ApoList – August 2013

Bcl-2 family proteins


Assembly of the Bak apoptotic pore: A critical role for the Bak {alpha}6 helix in the multimerization of homodimers during apoptosis
Stephen Ma, Colin Hockings, Khatira Anwari, Tobias Kratina, Stephanie Fennell, Michael Lazarou, Michael T. Ryan, Ruth M. Kluck, and Grant Dewson

Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK
S G Katz, J K Fisher, M Correll, R T Bronson, K L Ligon and L D Walensky

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells
Wim Pierson, Bénédicte Cauwe, Antonia Policheni, Susan M Schlenner, Dean Franckaert, Julien Berges, Stephanie Humblet-Baron, Susann Schönefeldt, Marco J Herold, David Hildeman, Andreas Strasser, Philippe Bouillet, Li-Fan Lu, Patrick Matthys, Antonio A Freitas, Rita J Luther, Casey T Weaver, James Dooley, Daniel H D Gray & Adrian Liston

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia
Brian Koss, Jeffrey Morrison, Rhonda M. Perciavalle, Harpreet Singh, Jerold E. Rehg, Richard T. Williams, and Joseph T. Opferman

Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1
Arnim Weber , David Ausländer & Georg Häcker

Obesity Promotes Liver Carcinogenesis via Mcl-1 Stabilization Independent of IL-6Rα Signaling
Sabine Gruber, Beate K. Straub, P. Justus Ackermann, Claudia M. Wunderlich, Jan Mauer, Jens M. Seeger, Hildegard Büning, Lukas Heukamp, Hamid Kashkar, Peter Schirmacher, Jens C. Brüning, F. Thomas Wunderlich

Optimization and validation of mitochondria-based functional assay as a useful tool to identify BH3-like molecules selectively targeting anti-apoptotic Bcl-2 proteins
Long, Jianting; Liu, Liu; Nikolovska-Coleska, Zaneta; Shangary, Sanjeev; Yi, Han; Wang, Shenming; Wang, Shaomeng

Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish
Julien Prudent, Nikolay Popgeorgiev, Benjamin Bonneau, Julien Thibaut, Rudy Gadet, Jonathan Lopez, Philippe Gonzalo, Ruth Rimokh, Stephen Manon, Corinne Houart, Philippe Herbomel, Abdel Aouacheria and Germain Gillet 

Regulation of mammalian target of rapamycin complex 1 by Bcl-2 and Bcl-XL Huafei Zou, Yumei Lai, Xuwen Zhao, Gonghong Yan, Dongzhu Ma, Nayra Cardenes, Sruti Shiva, Yongjian Liu, Xiaochun Bai, Yong Jiang, and Yu Jiang

The Bcl-2 homology 3 (BH3)-only proteins Bim and Bid are functionally active and restrained by anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins in healthy liver
Takahiro Kodama, Hayato Hikita, Tsukasa Kawaguchi, Yoshinobu Saito, Satoshi Tanaka, Minoru Shigekawa, Satoshi Shimizu, Wei Li, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi, and Tetsuo Takehara

Death receptors

TNFα-induced lysosomal membrane permeability (LMP) is downstream of MOMP and triggered by caspase-mediated p75 cleavage and ROS formation.
Huai J, Vögtle FN, Jöckel L, Li Y, Kiefer T, Ricci JE, Borner C.

