. Tangallapally, Manabu Kurokawa, Richard E. Lee, Anang A. Shelat, Taosheng Chen, Douglas R. Green, Robert A. Harris, Sue-Hwa Lin, Rafael A. Fissore, Roger J. Colbran, Leta K. Nutt

Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from “liponecrosis”, a previously unknown form of programmed cell death
Sara Sheibani, Vincent R Richard, Adam Beach, Anna Leonov, Rachel Feldman, Leila Khelghatybana, Amanda Piano, Michael Greenwood, Hojatollah Vali and Vladimir I Titorenko

Programmed Cell Senescence during Mammalian Embryonic Development
Daniel Muñoz-Espín, Marta Cañamero, Antonio Maraver, Gonzalo Gómez-López, Julio Contreras, Silvia Murillo-Cuesta, Alfonso Rodríguez-Baeza, Isabel Varela-Nieto, Jesús Ruberte, Manuel Collado, Manuel Serrano

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
Mekayla Storer, Alba Mas, Alexandre Robert-Moreno, Matteo Pecoraro, M. Carmen Ortells, Valeria Di Giacomo, Reut Yosef, Noam Pilpel, Valery Krizhanovsky, James Sharpe, William M. Keyes

Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors.
Adriana Aporta, Elena Catalán, Patricia Galán-Malo, Ariel Ramírez-Labrada, Marta Pérez, Gemma Azaceta, Luis Palomera, Javier Naval, Isabel Marzo, Julián Pardo, Alberto Anel


Mitochondria: gatekeepers of response to chemotherapy
Kristopher A. Sarosiek, Triona Ni Chonghaile, Anthony Letai

On the TRAIL of obesity and diabetes
Hanis H. Harith, Margaret J. Morris, Mary M. Kavurma

Structural biology of the Bcl-2 family and its mimicry by viral proteins
M Kvansakul and M G Hinds

Evading apoptosis in cancer
Kaleigh Fernald, Manabu Kurokawa

Developmentally programmed cell death in Drosophila
Donna Denton, May T. Aung-Htut, Sharad Kumar

When ER stress reaches a dead end
Hery Urra, Estefanie Dufey, Fernanda Lisbona, Diego Rojas-Rivera, Claudio Hetz

Crosstalk between apoptosis, necrosis and autophagy
Vassiliki Nikoletopoulou, Maria Markaki, Konstantinos Palikaras, Nektarios Tavernarakis

ER stress-induced cell death mechanisms
Renata Sano, John C. Reed

Cell death by cornification
Leopold Eckhart, Saskia Lippens, Erwin Tschachler, Wim Declercq

Anoikis molecular pathways and its role in cancer progression
Paolo Paoli, Elisa Giannoni, Paola Chiarugi

Mitosis and apoptosis: how is the balance set?
Caroline H Topham, Stephen S Taylor


Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location?
Marion C Hogg and Jochen H M Prehn

BH3-only proteins, Bmf and Bim, in autophagy
Monica Delgado and Yohannes Tesfaigzi

MCL1 is critical for mitochondrial function and autophagy in the heart
Robert L Thomas and Åsa B Gustafsson

Proapoptotic BH3-Only Proteins Have Different Activation Preferences



ApoList – October 2013

Death receptors, necroptosis

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis.
Ricardo Weinlich, Andrew Oberst, Christopher P Dillon, Laura J Janke, Sandra Milasta, John R Lukens, Diego A Rodriguez, Prajwal Gurung, Chandra Savage, Thirumala D Kanneganti, Douglas R Green

cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis
Diana Panayotova-Dimitrova, Maria Feoktistova, Michaela Ploesser, Beate Kellert, Mike Hupe, Sebastian Horn, Roman Makarov, Federico Jensen, Stefan Porubsky, Astrid Schmieder, Ana Claudia Zenclussen, Alexander Marx, Andreas Kerstan, Peter Geserick, You-Wen He, Martin Leverkus

[… and the accompanying video]
Roles of C-FLIP and Caspase-8 in Adult Tissue Homeostasis

Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α
Shuo Yang, Bingwei Wang, Lisa S. Tang, Jakub Siednienko, John J. Callanan and Paul N. Moynagh

Activated Cdc42-Associated Kinase 1 (ACK1) is required for TRAIL Receptor Recruitment to Lipid Rafts and Induction of Cell Death
Emma Linderoth, Giulia Pilia, Nupam Mahajan, and Ingvar Ferby

Structural Insights into RIP3-Mediated Necroptotic Signaling
Tian Xie, Wei Peng, Chuangye Yan, Jianping Wu, Xinqi Gong, Yigong Shi

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor
Nima Etemadi, Jessica K. Holien, Diep Chau, Grant Dewson, James M. Murphy, Warren S. Alexander, Michael W. Parker, John Silke and Ueli Nachbur

Bcl-2 family proteins

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice
Ophélie Meynet, Barbara Zunino, Lina Happo, Ludivine A. Pradelli, Johanna Chiche, Marie A. Jacquin, Laura Mondragón, Jean-François Tanti, Bruno Taillan, Georges Garnier, Julie Reverso-Meinietti, Nicolas Mounier, Jean-François Michiels, Ewa M. Michalak, Michel Carles, Clare L. Scott, and Jean-Ehrland Ricci

Proapoptotic Bax and Bak form stable protein-permeable pores of tunable size
Stephanie Bleicken, Olatz Landeta, Ane Landajuela, Gorka Basañez, and Ana J. García-Sáez

Structural insights of tBid, the caspase-8 activated Bid, and its BH3 domain
Yu Wang and Nico Tjandra

BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells
Stephanie Beurlet, Nader Omidvar, Petra Gorombei, Patricia Krief, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe Leboeuf, Anne Janin, Maria-Elena Noguera, Florence Hervatin, Laure Sarda-Mantel, Marina Konopleva, Michael Andreeff, Andrea W. Tu, Alice C. Fan, Dean W. Felsher, Anthony Whetton, Marika Pla, Robert West, Pierre Fenaux, Christine Chomienne, and Rose Ann Padua

Evaluation and critical assessment of putative MCL-1 inhibitors
S Varadarajan, M Vogler, M Butterworth, D Dinsdale, L D Walensky and G M Cohen

Pan-mTOR inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by downregulating Mcl-1
Ellen Preuss, Manuela Hugle, Romy Reimann, Marcel Schlecht, and Simone Fulda

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein
Marco J Herold, Leona Rohrbeck, Mathias J Lang, Raelene Grumont, Steve Gerondakis, Lin Tai, Philippe Bouillet, Thomas Kaufmann and Andreas Strasser

Beyond Cell Death – Antiapoptotic Bcl-2 Proteins Regulate Migration and Invasion of Colorectal Cancer Cells In Vitro
Bruno Christian Koehler, Anna-Lena Scherr, Stephan Lorenz, Toni Urbanik, Nicole Kautz, Christin Elssner, Stefan Welte, Justo Lorenzo Bermejo, Dirk Jäger, Henning Schulze-Bergkamen

BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis
Felix M. Wensveen , Christian R. Geest , Sten F. W. M. Libregts , Ingrid A. M. Derks , Paul G. Ekert , Verena Labi , Andreas Villunger , Martijn A. Nolte & Eric Eldering

Non-apoptotic cell death

Phagocytosis executes delayed neuronal death after focal brain ischemia
Jonas J. Neher, Julius V. Emmrich, Michael Fricker, Palwinder K. Mander, Clotilde Théry, and Guy C. Brown

p53 regulates a non-apoptotic death induced by ROS
J Montero, C Dutta, D van Bodegom, D Weinstock and A Letai


Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells
E Passante, M L Würstle, C T Hellwig, M Leverkus and M Rehm

p62/sequestosome-1 Upregulation Promotes ABT-263-induced Caspase-8 Aggregation/Activation on the Autophagosome
Shengbing Huang, Koichi Okamoto, Chunrong Yu, and Frank A. Sinicrope

Reviews / previews / other

TRAIL on trial: preclinical advances in cancer therapy
Daniel W. Stuckey and Khalid Shah

Current Understanding of the Mechanisms for Clearance of Apoptotic Cells—A Fine Balance
Lois A. Hawkins and Andrew Devitt

Diversity of cell death pathways: insight from the fly ovary
Victoria K. Jenkins, Allison K. Timmons, Kimberly McCall

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death
Dimitry Ofengeim & Junying Yuan

Seeking a MCL-1 inhibitor
G Brumatti and P G Ekert

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis
Yidan Wang, Isabelle Martins, Yuting Ma, Oliver Kepp, Lorenzo Galluzzi and Guido Kroemer

An appointment with death, cdd2013121e1jpg13K9726: 2013 Cold Spring Harbor Asia meeting ‘Mechanisms and Functions of Non-Apoptotic Cell Death’
J M Hildebrand, L Sun and J Silke