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
Shan Li, Li Zhang, Qing Yao, Lin Li,  Na Dong,  Jie Rong,  Wenqing Gao,  Xiaojun Ding, Liming Sun,  Xing Chen, She Chen  & Feng Shao

Fas signal promotes the immunosuppressive function of regulatory dendritic cells via ERK/{beta}-catenin pathway
Cheng Qian, Li Qian, Yizhi Yu, Huazhang An, Zhenhong Guo, Yanmei Han, Yongjian Chen, Yi Bai, Qingqing Wang, and Xuetao Cao

Caspases and IAPs


Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice
M J Parsons, L McCormick, L Janke, A Howard, L Bouchier-Hayes and D R Green

Caspase-dependent regulation of the ubiquitin–proteasome system through direct substrate targeting
Ting-Chun Yeh and Shawn B. Bratton

XIAP Regulates Caspase Activity in Degenerating Axons
Nicolas Unsain, Julia M. Higgins, Kristen N. Parker, Aaron D. Johnstone, Philip A. Barker

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity
Zaida G Ramirez-Ortiz, William F Pendergraft III, Amit Prasad, Michael H Byrne, Tal Iram, Christopher J Blanchette, Andrew D Luster, Nir Hacohen, Joseph El Khoury & Terry K Means

A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma
Ning Wang, Yibin Feng, Meifen Zhu, Fung-Ming Siu, Kwan-Ming Ng, Chi-Ming Che

XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling
The ubiquitin ligase XIAP, a major regulator of apoptosis, has an unexpected function as a repressor of autophagy by regulating the degradation of Mdm2 downstream of PI3K/Akt signalling, which contributes to XIAP’s tumorigenecity.
Xing Huang, Zhengsheng Wu, Yide Mei and Mian Wu

Non-apoptotic cell death


Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
F Basit, S Cristofanon and S Fulda

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
V Sagulenko, S J Thygesen, D P Sester, A Idris, J A Cridland, P R Vajjhala, T L Roberts, K Schroder, J E Vince, J M Hill, J Silke and K J Stacey

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis
O Susanto, S E Stewart, I Voskoboinik, D Brasacchio, M Hagn, S Ellis, S Asquith, K A Sedelies, P I Bird, N J Waterhouse and J A Trapani

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases
Roshan J. Thapa, Shoko Nogusa, Peirong Chen, Jenny L. Maki, Anthony Lerro, Mark Andrake, Glenn F. Rall, Alexei Degterev, and Siddharth Balachandran



Tango7 directs cellular remodeling by the Drosophila apoptosome
Alejandro D’Brot, Po Chen, Mahesh Vaishnav, Shujun Yuan, Christopher W. Akey, and John M. Abrams

Resilience of death: intrinsic disorder in proteins involved in the programmed cell death
Z Peng, B Xue, L Kurgan and V N Uversky

Structural and Functional Characterization of the Recombinant Death Domain from Death-Associated Protein Kinase
Evangelos Dioletis, Andrew J. Dingley, Paul C. Driscoll

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation
Mihael Vucur, Florian Reisinger, Jérémie Gautheron, Joern Janssen, Christoph Roderburg, David Vargas Cardenas, Karina Kreggenwinkel, Christiane Koppe, Linda Hammerich, Razq Hakem, Kristian Unger, Achim Weber, Nikolaus Gassler, Mark Luedde, Norbert Frey, Ulf Peter Neumann, Frank Tacke, Christian Trautwein, Mathias Heikenwalder, Tom Luedde



Caspase-2 as a tumour suppressor
J Puccini, L Dorstyn and S Kumar

Viral modulation of programmed necrosis.
Kaiser WJ, Upton JW, Mocarski ES.

RIP3: a molecular switch for necrosis and inflammation
Kenta Moriwaki and Francis Ka-Ming Chan

Various modes of cell death induced by DNA damage
O Surova and B Zhivotovsky

Previews / comments / other

Autophagic cell death RIPs into tumors
A Oberst

XIAP, a powerful repressor of apoptosis, promotes tumorigenesis through a previously uncharacterized function as inhibitor of autophagy by affecting Mdm2/p53 signalling.
Paola Merlo and Francesco Cecconi

dsDNA ASCs for caspase 8-mediated apoptosis
T Grabinger, P Peterburs and T Brunner

Interferon-induced necroptosis

Cell death: Balance through a bivalent regulator

Cycling to death, in the Tyrolean Alps
F J Bock, K Brinkmann, Y W Chan and L L Fava